-
Články
Top novinky
Reklama- Vzdělávání
- Časopisy
Top články
Nové číslo
- Témata
Top novinky
Reklama- Kongresy
- Videa
- Podcasty
Nové podcasty
Reklama- Kariéra
Doporučené pozice
Reklama- Praxe
Top novinky
ReklamaEffects of the Best Possible Self intervention: A systematic review and meta-analysis
Authors: Alba Carrillo aff001; María Rubio-Aparicio aff002; Guadalupe Molinari aff003; Ángel Enrique aff005; Julio Sánchez-Meca aff006; Rosa M. Baños aff001
Authors place of work: Department of Personality, Assessment and Psychological Treatments, University of Valencia, Valencia, Spain aff001; Department of Health Psychology, University of Alicante, Alicante, Spain aff002; Department of Basic, Clinical and Biological Psychology, University Jaume I, Castellón, Spain aff003; CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto Carlos III, Madrid, Spain aff004; School of Psychology, University of Dublin Trinity College, Dublin, Ireland aff005; Department of Basic Psychology and Methodology, University of Murcia, Murcia, Spain aff006
Published in the journal: PLoS ONE 14(9)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0222386Summary
The Best Possible Self (BPS) exercise promotes a positive view of oneself in the best possible future, after working hard towards it. Since the first work that attempted to examine the benefits of this intervention in 2001, studies on the BPS have grown exponentially and, currently, this is one of the most widely used Positive Psychology Interventions. However, little is yet known about its overall effectiveness in increasing wellbeing outcomes. Thus, the aim of this meta-analysis is to shed light on this question. A systematic literature search was conducted, and 29 studies (in 26 articles) met the inclusion criteria of empirically testing the intervention and comparing it to a control condition. In addition, BPS was compared to gratitude interventions in some of the included studies. A total of 2,909 participants were involved in the analyses. The outcome measures were wellbeing, optimism, depressive symptoms, and positive and negative affect. Results showed that the BPS is an effective intervention to improve wellbeing (d+ = .325), optimism (d+ = .334) and positive affect (d+ = .511) comparing to controls. Small effect sizes were obtained for negative affect and depressive symptoms. Moderator analyses did not show statistically significant results for wellbeing, except for a trend towards significance in the age of the participants (years) and the magnitude of the intervention (total minutes of practice). In addition, the BPS was found to be more beneficial for positive and negative affect than gratitude interventions (d+ = .326 and d+ = .485, respectively). These results indicate that the BPS can be considered a valuable Positive Psychology Intervention to improve clients’ wellbeing, and it seems that it might be more effective for older participants and with shorter practices (measured as total minutes of practice).
Keywords:
Database searching – depression – Undergraduates – Publication ethics – Test statistics – Gratitude – Happiness
Introduction
Since the beginning of the Positive Psychology movement, research on positive functioning and wellbeing has grown exponentially [1]. Many efforts have been made to develop and validate different Positive Psychology Interventions (PPIs), defined as interventions or intentional activities whose aim is to cultivate positive feelings, cognitions, and behaviors [2]. Several meta-analyses have shown that these interventions are, in general, effective in increasing wellbeing levels and decreasing depressive symptoms [2,3]. Specifically, the latest meta-analysis of the effectiveness of PPIs [3] revealed small to moderate effect sizes for wellbeing (d = .20 for psychological wellbeing and d = .34 for subjective wellbeing) [4]. These reviews provided very relevant data about the effectiveness of PPIs, but they included a wide range of interventions. Even though PPIs share the same aim, they are quite heterogeneous in their specific target (e.g. interventions that promote optimism, gratitude, or social connectedness), form (e.g. writing a gratitude letter or savoring the moment), and dosage (e.g. one single session or a 1-month program), and they are delivered through different procedures (e.g. individually or in groups, face-to-face or online). Therefore, their analyses and conclusions are rather generic and do not provide specific information about the effectiveness of a particular PPI. Thus, more precise reviews are needed to complement their results.
One widely used PPI is the “Best Possible Self” (BPS) intervention, which consists of writing about one’s best possible self in the future after everything has gone as well as it possibly could. The first study to use this paradigm compared its effectiveness to a disclosive writing condition about a traumatic event [5]. Results indicated that the BPS produced significant improvements in wellbeing at posttest, and it was rated as less upsetting than a trauma-writing exercise. Since the publication of this work, many studies have been carried out on the BPS using different approaches and delivery methods [6,7].
Due to the large number of studies on the BPS, some reviews have been performed. A recent meta-analysis of the effectiveness of interventions to increase optimism showed a moderate effect size (g = .41) for experimental conditions compared to controls on optimism levels [4,7]. This review included any intervention designed to improve optimism levels, comprising not only BPS studies but also other interventions. Moderator analyses showed that BPS was more effective (g = .64) than other interventions (g = .28) in increasing optimism levels. However, this review only addressed optimism as the outcome variable, and, therefore, it exclusively analyzed BPS studies that measured optimism (k = 10). Recently, a qualitative review of BPS interventions [6] concluded that the BPS is a recommended intervention to improve wellbeing, which is flexible in its delivery (i.e. online or face-to-face) and implementation (e.g. written or spoken). However, neither quantitative analyses of the effectiveness of the interventions nor evaluations of the quality of the studies were performed. Therefore, almost two decades after the first study on the BPS, little is known about the overall effectiveness of this intervention on wellbeing. A quantitative and systematic approach is needed to shed light on the effectiveness of this intervention and to analyze potential moderators that can influence its effectiveness.
Consequently, the aim of the present study is to conduct a meta-analysis of the effectiveness of the BPS intervention on wellbeing compared to controls. Potential moderators will be examined, as well as the methodological quality of the studies. Additionally, if there are enough studies with other experimental conditions equivalent to the BPS (i.e. another type of PPI), further comparisons of their effectiveness will be carried out.
Method
This meta-analysis was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines [8]. S1 Checklist presents the PRISMA 2009 Checklist.
Eligibility criteria
The inclusion criteria were:
Empirical test of the effects of the BPS intervention. A BPS intervention was defined as an exercise in which participants write about the best version of themselves in the future after everything has gone as well as possible [5,9,10]. Studies that included this intervention as part of a multi-component intervention but did not analyze the effects of the BPS separately, were excluded.
A minimum of two groups, one BPS condition and one control condition (whether active or waiting list). The active control conditions were defined as active neutral exercises not considered PPIs, such as writing about one’s daily activities.
At least one measure of wellbeing (e.g. wellbeing, satisfaction with life, positive affect, happiness), optimism, or depression, and two time points (before–pretest, and after the intervention–posttest).
Enough statistical data to perform the calculations of the standardized effect sizes (means and standards deviations of the different groups at pretest and posttest). If necessary, authors would be contacted to provide missing information.
Study written in English or Spanish.
Search strategy
A systematic literature search was carried out in the PsychInfo, ISI Web of Science, Cochrane, Scopus, and PubMed databases, including all the works published until November 2017 (when the search was conducted). In addition, this search was carried out in the databases of the main journals that commonly published works on PPIs: Journal of Positive Psychology, Journal of Happiness Studies, and Social Indicators Research. The terms used in the search were the two names used for the intervention in the initial study and later published studies: “Best Possible Self” and “Best Possible Selves”. Furthermore, systematic reviews of PPIs [2,3,6,7] and the references from the retrieved studies were revised, and experts in the field were consulted. Finally, a cited reference search for the initial work on the BPS by King [5] was carried out in the ISI Web of Science database, looking for all works that cited this original paper.
Outcome measures
In this meta-analysis, several outcome measures were included: wellbeing (which included measures of wellbeing, positive and negative affect, life satisfaction, or happiness), optimism (because the BPS intervention is a future-oriented positive activity that promotes a positive outlook on the future), and depressive symptoms.
For wellbeing, the most frequent scales used were the Positive and Negative Affect Schedule (PANAS) [11], the Satisfaction With Life Scale (SWLS) [12], the Brief Multidimensional Students’ Life Satisfaction Scale (BMSLSS) [13], the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) [14], and the Subjective Happiness Scale (SHS) [15]. Optimism was mainly measured with the Future Expectancies Scale (FEX) [16], the Life Orientation Test-Revised (LOT-R) [17], the Subjective Probability Task (SPT) [18], and the Attributional Style Questionnaire (ASQ) [19]. Finally, depression was measured by the Centre of Epidemiological Studies Depression Scale (CES-D) [20], the State-Trait-Anxiety-Depression Inventory (STADI) subscales of state euthymia (inverted), and state dysthymia [21], and the Beck Depression Inventory (BDI-II) [22].
Study selection criteria
Selection of studies was carried out independently by two reviewers (AC and GM). After duplicates were removed, the studies were screened by title and abstract. When at least one of the coders selected a study as potentially eligible, this study passed to the second phase. In this phase, the selected studies went through a full-text analysis by both reviewers. Inconsistencies between the coders were resolved by consensus.
Kappa coefficients (for the categorical variables) and intra-class correlations (for the continuous variables) were calculated to check the reliability of the coding process.
Coding of moderator variables
Extracted data were:
Delivery method of the intervention: information was collected about whether the exercise was applied individually (i.e. only one participant at a time) or in groups (i.e. more than one participant at a time in the same room), and face-to-face (e.g. if participants attended laboratory sessions or the exercise was applied in a room at the University) or online (i.e. if participants received the instructions through a webpage and did not physically attend a practice session).
Contextual aspects: whether participants received compensation for participating (in the form of money or University credits) as a reflection of the intrinsic motivation of participants.
Components of the intervention. The BPS is a PPI that requires participants to envision themselves in the future. However, not all studies have included explicit instructions to visualize the written content or a specific period of time to perform the visualization (e.g. 5 minutes). Therefore, the “imagery component” variable was coded as present if the study described an explicit method to implement this visualization in the practice of the exercise.
Duration of the intervention. Interventions in BPS studies have had different durations (e.g. one day or one month) and different practice intensities (e.g. daily practice or once a week). Consequently, three variables were coded in this area as potential moderators: length, intensity, and magnitude. Length refers to the total number of days that participants practiced the exercise (e.g. 7 days). Intensity refers to the number of minutes of practice per week (e.g. 20 minutes per week). Finally, magnitude refers to the total number of minutes of practice. When this information was not directly provided in the studies, it was calculated by the authors of this paper.
Population. Lately, some authors have highlighted the relevance of personal characteristics of participants who practice PPIs, pointing out the need to examine sociodemographic variables when assessing the efficacy of these activities [23]. Previous studies have shown that variables such as age, sex or country of origin play an important role on the effects produced by these activities (e.g. [24–27]). In this meta-analysis, the following data were collected: country of the study (later grouped by continent), target population (community or undergraduate students), age, percentage of women, and group sizes. The sample size in the studies was included as they might produce differences in the results (i.e. larger sample sizes could present greater heterogeneity among the participants in the sample).
Quality of the studies
The specific characteristics of each meta-analysis lead to elaborate precise items for assessing methodological quality of primary studies. In this case, the methodological quality of the included studies was assessed with a 9-item scale [28], based on items usually included in many of the quality scales and checklists proposed in the literature. In particular, the quality criteria used were mainly based on the PEDRO scale [29] and on the risk of bias items from the Cochrane Collaboration [30].
Each criterion was rated as 0 when the criterion was not met (or not reported), or 1 when the criterion was met. The following criteria were included: (1) randomized assignment of participants; (2) baseline comparability between experimental and control conditions (i.e., if groups were matched on pretest measures or whether there were no statistically significant differences between the groups at pretest on relevant variables); (3) baseline comparability between dropouts and completers (if there were no dropouts, this item was also coded as 1); (4) type of control group (active group coded as 1, and waiting list coded as 0); (5) concealment of assessors of the participants’ assigned condition; (6) standardized scales used to assess the outcome measures; (7) attrition rate ≤ 10%; (8) intention-to-treat analyses (if there were no dropouts, this item was also coded as 1); and (9) reporting bias (if all measures described in the method section were reported in the results section).
Computation of effect sizes
The effect size index was the standardized mean difference between the change scores of the BPS and control groups. This index, although scarcely used in practice, has the advantage of controlling for pretest differences between the groups, as well as for maturation, history, or testing effects from pretest to posttest [31,32]. For each study, this index was calculated by subtracting the mean pretest-posttest difference of the control group (y-pre,C and y-pos,C) from the mean pretest-posttest difference of the experimental group (y-pre,T and y-pos,T), and dividing this difference by the pooled standard deviation of both groups on the pretest (Spre), with c(m) being a correction factor for small sample sizes:
In general, the d index was calculated to compare the BPS and control groups. However, we found that 7 of the included studies contained a gratitude group in addition to a control group. That is, these studies included an extra group that practiced a PPI designed to increase or promote feelings of gratitude, such as writing down things that went well during the day or writing a letter of gratitude [33]. In these cases, the d index was also applied to compare the BPS and gratitude groups (independently of the d index that compared the BPS and control groups). Positive d values indicated a better result for BPS than for the control and gratitude groups.
In each study, a d index was calculated for each of the three different types of outcomes (wellbeing, optimism, and depression). The calculations of d indices for wellbeing encompassed measures of satisfaction with life, happiness, wellbeing, positive affect, and negative affect (this measure was inverted for the calculus of the wellbeing d index). Optimism was composed of measures of optimism and positive future expectancies. Regarding depression, only instruments that explicitly addressed depressive symptoms were included. Additionally, due to the large number of studies that applied the PANAS scale [11], two additional meta-analyses were carried out for the positive and negative affect outcomes measured with this instrument. Thus, two additional d indices were calculated in the studies that included the PANAS scale, one for positive affect and another for negative affect. Hence, the number of separate meta-analyses was increased to five, analyzing the effectiveness of the intervention for wellbeing, optimism, depression, positive affect, and negative affect.
When a study applied several measures of the same construct (e.g., two different scales of optimism), a d index was calculated for each measure. Then, in order to avoid dependence problems, they were averaged to represent the specific study, with a d value only for that type of outcome (optimism in the example). Separate meta-analyses were conducted for each type of outcome, and the individual studies did not necessarily have to include measures of all of them. For example, there were studies that only reported measures for wellbeing and optimism, but not for depression, and these studies contributed only to the corresponding meta-analyses.
Statistical analyses
Separate meta-analyses were carried out with the effect sizes for each of the five outcomes and for the comparison of the BPS with the control and gratitude groups.
In order to address the variability exhibited by the effect sizes, a random-effects model was assumed [34,35]. This model involves weighting each effect size by its inverse variance, defined as the sum of the within-study and between-studies variances. The between-studies variance was estimated using restricted maximum likelihood.
The interpretation of the clinical significance of the mean effect sizes obtained in this work was assessed by comparing them with the 25%, 50%, and 75% percentiles of the distribution of effect sizes obtained in a methodological review of 50 meta-analyses within the field of the effectiveness of clinical psychological interventions [31], which was considered as a representative means of interpreting the effect sizes of psychological interventions.
Several analyses were carried out in order to test whether publication bias could be a threat to the validity of the meta-analytic results. In particular, the Egger test was applied, and funnel plots were constructed with the trim-and-fill method [36]. The Egger test consists of constructing an unweighted simple regression, with the effect size as the dependent variable and the standard error of each effect size as the independent variable. A statistically non-significant result of the t-test for the hypothesis of an intercept equal to zero permits to discard publication bias.
Heterogeneity among the effect sizes was assessed with the Q statistic and the I2 index. I2 values of approximately 25%, 50%, and 75% can be considered to reflect low, moderate, and large heterogeneity, respectively [37].
Assuming a mixed-effects model, the influence of moderator variables on the effect sizes was calculated through ANOVAs and meta-regressions for the categorical and continuous variables, respectively [38,39]. The improved method proposed by Knapp and Hartung [40] was applied to test the statistical significance of each moderator variable. The F statistic makes it possible to test the statistical association between a moderator variable and the effect sizes, and the QE and QW statistics enable us to examine the model misspecification for the continuous and categorical moderators, respectively. Statistically significant results for the QE and QW indicate whether the ANOVAs and simple meta-regressions are misspecified, that is, whether other moderator variables could also affect the effect size variability. In addition, an estimate of the proportion of variance accounted for by the moderator variable was calculated by means of R2=1-τ^Res2/τ^Total2, with τ^Res2 and τ^Total2 being the residual and total heterogeneity variance estimates, respectively [41]. Following the recommendations of Aguinis, Gottfredson, and Wright [42] and Viechtbauer et al. [39], moderator analyses were applied only for outcome measures with at least 20 studies (i.e., wellbeing).
The statistical analyses were carried out with the metafor package in R [43].
Results
Coding reliability
To check the reliability of the coding process of the study characteristics, all studies were doubly coded by two independent coders (AC and GM). The results were highly satisfactory overall, with kappa coefficients ranging between .684 and 1.0 (M = .920) for qualitative characteristics, and intra-class correlations between .958 and 1.0 (M = .994) for the continuous variables. The inconsistencies between the coders were resolved by consensus.
Descriptive characteristics of the studies
The selection process is illustrated in Fig 1. First, 350 titles were retrieved from the databases, and 2 additional titles were retrieved by searching reference lists and consulting experts. After duplicates were removed, 236 records were screened, and 181 of them were excluded after reading the abstracts. Finally, 55 articles were selected as potentially eligible studies, of which 29 did not meet the inclusion criteria.
