PLOS Genetics - Číslo 1/2013


Emerging Function of Fat Mass and Obesity-Associated Protein (Fto)
Genetics of Ribosomal Proteins: “Curiouser and Curiouser”


Transposable Elements Re-Wire and Fine-Tune the Transcriptome


Life, the Universe, and Everything: An Interview with David Haussler

Research Article

A Model of High Sugar Diet-Induced Cardiomyopathy
Comparative Genome Structure, Secondary Metabolite, and Effector Coding Capacity across Pathogens
Positional Cloning Reveals Strain-Dependent Expression of to Alter Susceptibility to Bleomycin-Induced Pulmonary Fibrosis in Mice
Function and Regulation of , a Gene Implicated in Autism and Human Evolution
MAML1 Enhances the Transcriptional Activity of Runx2 and Plays a Role in Bone Development
Predicting Mendelian Disease-Causing Non-Synonymous Single Nucleotide Variants in Exome Sequencing Studies
A Systematic Mapping Approach of 16q12.2/ and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study
Transcription of the Major microRNA–Like Small RNAs Relies on RNA Polymerase III
Histone H3K56 Acetylation, Rad52, and Non-DNA Repair Factors Control Double-Strand Break Repair Choice with the Sister Chromatid
Genome-Wide Association Study Identifies a Novel Susceptibility Locus at 12q23.1 for Lung Squamous Cell Carcinoma in Han Chinese
Genetic Disruption of the Copulatory Plug in Mice Leads to Severely Reduced Fertility
The [] Prion Exists as a Dynamic Cloud of Variants
Adult Onset Global Loss of the Gene Alters Body Composition and Metabolism in the Mouse
Fis Protein Insulates the Gene from Uncontrolled Transcription
The Meiotic Nuclear Lamina Regulates Chromosome Dynamics and Promotes Efficient Homologous Recombination in the Mouse
Genome-Wide Haplotype Analysis of Expression Quantitative Trait Loci in Monocytes
TATES: Efficient Multivariate Genotype-Phenotype Analysis for Genome-Wide Association Studies
Structural Basis of a Histone H3 Lysine 4 Demethylase Required for Stem Elongation in Rice
The Ecm11-Gmc2 Complex Promotes Synaptonemal Complex Formation through Assembly of Transverse Filaments in Budding Yeast
MCM8 Is Required for a Pathway of Meiotic Double-Strand Break Repair Independent of DMC1 in
Comparative Genomic Analysis of the Endosymbionts of Herbivorous Insects Reveals Eco-Environmental Adaptations: Biotechnology Applications
Integration of Nodal and BMP Signals in the Heart Requires FoxH1 to Create Left–Right Differences in Cell Migration Rates That Direct Cardiac Asymmetry
Pharmacodynamics, Population Dynamics, and the Evolution of Persistence in
A Hybrid Likelihood Model for Sequence-Based Disease Association Studies
Aberration in DNA Methylation in B-Cell Lymphomas Has a Complex Origin and Increases with Disease Severity
Multiple Opposing Constraints Govern Chromosome Interactions during Meiosis
Transcriptional Dynamics Elicited by a Short Pulse of Notch Activation Involves Feed-Forward Regulation by Genes
Dynamic Large-Scale Chromosomal Rearrangements Fuel Rapid Adaptation in Yeast Populations
Heterologous Gln/Asn-Rich Proteins Impede the Propagation of Yeast Prions by Altering Chaperone Availability
Gene Copy-Number Polymorphism Caused by Retrotransposition in Humans
An Incompatibility between a Mitochondrial tRNA and Its Nuclear-Encoded tRNA Synthetase Compromises Development and Fitness in
Secondary Metabolism and Development Is Mediated by LlmF Control of VeA Subcellular Localization in
Single-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination
Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes and
Suv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene
A Conserved Helicase Processivity Factor Is Needed for Conjugation and Replication of an Integrative and Conjugative Element
Telomerase-Null Survivor Screening Identifies Novel Telomere Recombination Regulators
Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds
Coordinated Degradation of Replisome Components Ensures Genome Stability upon Replication Stress in the Absence of the Replication Fork Protection Complex
Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity
HIF- and Non-HIF-Regulated Hypoxic Responses Require the Estrogen-Related Receptor in
Delineating a Conserved Genetic Cassette Promoting Outgrowth of Body Appendages
The Telomere Capping Complex CST Has an Unusual Stoichiometry, Makes Multipartite Interaction with G-Tails, and Unfolds Higher-Order G-Tail Structures
