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PLOS Genetics - Číslo 3/2013

Research Article

32767

Power and Predictive Accuracy of Polygenic Risk Scores

Rare Copy Number Variants Are a Common Cause of Short Stature

Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs

Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans

Genomic Evidence for Island Population Conversion Resolves Conflicting Theories of Polar Bear Evolution

Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism

Genome-Wide Association Study and Gene Expression Analysis Identifies as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis

Mouse HFM1/Mer3 Is Required for Crossover Formation and Complete Synapsis of Homologous Chromosomes during Meiosis

Alternative Splicing and Subfunctionalization Generates Functional Diversity in Fungal Proteomes

A WRKY Transcription Factor Recruits the SYG1-Like Protein SHB1 to Activate Gene Expression and Seed Cavity Enlargement

Microhomology-Mediated Mechanisms Underlie Non-Recurrent Disease-Causing Microdeletions of the Gene or Its Regulatory Domain

Ancient Evolutionary Trade-Offs between Yeast Ploidy States

Differential Evolutionary Fate of an Ancestral Primate Endogenous Retrovirus Envelope Gene, the EnvV , Captured for a Function in Placentation

A Feed-Forward Loop Coupling Extracellular BMP Transport and Morphogenesis in Wing

The Tomato Yellow Leaf Curl Virus Resistance Genes and Are Allelic and Code for DFDGD-Class RNA–Dependent RNA Polymerases

The U-Box E3 Ubiquitin Ligase TUD1 Functions with a Heterotrimeric G α Subunit to Regulate Brassinosteroid-Mediated Growth in Rice

Role of the DSC1 Channel in Regulating Neuronal Excitability in : Extending Nervous System Stability under Stress

–Independent Phenotypic Switching in and a Dual Role for Wor1 in Regulating Switching and Filamentation

Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204

Blood-Informative Transcripts Define Nine Common Axes of Peripheral Blood Gene Expression

Genetic Architecture of Skin and Eye Color in an African-European Admixed Population

Fine Characterisation of a Recombination Hotspot at the Locus and Resolution of the Paradoxical Excess of Duplications over Deletions in the General Population

Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status

Complex Patterns of Genomic Admixture within Southern Africa

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

Molecular Networks of Human Muscle Adaptation to Exercise and Age

Alp/Enigma Family Proteins Cooperate in Z-Disc Formation and Myofibril Assembly

Polycomb Group Gene Regulates Rice () Seed Development and Grain Filling via a Mechanism Distinct from

RFX Transcription Factor DAF-19 Regulates 5-HT and Innate Immune Responses to Pathogenic Bacteria in

Distinct Molecular Strategies for Hox-Mediated Limb Suppression in : From Cooperativity to Dispensability/Antagonism in TALE Partnership

A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and

Recurrent Rearrangement during Adaptive Evolution in an Interspecific Yeast Hybrid Suggests a Model for Rapid Introgression

Genome-Wide Association Study in Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease

Identification of a -Specific Modifier Locus at 6p24 Related to Breast Cancer Risk

A Novel Function for the Hox Gene in the Male Accessory Gland Regulates the Long-Term Female Post-Mating Response in

A Novel Role for the RNA–Binding Protein FXR1P in Myoblasts Cell-Cycle Progression by Modulating mRNA Stability

Association Mapping and the Genomic Consequences of Selection in Sunflower

Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte Maturation in Mouse

A Novel Mutation in the Upstream Open Reading Frame of the Gene Causes a MEN4 Phenotype

Ataxin1L Is a Regulator of HSC Function Highlighting the Utility of Cross-Tissue Comparisons for Gene Discovery

Human Spermatogenic Failure Purges Deleterious Mutation Load from the Autosomes and Both Sex Chromosomes, including the Gene

A Conserved Upstream Motif Orchestrates Autonomous, Germline-Enriched Expression of piRNAs

Statistical Analysis Reveals Co-Expression Patterns of Many Pairs of Genes in Yeast Are Jointly Regulated by Interacting Loci

Matefin/SUN-1 Phosphorylation Is Part of a Surveillance Mechanism to Coordinate Chromosome Synapsis and Recombination with Meiotic Progression and Chromosome Movement

A Role for the Malignant Brain Tumour (MBT) Domain Protein LIN-61 in DNA Double-Strand Break Repair by Homologous Recombination

The Population and Evolutionary Dynamics of Phage and Bacteria with CRISPR–Mediated Immunity

Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

DNA Topoisomerase III Localizes to Centromeres and Affects Centromeric CENP-A Levels in Fission Yeast

Genome-Wide Control of RNA Polymerase II Activity by Cohesin

Divergent Selection Drives Genetic Differentiation in an R2R3-MYB Transcription Factor That Contributes to Incipient Speciation in

NODULE INCEPTION Directly Targets Subunit Genes to Regulate Essential Processes of Root Nodule Development in

Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in

Deficiency in Origin Licensing Proteins Impairs Cilia Formation: Implications for the Aetiology of Meier-Gorlin Syndrome

Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice

The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in

Functional Genomic Analysis of the Regulatory Network in

Astakine 2—the Dark Knight Linking Melatonin to Circadian Regulation in Crustaceans

CRL2 E3-Ligase Regulates Proliferation and Progression through Meiosis in the Germline

Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in

PRMT4 Is a Novel Coactivator of c-Myb-Dependent Transcription in Haematopoietic Cell Lines

A Copy Number Variant at the Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit

Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors

HIV Infection Disrupts the Sympatric Host–Pathogen Relationship in Human Tuberculosis

Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained

A Gene Transfer Agent and a Dynamic Repertoire of Secretion Systems Hold the Keys to the Explosive Radiation of the Emerging Pathogen

The Role of ATM in the Deficiency in Nonhomologous End-Joining near Telomeres in a Human Cancer Cell Line

Dynamic Circadian Protein–Protein Interaction Networks Predict Temporal Organization of Cellular Functions

Nuclear Myosin 1c Facilitates the Chromatin Modifications Required to Activate rRNA Gene Transcription and Cell Cycle Progression

Robust Prediction of Expression Differences among Human Individuals Using Only Genotype Information

A Single Cohesin Complex Performs Mitotic and Meiotic Functions in the Protist

The Role of the Arabidopsis Exosome in siRNA–Independent Silencing of Heterochromatic Loci

Elevated Expression of the Integrin-Associated Protein PINCH Suppresses the Defects of Muscle Hypercontraction Mutants

Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest

Genome-Wide Testing of Putative Functional Exonic Variants in Relationship with Breast and Prostate Cancer Risk in a Multiethnic Population

Heteroduplex DNA Position Defines the Roles of the Sgs1, Srs2, and Mph1 Helicases in Promoting Distinct Recombination Outcomes

Interview

32767

Problem Solved: An Interview with Sir Edwin Southern

Perspective

32767

Tdp2: A Means to Fixing the Ends

Review

32767

Long Interspersed Element–1 (LINE-1): Passenger or Driver in Human Neoplasms?

PLOS Genetics

2013 Číslo 3

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