PLOS Genetics - Číslo 3/2012


Too Much Cleavage of Cyclin E Promotes Breast Tumorigenesis
Imprinted Genes … and the Number Is?
The Silkworm Coming of Age—Early


Modelling Human Regulatory Variation in Mouse: Finding the Function in Genome-Wide Association Studies and Whole-Genome Sequencing

Research Article

Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database
Genomic Analysis of the Hydrocarbon-Producing, Cellulolytic, Endophytic Fungus
Networks of Neuronal Genes Affected by Common and Rare Variants in Autism Spectrum Disorders
Akirin Links Twist-Regulated Transcription with the Brahma Chromatin Remodeling Complex during Embryogenesis
Genetic Architecture of Highly Complex Chemical Resistance Traits across Four Yeast Strains
Exploring the Complexity of the HIV-1 Fitness Landscape
MNS1 Is Essential for Spermiogenesis and Motile Ciliary Functions in Mice
A Fundamental Regulatory Mechanism Operating through OmpR and DNA Topology Controls Expression of Pathogenicity Islands SPI-1 and SPI-2
Evidence for Positive Selection on a Number of MicroRNA Regulatory Interactions during Recent Human Evolution
Variation in Modifies Risk of Neonatal Intestinal Obstruction in Cystic Fibrosis
PIF4–Mediated Activation of Expression Integrates Temperature into the Auxin Pathway in Regulating Hypocotyl Growth
Critical Evaluation of Imprinted Gene Expression by RNA–Seq: A New Perspective
A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans
Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis
Transcriptional Control in Cardiac Progenitors: Tbx1 Interacts with the BAF Chromatin Remodeling Complex and Regulates
Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators
APOBEC3G-Induced Hypermutation of Human Immunodeficiency Virus Type-1 Is Typically a Discrete “All or Nothing” Phenomenon
Interpreting Meta-Analyses of Genome-Wide Association Studies
Error-Prone ZW Pairing and No Evidence for Meiotic Sex Chromosome Inactivation in the Chicken Germ Line
-Dependent Chemosensory Functions Contribute to Courtship Behavior in
Diverse Forms of Splicing Are Part of an Evolving Autoregulatory Circuit
Phenotypic Plasticity of the Drosophila Transcriptome
Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1
Precocious Metamorphosis in the Juvenile Hormone–Deficient Mutant of the Silkworm,
Igf1r Signaling Is Indispensable for Preimplantation Development and Is Activated via a Novel Function of E-cadherin
Accurate Prediction of Inducible Transcription Factor Binding Intensities In Vivo
Mitochondrial Oxidative Stress Alters a Pathway in Strongly Resembling That of Bile Acid Biosynthesis and Secretion in Vertebrates
Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells
Tcf7 Is an Important Regulator of the Switch of Self-Renewal and Differentiation in a Multipotential Hematopoietic Cell Line
REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells
Intronic -Regulatory Modules Mediate Tissue-Specific and Microbial Control of / Transcription
Age-Dependent Brain Gene Expression and Copy Number Anomalies in Autism Suggest Distinct Pathological Processes at Young Versus Mature Ages
A Genome-Wide Association Study Identifies Variants Underlying the Shade Avoidance Response
-by- Regulatory Divergence Causes the Asymmetric Lethal Effects of an Ancestral Hybrid Incompatibility Gene
Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
A Natural System of Chromosome Transfer in
Cell Size and the Initiation of DNA Replication in Bacteria
Probing the Informational and Regulatory Plasticity of a Transcription Factor DNA–Binding Domain
Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes
Temporal Transcriptional Profiling of Somatic and Germ Cells Reveals Biased Lineage Priming of Sexual Fate in the Fetal Mouse Gonad
Rapid Analysis of Genome Rearrangements by Multiplex Ligation–Dependent Probe Amplification
