PLOS Genetics - Číslo 3/2013

Review

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Long Interspersed Element–1 (LINE-1): Passenger or Driver in Human Neoplasms?

Perspective

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Tdp2: A Means to Fixing the Ends

Interview

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Problem Solved: An Interview with Sir Edwin Southern

Research Article

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Power and Predictive Accuracy of Polygenic Risk Scores
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DNA Topoisomerase III Localizes to Centromeres and Affects Centromeric CENP-A Levels in Fission Yeast
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Deficiency Reduces Adipose OXPHOS Capacity and Triggers Inflammation and Insulin Resistance in Mice
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Deficiency in Origin Licensing Proteins Impairs Cilia Formation: Implications for the Aetiology of Meier-Gorlin Syndrome
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Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in
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NODULE INCEPTION Directly Targets Subunit Genes to Regulate Essential Processes of Root Nodule Development in
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Divergent Selection Drives Genetic Differentiation in an R2R3-MYB Transcription Factor That Contributes to Incipient Speciation in
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Genome-Wide Control of RNA Polymerase II Activity by Cohesin
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Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response
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Functional Genomic Analysis of the Regulatory Network in
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Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB
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The Population and Evolutionary Dynamics of Phage and Bacteria with CRISPR–Mediated Immunity
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A Role for the Malignant Brain Tumour (MBT) Domain Protein LIN-61 in DNA Double-Strand Break Repair by Homologous Recombination
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Matefin/SUN-1 Phosphorylation Is Part of a Surveillance Mechanism to Coordinate Chromosome Synapsis and Recombination with Meiotic Progression and Chromosome Movement
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Statistical Analysis Reveals Co-Expression Patterns of Many Pairs of Genes in Yeast Are Jointly Regulated by Interacting Loci
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A Conserved Upstream Motif Orchestrates Autonomous, Germline-Enriched Expression of piRNAs
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Human Spermatogenic Failure Purges Deleterious Mutation Load from the Autosomes and Both Sex Chromosomes, including the Gene
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The Conserved SKN-1/Nrf2 Stress Response Pathway Regulates Synaptic Function in
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Astakine 2—the Dark Knight Linking Melatonin to Circadian Regulation in Crustaceans
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A Novel Mutation in the Upstream Open Reading Frame of the Gene Causes a MEN4 Phenotype
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Dynamic Circadian Protein–Protein Interaction Networks Predict Temporal Organization of Cellular Functions
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Genome-Wide Testing of Putative Functional Exonic Variants in Relationship with Breast and Prostate Cancer Risk in a Multiethnic Population
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Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest
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Elevated Expression of the Integrin-Associated Protein PINCH Suppresses the Defects of Muscle Hypercontraction Mutants
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The Role of the Arabidopsis Exosome in siRNA–Independent Silencing of Heterochromatic Loci
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A Single Cohesin Complex Performs Mitotic and Meiotic Functions in the Protist
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Robust Prediction of Expression Differences among Human Individuals Using Only Genotype Information
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Nuclear Myosin 1c Facilitates the Chromatin Modifications Required to Activate rRNA Gene Transcription and Cell Cycle Progression
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The Role of ATM in the Deficiency in Nonhomologous End-Joining near Telomeres in a Human Cancer Cell Line
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CRL2 E3-Ligase Regulates Proliferation and Progression through Meiosis in the Germline
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A Gene Transfer Agent and a Dynamic Repertoire of Secretion Systems Hold the Keys to the Explosive Radiation of the Emerging Pathogen
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Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
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HIV Infection Disrupts the Sympatric Host–Pathogen Relationship in Human Tuberculosis
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Evidence of Gene–Environment Interactions between Common Breast Cancer Susceptibility Loci and Established Environmental Risk Factors
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A Copy Number Variant at the Locus Likely Confers Risk for Canine Squamous Cell Carcinoma of the Digit
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PRMT4 Is a Novel Coactivator of c-Myb-Dependent Transcription in Haematopoietic Cell Lines
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Both the Caspase CSP-1 and a Caspase-Independent Pathway Promote Programmed Cell Death in Parallel to the Canonical Pathway for Apoptosis in
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Ataxin1L Is a Regulator of HSC Function Highlighting the Utility of Cross-Tissue Comparisons for Gene Discovery