Comprehensive Methylome Characterization of and at Single-Base Resolution
Loci Associated with -Glycosylation of Human Immunoglobulin G Show Pleiotropy with Autoimmune Diseases and Haematological Cancers
Switchgrass Genomic Diversity, Ploidy, and Evolution: Novel Insights from a Network-Based SNP Discovery Protocol
Centromere-Like Regions in the Budding Yeast Genome
Sequencing of Loci from the Elephant Shark Reveals a Family of Genes in Vertebrate Genomes, Forged by Ancient Duplications and Divergences
Mendelian and Non-Mendelian Regulation of Gene Expression in Maize
Mutational Spectrum Drives the Rise of Mutator Bacteria
Human Disease-Associated Genetic Variation Impacts Large Intergenic Non-Coding RNA Expression
The Roles of Whole-Genome and Small-Scale Duplications in the Functional Specialization of Genes
Sex-Specific Signaling in the Blood–Brain Barrier Is Required for Male Courtship in
A Newly Uncovered Group of Distantly Related Lysine Methyltransferases Preferentially Interact with Molecular Chaperones to Regulate Their Activity
Is Required for Leptin-Mediated Depolarization of POMC Neurons in the Hypothalamic Arcuate Nucleus in Mice
Unlocking the Bottleneck in Forward Genetics Using Whole-Genome Sequencing and Identity by Descent to Isolate Causative Mutations
The Role of Autophagy in Genome Stability through Suppression of Abnormal Mitosis under Starvation
MTERF3 Regulates Mitochondrial Ribosome Biogenesis in Invertebrates and Mammals
Downregulation and Altered Splicing by in a Mouse Model of Facioscapulohumeral Muscular Dystrophy (FSHD)
NBR1-Mediated Selective Autophagy Targets Insoluble Ubiquitinated Protein Aggregates in Plant Stress Responses
Retroactive Maintains Cuticle Integrity by Promoting the Trafficking of Knickkopf into the Procuticle of
Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
Genetic and Functional Modularity of Activities in the Specification of Limb-Innervating Motor Neurons
A Population Genetic Model for the Maintenance of R2 Retrotransposons in rRNA Gene Loci
A Quartet of PIF bHLH Factors Provides a Transcriptionally Centered Signaling Hub That Regulates Seedling Morphogenesis through Differential Expression-Patterning of Shared Target Genes in
A Genome-Wide Integrative Genomic Study Localizes Genetic Factors Influencing Antibodies against Epstein-Barr Virus Nuclear Antigen 1 (EBNA-1)
Mutation of the Diamond-Blackfan Anemia Gene in Mouse Results in Morphological and Neuroanatomical Phenotypes
Alternative Oxidase Expression in the Mouse Enables Bypassing Cytochrome Oxidase Blockade and Limits Mitochondrial ROS Overproduction
An Evolutionarily Conserved Synthetic Lethal Interaction Network Identifies FEN1 as a Broad-Spectrum Target for Anticancer Therapeutic Development
The Flowering Repressor Underlies a Novel QTL Interacting with the Genetic Background
Telomerase Is Required for Zebrafish Lifespan
and Diversified Expression of the Gene Family Bolster the Floral Stem Cell Network
Susceptibility Loci Associated with Specific and Shared Subtypes of Lymphoid Malignancies
An Insertion in 5′ Flanking Region of Causes Blue Eggshell in the Chicken
Increased Maternal Genome Dosage Bypasses the Requirement of the FIS Polycomb Repressive Complex 2 in Arabidopsis Seed Development
WNK1/HSN2 Mutation in Human Peripheral Neuropathy Deregulates Expression and Posterior Lateral Line Development in Zebrafish ()
Synergistic Interaction of Rnf8 and p53 in the Protection against Genomic Instability and Tumorigenesis
Dot1-Dependent Histone H3K79 Methylation Promotes Activation of the Mek1 Meiotic Checkpoint Effector Kinase by Regulating the Hop1 Adaptor
A Heterogeneous Mixture of F-Series Prostaglandins Promotes Sperm Guidance in the Reproductive Tract
Starvation, Together with the SOS Response, Mediates High Biofilm-Specific Tolerance to the Fluoroquinolone Ofloxacin
Directed Evolution of a Model Primordial Enzyme Provides Insights into the Development of the Genetic Code
Genome-Wide Screens for Tinman Binding Sites Identify Cardiac Enhancers with Diverse Functional Architectures

Kurzy Doporučená témata Časopisy
Zapomenuté heslo

Nemáte účet?  Registrujte se

Zapomenuté heslo

Zadejte e-mailovou adresu se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.


Nemáte účet?  Registrujte se

VIRTUÁLNÍ ČEKÁRNA ČR Jste praktický lékař nebo pediatr? Zapojte se! Jste praktik nebo pediatr? Zapojte se!