Fig. 1. Flow diagram. Main characteristics of the studies can be found in Table 1. One article included two studies [44], and two articles included BPS and control groups delivered through different methods, either writing or talking [45], or online or face-to-face [46]. These comparisons were treated as independent studies. One of the included studies was an unpublished dissertation [47], and one of them was a conference proceeding [48].
Tab. 1. Characteristics of the studies that examined the effects of the BPS intervention. The 26 selected articles (with 29 studies) included 2,909 participants (1,270 in BPS groups, 1,178 in control groups, and 461 in gratitude groups). The majority of them administered the interventions to University students (k = 20), some of them combined University students with the general population (k = 4), and only two studies were carried out completely in the general population (community). Participants’ mean age was 23.56 (range from 17.83 to 35.62), with a standard deviation of 4.53 (range from 1.12 to 13.99), and the mean percentage of women was 74.41% (range from 52.70 to 100). Regarding the components of the intervention, fifteen studies included an imagery component. Specifically, one included explicit instructions for the visualization [49], and fourteen specified a period of time in which participants should visualize their BPS after the writing period (generally, 5 minutes). The majority of the studies (k = 21) gave participants money or University credits as compensation for their participation (vs. no compensation for participating), four studies administered the intervention in small groups (vs. individually), and six through the Internet (vs. face-to-face). With regard to control conditions, only one study used a waiting list as a control group [49], whereas the remaining studies included an active control group that had to write about a neutral topic. Specifically, participants in the control conditions wrote about what they did in the past 24 hours, the past week, or on a typical day [10,16, 26,46,48,50–62], their plans for the coming week or the next day [5,45,63], the layout of a place where they had been earlier [64], early memories [47], a description of a book or a film [65], or a combination of neutral topics [66]. Moreover, seven studies included a gratitude group in addition to the control and BPS groups. Explicitly, four studies asked participants to write lists of things they were grateful for [47,49,53,63], and one study asked participants to write (but not to send) a letter of gratitude to another person who did something for them [61]. In all the included studies, the control and gratitude exercises were equal to the BPS condition in the delivery method, contextual aspects, components, duration, and population (except for the control condition in the study with the waiting list as a control group). The interventions lasted from 1 to 56 days (M = 14), with an intensity ranging from 10 to 75 minutes per week (M = 24), and a magnitude ranging from 20 to 170 minutes of practice in total (M = 45).
Regarding the assessed quality of the studies (see Table 2), scores of the included studies ranged from 4 to 8 on a scale from 0 to 9 (M = 6.58; SD = 1.35). None of the studies met all the quality criteria, and only one study reported concealment of the assessors. All the studies randomized the participants to each condition and used standardized scales. The majority of the studies (k = 28) presented the measures reported in the method section in the results section. Eighteen studies reported baseline comparability between dropouts and completers, and 22 studies reported baseline comparability between BPS and control groups. All studies except one used active control groups. Only half of the studies (15/29) used intention-to-treat analyses, and attrition rates were below 10% in 21 studies.
Tab. 2. Quality assessment per study. Mean effect size and heterogeneity
Table 3 presents the results of the effectiveness of the BPS comparing to control groups for wellbeing, positive affect, negative affect, optimism, and depression. The largest mean effect size was found for positive affect (d+ = .511), which can be considered a moderate effect size, followed by wellbeing (d+ = .325) and optimism (d+ = .334), which reflect medium magnitudes [31]. For negative affect and depression, the obtained effect sizes were considerably small (d+ = .192 and d+ = .115, respectively). Fig 2 presents a forest plot for wellbeing effect sizes, and S1 File presents forest plots for positive affect, negative affect, and optimism (Figs A, B and C in S1 File, respectively).
Tab. 3. Mean effect size, 95% confidence intervals, and heterogeneity statistics for the effectiveness of the BPS versus control group. Fig. 2. Forest plot displaying the effect sizes (and 95% confidence intervals) for wellbeing. Given the similarity of the activities performed in the control groups, which consisted on writing about a neutral topic (see descriptive characteristics of the studies), no further comparisons were performed between the active control groups. However, as mentioned above, all of the included studies compared the BPS to an active control group except for one study that compared the BPS exercise to a non-active control group (waiting list). This study reported effect sizes for wellbeing and positive and negative affect. When the only BPS-non-active control effect size was compared to the BPS-active control effect sizes, statistically significant differences were found for wellbeing, F(1, 27) = 9.07, p = .006 (BPS-active controls: d+ = 0.292, 95% CI [0.170, 0.414], k = 28; BPS-non-active control: d = 1.166, 95% CI [0.583, 1.749]). For positive affect, there were no statistically significant differences, F(1, 11) = 0.35, p = .565 (BPS-active controls: d+ = 0.534, 95% CI [0.258, 0.810], k = 12; BPS-non-active control: d = 0.284, 95% CI [-0.604, 1.171]). Finally, for negative affect, statistically significant differences were found, F(1, 11) = 262.12, p < .001 (BPS-active controls: d+ = -0.047, 95% CI [-0.145, 0.050], k = 12; BPS-non-active control: d = 3.013, 95% CI [2.608, 3.417]). As it can be seen, the average effect sizes for wellbeing and positive affect reported in Table 3 were very similar to those obtained for the BPS-active control comparison. However, for negative affect, the average BPS-active control effect size was practically null.
Table 4 presents the results of the comparison of the effectiveness of the BPS and gratitude interventions for wellbeing, positive affect, and negative affect. The largest mean effect sizes were found for positive affect (d+ = .326) and negative affect (d+ = .485), estimates that reflect medium and moderate magnitudes, respectively [31]. For wellbeing, the average effect size was null. Effect sizes presented great heterogeneity, with the Q statistics reaching statistical significance and the I2 indices above 60% in all cases.
Tab. 4. Mean effect size, 95% confidence intervals, and heterogeneity statistics for the effectiveness of the BPS versus gratitude interventions. Analysis of publication bias
For wellbeing, optimism and positive and negative affect outcomes, publication bias was assessed through Egger tests and funnel plots, applying the trim-and-fill method. In the case of depression, this was not possible due to the small number of studies.
For wellbeing, a non-significant result for the interception was obtained with the Egger test: t(27) = -1.067; p = .296. Fig 3 presents the funnel plot obtained with the original 29 standardized d indices. Applying the trim-and-fill method, no standardized mean change differences had to be imputed to achieve symmetry in the funnel plot.
Fig. 3. Funnel plot of the 29 standardized mean change difference indices for wellbeing. The effect sizes obtained for positive affect, negative affect, and optimism outcomes also exhibited a statistically non-significant result for the intercept (p = .206, p = .569, p = .526, respectively). S1 File presents the funnel plots for the standardized mean change difference indices for each of these outcomes. In particular, for positive and negative affect, the funnel plots were symmetric, and no additional indices had to be imputed (see Figs D and E in S1 File). With regard to optimism, by applying the trim-and-fill method, four additional standardized mean change difference estimates were imputed to the set of the original estimates to achieve symmetry in the funnel plot (see Fig F in S1 File). When a mean effect (and its 95% CI) was calculated with the 13 d indices plus the four imputed values, the average effect was d+ = 0.28 (95% CI [0.19,0.37]). If we compare the new effect to what was obtained with the 13 original d indices (d+ = 0.33; 95% CI [0.26, 0.42]), only slight differences were found. Therefore, the results obtained with the Egger test and the funnel plot obtained using the trim-and-fill method led us to discard publication bias as a threat to these meta-analytic results.
In addition, with the purpose of determining whether publication bias might be a problem of published research on this topic, publication bias methods were also applied by excluding unpublished effect sizes from the analyses. The results for funnel plots, Egger tests, and trim-and-fill method remained unchanged, with the exception of positive affect. In particular, the Egger test reached statistical significance when only published studies were included in the analysis (p = .041), leading to evidence of publication bias on this research topic when assessing positive affect.
Analysis of moderator variables
The results presented in Table 3 about the effectiveness of BPS in comparison with controls show the existence of a large amount of heterogeneity, according to the QW test (p < .001). Consequently, the influence of several characteristics related to the intervention, methodology, and participants was examined for wellbeing. Given that positive and negative affect were included in the overall wellbeing outcome, and that only a small number of studies included these constructs, optimism or depression, analyses of moderator variables were not carried out for these outcomes. Table 5 shows the results of the simple meta-regressions applied on continuous moderator variables. All the moderators analyzed revealed statistically non-significant moderating effects with the effect sizes (p > .05). However, it is worth noting that the magnitude of the intervention, measured in total minutes of practice, and the mean age (in years) of participants presented marginally statistically significant results, as well as percentages of explained variance above 15% (see Table 5). Specifically, the magnitude of the intervention presented a marginal association with the effect sizes (p = .078), with 25% of the variance accounted for, and the mean age showed a marginal association with the effect sizes (p = .079), accounting for the 15% of the variance.
Tab. 5. Results of the simple meta-regressions of continuous moderator variables on the effect sizes for wellbeing. Table 6 presents weighted ANOVAs for the analysis of categorical moderator variables. Of the different moderators analyzed, only the continent where the study was conducted showed a statistically significant result (p = .029), accounting for a large percentage of the variance (35%). As it can be seen, the largest mean effect size was yielded by the only study carried out in Oceania (d+ = 1.166), which was also the only study with a non-active control group, whereas the mean effect sizes for the remaining continents were very similar. In fact, when these analyses were repeated without the Oceania study, this moderator did not reach a statistical association with the effect sizes (p = .449).
Tab. 6. Results of the weighted ANOVAs of categorical moderator variables on the effect sizes for wellbeing. Discussion
This is the first meta-analysis to examine the effectiveness of the Best Possible Self intervention, compared to controls, on wellbeing and other related outcomes. It included 26 articles (with 29 studies) and a total of 2,909 participants. Medium to moderate effect sizes were found for wellbeing, optimism, and positive affect, whereas the effects sizes found for negative affect and depressive symptoms were considerably small [31,67]. The effect sizes obtained for wellbeing (d+ = 0.325) in this work are lower than the effect sizes found in the meta-analyses of PPIs conducted by Sin and Lyubomirsky [2] (d = 0.61), but more similar that the ones found in the meta-analysis conducted by Bolier and colleagues [3], being greater in the case of psychological wellbeing (d = .20) and slightly smaller (but almost equal) in the case of subjective wellbeing (d = .34). These meta-analyses showed that PPIs (regardless of the specific type of PPI) produced medium to moderate effects on wellbeing [31], and similar results were found in this work on the effectiveness of the BPS intervention.
Moderator analyses of the quantitative variables did not show any significant moderating effects on wellbeing outcomes. However, in light of the large number of studies included, the marginal effects observed in these analyses are worth mentioning. Regarding the magnitude of the intervention, the negative slope suggests that interventions that included fewer total minutes of practice produced larger effect sizes. These results might indicate that processes such as the hedonic adaptation could affect the effectiveness of interventions practiced for longer periods of time, causing the effects of shorter practices to fade when participants are asked to practice more time [68]. In addition, the positive slopes for age showed that the interventions carried out with older participants were associated with the largest effect sizes. Nevertheless, these effects should be understood within a cohort of young adults from 18 to 35 years, indicating that interventions carried out with older participants in this age range lead to better outcomes. In addition, although no significant results emerged regarding the target population, larger effect sizes were observed in the community samples in comparison with the undergraduate students (usually, younger than the community samples). These results somehow contradict the theoretical assumptions of Lyubomirsky and Layous [23], who hypothesized that PPIs with a future-time orientation, like the BPS intervention, would be more beneficial for young people. It is possible that younger participants might find it difficult to envision their best possible self as their future is still undefined (e.g. which will be one’s future occupation or whether one will raise a family), while older participants might be more connected with their values and may have more established life goals due to their life experiences and normative factors. In any case, these results should be interpreted in the context of studies with considerably young participants and with a limited age range. Further research is needed with older samples in order to explore the role of age in this intervention, as well as with more heterogeneous samples (with both young and older participants). With regard to the moderator analyses of the categorical variables, none of them showed a significant moderating effect on wellbeing.
Overall, the moderator analyses observed in this study support statements from a recent qualitative review of the BPS intervention suggesting that BPS is a flexible and effective intervention, regardless of the delivery method or the participants’ characteristics [6].
The BPS exercise has been widely used to specifically promote optimism. Interestingly, the effect size of the BPS intervention on optimism is similar to the one obtained for wellbeing, which suggests that its effectiveness is similar for both constructs. Overall, the effect sizes obtained for optimism outcomes in our meta-analysis are lower than those observed in the meta-analysis by Malouff and colleagues [7]. In this case, the different studies included and the type of calculation of the effect size could account for this difference.
Regarding depression, only three studies could be entered into the effect size calculus, which was small (d+ = 0.115). These results are slightly lower than those presented in the last meta-analysis of PPIs [3] (d = .23), although both are considered small [4,31]. The review by Loveday [6] concluded that BPS can be used with depressive patients, among others. Nevertheless, considering the small number of included studies that assessed depressive symptoms, quantitative results for the effects of BPS interventions on depression should be viewed with caution.
Because a large number of studies included the PANAS scale [11], we were able to conduct a separate meta-analysis for the effects on positive and negative affect assessed with this specific questionnaire. This is one of the most widely used scales to measure positive and negative mood, and it has been validated in many countries, showing good psychometric properties in numerous studies [69–71]. Effects of BPS on positive affect showed a moderate effect size of d+ = .511, which was larger than the effect sizes obtained for the other related outcomes. By contrast, a small effect size was found for negative affect (d+ = .192) and excluding the only study with a non-active control group, this effect size was null (d+ = -0.047). These results imply that the BPS exercise might be more effective in increasing positive affect than in decreasing negative affect, which is consistent with the PPIs’ aim of promoting positive emotions rather than decreasing negative emotions.
The fact that some studies included a gratitude intervention group in addition to BPS and controls made it possible to conduct a specific meta-analysis on the effectiveness of the BPS compared to gratitude interventions. A medium effect size was found for positive affect (d+ = .326), and a moderate effect size was found for negative affect (d+ = .485) [31]. The effect size on wellbeing was quite small (d+ = .092). It is possible to infer that the BPS seems to produce better results for positive and negative affect than gratitude interventions. However, a small number of studies were included in the analyses, and more research is needed to extend the knowledge about the comparability of these two PPIs.
No indication of publication bias was found in this meta-analysis for any of the different outcomes assessed. It included grey literature, which, along with some studies with negative results, might have helped to overcome the absence of trimmed studies by providing a more complete picture of the field. When considering the published research on this topic (thus excluding the unpublished works included in this meta-analysis), evidence of publication bias was only found for positive affect, and it did not appear in any of the remaining variables, which agrees with a recent meta-analysis on psychological wellbeing conducted by Weiss and colleagues [72].
This study has some limitations. First, regarding the quality of the included studies, none of them met all the quality criteria. For example, only one study included the concealment of the assessors, half of the studies did not use intention-to-treat analyses, and 11 of the 29 studies did not analyze baseline comparability between completers and dropouts (considering that some of the remaining 18 studies did not have any dropouts). Second, the type of population included in the studies was mainly based on University students and young participants, which limits the generalizability of the findings. This is a common issue in Psychology research [73,74], and future studies need to consider broadening the population in which the studies are carried out. Along the same lines, none of the studies (not even the ones that measured depression) delivered the intervention to clinical patients. Hence, it is still necessary to study the effectiveness of the BPS in this population. Third, regarding quantitative analyses, we were not able to adjust a multiple meta-regression model that included a subset of characteristics of studies that could explain the variability in the effect sizes on wellbeing. In addition, the analyses of the differences on the effect sizes between the studies with active or non-active control conditions included only one study in the non-active control group, which limits the strength of the analyses as a result of the lack of variance in this group. Fourth, follow-up analyses were not included due to the small number of studies that reported them: only three studies included follow-up measures beyond three months [26,58,63], which impeded the exploration of long-term effects. Future studies should include follow-ups in order to explore the maintenance of the results in the long-term and the ways to overcome potential obstacles, such as hedonic adaptation to the benefits produced by these interventions [68]. Finally, our approach of averaging dependent effect sizes from the same study could be considered a suboptimal strategy, as it might be more appropriate to apply methods to statistically integrate dependent effect sizes, such as the robust variance estimation method [75] or multilevel meta-analysis [76].
The results of this meta-analysis have several implications for research and clinical practice. Notably, the BPS has been shown to be an effective intervention to improve positive affect, wellbeing, and optimism. Small effect sizes were obtained for negative affect and depressive symptoms. These results indicate that this intervention is more effective in increasing positive outcomes than in decreasing negative ones, and this is consistent with the framework of PPIs, which were conceived to cultivate positive emotions [2]. For this reason, it is possible to state that the BPS exercise is able to produce the desired effects of these type of exercises and, therefore, can be an advantageous strategy to increase participants’ wellbeing.
