1. AaltoAP, PasquinelliAE (2012) Small non-coding RNAs mount a silent revolution in gene expression. Curr Opin in Cell Biol 24 (3)
2. KimVN, HanJ, SiomiMC (2009) Biogenesis of small RNAs in animals. Nature reviews Molecular cell biology 10: 126–139.
3. WinterJ, JungS, KellerS, GregoryRI, DiederichsS (2009) Many roads to maturity: microRNA biogenesis pathways and their regulation. Nature cell biology 11: 228–234.
4. HuntzingerE, IzaurraldeE (2011) Gene silencing by microRNAs: contributions of translational repression and mRNA decay. Nature reviews Genetics 12: 99–110.
5. PasquinelliAE (2012) MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nature reviews Genetics 13: 271–282.
6. ReinhartBJ, SlackFJ, BassonM, PasquinelliAE, BettingerJC, et al. (2000) The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403: 901–906.
7. SlackFJ, BassonM, LiuZ, AmbrosV, HorvitzHR, et al. (2000) The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Molecular cell 5: 659–669.
8. AmbrosV, HorvitzHR (1984) Heterochronic mutants of the nematode Caenorhabditis elegans. Science 226: 409–416.
9. AbrahanteJE, DaulAL, LiM, VolkML, TennessenJM, et al. (2003) The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Developmental cell 4: 625–637.
10. LinSY, JohnsonSM, AbrahamM, VellaMC, PasquinelliA, et al. (2003) The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Developmental cell 4: 639–650.
11. GrosshansH, JohnsonT, ReinertKL, GersteinM, SlackFJ (2005) The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans. Developmental cell 8: 321–330.
12. PasquinelliAE, ReinhartBJ, SlackF, MartindaleMQ, KurodaMI, et al. (2000) Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408: 86–89.
13. MondolV, PasquinelliAE (2012) Let's make it happen: the role of let-7 microRNA in development. Current topics in developmental biology 99: 1–30.
14. BoyerinasB, ParkSM, HauA, MurmannAE, PeterME (2010) The role of let-7 in cell differentiation and cancer. Endocrine-related cancer 17: F19–36.
15. ThorntonJE, GregoryRI (2012) How does Lin28 let-7 control development and disease? Trends Cell Biol 474–82 doi:10.1016/j.tcb.2012.06.001.
16. HeoI, JooC, ChoJ, HaM, HanJ, et al. (2008) Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Molecular cell 32: 276–284.
17. NewmanMA, ThomsonJM, HammondSM (2008) Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing. RNA 14: 1539–1549.
18. RybakA, FuchsH, SmirnovaL, BrandtC, PohlEE, et al. (2008) A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nature cell biology 10: 987–993.
19. ViswanathanSR, DaleyGQ, GregoryRI (2008) Selective blockade of microRNA processing by Lin28. Science 320: 97–100.
20. HeoI, JooC, KimYK, HaM, YoonMJ, et al. (2009) TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 138: 696–708.
21. LehrbachNJ, ArmisenJ, LightfootHL, MurfittKJ, BugautA, et al. (2009) LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nature structural & molecular biology 16: 1016–1020.
22. PiskounovaE, PolytarchouC, ThorntonJE, LaPierreRJ, PothoulakisC, et al. (2011) Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms. Cell 147: 1066–1079.
23. Van WynsberghePM, KaiZS, MassirerKB, BurtonVH, YeoGW, et al. (2011) LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans. Nature structural & molecular biology 18: 302–308.
24. ViswanathanSR, PowersJT, EinhornW, HoshidaY, NgTL, et al. (2009) Lin28 promotes transformation and is associated with advanced human malignancies. Nature genetics 41: 843–848.
25. ZhuH, Shyh-ChangN, SegreAV, ShinodaG, ShahSP, et al. (2011) The Lin28/let-7 axis regulates glucose metabolism. Cell 147: 81–94.
26. FrostRJ, OlsonEN (2011) Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs. Proceedings of the National Academy of Sciences of the United States of America 108: 21075–21080.