Metabolic Profiling of a Mapping Population Exposes New Insights in the Regulation of Seed Metabolism and Seed, Fruit, and Plant Relations
The Atypical Calpains: Evolutionary Analyses and Roles in Cellular Degeneration
Development of a Panel of Genome-Wide Ancestry Informative Markers to Study Admixture Throughout the Americas
Balanced Codon Usage Optimizes Eukaryotic Translational Efficiency
The Min System and Nucleoid Occlusion Are Not Required for Identifying the Division Site in but Ensure Its Efficient Utilization
Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans
Statistical Analysis of Readthrough Levels for Nonsense Mutations in Mammalian Cells Reveals a Major Determinant of Response to Gentamicin
Gene Reactivation by 5-Aza-2′-Deoxycytidine–Induced Demethylation Requires SRCAP–Mediated H2A.Z Insertion to Establish Nucleosome Depleted Regions
The miR-35-41 Family of MicroRNAs Regulates RNAi Sensitivity in
Genetic Basis of Hidden Phenotypic Variation Revealed by Increased Translational Readthrough in Yeast
An Alu Element–Associated Hypermethylation Variant of the Gene Is Associated with Childhood Obesity
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Polycomb-Like 3 Promotes Polycomb Repressive Complex 2 Binding to CpG Islands and Embryonic Stem Cell Self-Renewal
Insulin/IGF-1 and Hypoxia Signaling Act in Concert to Regulate Iron Homeostasis in
EMF1 and PRC2 Cooperate to Repress Key Regulators of Arabidopsis Development
Three Essential Ribonucleases—RNase Y, J1, and III—Control the Abundance of a Majority of mRNAs
Contrasted Patterns of Molecular Evolution in Dominant and Recessive Self-Incompatibility Haplotypes in
A Machine Learning Approach for Identifying Novel Cell Type–Specific Transcriptional Regulators of Myogenesis
Genomic Tools for Evolution and Conservation in the Chimpanzee: Is a Genetically Distinct Population
Nos2 Inactivation Promotes the Development of Medulloblastoma in Mice by Deregulation of Gap43–Dependent Granule Cell Precursor Migration
Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure
Heritability and Genetic Correlations Explained by Common SNPs for Metabolic Syndrome Traits
A Genome-Wide Association Study of Nephrolithiasis in the Japanese Population Identifies Novel Susceptible Loci at 5q35.3, 7p14.3, and 13q14.1
DNA Damage in Nijmegen Breakage Syndrome Cells Leads to PARP Hyperactivation and Increased Oxidative Stress
DNA Resection at Chromosome Breaks Promotes Genome Stability by Constraining Non-Allelic Homologous Recombination
Genetic Analysis of Floral Symmetry in Van Gogh's Sunflowers Reveals Independent Recruitment of Genes in the Asteraceae
A Splice Site Variant in the Bovine Gene Compromises Growth and Regulation of the Inflammatory Response
Promoter Nucleosome Organization Shapes the Evolution of Gene Expression
The Nucleoside Diphosphate Kinase Gene Acts as Quantitative Trait Locus Promoting Non-Mendelian Inheritance
The Ciliogenic Transcription Factor RFX3 Regulates Early Midline Distribution of Guidepost Neurons Required for Corpus Callosum Development
Phosphorylation of the RNA–Binding Protein HOW by MAPK/ERK Enhances Its Dimerization and Activity
A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci
Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria
LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients
Mapping the Hsp90 Genetic Interaction Network in Reveals Environmental Contingency and Rewired Circuitry
Autoregulation of the Noncoding RNA Gene
The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
Spo0A∼P Imposes a Temporal Gate for the Bimodal Expression of Competence in
Antagonistic Regulation of Apoptosis and Differentiation by the Cut Transcription Factor Represents a Tumor-Suppressing Mechanism in
A Downstream CpG Island Controls Transcript Initiation and Elongation and the Methylation State of the Imprinted Macro ncRNA Promoter

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