1. DubeyJP (2008) The history of Toxoplasma gondii–the first 100 years. The Journal of eukaryotic microbiology 55: 467–475.
2. WeissLM, DubeyJP (2009) Toxoplasmosis: A history of clinical observations. International journal for parasitology 39: 895–901.
3. GazzinelliRT, WysockaM, HayashiS, DenkersEY, HienyS, et al. (1994) Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 153: 2533–2543.
4. SuzukiY, OrellanaMA, SchreiberRD, RemingtonJS (1988) Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 240: 516–518.
5. GazzinelliR, XuY, HienyS, CheeverA, SherA (1992) Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. Journal of immunology 149: 175–180.
6. GoldszmidRS, SherA (2010) Processing and presentation of antigens derived from intracellular protozoan parasites. Current opinion in immunology 22: 118–123.
7. DupontCD, ChristianDA, HunterCA (2012) Immune response and immunopathology during toxoplasmosis. Seminars in immunopathology 34: 793–813.
8. BrodeS, MacaryPA (2004) Cross-presentation: dendritic cells and macrophages bite off more than they can chew!. Immunology 112: 345–351.
9. SteinmanRM, HawigerD, NussenzweigMC (2003) Tolerogenic dendritic cells. Annual review of immunology 21: 685–711.
10. JohnB, HarrisTH, TaitED, WilsonEH, GreggB, et al. (2009) Dynamic Imaging of CD8(+) T cells and dendritic cells during infection with Toxoplasma gondii. PLoS Pathog 5: e1000505.
11. ChtanovaT, HanSJ, SchaefferM, van DoorenGG, HerzmarkP, et al. (2009) Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node. Immunity 31: 342–355.
12. GoldszmidRS, CoppensI, LevA, CasparP, MellmanI, et al. (2009) Host ER-parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii-infected dendritic cells. J Exp Med 206: 399–410.
13. DzierszinskiF, PepperM, StumhoferJS, LaRosaDF, WilsonEH, et al. (2007) Presentation of Toxoplasma gondii antigens via the endogenous major histocompatibility complex class I pathway in nonprofessional and professional antigen-presenting cells. Infect Immun 75: 5200–5209.
14. GubbelsMJ, StriepenB, ShastriN, TurkozM, RobeyEA (2005) Class I major histocompatibility complex presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondii. Infection and immunity 73: 703–711.
15. DenkersEY, YapG, Scharton-KerstenT, CharestH, ButcherBA, et al. (1997) Perforin-mediated cytolysis plays a limited role in host resistance to Toxoplasma gondii. Journal of immunology 159: 1903–1908.
16. LuderCG, LangT, BeuerleB, GrossU (1998) Down-regulation of MHC class II molecules and inability to up-regulate class I molecules in murine macrophages after infection with Toxoplasma gondii. Clinical and experimental immunology 112: 308–316.
17. LuderCG, WalterW, BeuerleB, MaeurerMJ, GrossU (2001) Toxoplasma gondii down-regulates MHC class II gene expression and antigen presentation by murine macrophages via interference with nuclear translocation of STAT1alpha. European journal of immunology 31: 1475–1484.
18. McKeeAS, DzierszinskiF, BoesM, RoosDS, PearceEJ (2004) Functional inactivation of immature dendritic cells by the intracellular parasite Toxoplasma gondii. J Immunol 173: 2632–2640.
19. NeefjesJ, JongsmaML, PaulP, BakkeO (2011) Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nature reviews Immunology 11: 823–836.
20. DongreAR, KovatsS, deRoosP, McCormackAL, NakagawaT, et al. (2001) In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analyses. European journal of immunology 31: 1485–1494.
21. NuchternJG, BiddisonWE, KlausnerRD (1990) Class II MHC molecules can use the endogenous pathway of antigen presentation. Nature 343: 74–76.
22. MalnatiMS, MartiM, LaVauteT, JaraquemadaD, BiddisonW, et al. (1992) Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells. Nature 357: 702–704.
23. PaludanC, SchmidD, LandthalerM, VockerodtM, KubeD, et al. (2005) Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science 307: 593–596.
24. NimmerjahnF, MilosevicS, BehrendsU, JaffeeEM, PardollDM, et al. (2003) Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy. European journal of immunology 33: 1250–1259.
25. BonifazLC, ArzateS, MorenoJ (1999) Endogenous and exogenous forms of the same antigen are processed from different pools to bind MHC class II molecules in endocytic compartments. European journal of immunology 29: 119–131.