27. JohnsonSM, GrosshansH, ShingaraJ, ByromM, JarvisR, et al. (2005) RAS is regulated by the let-7 microRNA family. Cell 120: 635–647.
28. JohnsonCD, Esquela-KerscherA, StefaniG, ByromM, KelnarK, et al. (2007) The let-7 microRNA represses cell proliferation pathways in human cells. Cancer research 67: 7713–7722.
29. BoyerinasB, ParkSM, ShomronN, HedegaardMM, VintherJ, et al. (2008) Identification of let-7-regulated oncofetal genes. Cancer research 68: 2587–2591.
30. ShellS, ParkSM, RadjabiAR, SchickelR, KistnerEO, et al. (2007) Let-7 expression defines two differentiation stages of cancer. Proceedings of the National Academy of Sciences of the United States of America 104: 11400–11405.
31. YuF, YaoH, ZhuP, ZhangX, PanQ, et al. (2007) let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131: 1109–1123.
32. LeeYS, DuttaA (2007) The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes & development 21: 1025–1030.
33. MayrC, HemannMT, BartelDP (2007) Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 315: 1576–1579.
34. Esquela-KerscherA, TrangP, WigginsJF, PatrawalaL, ChengA, et al. (2008) The let-7 microRNA reduces tumor growth in mouse models of lung cancer. Cell cycle 7: 759–764.
35. KumarMS, ErkelandSJ, PesterRE, ChenCY, EbertMS, et al. (2008) Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proceedings of the National Academy of Sciences of the United States of America 105: 3903–3908.
36. EnrightAJ, JohnB, GaulU, TuschlT, SanderC, et al. (2003) MicroRNA targets in Drosophila. Genome biology 5: R1.
37. LewisBP, ShihIH, Jones-RhoadesMW, BartelDP, BurgeCB (2003) Prediction of mammalian microRNA targets. Cell 115: 787–798.
38. LallS, GrunD, KrekA, ChenK, WangYL, et al. (2006) A genome-wide map of conserved microRNA targets in C. elegans. Current biology : CB 16: 460–471.
39. MirandaKC, HuynhT, TayY, AngYS, TamWL, et al. (2006) A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell 126: 1203–1217.
40. KerteszM, IovinoN, UnnerstallU, GaulU, SegalE (2007) The role of site accessibility in microRNA target recognition. Nature genetics 39: 1278–1284.
41. HammellM, LongD, ZhangL, LeeA, CarmackCS, et al. (2008) mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein-enriched transcripts. Nature methods 5: 813–819.
42. BartelDP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215–233.
43. ShinC, NamJW, FarhKK, ChiangHR, ShkumatavaA, et al. (2010) Expanding the microRNA targeting code: functional sites with centered pairing. Molecular cell 38: 789–802.
44. RigoutsosI (2009) New tricks for animal microRNAS: targeting of amino acid coding regions at conserved and nonconserved sites. Cancer research 69: 3245–3248.
45. WightmanB, HaI, RuvkunG (1993) Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75: 855–862.
46. LeeRC, FeinbaumRL, AmbrosV (1993) The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843–854.
47. ThomsonDW, BrackenCP, GoodallGJ (2011) Experimental strategies for microRNA target identification. Nucleic acids research 39: 6845–6853.
48. HuangJC, BabakT, CorsonTW, ChuaG, KhanS, et al. (2007) Using expression profiling data to identify human microRNA targets. Nature methods 4: 1045–1049.
49. LimLP, LauNC, Garrett-EngeleP, GrimsonA, SchelterJM, et al. (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433: 769–773.
50. SchmitterD, FilkowskiJ, SewerA, PillaiRS, OakeleyEJ, et al. (2006) Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells. Nucleic acids research 34: 4801–4815.
51. SoodP, KrekA, ZavolanM, MacinoG, RajewskyN (2006) Cell-type-specific signatures of microRNAs on target mRNA expression. Proceedings of the National Academy of Sciences of the United States of America 103: 2746–2751.
52. BaekD, VillenJ, ShinC, CamargoFD, GygiSP, et al. (2008) The impact of microRNAs on protein output. Nature 455: 64–71.