In relation to the moderator variables, analyses showed that the intervention can be equally effective independently of the delivery method, contextual aspects, and components of the intervention: whether administered individually or in groups, online or face-to-face, with or without an explicit imagery component, similar outcomes seem to be produced. Marginally significant differences were found in the characteristics of the population where the intervention was administered, specifically regarding age, indicating that the age of the participants could play a role in the effectiveness of the intervention. It is important for future studies to include more heterogeneous age groups and older participants in order to address this issue. As to the duration of the intervention, no differences were found in length and intensity, but a marginally significant difference emerged in the magnitude of the intervention. This result suggests that shorter practices (in total number of minutes) may lead to more benefits from the BPS. However, these results should be further explored. In this regard, further studies that include qualitative data (for example, content analyses of the texts) could help to shed light on these results, and on possible variables that might play a role in the effectiveness of the BPS which cannot be addressed through a quantitative approach.
In conclusion, this study contributes to a better understanding of the effectiveness of a widely used PPI. Psychologists and other professionals can consider administering the BPS intervention if they are interested in increasing their clients’ wellbeing levels, given that the BPS emerged as a valuable intervention to increase wellbeing, optimism, and positive affect.
Supporting information
S1 Checklist [pdf]
PRISMA 2009 Checklist.S1 File [pdf]
Forest and funnel plots.
Zdroje
1. Seligman MEP, Csikszentmihalyi M. Positive Psychology: An Introduction. Am Psychol. 2000;55 : 5–14. doi: 10.1037//0003-066x.55.1.5 11392865
2. Sin NL, Lyubomirsky S. Enhancing Well-Being and Alleviating Depressive Symptoms With Positive Psychology Interventions: A Practice-Friendly Meta-Analysis. J Clin Psychol. 2009;65 : 467–487. doi: 10.1002/jclp.20593 19301241
3. Bolier L, Haverman M, Westerhof GJ, Riper H, Smit F, Bohlmeijer E. Positive psychology interventions: A meta-analysis of randomized controlled studies. BMC Public Health. 2013;13 : 1.
4. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale: Erlbaum; 1988.
5. King LA. The health benefits of writing about life goals. Personal Soc Psychol Bull. 2001;27 : 798–807.
6. Loveday PM, Lovell GP, Jones CM. The Best Possible Selves Intervention: A Review of the Literature to Evaluate Efficacy and Guide Future Research. J Happiness Stud. Springer Netherlands; 2016; 1–22. doi: 10.1007/s10902-016-9824-z
7. Malouff JM, Schutte NS. Can psychological interventions increase optimism? A meta-analysis. J Posit Psychol. 2016;12 : 1–11. doi: 10.1080/17439760.2016.1221122
8. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med. 2009;6: e1000097. doi: 10.1371/journal.pmed.1000097 19621072
9. Scheier MF, Wrosch C, Baum A, Cohen S, Martire LM, Matthews KA, et al. The life engagement test: Assessing purpose in life. J Behav Med. 2006;29 : 291–298. doi: 10.1007/s10865-005-9044-1 16565785
10. Meevissen YM, Peters ML, Alberts HJ. Become more optimistic by imagining a best possible self: Effects of a two week intervention. J Behav Ther Exp Psychiatry. 2011;42 : 371–378. doi: 10.1016/j.jbtep.2011.02.012 21450262
11. Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol. 1988;54 : 1063–1070. doi: 10.1037//0022-3514.54.6.1063 3397865
12. Diener E, Emmons RA, Larsen RJ, Griffin S. The Satisfaction With Life Scale. J Pers Assess. 1985;49 : 71–75. doi: 10.1207/s15327752jpa4901_13 16367493
13. Seligson JL, Huebner ES, Valois RF. Preliminary Validation of the Brief Multidimensional Students’ Life Satisfaction Scale (BMSLSS). Soc Indic Res. 2003;61 : 121–145. doi: 10.1023/A:1021326822957
14. Tennant R, Hiller L, Fishwick R, Platt S, Joseph S, Weich S, et al. The Warwick-Edinburgh Mental Well-being Scale (WEMWBS): development and UK validation. Health Qual Life Outcomes. 2007;5 : 63. doi: 10.1186/1477-7525-5-63 18042300
15. Lyubomirsky S, Lepper HS. A Measure of Subjective Happiness: Preliminary Reliability and Construct Validation. Soc Indic Res. 1999;46 : 137–155. doi: 10.1023/A:1006824100041
16. Hanssen MM, Peters ML, Vlaeyen JWS, Meevissen YMC, Vancleef LMG. Optimism lowers pain: evidence of the causal status and underlying mechanisms. Pain. Netherlands; 2013;154 : 53–58. doi: 10.1016/j.pain.2012.08.006 23084002
17. Scheier MF, Carver CS, Bridges MW. Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): A reevaluation of the Life Orientation Test. J Pers Soc Psychol. 1994;67 : 1063–1078. doi: 10.1037//0022-3514.67.6.1063 7815302
18. Hanssen MM, Vancleef LM, Peters ML. What does it mean to be an optimist in an ambiguous world? Investigating negative versus positive interpretation patterns of optimists [Internet]. University of Maastricht. 2014. https://cris.maastrichtuniversity.nl/portal/files/728202/guid-1c673de5-2ce0-4b00-b64b-deaf21599d99-ASSET1.0
19. Seligman ME, Abramson LY, Semmel A, von Baeyer C. Depressive attributional style. J Abnorm Psychol. 1979;88 : 242–247. doi: 10.1037//0021-843x.88.3.242 500951
20. Radloff LS. The CES-D Scale. Appl Psychol Meas. 1977;1 : 385–401.
21. Laux L, Hock M, Bergner-Köther R, Hodapp V, Renner K-H. Das state-trait-angstdepressions - inventar (STADI). Göttingen: Hogrefe; 2013.
22. Beck AT, Steer RA, Brown GK. Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation; 1996.
23. Lyubomirsky S, Layous K. How Do Simple Positive Activities Increase Well-Being? Curr Dir Psychol Sci. 2013;22 : 57–62. doi: 10.1177/0963721412469809
24. Nelson SK, Della Porta MD, Jacobs Bao K, Lee HC, Choi I, Lyubomirsky S. ‘It’s up to you’: Experimentally manipulated autonomy support for prosocial behavior improves well-being in two cultures over six weeks. J Posit Psychol. 2015;10 : 463–476. doi: 10.1080/17439760.2014.983959
25. Layous K, Lee H, Choi I, Lyubomirsky S. Culture Matters When Designing a Successful Happiness-Increasing Activity. J Cross Cult Psychol. 2013;44 : 1294–1303. doi: 10.1177/0022022113487591
26. Boehm JK, Lyubomirsky S, Sheldon KM. A longitudinal experimental study comparing the effectiveness of happiness-enhancing strategies in Anglo Americans and Asian Americans. Cogn Emot. 2011;25 : 1263–1272. doi: 10.1080/02699931.2010.541227 21432648
27. Thompson RB, Peura C, Gayton WF. Gender differences in the person-activity fit for positive psychology interventions. J Posit Psychol. 2015;10 : 179–183. doi: 10.1080/17439760.2014.927908
28. Sánchez-Meca J, López-Pina JA, López-López JA, Marín-Martínez F, Rosa-Alcázar AI, …, et al. Analysis of the concordance between scales to assess the methodological quality of primary studies in meta-analysis. Analysis of the concordance between scales to assess the methodological quality of primary studies in meta-analysis. Tenerife; 2013.
29. Verhagen AP, de Vet HC, de Bie RA, Kessels AG, Boers M, Bouter LM, et al. The Delphi list: a criteria list for quality assessment of randomized clinical trials for conducting systematic reviews developed by Delphi consensus. J Clin Epidemiol. 1998;51 : 1235–41. doi: 10.1016/s0895-4356(98)00131-0 10086815
30. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions 5.1.0 [Updated March 2011]. Chichester, UK: John Wiley & Sons; 2011.
31. Rubio-Aparicio M, Marín-Martínez F, Sánchez-Meca J, López-López JA. A methodological review of meta-analyses of the effectiveness of clinical psychology treatments. Behav Res Methods. 2017; 1–17.
32. Morris SB. Estimating Effect Sizes From Pretest-Posttest-Control Group Designs. Organ Res Methods. 2008;11 : 364–386. doi: 10.1177/1094428106291059
33. Davis DE, Choe E, Meyers J, Wade N, Varjas K, Gifford A, et al. Thankful for the little things: A meta-analysis of gratitude interventions. J Couns Psychol. 2016;63 : 20–31. doi: 10.1037/cou0000107 26575348
34. Borenstein M, Hedges L V., Higgins JPT, Rothstein HR. A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 2010;1 : 97–111. doi: 10.1002/jrsm.12 26061376
35. Sánchez-Meca J, Marín-Martínez F. Confidence Intervals for the Overall Effect Size in Random-Effects Meta-Analysis. Psychol Methods. 2008;13 : 31–48. doi: 10.1037/1082-989X.13.1.31 18331152
36. Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56 : 455–63. 10877304
37. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327 : 557–560. doi: 10.1136/bmj.327.7414.557 12958120
38. Rubio-Aparicio M, Sánchez-Meca J, López-López JA, Botella J, Marín-Martínez F. Analysis of categorical moderators in mixed-effects meta-analysis: Consequences of using pooled versus separate estimates of the residual between-studies variances. Br J Math Stat Psychol. 2017;70 : 439–456. doi: 10.1111/bmsp.12092 28164265
39. Viechtbauer W, López-López JA, Sánchez-Meca J, Marín-Martínez F. A comparison of procedures to test for moderators in mixed-effects meta-regression models. Psychol Methods. 2015;20 : 360–374. doi: 10.1037/met0000023 25110905
40. Knapp G, Hartung J. Improved tests for a random effects meta-regression with a single covariate. Stat Med. 2003;22 : 2693–2710. doi: 10.1002/sim.1482 12939780
41. López-López JA, Marín-Martínez F, Sánchez-Meca J, Van den Noortgate W, Viechtbauer W. Estimation of the predictive power of the model in mixed-effects meta-regression: A simulation study. Br J Math Stat Psychol. 2014;67 : 30–48. doi: 10.1111/bmsp.12002 23297709
42. Aguinis H, Gottfredson RK, Wright TA. Best-practice recommendations for estimating interaction effects using meta-analysis. J Organ Behav. 2011;32 : 1033–1043. doi: 10.1002/job.719
43. Viechtbauer W. Conducting Meta-Analyses in R with the metafor Package. J Stat Softw. 2010;36 : 1–48. doi: 10.18637/jss.v036.i03
44. Boselie JJLM, Vancleef LMG, Peters ML. The effects of experimental pain and induced optimism on working memory task performance. Scand J Pain. 2016;12 : 25–32. doi: 10.1016/j.sjpain.2016.03.001 28850487
45. Harrist S, Carlozzi BL, McGovern AR, Harrist AW. Benefits of expressive writing and expressive talking about life goals. J Res Pers. 2007;41 : 923–930. doi: 10.1016/j.jrp.2006.09.002
46. Layous K, Nelson SK, Lyubomirsky S. What Is the Optimal Way to Deliver a Positive Activity Intervention? The Case of Writing About One’s Best Possible Selves. J Happiness Stud. 2013;14 : 635–654. doi: 10.1007/s10902-012-9346-2
47. Summerfield T. Positive Interventions: : A comparison of the effects of three good things, best possible selves and a control task of early memories on dispositional gratefulness, life satisfaction, positive affect and negative affect [Internet]. University of Derby. 2015. https://e-space.mmu.ac.uk/599279/
48. Meevissen Y, Peters M, Alberts H. Overcoming ego depletion: The effects of an optimism manipulation on repeated acts of self-control. BMC complementary and alternative medicine. 2012. http://onlinelibrary.wiley.com/o/cochrane/clcentral/articles/275/CN-01030275/frame.html
49. Odou N, Vella-Brodrick DA. The Efficacy of Positive Psychology Interventions to Increase Well-Being and the Role of Mental Imagery Ability. Soc Indic Res. 2013;110 : 111–129. doi: 10.1007/s11205-011-9919-1
50. Peters ML, Vieler JSE, Lautenbacher S. Dispositional and induced optimism lead to attentional preference for faces displaying positive emotions: An eye-tracker study. J Posit Psychol. 2016;11 : 258–269. doi: 10.1080/17439760.2015.1048816
51. Renner F, Schwarz P, Peters ML, Huibers MJH. Effects of a best-possible-self mental imagery exercise on mood and dysfunctional attitudes. Psychiatry Res. 2014;215 : 105–110. doi: 10.1016/j.psychres.2013.10.033 24252218
52. Liau AK, Neihart MF, Teo CT, Lo CHM. Effects of the Best Possible Self Activity on Subjective Well-Being and Depressive Symptoms. Asia-Pacific Educ Res. 2016;25 : 473–481.
53. Sheldon KM, Lyubomirsky S. How to increase and sustain positive emotion: The effects of expressing gratitude and visualizing best possible selves. J Posit Psychol. 2006;1 : 73–82. doi: 10.1080/17439760500510676
54. Peters ML, Flink IK, Boersma K, Linton SJ. Manipulating optimism: Can imagining a best possible self be used to increase positive future expectancies? J Posit Psychol. 2010;5 : 204–211. doi: 10.1080/17439761003790963
55. Peters ML, Meevissen YMC, Hanssen MM. Specificity of the Best Possible Self intervention for increasing optimism: Comparison with a gratitude intervention. Ter Psicol. 2013;31 : 93–100. doi: 10.4067/S0718-48082013000100009
56. Maddalena CJ, Saxey-Reese R, Barnes EL. Targeting writing interventions to emotional processing level: a factorial experimental design. Qual Quant. 2014;48 : 2939–2962.
57. Boselie JJLM, Vancleef LMG, Peters ML. The effects of experimental pain and induced optimism on working memory task performance. Scand J Pain. 2016;12 : 25–32. doi: 10.1016/j.sjpain.2016.03.001 28850487
58. Enrique Á, Bretón-López J, Molinari G, Baños RM, Botella C. Efficacy of an adaptation of the best possible self intervention implemented through positive technology: A randomized control trial. Appl Res Qual Life. 2017; 1–19.
59. Geschwind N, Meulders M, Peters ML, Vlaeyen JWS, Meulders A. Can experimentally induced positive affect attenuate generalization of fear of movement-related pain? J Pain. 2015;16 : 258–269. doi: 10.1016/j.jpain.2014.12.003 25536535
60. Boselie JJLM, Vancleef LMG, Smeets T, Peters ML. Increasing optimism abolishes pain-induced impairments in executive task performance. Pain. 2014;155 : 334–340. doi: 10.1016/j.pain.2013.10.014 24145210
61. Lyubomirsky S, Dickerhoof R, Boehm JK, Sheldon KM. Becoming happier takes both a will and a proper way: An experimental longitudinal intervention to boost well-being. Emotion. 2011;11 : 391–402. doi: 10.1037/a0022575 21500907
62. Boselie JJLM, Vancleef LMG, Peters ML. Increasing Optimism Protects Against Pain-Induced Impairment in Task-Shifting Performance. J Pain. 2017;18 : 446–455. doi: 10.1016/j.jpain.2016.12.007 28039101
63. Manthey L, Vehreschild V, Renner K-H. Effectiveness of Two Cognitive Interventions Promoting Happiness with Video-Based Online Instructions. J Happiness Stud. 2016;17 : 319–339.
64. Ng W. Use of positive interventions: Does neuroticism moderate the sustainability of their effects on happiness? J Posit Psychol. 2016;11 : 51–61.
65. Troop NA, Chilcot J, Hutchings L, Varnaite G. Expressive writing, self-criticism, and self-reassurance. Psychol Psychother Theory, Res Pract. 2013;86 : 374–386. doi: 10.1111/j.2044-8341.2012.02065.x 24217863
66. Yogo M, Fujihara S. Working memory capacity can be improved by expressive writing: A randomized experiment in a Japanese sample. Br J Health Psychol. 2008;13 : 77–80. doi: 10.1348/135910707X252440 18230236
67. Lipsey MW, Wilson DB. The efficacy of psychological, educational, and behavioral treatment. Confirmation from meta-analysis. Am Psychol. 1993;48 : 1181–209. http://www.ncbi.nlm.nih.gov/pubmed/8297057 doi: 10.1037//0003-066x.48.12.1181 8297057
68. Diener E, Lucas RE, Scollon CN. Beyond the hedonic treadmill: Revising the adaptation theory of well-being. Am Psychol. 2006;61 : 305–314. doi: 10.1037/0003-066X.61.4.305 16719675
69. Crawford JR, Henry JD. The Positive and Negative Affect Schedule (PANAS): Construct validity, measurement properties and normative data in a large non-clinical sample. Br J Clin Psychol. 2004;43 : 245–265. 15333231
70. Thompson ER. Development and validation of an internationally reliable short-form of the Positive and Negative Affect Schedule (PANAS). J Cross Cult Psychol. 2007;38 : 227–242. doi: 10.1177/0022022106297301
71. López-Gómez I, Hervás G, Vázquez C. Adaptación de las “escalas de afecto positivo y negativo” (panas) en una muestra general Española. Behav Psychol Psicol Conduct. 2015;23 : 529–548.