26. AichingerG, KarlssonL, JacksonMR, VestbergM, VaughanJH, et al. (1997) Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins. The Journal of biological chemistry 272: 29127–29136.
27. JaraquemadaD, MartiM, LongEO (1990) An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells. The Journal of experimental medicine 172: 947–954.
28. WeissS, BogenB (1991) MHC class II-restricted presentation of intracellular antigen. Cell 64: 767–776.
29. LichJD, ElliottJF, BlumJS (2000) Cytoplasmic processing is a prerequisite for presentation of an endogenous antigen by major histocompatibility complex class II proteins. The Journal of experimental medicine 191: 1513–1524.
30. IwasakiA, MedzhitovR (2010) Regulation of adaptive immunity by the innate immune system. Science 327: 291–295.
31. FoxBA, BzikDJ (2002) De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Nature 415: 926–929.
32. WilsonDC, MatthewsS, YapGS (2008) IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection. J Immunol 180: 5935–5945.
33. WilsonDC, GrotenbregGM, LiuK, ZhaoY, FrickelEM, et al. (2010) Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells. PLoS Pathog 6: e1000815.
34. SafferLD, Long KrugSA, SchwartzmanJD (1989) The role of phospholipase in host cell penetration by Toxoplasma gondii. The American journal of tropical medicine and hygiene 40: 145–149.
35. RavindranS, LodoenMB, VerhelstSH, BogyoM, BoothroydJC (2009) 4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion. PloS one 4: e8143.
36. MorgadoP, OngYC, BoothroydJC, LodoenMB (2011) Toxoplasma gondii induces B7-2 expression through activation of JNK signal transduction. Infection and immunity 79: 4401–4412.
37. ChikteS, PanchalN, WarnesG (2013) Use of LysoTracker dyes: A flow cytometric study of autophagy. Cytometry Part A : the journal of the International Society for Analytical Cytology 85(2): 169–78.
38. JordanKA, WilsonEH, TaitED, FoxBA, RoosDS, et al. (2009) Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii. Infection and immunity 77: 3894–3901.
39. HowardJC, HunnJP, SteinfeldtT (2011) The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii. Current opinion in microbiology 14: 414–421.
40. LingYM, ShawMH, AyalaC, CoppensI, TaylorGA, et al. (2006) Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. The Journal of experimental medicine 203: 2063–2071.
41. MartensS, ParvanovaI, ZerrahnJ, GriffithsG, SchellG, et al. (2005) Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases. PLoS pathogens 1: e24.
42. GigleyJP, FoxBA, BzikDJ (2009) Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication. J Immunol 182: 1069–1078.
43. ParraD, RiegerAM, LiJ, ZhangYA, RandallLM, et al. (2012) Pivotal advance: peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+ T cells. Journal of leukocyte biology 91: 525–536.
44. GoldszmidRS, CasparP, RivollierA, WhiteS, DzutsevA, et al. (2012) NK cell-derived interferon-gamma orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection. Immunity 36: 1047–1059.
45. JungS, UnutmazD, WongP, SanoG, De los SantosK, et al. (2002) In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 17: 211–220.
46. PepperM, PaganAJ, IgyartoBZ, TaylorJJ, JenkinsMK (2011) Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells. Immunity 35: 583–595.
47. GroverHS, BlanchardN, GonzalezF, ChanS, RobeyEA, et al. (2012) The Toxoplasma gondii peptide AS15 elicits CD4 T cells that can control parasite burden. Infection and immunity 80: 3279–3288.
48. RaiD, PhamNL, HartyJT, BadovinacVP (2009) Tracking the total CD8 T cell response to infection reveals substantial discordance in magnitude and kinetics between inbred and outbred hosts. Journal of immunology 183: 7672–7681.
49. McDermottDS, VargaSM (2011) Quantifying antigen-specific CD4 T cells during a viral infection: CD4 T cell responses are larger than we think. Journal of immunology 187: 5568–5576.
50. ScholzenT, GerdesJ (2000) The Ki-67 protein: from the known and the unknown. Journal of cellular physiology 182: 311–322.
51. McKennaHJ, StockingKL, MillerRE, BraselK, De SmedtT, et al. (2000) Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood 95: 3489–3497.
52. HildnerK, EdelsonBT, PurthaWE, DiamondM, MatsushitaH, et al. (2008) Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T cell immunity. Science 322: 1097–1100.