53. SelbachM, SchwanhausserB, ThierfelderN, FangZ, KhaninR, et al. (2008) Widespread changes in protein synthesis induced by microRNAs. Nature 455: 58–63.
54. JovanovicM, ReiterL, PicottiP, LangeV, BoganE, et al. (2010) A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans. Nature methods 7: 837–842.
55. GuoH, IngoliaNT, WeissmanJS, BartelDP (2010) Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466: 835–840.
56. StadlerM, ArtilesK, PakJ, FireA (2012) Contributions of mRNA abundance, ribosome loading, and post- or peri-translational effects to temporal repression of C. elegans heterochronic miRNA targets. Genome Res 22 (12)
57. BeitzingerM, PetersL, ZhuJY, KremmerE, MeisterG (2007) Identification of human microRNA targets from isolated argonaute protein complexes. RNA biology 4: 76–84.
58. EasowG, TelemanAA, CohenSM (2007) Isolation of microRNA targets by miRNP immunopurification. RNA 13: 1198–1204.
59. HendricksonDG, HoganDJ, HerschlagD, FerrellJE, BrownPO (2008) Systematic identification of mRNAs recruited to argonaute 2 by specific microRNAs and corresponding changes in transcript abundance. PLoS ONE 3: e2126 doi:10.1371/journal.pone.0002126.
60. KarginovFV, ConacoC, XuanZ, SchmidtBH, ParkerJS, et al. (2007) A biochemical approach to identifying microRNA targets. Proceedings of the National Academy of Sciences of the United States of America 104: 19291–19296.
61. LandthalerM, GaidatzisD, RothballerA, ChenPY, SollSJ, et al. (2008) Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs. RNA 14: 2580–2596.
62. ZhangL, DingL, CheungTH, DongMQ, ChenJ, et al. (2007) Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Molecular cell 28: 598–613.
63. ChiSW, ZangJB, MeleA, DarnellRB (2009) Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 460: 479–486.
64. HafnerM, LandthalerM, BurgerL, KhorshidM, HausserJ, et al. (2010) Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell 141: 129–141.
65. LeungAK, YoungAG, BhutkarA, ZhengGX, BossonAD, et al. (2011) Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nature structural & molecular biology 18: 237–244.
66. ZisoulisDG, LovciMT, WilbertML, HuttKR, LiangTY, et al. (2010) Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans. Nature structural & molecular biology 17: 173–179.
67. BaggaS, BrachtJ, HunterS, MassirerK, HoltzJ, et al. (2005) Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122: 553–563.
68. DingXC, GrosshansH (2009) Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins. The EMBO journal 28: 213–222.
69. LewisBP, BurgeCB, BartelDP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120: 15–20.
70. VellaMC, ChoiEY, LinSY, ReinertK, SlackFJ (2004) The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3′UTR. Genes & development 18: 132–137.
71. NimmoRA, SlackFJ (2009) An elegant miRror: microRNAs in stem cells, developmental timing and cancer. Chromosoma 118: 405–418.
72. BettingerJC, LeeK, RougvieAE (1996) Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development. Development 122: 2517–2527.
73. RougvieAE, AmbrosV (1995) The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in Caenorhabditis elegans. Development 121: 2491–2500.
74. DingXC, SlackFJ, GrosshansH (2008) The let-7 microRNA interfaces extensively with the translation machinery to regulate cell differentiation. Cell cycle 7: 3083–3090.
75. KamathRS, FraserAG, DongY, PoulinG, DurbinR, et al. (2003) Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature 421: 231–237.
76. RualJF, CeronJ, KorethJ, HaoT, NicotAS, et al. (2004) Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library. Genome research 14: 2162–2168.
77. SternbergPW (2005) Vulval development. WormBook : the online review of C elegans biology 1–28.
78. SherwoodDR, ButlerJA, KramerJM, SternbergPW (2005) FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans. Cell 121: 951–962.
79. MohamadnejadM, SwensonES (2008) Induced pluripotent cells mimicking human embryonic stem cells. Archives of Iranian medicine 11: 125–128.
80. YuJ, VodyanikMA, Smuga-OttoK, Antosiewicz-BourgetJ, FraneJL, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917–1920.