72. Weiss LA, Westerhof GJ, Bohlmeijer ET. Can we increase psychological well-being? The effects of interventions on psychological well-being: A meta-analysis of randomized controlled trials. PLoS One. 2016;11. doi: 10.1371/journal.pone.0158092 27328124
73. Peterson RA. On the Use of College Students in Social Science Research: Insights from a Second-Order Meta-analysis. J Consum Res. 2001;28 : 450–461. doi: 10.1086/323732
74. Henrich J, Heine SJ, Norenzayan A. The weirdest people in the world? Behav Brain Sci. 2010;33 : 61–83. doi: 10.1017/S0140525X0999152X 20550733
75. Hedges L V., Tipton E, Johnson MC. Robust variance estimation in meta-regression with dependent effect size estimates. Res Synth Methods. 2010;1 : 39–65. doi: 10.1002/jrsm.5 26056092
76. Van den Noortgate W, López-López JA, Marín-Martínez F, Sánchez-Meca J. Meta-analysis of multiple outcomes: a multilevel approach. Behav Res Methods. 2015;47 : 1274–1294. doi: 10.3758/s13428-014-0527-2 25361866
Článek Drink driving engagement in women: An exploration of context, hazardous alcohol use, and behaviourČlánek Rare earth elements in paddy fields from eroded granite hilly land in a southern China watershedČlánek Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitroČlánek Unexpected sawtooth artifact in beat-to-beat pulse transit time measured from patient monitor dataČlánek Vibrational behavior of psyllids (Hemiptera: Psylloidea): Functional morphology and mechanismsČlánek Free will beliefs are better predicted by dualism than determinism beliefs across different culturesČlánek The anatomy of a crushing bite: The specialised cranial mechanics of a giant extinct kangarooČlánek The genetic alteration spectrum of the SWI/SNF complex: The oncogenic roles of BRD9 and ACTL6AČlánek Myotendinous asymmetries derived from the prolonged practice of badminton in professional playersČlánek Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylationČlánek Genetic variability and consequence of Mycobacterium tuberculosis lineage 3 in Kampala-UgandaČlánek Residual stenosis after carotid artery stenting: Effect on periprocedural and long-term outcomesČlánek uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading framesČlánek Medicine and the media: Medical experts’ problems and solutions while working with journalistsČlánek Primary hyperhidrosis prevalence and characteristics among medical students in Rio de JaneiroČlánek Antibacterial activity of silver nanoparticles of different particle size against Vibrio NatriegensČlánek Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysisČlánek Association between the posterior part of the circle of Willis and the vertebral artery hypoplasiaČlánek Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitisČlánek Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizineČlánek The intake pattern and feed preference of layer hens selected for high or low feed conversion ratioČlánek Individualized pattern recognition for detecting mind wandering from EEG during live lecturesČlánek Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapyČlánek Feeling the heat: Elevated temperature affects male display activity of a lekking grassland birdČlánek A zero-shot learning approach to the development of brain-computer interfaces for image retrievalČlánek Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogsČlánek Supplementation strategies affect the feed intake and performance of grazing replacement heifersČlánek Prediction of cardiovascular disease risk among people with severe mental illness: A cohort studyČlánek Factors influencing the admission decision for Medical Psychiatry Units: A concept mapping approachČlánek Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)Článek Correction: Unraveling the genetic complexity underlying sorghum response to water availabilityČlánek Is this a man’s world? The effect of gender diversity and gender equality on firm innovativenessČlánek Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cellsČlánek Correction: The prognosis of heart failure patients: Does sodium level play a significant role?Článek Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal populationČlánek The impact of admission serum lactate on children with moderate to severe traumatic brain injuryČlánek PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophilsČlánek Ecophysiological impacts of Esca, a devastating grapevine trunk disease, on Vitis vinifera L.Článek Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small IntestineČlánek Synteny and phylogenetic analysis of paralogous thyrostimulin beta subunits (GpB5) in vertebratesČlánek The conditional Fama-French model and endogenous illiquidity: A robust instrumental variables testČlánek Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulationČlánek Differences in the impedance of cochlear implant devices within 24 hours of their implantationČlánek Changing educational gradient in long-term care-free life expectancy among German men, 1997-2012Článek Organic resolution function and effects of platinum nanoparticles on bacteria and organic matterČlánek Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responsesČlánek National trends in inpatient endometriosis admissions: Patients, procedures and outcomes, 2006−2015Článek Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in MalaysiaČlánek Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissuesČlánek Time-related immunomodulation by stressors and corticosterone transdermal application in toadsČlánek Retraction: Adaptive double threshold energy detection based on Markov model for cognitive radioČlánek Out-of-pocket health spending among Medicare beneficiaries: Which chronic diseases are most costly?Článek Lipidome profiles of postnatal day 2 vaginal swabs reflect fat composition of gilt’s postnatal dietČlánek The CrowdWater game: A playful way to improve the accuracy of crowdsourced water level class dataČlánek Self-management action and motivation of Pacific adults in New Zealand with end-stage renal diseaseČlánek The ‘Saw but Forgot’ error: A role for short-term memory failures in understanding junction crashes?Článek Effects of inorganic nitrogen and litters of Masson Pine on soil organic carbon decompositionČlánek Dorsal tongue porphyrin autofluorescence and Candida saprophytism: A prospective observational studyČlánek Resource consumption of multi-substance users in the emergency room: A neglected patient groupČlánek Human papillomavirus infection among head and neck squamous cell carcinomas in southern ChinaČlánek Quartet-based inference of cell differentiation trees from ChIP-Seq histone modification dataČlánek The genome of Alcaligenes aquatilis strain BU33N: Insights into hydrocarbon degradation capacityČlánek LMX1A inhibits C-Myc expression through ANGPTL4 to exert tumor suppressive role in gastric cancerČlánek Global smoking trends in inflammatory bowel disease: A systematic review of inception cohortsČlánek A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)Článek Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1Článek Advancing computational biology and bioinformatics research through open innovation competitionsČlánek A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic dietČlánek A high-density exome capture genotype-by-sequencing panel for forestry breeding in Pinus radiataČlánek The erythrocyte membrane stability is associated with sleep time and social jetlag in shift workersČlánek In-hospital cardiopulmonary resuscitation of patients with cirrhosis: A population-based analysisČlánek Spatiotemporal clustering of malaria in southern-central Ethiopia: A community-based cohort studyČlánek Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seekingČlánek Correction: Reward abundance interferes with error-based learning in a visuomotor adaptation taskČlánek Metabolisable energy content in canine and feline foods is best predicted by the NRC2006 equationČlánek Sign and goal tracker rats process differently the incentive salience of a conditioned stimulusČlánek Modeling spatial variation in density of golden eagle nest sites in the western United StatesČlánek Correction: Development of a high-throughput assay to measure measles neutralizing antibodiesČlánek Research on multi-agent genetic algorithm based on tabu search for the job shop scheduling problemČlánek Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiotaČlánek DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1
Článek vyšel v časopisePLOS One
Nejčtenější tento týden
2019 Číslo 9- Proč endometrióza vyžaduje principy precizní medicíny
- Precizní psychiatrie má svou cestovní mapu
- „Jednohubky“ z klinického výzkumu – 2026/4
- Infekce močových cest u dospělých – mezery v současných guidelines a doporučení pro klinickou praxi
- Vakcinace stojí díky inovativním technologiím na prahu nové éry
-
Všechny články tohoto čísla
- "The dead shall be raised": Multidisciplinary analysis of human skeletons reveals complexity in 19th century immigrant socioeconomic history and identity in New Haven, Connecticut
- Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Drink driving engagement in women: An exploration of context, hazardous alcohol use, and behaviour
- The effect of birth weight on body composition: Evidence from a birth cohort and a Mendelian randomization study
- Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: A systematic review and meta-analysis
- Expression profile of genes encoding allatoregulatory neuropeptides in females of the spider Parasteatoda tepidariorum (Araneae, Theridiidae)
- “My life after stroke through a camera lens”- A photovoice study on participation in Sweden
- Bacterial community composition of biofilms in milking machines of two dairy farms assessed by a combination of culture-dependent and –independent methods
- Health differences between multiple and single job holders in precarious employment in the Netherlands: A cross-sectional study among Dutch workers
- Clinical evaluation and budget impact analysis of cervical cancer screening using cobas 4800 HPV screening technology in the public sector of South Africa
- Rare earth elements in paddy fields from eroded granite hilly land in a southern China watershed
- High-throughput sequencing analysis of microbial community diversity in response to indica and japonica bar-transgenic rice paddy soils
- Physiological and molecular responses to drought stress in teak (Tectona grandis L.f.)
- Long-term performance of an atrial lead capable of accelerometer based detection of cardiac contractility in patients receiving cardiac resynchronisation therapy
- Ectomycorrhizal fungal communities of secondary tropical forests dominated by Tristaniopsis in Bangka Island, Indonesia
- Downregulation of hippocampal NR2A/2B subunits related to cognitive impairment in a pristane-induced lupus BALB/c mice
- Demonstrating specificity of bioactive peptide nucleic acids (PNAs) targeting microRNAs for practical laboratory classes of applied biochemistry and pharmacology
- Xenopus fraseri: Mr. Fraser, where did your frog come from?
- Competing priorities and second chances - A qualitative exploration of prisoners’ journeys through the Hepatitis C continuum of care
- Evaluating coral trophic strategies using fatty acid composition and indices
- Amyloid β oligomers inhibit growth of human cancer cells
- Distraction of olfactory bulb-medial prefrontal cortex circuit may induce anxiety-like behavior in allergic rhinitis
- Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women
- 'He usually has what we call normal fevers’: Cultural perspectives on healthy child growth in rural Southeastern Tanzania: An ethnographic enquiry
- Anatomical connections underlying personally-familiar face processing
- Fe limitation decreases transcriptional regulation over the diel cycle in the model diatom Thalassiosira pseudonana
- Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts
- Correction: Development of interval-valued fuzzy GRA with SERVPERF based on subjective and objective weights for evaluation of airline service quality: A case study of Korea low-cost carriers
- Anatomical analysis of antebrachial cutaneous nerve distribution pattern and its clinical implications for sensory reconstruction
- Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival epithelial cell line
- Topographic correlation and asymmetry analysis of ganglion cell layer thinning and the retinal nerve fiber layer with localized visual field defects
- Structuring a conceptual model for cost-effectiveness analysis of frailty interventions
- Characteristics of sarcopenia after distal gastrectomy in elderly patients
- Action spectrum for photoperiodic control of thyroid-stimulating hormone in Japanese quail (Coturnix japonica)
- The determinants of lung cancer after detecting a solitary pulmonary nodule are different in men and women, for both chest radiograph and CT
- Taste perception and oral microbiota are associated with obesity in children and adolescents
- Target women: Equity in access to mHealth technology in a non-communicable disease care intervention in Kenya
- Correction: Attitudes to and experiences with body weight control and changes in body weight in relation to all-cause mortality in the general population
- Homogenous HIV-1 subtype B from the Brazilian Amazon with infrequent diverse BF1 recombinants, subtypes F1 and C among blood donors
- Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes
- Loss of control as a violation of expectations: Testing the predictions of a common inconsistency compensation approach in an inclusionary cyberball game
- Living on the edge - circadian habitat usage in pre-weaning European hares (Lepus europaeus) in an intensively used agricultural area
- NMDA receptor activation induces long-term potentiation of glycine synapses
- Antibody response in snakes with boid inclusion body disease
- Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates
- Affirmative citation bias in scientific myth debunking: A three-in-one case study
- Streaming chunk incremental learning for class-wise data stream classification with fast learning speed and low structural complexity
- Time trends in healthy lifestyle among adults in Germany: Results from three national health interview and examination surveys between 1990 and 2011
- The impact of door-to-electrocardiogram time on door-to-balloon time after achieving the guideline-recommended target rate
- A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss
- Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitro
- CCR2 knockout ameliorates obesity-induced kidney injury through inhibiting oxidative stress and ER stress
- Multi-method assessment of whale shark (Rhincodon typus) residency, distribution, and dispersal behavior at an aggregation site in the Red Sea
- Duration of symptoms in the quantification of upper limb disability and impairment for individuals with mild degenerative cervical myelopathy (DCM)
- Expression of genes in the skeletal muscle of individuals with cachexia/sarcopenia: A systematic review
- Correction: Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease
- Alcohol, tobacco and cannabis use are associated with job loss at follow-up: Findings from the CONSTANCES cohort
- Estimation of the incidence of animal rabies in Punjab, India
- G-protein-coupled receptor 40 agonist GW9508 potentiates glucose-stimulated insulin secretion through activation of protein kinase Cα and ε in INS-1 cells
- Reasons behind stymied public hospital governance reform in China
- Cognitive and social congruence in peer-assisted learning – A scoping review
- The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU
- Associations between sexual activity and weight status: Findings from the English Longitudinal Study of Ageing
- Knowledge and practices regarding toxoplasmosis in housewives: A cross sectional study in a northern Mexican city
- Citation gaming induced by bibliometric evaluation: A country-level comparative analysis
- Can we predict which species win when new habitat becomes available?
- Wetlands are keystone habitats for jaguars in an intercontinental biodiversity hotspot
- Research applications of primary biodiversity databases in the digital age
- The Edinburgh Postpartum Depression Scale: Stable structure but subscale of limited value to detect anxiety
- EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation
- Post-exercise high-sensitivity troponin T levels in patients with suspected unstable angina
- Unexpected sawtooth artifact in beat-to-beat pulse transit time measured from patient monitor data
- Development of highly sensitive and low-cost DNA agarose gel electrophoresis detection systems, and evaluation of non-mutagenic and loading dye-type DNA-staining reagents
- Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury
- Macrophage phenotype and its relationship with renal function in human diabetic nephropathy
- Phylogeography of the dugong (Dugong dugon) based on historical samples identifies vulnerable Indian Ocean populations
- Vibrational behavior of psyllids (Hemiptera: Psylloidea): Functional morphology and mechanisms
- Evaluation of the effectiveness and equity of the maternity protection reform in Chile from 2000 to 2015
- Baseline human gut microbiota profile in healthy people and standard reporting template
- Are screening methods useful in feature selection? An empirical study
- Free will beliefs are better predicted by dualism than determinism beliefs across different cultures
- How does the content of nutrients in soil affect the health status of trees in city parks?