53. DunayIR, FuchsA, SibleyLD (2010) Inflammatory monocytes but not neutrophils are necessary to control infection with Toxoplasma gondii in mice. Infect Immun 78: 1564–1570.
54. SavinaA, JancicC, HuguesS, GuermonprezP, VargasP, et al. (2006) NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells. Cell 126: 205–218.
55. SubausteCS, WessendarpM (2000) Human dendritic cells discriminate between viable and killed Toxoplasma gondii tachyzoites: dendritic cell activation after infection with viable parasites results in CD28 and CD40 ligand signaling that controls IL-12-dependent and -independent T cell production of IFN-gamma. Journal of immunology 165: 1498–1505.
56. SeiderK, HeykenA, LuttichA, MiramonP, HubeB (2010) Interaction of pathogenic yeasts with phagocytes: survival, persistence and escape. Current opinion in microbiology 13: 392–400.
57. ShinS, RoyCR (2008) Host cell processes that influence the intracellular survival of Legionella pneumophila. Cellular microbiology 10: 1209–1220.
58. RohdeK, YatesRM, PurdyGE, RussellDG (2007) Mycobacterium tuberculosis and the environment within the phagosome. Immunological reviews 219: 37–54.
59. da SilvaCV, CruzL, Araujo NdaS, AngeloniMB, FonsecaBB, et al. (2012) A glance at Listeria and Salmonella cell invasion: different strategies to promote host actin polymerization. International journal of medical microbiology : IJMM 302: 19–32.
60. DunnJD, ValdiviaRH (2010) Uncivil engineers: Chlamydia, Salmonella and Shigella alter cytoskeleton architecture to invade epithelial cells. Future microbiology 5: 1219–1232.
61. RomanoPS, CuetoJA, CasassaAF, VanrellMC, GottliebRA, et al. (2012) Molecular and cellular mechanisms involved in the Trypanosoma cruzi/host cell interplay. IUBMB life 64: 387–396.
62. OverstreetMG, CockburnIA, ChenYC, ZavalaF (2008) Protective CD8 T cells against Plasmodium liver stages: immunobiology of an ‘unnatural’ immune response. Immunological reviews 225: 272–283.
63. LangC, AlgnerM, BeinertN, GrossU, LuderCG (2006) Diverse mechanisms employed by Toxoplasma gondii to inhibit IFN-gamma-induced major histocompatibility complex class II gene expression. Microbes and infection/Institut Pasteur 8: 1994–2005.
64. WalsengE, FurutaK, GoldszmidRS, WeihKA, SherA, et al. (2010) Dendritic cell activation prevents MHC class II ubiquitination and promotes MHC class II survival regardless of the activation stimulus. The Journal of biological chemistry 285: 41749–41754.
65. SubausteCS, de Waal MalefytR, FuhF (1998) Role of CD80 (B7.1) and CD86 (B7.2) in the immune response to an intracellular pathogen. Journal of immunology 160: 1831–1840.
66. BairdJR, FoxBA, SandersKL, LizottePH, Cubillos-RuizJR, et al. (2013) Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Cancer research 73: 3842–3851.
67. Mourao-SaD, RoyS, BlanderJM (2013) Vita-PAMPs: signatures of microbial viability. Advances in experimental medicine and biology 785: 1–8.
68. LambertH, HitzigerN, DellacasaI, SvenssonM, BarraganA (2006) Induction of dendritic cell migration upon Toxoplasma gondii infection potentiates parasite dissemination. Cellular microbiology 8: 1611–1623.
69. WeidnerJM, BarraganA (2013) Tightly regulated migratory subversion of immune cells promotes the dissemination of Toxoplasma gondii. International journal for parasitology 44(2): 85–90.
70. FuksJM, ArrighiRB, WeidnerJM, Kumar MenduS, JinZ, et al. (2012) GABAergic signaling is linked to a hypermigratory phenotype in dendritic cells infected by Toxoplasma gondii. PLoS pathogens 8: e1003051.
71. WeidnerJM, KanataniS, Hernandez-CastanedaMA, FuksJM, RethiB, et al. (2013) Rapid cytoskeleton remodelling in dendritic cells following invasion by Toxoplasma gondii coincides with the onset of a hypermigratory phenotype. Cellular microbiology 15: 1735–1752.
72. LambertH, Dellacasa-LindbergI, BarraganA (2011) Migratory responses of leukocytes infected with Toxoplasma gondii. Microbes and infection/Institut Pasteur 13: 96–102.