81. TayY, ZhangJ, ThomsonAM, LimB, RigoutsosI (2008) MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 455: 1124–1128.
82. HayesGD, FrandAR, RuvkunG (2006) The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development 133: 4631–4641.
83. SulstonJE, HorvitzHR (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Developmental biology 56: 110–156.
84. SmithJA, McGarrP, GilleardJS (2005) The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion. Journal of cell science 118: 5709–5719.
85. AbbottAL, Alvarez-SaavedraE, MiskaEA, LauNC, BartelDP, et al. (2005) The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Developmental cell 9: 403–414.
86. BethkeA, FielenbachN, WangZ, MangelsdorfDJ, AntebiA (2009) Nuclear hormone receptor regulation of microRNAs controls developmental progression. Science 324: 95–98.
87. HammellCM, KarpX, AmbrosV (2009) A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 106: 18668–18673.
88. ZisoulisDG, KaiZS, ChangRK, PasquinelliAE (2012) Autoregulation of microRNA biogenesis by let-7 and Argonaute. Nature 486: 541–544.
89. BussingI, SlackFJ, GrosshansH (2008) let-7 microRNAs in development, stem cells and cancer. Trends in molecular medicine 14: 400–409.
90. RoushSF, SlackFJ (2009) Transcription of the C. elegans let-7 microRNA is temporally regulated by one of its targets, hbl-1. Developmental biology 334: 523–534.
91. MeissnerB, BollM, DanielH, BaumeisterR (2004) Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans. The Journal of biological chemistry 279: 36739–36745.
92. VeljkovicE, StasiukS, SkellyPJ, ShoemakerCB, VerreyF (2004) Functional characterization of Caenorhabditis elegans heteromeric amino acid transporters. The Journal of biological chemistry 279: 7655–7662.
93. YamagataK, DaitokuH, TakahashiY, NamikiK, HisatakeK, et al. (2008) Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Molecular cell 32: 221–231.
94. NehrkeK (2003) A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span. The Journal of biological chemistry 278: 44657–44666.
95. SpanierB, LaschK, MarschS, BennerJ, LiaoW, et al. (2009) How the intestinal peptide transporter PEPT-1 contributes to an obesity phenotype in Caenorhabditits elegans. PLoS ONE 4: e6279 doi:10.1371/journal.pone.0006279.
96. Esquela-KerscherA, JohnsonSM, BaiL, SaitoK, PartridgeJ, et al. (2005) Post-embryonic expression of C. elegans microRNAs belonging to the lin-4 and let-7 families in the hypodermis and the reproductive system. Developmental dynamics : an official publication of the American Association of Anatomists 234: 868–877.
97. JohnsonSM, LinSY, SlackFJ (2003) The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter. Developmental biology 259: 364–379.
98. MartinezNJ, OwMC, Reece-HoyesJS, BarrasaMI, AmbrosVR, et al. (2008) Genome-scale spatiotemporal analysis of Caenorhabditis elegans microRNA promoter activity. Genome research 18: 2005–2015.
99. StrahlBD, BriggsSD, BrameCJ, CaldwellJA, KohSS, et al. (2001) Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Current biology : CB 11: 996–1000.
100. WangH, HuangZQ, XiaL, FengQ, Erdjument-BromageH, et al. (2001) Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science 293: 853–857.
101. TakahashiY, DaitokuH, HirotaK, TamiyaH, YokoyamaA, et al. (2011) Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16. Cell metabolism 13: 505–516.
102. BrennerS (1974) The genetics of Caenorhabditis elegans. Genetics 77: 71–94.
103. IrizarryRA, HobbsB, CollinF, Beazer-BarclayYD, AntonellisKJ, et al. (2003) Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249–264.
104. Huang daW, ShermanBT, LempickiRA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature protocols 4: 44–57.
105. Huang daW, ShermanBT, LempickiRA (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic acids research 37: 1–13.
106. YeoGW, Van NostrandEL, LiangTY (2007) Discovery and analysis of evolutionarily conserved intronic splicing regulatory elements. PLoS Genet 3: e85 doi:10.1371/journal.pgen.0030085.