- Understanding the intricacy of canid social systems: Structure and temporal stability of red fox (Vulpes vulpes) groups
- The anatomy of a crushing bite: The specialised cranial mechanics of a giant extinct kangaroo
- Nurse-led medicines’ monitoring in care homes, implementing the Adverse Drug Reaction (ADRe) Profile improvement initiative for mental health medicines: An observational and interview study
- Projecting burden of hypertension and its management in Turkey, 2015-2030
- Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase
- Cytokines in agitated and non-agitated patients admitted to an acute psychiatric department: A cross-sectional study
- Acute pancreatitis risk after kidney transplantation: Propensity score matching analysis of a national cohort
- Understanding the effect of producers’ attitudes, perceived norms, and perceived behavioral control on intentions to use antimicrobials prudently on New York dairy farms
- Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity
- Theory of mind in remitted bipolar disorder: Interpersonal accuracy in recognition of dynamic nonverbal signals
- Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats
- Ecological conditions experienced by offspring during pregnancy and early post-natal life determine mandible size in roe deer
- Calculation of the contribution rate of China’s hydraulic science and technology based on a feedforward neural network
- ViraMiner: Deep learning on raw DNA sequences for identifying viral genomes in human samples
- The absence of interleukin 10 affects the morphology, differentiation, granule content and the production of cryptidin-4 in Paneth cells in mice
- Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis
- Moving model analysis on the transient pressure and slipstream caused by a metro train passing through a tunnel
- The importance of assigning responsibility during evaluation in order to increase student satisfaction from physical education classes: A structural equation model
- Lower dormancy with rapid germination is an important strategy for seeds in an arid zone with unpredictable rainfall
- Gene Cascade Finder: A tool for identification of gene cascades and its application in Caenorhabditis elegans
- Proteomics approach to identify serum biomarkers associated with the progression of diabetes in Korean patients with abdominal obesity
- Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity
- Transcriptome analysis of a nematode resistant and susceptible upland cotton line at two critical stages of Meloidogyne incognita infection and development
- Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies
- Distinguishing mild cognitive impairment from healthy aging and Alzheimer’s Disease: The contribution of the INECO Frontal Screening (IFS)
- Novel application of amino-acid buffered solution for neuroprotection against ischemia/reperfusion injury
- Are unpopular children more likely to get sick? Longitudinal links between popularity and infectious diseases in early childhood
- Vegetation communities on commercial developments are heterogenous and determined by development and landscaping decisions, not socioeconomics
- Falls among community-dwelling older adults in Ethiopia; A preliminary cross-sectional study
- Retraction: Social success of perfumes
- The effect of ethyl alcohol on the severity of injuries in fatal pedestrian victims of traffic crashes
- Drought stress has transgenerational effects on soybean seed germination and seedling vigor
- Prevalence of benign osseous lesions of the spine and association with spinal pain in the general population in whole body MRI
- Age-related differences of inter-joint coordination in elderly during squat jumping
- Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient
- Diagnostic performance and image quality of iterative model-based reconstruction of coronary CT angiography using 100 kVp for heavily calcified coronary vessels
- CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer
- Getting your game on: Using virtual reality to improve real table tennis skills
- Microbiological contamination of young children’s hands in rural Bangladesh: Associations with child age and observed hand cleanliness as proxy
- Expansion of the agricultural frontier in the largest South American Dry Forest: Identifying priority conservation areas for snakes before everything is lost
- Utility of lung ultrasound in ANCA-associated vasculitis with lung involvement
- Aerial surveys cause large but ephemeral decreases in bear presence at salmon streams in Kodiak, Alaska
- Exposure to particle debris generated from passenger and truck tires induces different genotoxicity and inflammatory responses in the RAW 264.7 cell line
- Influence of the cultivation medium and pH on the pigmentation of Trichophyton rubrum
- Intra-arterial catheter-directed CT angiography for assessment of endovascular aortic aneurysm repair
- Association of antibiotic exposure with the mortality in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy: A hospital-based retrospective cohort study
- The genetic alteration spectrum of the SWI/SNF complex: The oncogenic roles of BRD9 and ACTL6A
- Plasma chemistry in nesting leatherback sea turtles (Dermochelys coriacea) from Florida: Understanding the importance of sample hemolysis effects on blood analytes
- Myotendinous asymmetries derived from the prolonged practice of badminton in professional players
- Computational tools to detect signatures of mutational processes in DNA from tumours: A review and empirical comparison of performance
- Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice
- Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it
- Comparative compositional and functional analyses of Bothrops moojeni specimens reveal several individual variations
- Radiation hardness of cadmium telluride solar cells in proton therapy beam mode
- Bourdieu, networks, and movements: Using the concepts of habitus, field and capital to understand a network analysis of gender differences in undergraduate physics
- A 32-channel parallel transmit system add-on for 7T MRI
- Comparison between Aptima Assays (Hologic) and the Allplex STI Essential Assay (Seegene) for the diagnosis of Sexually transmitted infections
- Knowledge gaps of STIs in Africa; Systematic review
- Correction: Bovine herpesvirus 1 can cross the intact zona pellucida of bovine oocytes after artificial infection
- Distribution of corneal spherical aberration in a Tanzanian population
- Correction: Determinants of physical activity: A path model based on an ecological model of active living
- Wild pollinator activity negatively related to honey bee colony densities in urban context
- Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status
- The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century
- Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation
- Nitric oxide regulates the expression of heme carrier protein-1 via hypoxia inducible factor-1α stabilization
- Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes
- Construction of pseudomolecule sequences of Brassica rapa ssp. pekinensis inbred line CT001 and analysis of spontaneous mutations derived via sexual propagation
- Effects of flavoring compounds used in electronic cigarette refill liquids on endothelial and vascular function
- Rural pipeline and willingness to work in rural areas: Mixed method study on students in midwifery and obstetric nursing in Mali
- Role of phospholipase A2 receptor 1 antibody level at diagnosis for long-term renal outcome in membranous nephropathy
- Prevalence of anemia in diabetic adult outpatients in Northeast Ethiopia
- Characterization of melanin and optimal conditions for pigment production by an endophytic fungus, Spissiomyces endophytica SDBR-CMU319
- Genetic variability and consequence of Mycobacterium tuberculosis lineage 3 in Kampala-Uganda
- Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes
- Current and potential contributions of community pharmacy teams to self-harm and suicide prevention: A qualitative interview study
- Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway
- With or without U(K): A pre-Brexit network analysis of the EU ETS
- Graph-theoretical analysis for energy landscape reveals the organization of state transitions in the resting-state human cerebral cortex
- Task-uninformative visual stimuli improve auditory spatial discrimination in humans but not the ideal observer
- Residual stenosis after carotid artery stenting: Effect on periprocedural and long-term outcomes
- gapFinisher: A reliable gap filling pipeline for SSPACE-LongRead scaffolder output
- A plant biostimulant made from the marine brown algae Ascophyllum nodosum and chitosan reduce Fusarium head blight and mycotoxin contamination in wheat
- Monte-Carlo value analysis of High-Throughput Satellites: Value levers, tradeoffs, and implications for operators and investors
- Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm
- Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning
- Neuropathy and neural plasticity in the subcutaneous white adipose depot
- Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells
- The enemy’s gaze: Immersive virtual environments enhance peace promoting attitudes and emotions in violent intergroup conflicts
- Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae
- Koopman Mode Analysis of agent-based models of logistics processes
- Empirical mode decomposition based long short-term memory neural network forecasting model for the short-term metro passenger flow
- Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy
- Multi-agent reinforcement learning with approximate model learning for competitive games
- Identification of olfactory genes and functional analysis of BminCSP and BminOBP21 in Bactrocera minax
- The use of urinary fluoride excretion to facilitate monitoring fluoride intake: A systematic scoping review
- Development of a family caregiver needs-assessment scale for end-of-life care for senility at home (FADE)
- Epidemiology of pneumonia in the pre-pneumococcal conjugate vaccine era in children 2-59 months of age, in Ulaanbaatar, Mongolia, 2015-2016
- H-EM: An algorithm for simultaneous cell diameter and intensity quantification in low-resolution imaging cytometry
- Public expenditure on Non-Communicable Diseases & Injuries in India: A budget-based analysis
- Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways
- uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading frames
- Comparative analysis of postural control and vertical jump performance between three different measurement devices
- Hierarchical multi-view aggregation network for sensor-based human activity recognition
- Clavien–Dindo classification for grading complications after total pharyngolaryngectomy and free jejunum transfer
- Significantly different expression levels of microRNAs associated with vascular invasion in hepatocellular carcinoma and their prognostic significance after surgical resection
- Clinical correlates of workplace injury occurrence and recurrence in adults
- Medicine and the media: Medical experts’ problems and solutions while working with journalists
- Phylogenic classification and virulence genes profiles of uropathogenic E. coli and diarrhegenic E. coli strains isolated from community acquired infections
- Genetic relatedness in carbapenem-resistant isolates from clinical specimens in Ghana using ERIC-PCR technique
- Forest resilience under global environmental change: Do we have the information we need? A systematic review
- Improving the production of podophyllotoxin in hairy roots of Hyptis suaveolens induced from regenerated plantlets
- Controls on planktonic foraminifera apparent calcification depths for the northern equatorial Indian Ocean
- Notch and Delta are required for survival of the germline stem cell lineage in testes of Drosophila melanogaster
- Children with HIV: A scoping review of auditory processing skills
- Correction: Two distinct actin waves correlated with turns-and-runs of crawling microglia
- Expression of Concern: Neurotoxicity Induced by Bupivacaine via T-Type Calcium Channels in SH-SY5Y Cells
- Sex-dependent and -independent transcriptional changes during haploid phase gametogenesis in the sugar kelp Saccharina latissima
- Vehicle modeling for the analysis of the response of detectors based on inductive loops
- New Mycobacteroides abscessus subsp. massiliense strains with recombinant hsp65 gene laterally transferred from Mycobacteroides abscessus subsp. abscessus: Potential for misidentification of M. abscessus strains with the hsp65-based method
- A prognostic Bayesian network that makes personalized predictions of poor prognostic outcome post resection of pancreatic ductal adenocarcinoma
- Impact of care provider network characteristics on patient outcomes: Usage of social network analysis and a multi-scale community detection
- Valid group comparisons can be made with the Patient Health Questionnaire (PHQ-9): A measurement invariance study across groups by demographic characteristics
- Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Upgraded molecular models of the human KCNQ1 potassium channel
- Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells
- The extraordinary osteology and functional morphology of the limbs in Palorchestidae, a family of strange extinct marsupial giants
- Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro
- Implementation of home blood pressure monitoring among French GPs: A long and winding road
- In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues
- Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
- The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study
- Retraction: Comprehensive Comparison of Three Different Immunosuppressive Regimens for Liver Transplant Patients with Hepatocellular Carcinoma: Steroid-Free Immunosuppression, Induction Immunosuppression and Standard Immunosuppression
- Can acute suicidality be predicted by Instagram data? Results from qualitative and quantitative language analyses
- Computational and experimental analysis of the glycophosphatidylinositol-anchored proteome of the human parasitic nematode Brugia malayi
- Antibacterial activity of silver nanoparticles of different particle size against Vibrio Natriegens
- Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
- To eat or not to eat: Reward delay impulsivity in children with loss of control eating, attention deficit / hyperactivity disorder, a double diagnosis, and healthy children
- Factors associated with newborn care knowledge and practices in the upper Himalayas
- Correction: A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment
- Correlates of concurrent partnerships and patterns of condom use among men who have sex with men and transgender women in Peru
- Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma
- Development of a denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis for arthroplasty: A phantom study
- Low-level sensory processes play a more crucial role than high-level cognitive ones in the size-weight illusion
- The prevalence of asthma and allergic rhinitis in Nigeria: A nationwide survey among children, adolescents and adults
- Retraction: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium
- Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study
- Characteristics of diabetic macular edema patients refractory to anti-VEGF treatments and a dexamethasone implant
- Correction: Effects of dietary n-6: n-3 polyunsaturated fatty acid ratios on meat quality, carcass characteristics, tissue fatty acid profiles, and expression of lipogenic genes in growing goats
- Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study
- Impact of pterygium on the ocular surface and meibomian glands
- Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- Transcriptome divergence during leaf development in two contrasting switchgrass (Panicum virgatum L.) cultivars
- Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis
- Circulating progenitor cells and the expression of Cxcl12, Cxcr4 and angiopoietin-like 4 during wound healing in the murine ear
- EUSKOR: End-to-end coreference resolution system for Basque
- Inactivating pathogenic bacteria in greywater by biosynthesized Cu/Zn nanoparticles from secondary metabolite of Aspergillus iizukae; optimization, mechanism and techno economic analysis
- Exopolysaccharide producing rhizobacteria and their impact on growth and drought tolerance of wheat grown under rainfed conditions
- Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes
- Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study
- Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
- Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae)
- PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
- Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients
- “I do all I can but I still fail them”: Health system barriers to providing Option B+ to pregnant and lactating women in Malawi
- Impact of major illnesses and geographic regions on do-not-resuscitate rate and its potential cost savings in Taiwan
- Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis
- Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration
- Correction: Artificial neural networks reveal individual differences in metacognitive monitoring of memory
- Combining fish and environmental PCR for diagnostics of diseased laboratory zebrafish in recirculating systems
- Reading skill modulates the effect of parafoveal distractors on foveal lexical decision in deaf students
- Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia
- Exposure to marital conflict: Gender differences in internalizing and externalizing problems among children
- Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials
- The effect of age and perturbation time on online control during rapid pointing
- Oilseed rape (Brassica napus) resistance to growth of Leptosphaeria maculans in leaves of young plants contributes to quantitative resistance in stems of adult plants
- Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitis
- Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin
- Genomic characterization of the complete terpene synthase gene family from Cannabis sativa
- Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine
- Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana
- Plant growth promoting rhizobacterium Stenotrophomonas maltophilia BJ01 augments endurance against N2 starvation by modulating physiology and biochemical activities of Arachis hypogea
- Hierarchical integrated and segregated processing in the functional brain default mode network within attention-deficit/hyperactivity disorder
- Rising co-payments coincide with unwanted effects on continuity of healthcare for patients with schizophrenia in the Netherlands
- Analysis of Zobellella denitrificans ZD1 draft genome: Genes and gene clusters responsible for high polyhydroxybutyrate (PHB) production from glycerol under saline conditions and its CRISPR-Cas system
- False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases
- Identification of potassium phosphite responsive miRNAs and their targets in potato
- Quantification of bell-shaped size selectivity in shrimp trawl fisheries using square mesh panels and a sorting cone after a Nordmøre grid
- Deactivation of somatosensory and visual cortices during vestibular stimulation is associated with older age and poorer balance
- Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice
- Flooding performance evaluation of alkyl aryl sulfonate in various alkaline environments
- An artificial intelligent diagnostic system on mobile Android terminals for cholelithiasis by lightweight convolutional neural network
- Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads
- COI metabarcoding primer choice affects richness and recovery of indicator taxa in freshwater systems
- Retraction: APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway
- The intake pattern and feed preference of layer hens selected for high or low feed conversion ratio
- Individualized pattern recognition for detecting mind wandering from EEG during live lectures
- Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison
- Post-activation potentiation effect of eccentric overload and traditional weightlifting exercise on jumping and sprinting performance in male athletes
- Effectiveness of different central venous catheter fixation suture techniques: An in vitro crossover study
- Quantitative detection of ALK fusion breakpoints in plasma cell-free DNA from patients with non-small cell lung cancer using PCR-based target sequencing with a tiling primer set and two-step mapping/alignment
- Nuclei deformation reveals pressure distributions in 3D cell clusters
- Strategies for increasing diagnostic yield of community-onset bacteraemia within the emergency department: A retrospective study
- Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry
- Certified service dogs – A cost-effectiveness analysis appraisal
- Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy
- Assessing the impact of a research funder’s recommendation to consider core outcome sets
- Validity of six consumer-level activity monitors for measuring steps in patients with chronic heart failure
- Detection of deceptive motions in rugby from visual motion cues
- The impact of antenatal care on neonatal mortality in sub-Saharan Africa: A systematic review and meta-analysis
- Epidemiological investigation and management of bloody diarrhea among children in India
- Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation
- Bacteria isolated from Bengal cat (Felis catus × Prionailurus bengalensis) anal sac secretions produce volatile compounds potentially associated with animal signaling
- Petri net–based model of the human DNA base excision repair pathway
- Complexation and conformation of lead ion with poly-γ-glutamic acid in soluble state
- The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- The Youth-Physical Activity Towards Health (Y-PATH) intervention: Results of a 24 month cluster randomised controlled trial
- The COPD multi-dimensional phenotype: A new classification from the STORICO Italian observational study
- Morphological identification of Amphitetranychus species (Acari: Tetranychidae) with crossbreeding, esterase zymograms and DNA barcode data
- Maintaining hope after a disabling stroke: A longitudinal qualitative study of patients’ experiences, views, information needs and approaches towards making treatment decisions
- Cultural differences in the use of acoustic cues for musical emotion experience
- Effects of a rifampicin pre-treatment on linezolid pharmacokinetics
- High prevalence of multidrug resistant Enterobacteriaceae among residents of long term care facilities in Amsterdam, the Netherlands
- Infection/inflammation-associated preterm delivery within 14 days of presentation with symptoms of preterm labour: A multivariate predictive model
- Prognostic value of preoperative hydronephrosis in patients with bladder cancer undergoing radical cystectomy: A meta-analysis
- Correction: Early life predictors of midlife allostatic load: A prospective cohort study
- PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations
- Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments
- Symbiotic incompatibility between soybean and Bradyrhizobium arises from one amino acid determinant in soybean Rj2 protein
- Does anticoagulation needed for distally located incidental pulmonary thromboembolism in patients with active cancer?
- Control of human testis-specific gene expression
- Speaking up culture of medical students within an academic teaching hospital: Need of faculty working in patient safety
- Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations
- Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study
- Results of scoping review do not support mild traumatic brain injury being associated with a high incidence of chronic cognitive impairment: Commentary on McInnes et al. 2017
- Native seed, soil and atmosphere respond to boreal forest topsoil (LFH) storage
- Development of a quantitative polymerase chain reaction assay and environmental DNA sampling methods for Giant Gartersnake (Thamnophis gigas)
- Genetic diversity and population structure of four Chinese rabbit breeds
- Knowledge, attitude and behaviors towards patients with mental illness: Results from a national Lebanese study
- Correction: An impact evaluation of two rounds of mass drug administration on the prevalence of active trachoma: A clustered cross sectional survey
- Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Graph convolutional network approach applied to predict hourly bike-sharing demands considering spatial, temporal, and global effects
- Impact of traffic variability on geographic accessibility to 24/7 emergency healthcare for the urban poor: A GIS study in Dhaka, Bangladesh
- Feeling the heat: Elevated temperature affects male display activity of a lekking grassland bird
- Constructing a comprehensive disaster resilience index: The case of Italy
- Intraocular pressure according to different types of tonometry (non-contact and Goldmann applanation) in patients with different degrees of bilateral tearing
- Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus
- Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging
- Nonverbal synchrony in virtual reality
- Do speed cameras reduce road traffic collisions?
