PLOS Genetics - Číslo 3/2013


Long Interspersed Element–1 (LINE-1): Passenger or Driver in Human Neoplasms?


Tdp2: A Means to Fixing the Ends


Problem Solved: An Interview with Sir Edwin Southern

Research Article

Power and Predictive Accuracy of Polygenic Risk Scores
Rare Copy Number Variants Are a Common Cause of Short Stature
Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs
Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans
Genomic Evidence for Island Population Conversion Resolves Conflicting Theories of Polar Bear Evolution
Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism
Genome-Wide Association Study and Gene Expression Analysis Identifies as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis
Mouse HFM1/Mer3 Is Required for Crossover Formation and Complete Synapsis of Homologous Chromosomes during Meiosis
Alternative Splicing and Subfunctionalization Generates Functional Diversity in Fungal Proteomes
A WRKY Transcription Factor Recruits the SYG1-Like Protein SHB1 to Activate Gene Expression and Seed Cavity Enlargement
Microhomology-Mediated Mechanisms Underlie Non-Recurrent Disease-Causing Microdeletions of the Gene or Its Regulatory Domain
Ancient Evolutionary Trade-Offs between Yeast Ploidy States
Differential Evolutionary Fate of an Ancestral Primate Endogenous Retrovirus Envelope Gene, the EnvV , Captured for a Function in Placentation
A Feed-Forward Loop Coupling Extracellular BMP Transport and Morphogenesis in Wing
The Tomato Yellow Leaf Curl Virus Resistance Genes and Are Allelic and Code for DFDGD-Class RNA–Dependent RNA Polymerases
The U-Box E3 Ubiquitin Ligase TUD1 Functions with a Heterotrimeric G α Subunit to Regulate Brassinosteroid-Mediated Growth in Rice
Role of the DSC1 Channel in Regulating Neuronal Excitability in : Extending Nervous System Stability under Stress
–Independent Phenotypic Switching in and a Dual Role for Wor1 in Regulating Switching and Filamentation
Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204
Blood-Informative Transcripts Define Nine Common Axes of Peripheral Blood Gene Expression
Genetic Architecture of Skin and Eye Color in an African-European Admixed Population
Fine Characterisation of a Recombination Hotspot at the Locus and Resolution of the Paradoxical Excess of Duplications over Deletions in the General Population
Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status
Complex Patterns of Genomic Admixture within Southern Africa
Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development
Molecular Networks of Human Muscle Adaptation to Exercise and Age
Alp/Enigma Family Proteins Cooperate in Z-Disc Formation and Myofibril Assembly
Polycomb Group Gene Regulates Rice () Seed Development and Grain Filling via a Mechanism Distinct from
RFX Transcription Factor DAF-19 Regulates 5-HT and Innate Immune Responses to Pathogenic Bacteria in
Distinct Molecular Strategies for Hox-Mediated Limb Suppression in : From Cooperativity to Dispensability/Antagonism in TALE Partnership
A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan
TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and
Recurrent Rearrangement during Adaptive Evolution in an Interspecific Yeast Hybrid Suggests a Model for Rapid Introgression
Genome-Wide Association Study in Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease
Identification of a -Specific Modifier Locus at 6p24 Related to Breast Cancer Risk
A Novel Function for the Hox Gene in the Male Accessory Gland Regulates the Long-Term Female Post-Mating Response in
A Novel Role for the RNA–Binding Protein FXR1P in Myoblasts Cell-Cycle Progression by Modulating mRNA Stability
Association Mapping and the Genomic Consequences of Selection in Sunflower
Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte Maturation in Mouse
A Novel Mutation in the Upstream Open Reading Frame of the Gene Causes a MEN4 Phenotype
Ataxin1L Is a Regulator of HSC Function Highlighting the Utility of Cross-Tissue Comparisons for Gene Discovery
Human Spermatogenic Failure Purges Deleterious Mutation Load from the Autosomes and Both Sex Chromosomes, including the Gene
A Conserved Upstream Motif Orchestrates Autonomous, Germline-Enriched Expression of piRNAs
Statistical Analysis Reveals Co-Expression Patterns of Many Pairs of Genes in Yeast Are Jointly Regulated by Interacting Loci
Matefin/SUN-1 Phosphorylation Is Part of a Surveillance Mechanism to Coordinate Chromosome Synapsis and Recombination with Meiotic Progression and Chromosome Movement
A Role for the Malignant Brain Tumour (MBT) Domain Protein LIN-61 in DNA Double-Strand Break Repair by Homologous Recombination
The Population and Evolutionary Dynamics of Phage and Bacteria with CRISPR–Mediated Immunity
Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB
Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response
DNA Topoisomerase III Localizes to Centromeres and Affects Centromeric CENP-A Levels in Fission Yeast
Genome-Wide Control of RNA Polymerase II Activity by Cohesin
Divergent Selection Drives Genetic Differentiation in an R2R3-MYB Transcription Factor That Contributes to Incipient Speciation in
NODULE INCEPTION Directly Targets Subunit Genes to Regulate Essential Processes of Root Nodule Development in
Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in
Deficiency in Origin Licensing Proteins Impairs Cilia Formation: Implications for the Aetiology of Meier-Gorlin Syndrome
Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice
The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in
Functional Genomic Analysis of the Regulatory Network in
Astakine 2—the Dark Knight Linking Melatonin to Circadian Regulation in Crustaceans
CRL2 E3-Ligase Regulates Proliferation and Progression through Meiosis in the Germline
Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in
PRMT4 Is a Novel Coactivator of c-Myb-Dependent Transcription in Haematopoietic Cell Lines
A Copy Number Variant at the Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit
Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors
HIV Infection Disrupts the Sympatric Host–Pathogen Relationship in Human Tuberculosis
Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
A Gene Transfer Agent and a Dynamic Repertoire of Secretion Systems Hold the Keys to the Explosive Radiation of the Emerging Pathogen
The Role of ATM in the Deficiency in Nonhomologous End-Joining near Telomeres in a Human Cancer Cell Line
Dynamic Circadian Protein–Protein Interaction Networks Predict Temporal Organization of Cellular Functions
Nuclear Myosin 1c Facilitates the Chromatin Modifications Required to Activate rRNA Gene Transcription and Cell Cycle Progression
Robust Prediction of Expression Differences among Human Individuals Using Only Genotype Information
A Single Cohesin Complex Performs Mitotic and Meiotic Functions in the Protist
The Role of the Arabidopsis Exosome in siRNA–Independent Silencing of Heterochromatic Loci
Elevated Expression of the Integrin-Associated Protein PINCH Suppresses the Defects of Muscle Hypercontraction Mutants
Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest
Genome-Wide Testing of Putative Functional Exonic Variants in Relationship with Breast and Prostate Cancer Risk in a Multiethnic Population
Heteroduplex DNA Position Defines the Roles of the Sgs1, Srs2, and Mph1 Helicases in Promoting Distinct Recombination Outcomes

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