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Histone Deacetylase 2 (HDAC2) Regulates Chromosome Segregation and Kinetochore Function via H4K16 Deacetylation during Oocyte Maturation in Mouse
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Rare Copy Number Variants Are a Common Cause of Short Stature
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Microhomology-Mediated Mechanisms Underlie Non-Recurrent Disease-Causing Microdeletions of the Gene or Its Regulatory Domain
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–Independent Phenotypic Switching in and a Dual Role for Wor1 in Regulating Switching and Filamentation
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Role of the DSC1 Channel in Regulating Neuronal Excitability in : Extending Nervous System Stability under Stress
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The U-Box E3 Ubiquitin Ligase TUD1 Functions with a Heterotrimeric G α Subunit to Regulate Brassinosteroid-Mediated Growth in Rice
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The Tomato Yellow Leaf Curl Virus Resistance Genes and Are Allelic and Code for DFDGD-Class RNA–Dependent RNA Polymerases
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A Feed-Forward Loop Coupling Extracellular BMP Transport and Morphogenesis in Wing
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Differential Evolutionary Fate of an Ancestral Primate Endogenous Retrovirus Envelope Gene, the EnvV , Captured for a Function in Placentation
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Ancient Evolutionary Trade-Offs between Yeast Ploidy States
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A WRKY Transcription Factor Recruits the SYG1-Like Protein SHB1 to Activate Gene Expression and Seed Cavity Enlargement
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Blood-Informative Transcripts Define Nine Common Axes of Peripheral Blood Gene Expression
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Alternative Splicing and Subfunctionalization Generates Functional Diversity in Fungal Proteomes
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Mouse HFM1/Mer3 Is Required for Crossover Formation and Complete Synapsis of Homologous Chromosomes during Meiosis
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Genome-Wide Association Study and Gene Expression Analysis Identifies as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis
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Mechanistic Insight into the Pathology of Polyalanine Expansion Disorders Revealed by a Mouse Model for X Linked Hypopituitarism
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Genomic Evidence for Island Population Conversion Resolves Conflicting Theories of Polar Bear Evolution
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Ubiquitous Polygenicity of Human Complex Traits: Genome-Wide Analysis of 49 Traits in Koreans
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Coordination of Flower Maturation by a Regulatory Circuit of Three MicroRNAs
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Pax6 Regulates Gene Expression in the Vertebrate Lens through miR-204
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Genetic Architecture of Skin and Eye Color in an African-European Admixed Population
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Association Mapping and the Genomic Consequences of Selection in Sunflower
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A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan
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A Novel Role for the RNA–Binding Protein FXR1P in Myoblasts Cell-Cycle Progression by Modulating mRNA Stability
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A Novel Function for the Hox Gene in the Male Accessory Gland Regulates the Long-Term Female Post-Mating Response in
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Identification of a -Specific Modifier Locus at 6p24 Related to Breast Cancer Risk
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Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease
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Genome-Wide Association Study in Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
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Recurrent Rearrangement during Adaptive Evolution in an Interspecific Yeast Hybrid Suggests a Model for Rapid Introgression
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TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and
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Distinct Molecular Strategies for Hox-Mediated Limb Suppression in : From Cooperativity to Dispensability/Antagonism in TALE Partnership
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Fine Characterisation of a Recombination Hotspot at the Locus and Resolution of the Paradoxical Excess of Duplications over Deletions in the General Population
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RFX Transcription Factor DAF-19 Regulates 5-HT and Innate Immune Responses to Pathogenic Bacteria in
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Polycomb Group Gene Regulates Rice () Seed Development and Grain Filling via a Mechanism Distinct from
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Alp/Enigma Family Proteins Cooperate in Z-Disc Formation and Myofibril Assembly
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Molecular Networks of Human Muscle Adaptation to Exercise and Age
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Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development
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Complex Patterns of Genomic Admixture within Southern Africa
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Estrogen Mediated-Activation of miR-191/425 Cluster Modulates Tumorigenicity of Breast Cancer Cells Depending on Estrogen Receptor Status
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Heteroduplex DNA Position Defines the Roles of the Sgs1, Srs2, and Mph1 Helicases in Promoting Distinct Recombination Outcomes

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