- A zero-shot learning approach to the development of brain-computer interfaces for image retrieval
- Use of non-HIV medication among people living with HIV and receiving antiretroviral treatment in Côte d’Ivoire, West Africa: A cross-sectional study
- DNA barcoding of southern African crustaceans reveals a mix of invasive species and potential cryptic diversity
- Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay
- Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs
- Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6
- Transport oil product consumption and GHG emission reduction potential in China: An electric vehicle-based scenario analysis
- Ontogenetic shift in the energy allocation strategy and physiological condition of larval plaice (Pleuronectes platessa)
- Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Diagnostic accuracy of Xpert MTB/RIF assay and non-molecular methods for the diagnosis of tuberculosis lymphadenitis
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
- Spatial distribution of breast cancer in Sudan 2010-2016
- Human-induced fire regime shifts during 19th century industrialization: A robust fire regime reconstruction using northern Polish lake sediments
- Enhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions
- Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
- Iron and manganese co-limit growth of the Southern Ocean diatom Chaetoceros debilis
- Bilateral and unilateral load-velocity profiling in a machine-based, single-joint, lower body exercise
- Veterans Health Administration nurses’ training and beliefs related to care of patients with traumatic brain injury
- Supplementation strategies affect the feed intake and performance of grazing replacement heifers
- Active transcutaneous bone conduction hearing implants: Systematic review and meta-analysis
- Parameterization-induced uncertainties and impacts of crop management harmonization in a global gridded crop model ensemble
- Acidification effects on isolation of extracellular vesicles from bovine milk
- GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve
- Mining version history to predict the class instability
- Humpback whale song occurrence reflects ecosystem variability in feeding and migratory habitat of the northeast Pacific
- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes
- Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading
- Reconstructing systematic persistent impacts of promotional marketing with empirical nonlinear dynamics
- Trans-national conservation and infrastructure development in the Heart of Borneo
- Prediction of cardiovascular disease risk among people with severe mental illness: A cohort study
- Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
- Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
- Reconstructing birth in Australopithecus sediba
- Value of contrast-enhanced ultrasound for preoperative assessment of liver reserve function in patients with liver tumors
- Correction: Identifying obesity/overweight status in children and adolescents; A cross-sectional medical record review of physicians’ weight screening practice in outpatient clinics, Saudi Arabia
- Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program
- Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
- Functional role and evolutionary contributions of floral gland morphoanatomy in the Paleotropical genus Acridocarpus (Malpighiaceae)
- On the efficiency of HIV transmission: Insights through discrete time HIV models
- Metabolic cost calculations of gait using musculoskeletal energy models, a comparison study
- Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype
- Evolutionary analysis of six chloroplast genomes from three Persea americana ecological races: Insights into sequence divergences and phylogenetic relationships
- Cultural transmission in a food preparation task: The role of interactivity, innovation and storytelling
- Correction: Effects of affective priming through music on the use of emotion words
- Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial
- Estimation of vaccination coverage from electronic healthcare records; methods performance evaluation – A contribution of the ADVANCE-project
- Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation
- Suicide by hanging: Results from a national survey in Switzerland and its implications for suicide prevention
- Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders
- Genome wide genetic dissection of wheat quality and yield related traits and their relationship with grain shape and size traits in an elite × non-adapted bread wheat cross
- Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
- Factors influencing the admission decision for Medical Psychiatry Units: A concept mapping approach
- Comparison of post-traumatic changes in circulating and bone marrow leukocytes between BALB/c and CD-1 mouse strains
- Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)
- Associations between birth order with mental wellbeing and psychological distress in midlife: Findings from the 1970 British Cohort Study (BCS70)
- Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
- The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
- Ancient technology and punctuated change: Detecting the emergence of the Edomite Kingdom in the Southern Levant
- Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- Randomized control trial of Tools of the Mind: Marked benefits to kindergarten children and their teachers
- Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration
- PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age
- Correction: Unraveling the genetic complexity underlying sorghum response to water availability
- Impact of tear metrics on the reliability of perimetry in patients with dry eye
- Using DNA barcoding to improve invasive pest identification at U.S. ports-of-entry
- Correction: Effects of Lactobacillus plantarum 15-1 and fructooligosaccharides on the response of broilers to pathogenic Escherichia coli O78 challenge
- Physico-chemical characterization and transcriptome analysis of 5-methyltryptophan resistant lines in rice
- Patient factors affecting successful linkage to treatment in a cervical cancer prevention program in Kenya: A prospective cohort study
- Is this a man’s world? The effect of gender diversity and gender equality on firm innovativeness
- Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit—The PROSACAB study
- Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock
- Quantitation of free glycation compounds in saliva
- Resolving an 87-year-old taxonomical curiosity with the description of Psylla frodobagginsi sp. nov. (Hemiptera: Sternorrhyncha: Psyllidae), a second distinct Psylla species on the New Zealand endemic plant kōwhai
- The effect of cathodal tDCS on fear extinction: A cross-measures study
- Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome
- Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells
- Investigating the dispersal of antibiotic resistance associated genes from manure application to soil and drainage waters in simulated agricultural farmland systems
- Continuous norming of psychometric tests: A simulation study of parametric and semi-parametric approaches
- Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method
- Cost-effectiveness of apixaban compared to other anticoagulants in patients with atrial fibrillation in the real-world and trial settings
- Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia
- Low genetic differentiation yet high phenotypic variation in the invasive populations of Spartina alterniflora in Guangxi, China
- A mathematical model for designing networks of C-Reactive Protein point of care testing
- Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis
- Femtosecond laser induced step-like structures inside transparent hydrogel due to laser induced threshold reduction
- From In Situ to satellite observations of pelagic Sargassum distribution and aggregation in the Tropical North Atlantic Ocean
- The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology
- BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis
- HIV prevalence and risk behavior among male and female adults screened for enrolment into a vaccine preparedness study in Maputo, Mozambique
- Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
- Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing
- Occurrence mechanism and coping paths of accidents of highly aggregated tourist crowds based on system dynamics
- Correction: Low Dose Aerosol Fitness at the Innate Phase of Murine Infection Better Predicts Virulence amongst Clinical Strains of Mycobacterium tuberculosis
- Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats
- Correction: Public reaction to Chikungunya outbreaks in Italy—Insights from an extensive novel data streams-based structural equation modeling analysis
- Correction: Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer’s dementia
- Intra-individual variability of sleep and nocturnal cardiac autonomic activity in elite female soccer players during an international tournament
- Therapeutic efficacy of equine botulism heptavalent antitoxin against all seven botulinum neurotoxins in symptomatic guinea pigs
- Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis
- Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis
- Scope and efficacy of the broad-spectrum topical antiseptic choline geranate
- Hematological and biochemical parameters for Chinese rhesus macaque
- Veterinary peer study groups as a method of continuous education—A new approach to identify and address factors associated with antimicrobial prescribing
- Correction: The prognosis of heart failure patients: Does sodium level play a significant role?
- Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin
- Systematic identification of facility-based stillbirths and neonatal deaths through the piloted use of an adapted RAPID tool in Liberia and Nepal
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis
- Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal population
- Reasons to care: Personal motivation as a key factor in the practice of the professional foster carer in Romania
- Determinants of clinical, functional and personal recovery for people with schizophrenia and other severe mental illnesses: A cross-sectional analysis
- Continuity of care for TB patients at a South African hospital: A qualitative participatory study of the experiences of hospital staff
- EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling
- The Better Management of Patients with Osteoarthritis Program: Outcomes after evidence-based education and exercise delivered nationwide in Sweden
- The negative effects of short-term extreme thermal events on the seagrass Posidonia oceanica are exacerbated by ammonium additions
- Pathogen invasion history elucidates contemporary host pathogen dynamics
- Chinese herbal formulae for the treatment of menopausal hot flushes: A systematic review and meta-analysis
- Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery
- Deconstruction of central line insertion guidelines based on the positive deviance approach—Reducing gaps between guidelines and implementation: A qualitative ethnographic research
- PBMCs transcriptome profiles identified breed-specific transcriptome signatures for PRRSV vaccination in German Landrace and Pietrain pigs
- The impact of admission serum lactate on children with moderate to severe traumatic brain injury
- Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface
- Determination of the bruise degree for cherry using Vis-NIR reflection spectroscopy coupled with multivariate analysis
- Genome-wide identification and expression profile analysis of nuclear factor Y family genes in Sorghum bicolor L. (Moench)
- Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007–2016: A retrospective cohort study
- Distribution of the Duffy genotypes in Malaysian Borneo and its relation to Plasmodium knowlesi malaria susceptibility
- Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
- A self-adaptive deep learning method for automated eye laterality detection based on color fundus photography
- The effect of child marriage on the utilization of maternal health care in Nepal: A cross-sectional analysis of Demographic and Health Survey 2016
- Identification of QTLs for powdery mildew (Podosphaera aphanis; syn. Sphaerotheca macularis f. sp. fragariae) susceptibility in cultivated strawberry (Fragaria ×ananassa)
- Chemical volatiles present in cotton gin trash: A by-product of cotton processing
- PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils
- Differential metabolomics networks analysis of menopausal status
- Experimental study of the temporal profile of breath alcohol concentration in a Chinese population after a light meal
- Association between regional brain volumes and BMI z-score change over one year in children
- Relationships between Potentially Toxic Elements in intertidal sediments and their bioaccumulation by benthic invertebrates
- Long-term outcomes of dialysis in patients with chronic kidney disease and new-onset atrial fibrillation: A population-based cohort study
- Hospital burden of pulmonary arterial hypertension in France
- Understanding the variability of Australian fire weather between 1973 and 2017
- Photon-counting cine-cardiac CT in the mouse
- Ecophysiological impacts of Esca, a devastating grapevine trunk disease, on Vitis vinifera L.
- Black “Reading the Mind in the Eyes” task: The development of a task assessing mentalizing from black faces
- Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae
- Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects
- Validation of the Rainbow Model of Integrated Care Measurement Tools (RMIC-MTs) in renal care for patient and care providers
- Multiple origins and the population genetic structure of Rubus takesimensis (Rosaceae) on Ulleung Island: Implications for the genetic consequences of anagenetic speciation
- Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction—Post-hoc analysis from the OMEGA-REMODEL randomized controlled trial
- A randomized controlled trial examining the efficacy of an internet-based cognitive behavioral therapy program for adolescents with anxiety disorders
- Optimising outputs from a validated online instrument to measure health-related quality of life (HRQL) in dogs
- Young adults’ perceptions of using wearables, social media and other technologies to detect worsening mental health: A qualitative study
- Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research
- Genetic characterization of fall armyworm (Spodoptera frugiperda) in Ecuador and comparisons with regional populations identify likely migratory relationships
- Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
- Cardiac resynchronization therapy-heart failure (CRT-HF) clinic: A novel model of care
- Synteny and phylogenetic analysis of paralogous thyrostimulin beta subunits (GpB5) in vertebrates
- Dual-Subpopulation as reciprocal optional external archives for differential evolution
- NGS analysis in Marfan syndrome spectrum: Combination of rare and common genetic variants to improve genotype-phenotype correlation analysis
- Optimization of cataract surgery follow-up: A standard set of questions can predict unexpected management changes at postoperative week one
- Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
- Clinical evaluation of General Electric new Swiftscan solution in bone scintigraphy on NaI-camera: A head to head comparison with Siemens Symbia
- Pharmacist-led academic detailing improves statin therapy prescribing for Malaysian patients with type 2 diabetes: Quasi-experimental design
- Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor
- Clinical outcomes with neoadjuvant versus adjuvant chemotherapy for triple negative breast cancer: A report from the National Cancer Database
- Identification and characterization of a novel heparan sulfate-binding domain in Activin A longest variants and implications for function
- Wikipedia network analysis of cancer interactions and world influence
- Using path signatures to predict a diagnosis of Alzheimer’s disease
- Development and verification of prediction models for preventing cardiovascular diseases
- Additive and heterozygous (dis)advantage GWAS models reveal candidate genes involved in the genotypic variation of maize hybrids to Azospirillum brasilense
- Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
- Transience effect in capture-recapture studies: The importance of its biological meaning
- Detailed global modelling of soil organic carbon in cropland, grassland and forest soils
- Oral dosing for antenatal corticosteroids in the Rhesus macaque
- Retraction: Modulation of the Pentose Phosphate Pathway Induces Endodermal Differentiation in Embryonic Stem Cells
- An analysis on HBsAg, Anti-HCV, Anti-HIV½ and VDRL test results in blood donors according to gender, age range and years
- Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study
- Meaningful work and resilience among teachers: The mediating role of work engagement and job crafting
- The conditional Fama-French model and endogenous illiquidity: A robust instrumental variables test
- Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes
- Characterization of sequentially-staged cancer cells using electrorotation
- Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model
- Genetic evidence for plural introduction pathways of the invasive weed Paterson’s curse (Echium plantagineum L.) to southern Australia
- Risk of major autoimmune diseases in female breast cancer patients: A nationwide, population-based cohort study
- Real-time three-dimensional MRI for the assessment of dynamic carpal instability
- Interim report on the effective intraperitoneal therapy of insulin-dependent diabetes mellitus in pet dogs using “Neo-Islets,” aggregates of adipose stem and pancreatic islet cells (INAD 012-776)
- The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue: A single centre experience
- Retraction: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection
- The association between role model presence and self-regulation in early adolescence: A cross-sectional study
- Correction: A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk
- Methamphetamine regulation of activity and topology of ventral midbrain networks
- Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis
- Occult periprosthetic femoral fractures occur frequently during a long, trapezoidal, double-tapered cementless femoral stem fixation in primary THA
- TCF4 induces enzalutamide resistance via neuroendocrine differentiation in prostate cancer
- Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation
- Comparing infiltration rates in soils managed with conventional and alternative farming methods: A meta-analysis
- Correction: Permissivity of Primary Human Hepatocytes and Different Hepatoma Cell Lines to Cell Culture Adapted Hepatitis C Virus
- Radiomics features of the primary tumor fail to improve prediction of overall survival in large cohorts of CT- and PET-imaged head and neck cancer patients
- The complete mitochondrial genome of Calyptogena marissinica (Heterodonta: Veneroida: Vesicomyidae): Insight into the deep-sea adaptive evolution of vesicomyids
- Correction: In vitro larval rearing protocol for the stingless bee species Melipona scutellaris for toxicological studies
- Correction: Morphological and molecular identification of the dioecious “African species Volvox rousseletii (Chlorophyceae) in the water column of a Japanese lake based on field-collected and cultured materials
- Upper versus lower airway microbiome and metagenome in children with cystic fibrosis and their correlation with lung inflammation
- “…or else I close my ears” How women with obesity want to be approached and treated regarding gestational weight management: A qualitative interview study
- Does a spinal implant alter dual energy X-ray absorptiometry body composition measurements?
- Economic and livestock health impacts of birds on dairies: Evidence from a survey of Washington dairy operators
- Repair of subtotal tympanic membrane perforations: A temporal bone study of several tympanoplasty materials
- Shifts in temperature influence how Batrachochytrium dendrobatidis infects amphibian larvae
- Sequential two-step chromatographic purification of infectious poliovirus using ceramic fluoroapatite and ceramic hydroxyapatite columns
- Frequency and distribution of corneal astigmatism and keratometry features in adult life: Methodology and findings of the UK Biobank study
- Differences in the impedance of cochlear implant devices within 24 hours of their implantation
- Suppressive impact of metronomic chemotherapy using UFT and/or cyclophosphamide on mediators of breast cancer dissemination and invasion
- Expression of Concern: miRNA 17 Family Regulates Cisplatin-Resistant and Metastasis by Targeting TGFbetaR2 in NSCLC
- Group leaders establish cooperative norms that persist in subsequent interactions
- Addis Ababa population-based pattern of cancer therapy, Ethiopia
- Agreement between the Cochrane risk of bias tool and Physiotherapy Evidence Database (PEDro) scale: A meta-epidemiological study of randomized controlled trials of physical therapy interventions
- Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and development
- DNA barcoding of coastal ray-finned fishes in Vietnam
- Comparison of climbing-specific strength and endurance between lead and boulder climbers
- The performance of different case definitions for severe influenza surveillance among HIV-infected and HIV-uninfected children aged <5 years in South Africa, 2011–2015
- Analgesic drug use in elderly persons: A population-based study in Southern Italy
- RCER: Reliable Cluster-based Energy-aware Routing protocol for heterogeneous Wireless Sensor Networks
- Beta-defensins and analogs in Helicobacter pylori infections: mRNA expression levels, DNA methylation, and antibacterial activity
- Changing educational gradient in long-term care-free life expectancy among German men, 1997-2012
- A non-parametric significance test to compare corpora
- Evaluating the impact of policies recommending PrEP to subpopulations of men and transgender women who have sex with men based on demographic and behavioral risk factors
- Different levels of statistical learning - Hidden potentials of sequence learning tasks
- Dry period heat stress induces microstructural changes in the lactating mammary gland
- Organic resolution function and effects of platinum nanoparticles on bacteria and organic matter
- High levels of fasting glucose and glycosylated hemoglobin values are associated with hyperfiltration in a Spanish prediabetes cohort. The PREDAPS Study
- Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responses
- Dynamic up- and down-regulation of the default (DMN) and extrinsic (EMN) mode networks during alternating task-on and task-off periods
- ERK1/ATF-2 signaling axis contributes to interleukin-1β-induced MMP-3 expression in dermal fibroblasts
- Cytokine profiles of umbilical cord blood mononuclear cells upon in vitro stimulation with lipopolysaccharides of different vaginal gram-negative bacteria
- Everolimus in de novo kidney transplant recipients participating in the Eurotransplant senior program: Results of a prospective randomized multicenter study (SENATOR)
- Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2
- Does effectiveness in performance appraisal improve with rater training?
- National trends in inpatient endometriosis admissions: Patients, procedures and outcomes, 2006−2015
- Affective and enjoyment responses to 12 weeks of high intensity interval training and moderate continuous training in adults with Crohn’s disease
- Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up
- Cabbage stem flea beetle’s (Psylliodes chrysocephala L.) susceptibility to pyrethroids and tolerance to thiacloprid in the Czech Republic
- Implicit learning of artificial grammatical structures after inferior frontal cortex lesions
- Potential survival benefits from optimized chemotherapy implementation in advanced ovarian cancer: Projections from a microsimulation model
- Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in Malaysia
- Heat stress responses in a large set of winter wheat cultivars (Triticum aestivum L.) depend on the timing and duration of stress
- Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model
- Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissues
- Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia
- Evaluation of suitable reference genes in Brassica juncea and its wild relative Camelina sativa for qRT-PCR analysis under various stress conditions
- Time-related immunomodulation by stressors and corticosterone transdermal application in toads
- Machine learning discovery of longitudinal patterns of depression and suicidal ideation
- Multi-scale patterns of tick occupancy and abundance across an agricultural landscape in southern Africa
- A matter of taste: Spatial and ontogenetic variations on the trophic ecology of the tiger shark at the Galapagos Marine Reserve
- Retraction: Adaptive double threshold energy detection based on Markov model for cognitive radio
- Adrenal gland size in obstructive sleep apnea: Morphological assessment of hypothalamic pituitary adrenal axis activity
- Out-of-pocket health spending among Medicare beneficiaries: Which chronic diseases are most costly?