73. ZhaoYO, KhaminetsA, HunnJP, HowardJC (2009) Disruption of the Toxoplasma gondii parasitophorous vacuole by IFNgamma-inducible immunity-related GTPases (IRG proteins) triggers necrotic cell death. PLoS pathogens 5: e1000288.
74. ZhaoZ, FuxB, GoodwinM, DunayIR, StrongD, et al. (2008) Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell host & microbe 4: 458–469.
75. RomaoS, GannageM, MunzC (2013) Checking the garbage bin for problems in the house, or how autophagy assists in antigen presentation to the immune system. Seminars in cancer biology 23(5): 391–6.
76. KoshyAA, FoutsAE, LodoenMB, AlkanO, BlauHM, et al. (2010) Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions. Nature methods 7: 307–309.
77. KoshyAA, DietrichHK, ChristianDA, MelehaniJH, ShastriAJ, et al. (2012) Toxoplasma co-opts host cells it does not invade. PLoS pathogens 8: e1002825.
78. GigleyJP, FoxBA, BzikDJ (2009) Long-term immunity to lethal acute or chronic type II Toxoplasma gondii infection is effectively induced in genetically susceptible C57BL/6 mice by immunization with an attenuated type I vaccine strain. Infect Immun 77: 5380–5388.
79. van HeijstJWJ, GerlachC, SwartE, SieD, Nunes-AlvesC, et al. (2009) Recruitment of Antigen-Specific CD8(+) T Cells in Response to Infection Is Markedly Efficient. Science 325: 1265–1269.
80. DreschC, LeverrierY, MarvelJ, ShortmanK (2012) Development of antigen cross-presentation capacity in dendritic cells. Trends in immunology 33: 381–388.
81. CurtsingerJM, MescherMF (2010) Inflammatory cytokines as a third signal for T cell activation. Current Opinion in Immunology 22: 333–340.
82. MoonJJ, HuangB, IrvineDJ (2012) Engineering nano- and microparticles to tune immunity. Advanced materials 24: 3724–3746.
83. WhitmarshRJ, GrayCM, GreggB, ChristianDA, MayMJ, et al. (2011) A critical role for SOCS3 in innate resistance to Toxoplasma gondii. Cell Host Microbe 10: 224–236.
84. PepperM, DzierszinskiF, CrawfordA, HunterCA, RoosD (2004) Development of a system to study CD4+-T-cell responses to transgenic ovalbumin-expressing Toxoplasma gondii during toxoplasmosis. Infect Immun 72: 7240–7246.
85. MessinaM, NiesmanI, MercierC, SibleyLD (1995) Stable DNA transformation of Toxoplasma gondii using phleomycin selection. Gene 165: 213–217.
86. HaqueA, GrailleM, KasperLH, HaqueS (1999) Immunization with heat-killed Toxoplasma gondii stimulates an early IFN-gamma response and induces protection against virulent murine malaria. Vaccine 17: 2604–2611.
87. RobbenPM, MordueDG, TruscottSM, TakedaK, AkiraS, et al. (2004) Production of IL-12 by macrophages infected with Toxoplasma gondii depends on the parasite genotype. Journal of immunology 172: 3686–3694.
88. BlasiE, RadziochD, MerlettiL, VaresioL (1989) Generation of macrophage cell line from fresh bone marrow cells with a myc/raf recombinant retrovirus. Cancer biochemistry biophysics 10: 303–317.
89. CurranMA, AllisonJP (2009) Tumor vaccines expressing flt3 ligand synergize with ctla-4 blockade to reject preimplanted tumors. Cancer research 69: 7747–7755.
90. MaraskovskyE, PulendranB, BraselK, TeepeM, RouxER, et al. (1997) Dramatic numerical increase of functionally mature dendritic cells in FLT3 ligand-treated mice. Advances in experimental medicine and biology 417: 33–40.
91. FentressSJ, BehnkeMS, DunayIR, MashayekhiM, RommereimLM, et al. (2010) Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell host & microbe 8: 484–495.
92. HenrySC, DaniellXG, BurroughsAR, IndaramM, HowellDN, et al. (2009) Balance of Irgm protein activities determines IFN-gamma-induced host defense. Journal of leukocyte biology 85: 877–885.
93. McIlvaineT (1921) A buffer solution for colorimetric comparaison. J Biol Chem 49: 183–186.