- A large-scale chromosomal inversion is not associated with life history development in rainbow trout from Southeast Alaska
- Deployment, suicide, and overdose among comorbidity phenotypes following mild traumatic brain injury: A retrospective cohort study from the Chronic Effects of Neurotrauma Consortium
- Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data
- Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
- A quantitative approach for the analysis of clinician recognition of acute respiratory distress syndrome using electronic health record data
- Morphological, microbiological and ultrastructural aspects of sepsis by Aeromonas hydrophila in Piaractus mesopotamicus
- Recidivism rates in individuals receiving community sentences: A systematic review
- The association of intensive care with utilization and costs of outpatient healthcare services and quality of life
- How well do cancer survivor self-classifications of anxiety, depression and stress agree with a standardised tool? Results of a cross-sectional study
- Comparative nutritional characteristics of the three major Chinese Dendrobium species with different growth years
- Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
- Geographic differentiation of agritourism activities in Poland vs. cultural and natural attractiveness of destinations at district level
- Social participation reduces isolation among Japanese older people in urban area: A 3-year longitudinal study
- Explaining age-related decline in theory of mind: Evidence for intact competence but compromised executive function
- Role of GDF15 in methylseleninic acid-mediated inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
- Black people are convicted more for being black than for being poor: The role of social norms and cultural prejudice on biased racial judgments
- Bulked segregant analysis RNA-seq (BSR-Seq) validated a stem resistance locus in Aegilops umbellulata, a wild relative of wheat
- Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits
- Barriers and enablers to the implementation of a complex quality improvement intervention for acute kidney injury: A qualitative evaluation of stakeholder perceptions of the Tackling AKI study
- Soil and vegetation conditions changes following the different sand dune restoration measures on the Zoige Plateau
- Experimental H1N1pdm09 infection in pigs mimics human seasonal influenza infections
- Emission characteristics of diethylhexyl phthalate (DEHP) from building materials determined using a passive flux sampler and micro-chamber
- Multi-focus microscope with HiLo algorithm for fast 3-D fluorescent imaging
- Pontoscolex corethrurus: A homeless invasive tropical earthworm?
- Modeling reciprocal effects in medical research: Critical discussion on the current practices and potential alternative models
- Does palliative chemotherapy really palliate and are we measuring it correctly? A mixed methods longitudinal study of health related quality of life in advanced soft tissue sarcoma
- Developing cookies formulated with goat cream enriched with conjugated linoleic acid
- The effects of combining focus of attention and autonomy support on shot accuracy in the penalty kick
- Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: A cross-sectional study
- A combined strategy of neuropeptide prediction and tandem mass spectrometry identifies evolutionarily conserved ancient neuropeptides in the sea anemone Nematostella vectensis
- Lipidome profiles of postnatal day 2 vaginal swabs reflect fat composition of gilt’s postnatal diet
- Antitumor activity of a novel dual functional podophyllotoxin derivative involved PI3K/AKT/mTOR pathway
- Genome-wide developed microsatellites reveal a weak population differentiation in the hoverfly Eupeodes corollae (Diptera: Syrphidae) across China
- Prognosis of severe acquired brain injury: Short and long-term outcome determinants and their potential clinical relevance after rehabilitation. A comprehensive approach to analyze cohort studies
- An in silico investigation of menthol metabolism
- Variant analysis pipeline for accurate detection of genomic variants from transcriptome sequencing data
- Identification of candidate flowering and sex genes in white Guinea yam (D. rotundata Poir.) by SuperSAGE transcriptome profiling
- Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation
- The quality of guidelines for diabetic foot ulcers: A critical appraisal using the AGREE II instrument
- Mastitis risk effect on the economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study
- Confounding by indication of the safety of de-escalation in community-acquired pneumonia: A simulation study embedded in a prospective cohort
- Effects from diet-induced gut microbiota dysbiosis and obesity can be ameliorated by fecal microbiota transplantation: A multiomics approach
- Drivers of HIV-1 transmission: The Portuguese case
- Integration of a FT expression cassette into CRISPR/Cas9 construct enables fast generation and easy identification of transgene-free mutants in Arabidopsis
- A biface production older than 600 ka ago at Notarchirico (Southern Italy) contribution to understanding early Acheulean cognition and skills in Europe
- Mass evacuation and increases in long-term care benefits: Lessons from the Fukushima nuclear disaster
- Circulating levels of free 25(OH)D increase at the onset of rheumatoid arthritis
- The expression of equine keratins K42 and K124 is restricted to the hoof epidermal lamellae of Equus caballus
- Soil respiration from fields under three crop rotation treatments and three straw retention treatments
- Inhibition of polymerase chain reaction: Pathogen-specific controls are better than human gene amplification
- Linkage disequilibrium and haplotype block patterns in popcorn populations
- Downscaling satellite soil moisture using geomorphometry and machine learning
- Choosing efficient actions: Deciding where to walk
- The zooarchaeology and isotopic ecology of the Bahamian hutia (Geocapromys ingrahami): Evidence for pre-Columbian anthropogenic management
- Synergy of the flow behaviour and disperse phase of cellulose nanoparticles in enhancing oil recovery at reservoir condition
- Accuracy of Determine TB-LAM Ag to detect TB in HIV infected patients associated with diagnostic methods used in Brazilian public health units
- Human papillomavirus infection among head and neck squamous cell carcinomas in southern China
- Comparison of feature point detectors for multimodal image registration in plant phenotyping
- Quartet-based inference of cell differentiation trees from ChIP-Seq histone modification data
- Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform
- Coralline algal calcification: A morphological and process-based understanding
- Comparing record linkage software programs and algorithms using real-world data
- Antimicrobial resistance and molecular genotyping of Salmonella enterica serovar Enteritidis clinical isolates from Guizhou province of Southwestern China
- Measuring sexual relationship power equity among young women and young men South Africa: Implications for gender-transformative programming
- Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice – Vie-KinD study
- The genome of Alcaligenes aquatilis strain BU33N: Insights into hydrocarbon degradation capacity
- A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome
- LMX1A inhibits C-Myc expression through ANGPTL4 to exert tumor suppressive role in gastric cancer
- Lung clearance index to detect the efficacy of Aztreonam lysine inhalation in patients with cystic fibrosis and near normal spirometry – A single-centre feasibility study
- Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh
- Effect of PEPFAR funding policy change on HIV service delivery in a large HIV care and treatment network in Nigeria
- Friends, relatives, sanity, and health: The costs of politics
- European public perceptions of homelessness: A knowledge, attitudes and practices survey
- An overview of the quality assurance programme for HIV rapid testing in South Africa: Outcome of a 2-year phased implementation of quality assurance program
- Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients at low and intermediate risk: A risk specific meta-analysis of randomized controlled trials
- Global smoking trends in inflammatory bowel disease: A systematic review of inception cohorts
- Identification of inflammatory markers suitable for non-invasive, repeated measurement studies in biobehavioral research: A feasibility study
- Genomic analyses reveal an absence of contemporary introgressive admixture between fin whales and blue whales, despite known hybrids
- Tipping the balance towards long-term retention in the HIV care cascade: A mixed methods study in southern Mozambique
- Diagnosis and classification of pediatric acute appendicitis by artificial intelligence methods: An investigator-independent approach
- Stylistic variation on the Donald Trump Twitter account: A linguistic analysis of tweets posted between 2009 and 2018
- Kinematic determinants of scoring success in the fencing flick: Logistic and linear multiple regression analysis
- Preferences for formal and traditional sources of childbirth and postnatal care among women in rural Africa: A systematic review
- Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix)
- Associations between industry involvement and study characteristics at the time of trial registration in biomedical research
- A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
- Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1
- The predictive performance of SAPS 2 and SAPS 3 in an intermediate care unit for internal medicine at a German university transplant center; A retrospective analysis
- Advancing computational biology and bioinformatics research through open innovation competitions
- Dynamic changes in the physicochemical properties of fresh-cut produce wash water as impacted by commodity type and processing conditions
- Mapping online hate: A scientometric analysis on research trends and hotspots in research on online hate
- Orthogonal projection to latent structures and first derivative for manipulation of PLSR and SVR chemometric models' prediction: A case study
- DNA vaccine based on conserved HA-peptides induces strong immune response and rapidly clears influenza virus infection from vaccinated pigs
- Malaria transmission through the mosquito requires the function of the OMD protein
- Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines
- Governing Tripolye: Integrative architecture in Tripolye settlements
- In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis
- Mortality, perception, and scale: Understanding how predation shapes space use in a wild prey population
- DNA analysis of elasmobranch products originating from Bangladesh reveals unregulated elasmobranch fishery and trade on species of global conservation concern
- Genome-wide analysis of methylation in giant pandas with cataract by methylation-dependent restriction-site associated DNA sequencing (MethylRAD)
- A spherical falling film gas-liquid equilibrator for rapid and continuous measurements of CO2 and other trace gases
- The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review
- Gastroenteritis and respiratory infection outbreaks in French nursing homes from 2007 to 2018: Morbidity and all-cause lethality according to the individual characteristics of residents
- A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction
- De novo transcriptome analysis of Viola ×wittrockiana exposed to high temperature stress
- Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates
- HMGB1 mediates the development of tendinopathy due to mechanical overloading
- Effects of the Best Possible Self intervention: A systematic review and meta-analysis
- Metabolomic profiling of oxalate-degrading probiotic Lactobacillus acidophilus and Lactobacillus gasseri
- Adjusting cotton planting density under the climatic conditions of Henan Province, China
- Multiple biomarkers of sepsis identified by novel time-lapse proteomics of patient serum
- PTSD in prison settings: A systematic review and meta-analysis of comorbid mental disorders and problematic behaviours
- The female presence in different organisational positions and performance in secondary schools: Does a woman leader function as mediator?
- Beta power encodes contextual estimates of temporal event probability in the human brain
- Molecular characterization of measles virus strains circulating in Cameroon during the 2013-2016 epidemics
- Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain
- Comprehensive analysis of the internal structure and firmness in American cranberry (Vaccinium macrocarpon Ait.) fruit
- Predicting spinal profile using 3D non-contact surface scanning: Changes in surface topography as a predictor of internal spinal alignment
- Assessment modelling approaches for stocks with spawning components, seasonal and spatial dynamics, and limited resources for data collection
- Qualitative analysis of ward staff experiences during research of a novel suicide-prevention psychological therapy for psychiatric inpatients: Understanding the barriers and facilitators
- De-climatizing food security: Lessons from climate change micro-simulations in Peru
- Influence of musculotendon geometry variability in muscle forces and hip bone-on-bone forces during walking
- An international survey of perceptions of the 2014 FIFA World Cup: National levels of corruption as a context for perceptions of institutional corruption
- Dissuasive effect, information provision, and consumer reactions to the term ‘Biotechnology’: The case of reproductive interventions in farmed fish
- "If I have a cancer, it is not my fault I am a refugee”: A qualitative study with expert stakeholders on cancer care management for Syrian refugees in Jordan
- The effect of the use of a decision aid with individual risk estimation on the mode of delivery after a caesarean section: A prospective cohort study
- Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale
- High-throughput RNA-sequencing identifies mesenchymal stem cell-induced immunological signature in a rat model of corneal allograft rejection
- Evaluation of the pain intensity differences among hospitalized cancer patients based on a nursing information system
- Effects of chitin synthesis inhibitor treatment on Lepeophtheirus salmonis (Copepoda, Caligidae) larvae
- Protective mechanism of 1-methylhydantoin against lung injury induced by paraquat poisoning
- Use of high-content analysis and machine learning to characterize complex microbial samples via morphological analysis
- Investigation of a spatial coupling relationship between carbon emission performance and regional urbanization in China
- A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic diet
- Excellent outcome after desensitization in high immunologic risk kidney transplantation
- Characterization of a new composite membrane for point of need paper-based micro-scale microbial fuel cell analytical devices
- Acute kidney injury during an ultra-distance race
- A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
- The role of C-reactive protein levels on the association of physical activity with lung function in adults
- The CrowdWater game: A playful way to improve the accuracy of crowdsourced water level class data
- Therapeutic efficacy of neuregulin 1-expressing human adipose-derived mesenchymal stem cells for ischemic stroke
- CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein
- Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model
- Improved ICU mortality prediction based on SOFA scores and gastrointestinal parameters
- Social information use and collective foraging in a pursuit diving seabird
- Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES)
- Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis
- Prevalence of Epstein-Barr virus, human papillomavirus, cytomegalovirus and herpes simplex virus type 1 in patients with diabetes mellitus type 2 in south-eastern Poland
- Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada
- Characterization of Monkeypox virus dissemination in the black-tailed prairie dog (Cynomys ludovicianus) through in vivo bioluminescent imaging
- LPS induces inflammatory chemokines via TLR-4 signalling and enhances the Warburg Effect in THP-1 cells
- How do seabirds modify their search behaviour when encountering fishing boats?
- The diagnostic value of pleural fluid homocysteine in malignant pleural effusion
- Spatio-temporal variations in wheat aphid populations and their natural enemies in four agro-ecological zones of Pakistan
- Factors associated with burnout amongst healthcare workers providing HIV care in Malawi
- A high-density exome capture genotype-by-sequencing panel for forestry breeding in Pinus radiata
- Self-management action and motivation of Pacific adults in New Zealand with end-stage renal disease
- Drought mediated physiological and molecular changes in muskmelon (Cucumis melo L.)
- A prospective randomized trial on abacavir/lamivudine plus darunavir/ritonavir or raltegravir in HIV-positive drug-naïve patients with CD4<200 cells/uL (the PRADAR study)
- Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
- Multi-dimensional evaluation of response to salt stress in wheat
- Tuberculosis in the wild boar: Frequentist and Bayesian estimations of diagnostic test parameters when Mycobacterium bovis is present in wild boars but at low prevalence
- Enhanced mechanical and thermal properties of electrically conductive TPNR/GNP nanocomposites assisted with ultrasonication
- Geospatial modeling of microcephaly and zika virus spread patterns in Brazil
- Maternal cardiovascular-related single nucleotide polymorphisms, genes, and pathways associated with early-onset preeclampsia
- A ten-year review of ESBL and non-ESBL Escherichia coli bloodstream infections among children at a tertiary referral hospital in South Africa
- Reference values for the cervical spinal canal and the vertebral bodies by MRI in a general population
- Dynamic mechanical characteristics and failure mode of serpentine under a three-dimensional high static load and frequent dynamic disturbance
- Incorporating statistical strategy into image analysis to estimate effects of steam and allyl isocyanate on weed control
- Regulation of NF-κB- and STAT1-mediated plasmacytoid dendritic cell functions by A20
- The erythrocyte membrane stability is associated with sleep time and social jetlag in shift workers
- New space-time block codes from spectral norm
- Mexican BRCA1 founder mutation: Shortening the gap in genetic assessment for hereditary breast and ovarian cancer patients
- GIVE me your attention: Differentiating goal identification and goal execution components of the anti-saccade effect
- Maternal serum retinol, 25(OH)D and 1,25(OH)2D concentrations during pregnancy and peak bone mass and trabecular bone score in adult offspring at 26-year follow-up
- Self Multi-Head Attention-based Convolutional Neural Networks for fake news detection
- Why are Chinese workers so unhappy? A comparative cross-national analysis of job satisfaction, job expectations, and job attributes
- Fecal indicator bacteria and virus removal in stormwater biofilters: Effects of biochar, media saturation, and field conditioning
- Personalized microstructural evaluation using a Mahalanobis-distance based outlier detection strategy on epilepsy patients’ DTI data – Theory, simulations and example cases
- Radiographic assessment of pectoral flipper bone maturation in bottlenose dolphins (Tursiops truncatus), as a novel technique to accurately estimate chronological age
- Intraoperative measurement of intraventricular pressure in dogs with communicating internal hydrocephalus
- Relative importance of gene effects for nitrogen-use efficiency in popcorn
- Comparative analysis uncovers the limitations of current molecular detection methods for Fusarium oxysporum f. sp. cubense race 4 strains
- The accuracy of the frontal extent in stereoscopic environments: A comparison of direct selection and virtual cursor techniques
- Confronting pastoralists’ knowledge of cattle breeds raised in the extensive production systems of Benin with multivariate analyses of morphological traits
- CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer’s disease
- Decontamination of aerosolised bacteria from a pig farm environment using a pH neutral electrochemically activated solution (Ecas4 anolyte)
- Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling
- Simultaneous transcriptome analysis of oil palm clones and Phytophthora palmivora reveals oil palm defense strategies
- Antifungal effects of a 1,3,4-thiadiazole derivative determined by cytochemical and vibrational spectroscopic studies
- Risk factors for unsuccessful tuberculosis treatment outcomes in children
- CRISPR-based tools for targeted transcriptional and epigenetic regulation in plants
- Reliability of high-resolution ultrasound and magnetic resonance arthrography of the shoulder in patients with sports-related shoulder injuries
- Spatial-temporal variation characteristics and evolution of the global industrial robot trade: A complex network analysis
- Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- On the sustainability of a family planning program in Nigeria when funding ends
- The epidemiology of antidepressant use in South Korea: Does short-term antidepressant use affect the relapse and recurrence of depressive episodes?
- Injury severity level and associated factors among road traffic accident victims attending emergency department of Tirunesh Beijing Hospital, Addis Ababa, Ethiopia: A cross sectional hospital-based study
- How chimpanzees (Pan troglodytes) share the spoils with collaborators and bystanders
- Seed treatment using methyl jasmonate induces resistance to rice water weevil but reduces plant growth in rice
- Placebo analgesia induced by verbal suggestion in the context of experimentally induced fear and anxiety
- Reconsidering the associations between self-reported alcohol use disorder and mental health problems in the light of co-occurring addictions in young Swiss men
- Learning to assist smokers through encounters with standardized patients: An innovative training for physicians in an Eastern European country
- Serum E-selectin concentration is associated with risk of metabolic syndrome in females
- Lipid and fatty acid dynamics by maternal Pacific bluefin tuna
- Adherence to evidence-based recommendations for surgical site infection prevention: Results among Italian surgical ward nurses
- Novel synergistic fungicidal mixtures of oxathiapiprolin protect sunflower seeds from downy mildew caused by Plasmopara halstedii
- Adjustment of a numerical model for pore pressure generation during an earthquake
- The risk, perceived and actual, of developing type 2 diabetes mellitus for mothers of preschool children in urban China
- Effects of turning frequency on the nutrients of Camellia oleifera shell co-compost with goat dung and evaluation of co-compost maturity
- Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers
- Distribution of SET/I2PP2A protein in gastrointestinal tissues
- Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs
- Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study
- Anatomy of a demand shock: Quantitative analysis of crowding in hospital emergency departments in Victoria, Australia during the 2009 influenza pandemic
- Oregano essential oil vapour prevents Plasmopara viticola infection in grapevine (Vitis Vinifera) and primes plant immunity mechanisms
- Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism
- Optimising poly(lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach
- Repetitive finger movement and circle drawing in persons with Parkinson’s disease
- The association between family members’ migration and cognitive function among people left behind in China
- Association between long-term adherence to class-I recommended medications and risk for potentially preventable heart failure hospitalizations among younger adults
- Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals
- Agreement between the spatiotemporal gait parameters from two different wearable devices and high-speed video analysis
- In-hospital cardiopulmonary resuscitation of patients with cirrhosis: A population-based analysis
- Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes
- Someone like me: Size-assortative pairing and mating in an Amazonian fish, sailfin tetra Crenuchus spilurus
- Seasonality of antenatal care attendance, maternal dietary intake, and fetal growth in the VHEMBE birth cohort, South Africa
- Are trials of psychological and psychosocial interventions for schizophrenia and psychosis included in the NICE guidelines pragmatic? A systematic review
- Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
- Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes
- Intensity modulated radiation therapy following lumpectomy in early-stage breast cancer: Patterns of use and cost consequences among Medicare beneficiaries
- The ‘Saw but Forgot’ error: A role for short-term memory failures in understanding junction crashes?
- Multiscale Modelling Tool: Mathematical modelling of collective behaviour without the maths
- A comparison of machine learning algorithms for the surveillance of autism spectrum disorder
- Drivers of deforestation in the basin of the Usumacinta River: Inference on process from pattern analysis using generalised additive models
- Structure of Dictyostelium discoideum telomeres. Analysis of possible replication mechanisms
- Multidrug-resistant profile and prevalence of extended spectrum β-lactamase and carbapenemase production in fermentative Gram-negative bacilli recovered from patients and specimens referred to National Reference Laboratory, Addis Ababa, Ethiopia
- Primary myelofibrosis marrow-derived CD14+/CD34- monocytes induce myelofibrosis-like phenotype in immunodeficient mice and give rise to megakaryocytes
- Intersubject MVPD: Empirical comparison of fMRI denoising methods for connectivity analysis
- Why Cohen’s Kappa should be avoided as performance measure in classification
- A novel strategy for interpreting the T-SPOT.TB test results read by an ELISPOT plate imager
- Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer’s patients
- NPHP proteins are binding partners of nucleoporins at the base of the primary cilium
- Intensive measures of luminescence in GaN/InGaN heterostructures
- The effect of a web-based training for improving primary health care providers’ knowledge about diabetes mellitus management in rural China: A pre-post intervention study
- Isolation, identification and characterization of Streptomyces metabolites as a potential bioherbicide
- Quantitative magnetic resonance imaging indicates brain tissue alterations in patients after liver transplantation
- DNA analysis of Castanea sativa (sweet chestnut) in Britain and Ireland: Elucidating European origins and genepool diversity
- Forecasting the impact of population ageing on tuberculosis incidence
- Conformation and mechanical property of rpoS mRNA inhibitory stem studied by optical tweezers and X-ray scattering
- Voxelwise statistical methods to localize practice variation in brain tumor surgery
- Identification and evolutionary characterization of salt-responsive transcription factors in the succulent halophyte Suaeda fruticosa
- Integrating temperature-dependent life table data into Insect Life Cycle Model for predicting the potential distribution of Scapsipedus icipe Hugel & Tanga
- Rollout of ShangRing circumcision with active surveillance for adverse events and monitoring for uptake in Kenya
- Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures
- Analyzing a networked social algorithm for collective selection of representative committees
- Gene expression profiling of skeletal myogenesis in human embryonic stem cells reveals a potential cascade of transcription factors regulating stages of myogenesis, including quiescent/activated satellite cell-like gene expression
- Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components
- EFForTS-LGraf: A landscape generator for creating smallholder-driven land-use mosaics
- Impact of the severity of negative energy balance on gene expression in the subcutaneous adipose tissue of periparturient primiparous Holstein dairy cows: Identification of potential novel metabolic signals for the reproductive system
- Precision and consistency of the passive leg raising maneuver for determining fluid responsiveness with bioreactance non-invasive cardiac output monitoring in critically ill patients and healthy volunteers
- Optimizing bacterial DNA extraction in urine
- Adherences to oral nutritional supplementation among hospital outpatients: An online cross-sectional survey in Japan
- Effects of inorganic nitrogen and litters of Masson Pine on soil organic carbon decomposition
- Antioxidant properties of potato tubers (Solanum tuberosum L.) as a consequence of genetic potential and growing conditions
- Transcatheter aortic valve implantation versus conservative management for severe aortic stenosis in real clinical practice
- “I put it in my head that the supplement would help me”: Open-placebo improves exercise performance in female cyclists
- Automated diagnosis of heart valve degradation using novelty detection algorithms and machine learning
- Spatiotemporal clustering of malaria in southern-central Ethiopia: A community-based cohort study
- Studying the link between physiological performance of Crotalaria ochroleuca and the distribution of Ca, P, K and S in seeds with X-ray fluorescence
- Characterization of bony changes localized to the cervical articular processes in a mixed population of horses
- Heat shock-induced chaperoning by Hsp70 is enabled in-cell
- Disability and its association with sociodemographic factors among elderly persons residing in an urban resettlement colony, New Delhi, India
- Correlates of prenatal and postnatal mother-to-infant bonding quality: A systematic review
- IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma
- Dietary supplementation with the extract from Eucommia ulmoides leaves changed epithelial restitution and gut microbial community and composition of weanling piglets
- How did that interaction make you feel? The relationship between quality of everyday social experiences and emotion in people with and without schizophrenia
- Effects of Lyse-It on endonuclease fragmentation, function and activity
- Overexpression of rice gene OsATG8b confers tolerance to nitrogen starvation and increases yield and nitrogen use efficiency (NUE) in Arabidopsis
- Gait can reveal sleep quality with machine learning models
- Blast vacuolization in AML patients indicates adverse-risk AML and is associated with impaired survival after intensive induction chemotherapy
- Mitochondrial fragmentation and network architecture in degenerative diseases
- Quadriceps muscle strength is a discriminant predictor of dependence in daily activities in nursing home residents
- Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds
- Skin-associated lactic acid bacteria from North American bullfrogs as potential control agents of Batrachochytrium dendrobatidis
- Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection
- The responses of extracellular enzyme activities and microbial community composition under nitrogen addition in an upland soil
- Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking
- Absolute pitch can be learned by some adults
- Anger while driving in Mexico City
- Glomerular hyperfiltration may be a novel risk factor of restrictive spirometry pattern: Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2015
- Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database
- Multiple evoked and induced alpha modulations in a visual attention task: Latency, amplitude and topographical profiles
- Heart rate variability reduction is related to a high amount of visceral adiposity in healthy young women
- Serum and urinary metabolomics and outcomes in cirrhosis
- Optimal threshold of adherence to lipid lowering drugs in predicting acute coronary syndrome, stroke, or mortality: A cohort study
- Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis
- How Knowledge Stock Exchanges can increase student success in Massive Open Online Courses
- CT-perfusion in peripheral arterial disease – Correlation with angiographic and hemodynamic parameters
- Pattern of health care utilization and traditional and complementary medicine use among Ebola survivors in Sierra Leone
- Respiratory variations in pulse pressure and photoplethysmographic waveform amplitude during positive expiratory pressure and continuous positive airway pressure in a model of progressive hypovolemia
- Dorsal tongue porphyrin autofluorescence and Candida saprophytism: A prospective observational study
- A usability study to improve a clinical decision support system for the prescription of antibiotic drugs
- Occurrence of and risk factors for extended-spectrum cephalosporin-resistant Enterobacteriaceae determined by sampling of all Norwegian broiler flocks during a six month period
- Healthcare facility-based strategies to improve tuberculosis testing and linkage to care in non-U.S.-born population in the United States: A systematic review
- Correction: Reward abundance interferes with error-based learning in a visuomotor adaptation task
- Correction: Potential user interest in new long-acting contraceptives: Results from a mixed methods study in Burkina Faso and Uganda
- Correction: Recombinant rabbit beta nerve growth factor production and its biological effects on sperm and ovulation in rabbits
- Critically ill patients with community-onset intraabdominal infections: Influence of healthcare exposure on resistance rates and mortality
- Validating a popular outpatient antibiotic database to reliably identify high prescribing physicians for patients 65 years of age and older
- Metabolisable energy content in canine and feline foods is best predicted by the NRC2006 equation
- Group conquers efficacy: Preschoolers’ imitation under conflict between minimal group membership and behavior efficacy
- Warmth and competence stereotypes about immigrant groups in Germany
- Social resistance drives persistent transmission of Ebola virus disease in Eastern Democratic Republic of Congo: A mixed-methods study
- ER stress activation in the intestinal mucosa but not in mesenteric adipose tissue is associated with inflammation in Crohn’s disease patients
- Enhancing percutaneous pedicle screw fixation with hydroxyapatite granules: A biomechanical study using an osteoporotic bone model
- Optimum plant density for crowding stress tolerant processing sweet corn
- Sign and goal tracker rats process differently the incentive salience of a conditioned stimulus
- Interocular symmetry, intraobserver repeatability, and interobserver reliability of cone density measurements in the 13-lined ground squirrel
- Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy
- Knowledge, attitudes and practices of livestock and aquaculture producers regarding antimicrobial use and resistance in Vietnam
- Scientific sinkhole: The pernicious price of formatting
- Resource consumption of multi-substance users in the emergency room: A neglected patient group
- Association between distress and knowledge among parents of autistic children
- Surgical approach for complete cochlear coverage in EAS-patients after residual hearing loss
- The impact of a rapid molecular identification test on positive blood cultures from critically ill with bacteremia: A pre-post intervention study
- Shortening duration of ertapenem in outpatient parenteral antimicrobial therapy for complicated urinary tract infections: A retrospective study
- Measurement and analysis of partial lightning currents in a head phantom
- Within species expressed genetic variability and gene expression response to different temperatures in the rotifer Brachionus calyciflorus sensu stricto
- Repeated transspinal stimulation decreases soleus H-reflex excitability and restores spinal inhibition in human spinal cord injury
- Expression of Concern: Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor
- Correlation of CT texture changes with treatment response during radiation therapy for esophageal cancer: An exploratory study
- Modeling spatial variation in density of golden eagle nest sites in the western United States
- Retraction: Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3
- Correction: In Porphyromonas gingivalis VimF Is Involved in Gingipain Maturation through the Transfer of Galactose
- Gibberellic acid in Citrus spp. flowering and fruiting: A systematic review
- Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey
- A novel therapeutic strategy for esophageal varices using endoscopic treatment combined with splenic artery embolization according to the Child-Pugh classification
- Correction: Development of a high-throughput assay to measure measles neutralizing antibodies
- Correction: Provider preference for payment method under a national health insurance scheme: A survey of health insurance-credentialed health care providers in Ghana
- Correction: Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis
- Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India
- Feed-forward visual processing suffices for coarse localization but fine-grained localization in an attention-demanding context needs feedback processing
- Level Set method-based two-dimensional numerical model for simulation of nonuniform open-channel flow
- Compared to non-drinkers, individuals who drink alcohol have a more favorable multisystem physiologic risk score as measured by allostatic load
- Effect of poor glycaemic control on plasma levels and activity of protein C, protein S, and antithrombin III in type 2 diabetes mellitus
- Retraction: IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
- Sugar transporters in Fabaceae, featuring SUT MST and SWEET families of the model plant Medicago truncatula and the agricultural crop Pisum sativum
- Prediction of lymphovascular space invasion in endometrial cancer using the 55-gene signature selected by DNA microarray analysis
- Research on multi-agent genetic algorithm based on tabu search for the job shop scheduling problem
- Diagnosing the current state of out-of-field teaching in high school science and mathematics
- Sensitivity of the fasciae to sex hormone levels: Modulation of collagen-I, collagen-III and fibrillin production
- Comorbidity of age-related macular degeneration with Alzheimer’s disease: A histopathologic case-control study
- Acute ex vivo changes in brain white matter diffusion tensor metrics
- Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock
- The effect of bacteria on planula-larvae settlement and metamorphosis in the octocoral Rhytisma fulvum fulvum
- Sodium alginate potentiates antioxidant defense and PR proteins against early blight disease caused by Alternaria solani in Solanum lycopersicum Linn.
- Ground reaction forces and muscle activity while walking on sand versus stable ground in individuals with pronated feet compared with healthy controls
- Correction: Roadway traffic crash prediction using a state-space model based support vector regression approach
- MET as resistance factor for afatinib therapy and motility driver in gastric cancer cells
- Genetic analysis and fine mapping of a qualitative trait locus wpb1 for albino panicle branches in rice
- Clinical features of pulmonary embolism in patients with lung cancer: A meta-analysis
- Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiota
- Factors restraining the population growth of Varroa destructor in Ethiopian honey bees (Apis mellifera simensis)
- Coastal proximity of populations in 22 Pacific Island Countries and Territories
- DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1
- Genetic characterization of Angiostrongylus larvae and their intermediate host, Achatina fulica, in Thailand
- Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy
- Influence of ocean circulation and the Kuroshio large meander on the 2018 Japanese eel recruitment season
- Growth response of the ichthyotoxic haptophyte, Prymnesium parvum Carter, to changes in sulfate and fluoride concentrations
- Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome
- Prognostic nomogram predicts overall survival in pulmonary large cell neuroendocrine carcinoma
- Microbiome profiling of the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae)
- Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
- Retraction: Impacts of rock properties on Danxia landform formation based on lithological experiments at Kongtongshan National Geopark, northwest China
- Correction: SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience
- Retraction: Plexin-B1 Activates NF-κB and IL-8 to Promote a Pro-Angiogenic Response in Endothelial Cells
- Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis
- Association between temperature, sunlight hours and alcohol consumption
- Using graph learning to understand adverse pregnancy outcomes and stress pathways
- Correction: The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?
- Surgical referral systems in low- and middle-income countries: A review of the evidence
- In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells
- Correction: The Economic Impact of Malignant Catarrhal Fever on Pastoralist Livelihoods
- Correction: Identification of miRNAs involved in fruit ripening by deep sequencing of Olea europaea L. transcriptome
- Correction: Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Correction: Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells
- Correction: Plant traits linked to field-scale flammability metrics in prescribed burns in Eucalyptus forest
- Correction: Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation
- Correction: To keep or not to keep? Decision making in adolescent pregnancies in Jamestown, Ghana
- PLOS One
- Archiv čísel
- Aktuální číslo
- Informace o časopisu
Nejčtenější v tomto čísle- Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats
- CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer’s disease
- Comparison between Aptima Assays (Hologic) and the Allplex STI Essential Assay (Seegene) for the diagnosis of Sexually transmitted infections
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
Kurzy
Zvyšte si kvalifikaci online z pohodlí domova
Autoři: prof. MUDr. Vladimír Palička, CSc., Dr.h.c., doc. MUDr. Václav Vyskočil, Ph.D., MUDr. Petr Kasalický, CSc., MUDr. Jan Rosa, Ing. Pavel Havlík, Ing. Jan Adam, Hana Hejnová, DiS., Jana Křenková
Autoři: MUDr. Irena Krčmová, CSc.
Autoři: MDDr. Eleonóra Ivančová, PhD., MHA
Autoři: prof. MUDr. Eva Kubala Havrdová, DrSc.
Všechny kurzyPřihlášení#ADS_BOTTOM_SCRIPTS#Zapomenuté hesloZadejte e-mailovou adresu, se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.
- Vzdělávání