PLOS Genetics - Číslo 3/2012

Review

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Modelling Human Regulatory Variation in Mouse: Finding the Function in Genome-Wide Association Studies and Whole-Genome Sequencing

Perspective

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Too Much Cleavage of Cyclin E Promotes Breast Tumorigenesis
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Imprinted Genes … and the Number Is?
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The Silkworm Coming of Age—Early

Research Article

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Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database
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An Alu Element–Associated Hypermethylation Variant of the Gene Is Associated with Childhood Obesity
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A Machine Learning Approach for Identifying Novel Cell Type–Specific Transcriptional Regulators of Myogenesis
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Contrasted Patterns of Molecular Evolution in Dominant and Recessive Self-Incompatibility Haplotypes in
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Three Essential Ribonucleases—RNase Y, J1, and III—Control the Abundance of a Majority of mRNAs
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EMF1 and PRC2 Cooperate to Repress Key Regulators of Arabidopsis Development
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Insulin/IGF-1 and Hypoxia Signaling Act in Concert to Regulate Iron Homeostasis in
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Polycomb-Like 3 Promotes Polycomb Repressive Complex 2 Binding to CpG Islands and Embryonic Stem Cell Self-Renewal
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Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
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Genetic Basis of Hidden Phenotypic Variation Revealed by Increased Translational Readthrough in Yeast
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Nos2 Inactivation Promotes the Development of Medulloblastoma in Mice by Deregulation of Gap43–Dependent Granule Cell Precursor Migration
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The miR-35-41 Family of MicroRNAs Regulates RNAi Sensitivity in
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Gene Reactivation by 5-Aza-2′-Deoxycytidine–Induced Demethylation Requires SRCAP–Mediated H2A.Z Insertion to Establish Nucleosome Depleted Regions
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Statistical Analysis of Readthrough Levels for Nonsense Mutations in Mammalian Cells Reveals a Major Determinant of Response to Gentamicin
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Neurobeachin, a Regulator of Synaptic Protein Targeting, Is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-Mass Index in Humans
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The Min System and Nucleoid Occlusion Are Not Required for Identifying the Division Site in but Ensure Its Efficient Utilization
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Balanced Codon Usage Optimizes Eukaryotic Translational Efficiency
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Development of a Panel of Genome-Wide Ancestry Informative Markers to Study Admixture Throughout the Americas
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Genomic Tools for Evolution and Conservation in the Chimpanzee: Is a Genetically Distinct Population
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Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure
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Metabolic Profiling of a Mapping Population Exposes New Insights in the Regulation of Seed Metabolism and Seed, Fruit, and Plant Relations
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A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci
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Antagonistic Regulation of Apoptosis and Differentiation by the Cut Transcription Factor Represents a Tumor-Suppressing Mechanism in
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Spo0A∼P Imposes a Temporal Gate for the Bimodal Expression of Competence in
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The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
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Autoregulation of the Noncoding RNA Gene
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Mapping the Hsp90 Genetic Interaction Network in Reveals Environmental Contingency and Rewired Circuitry
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LMW-E/CDK2 Deregulates Acinar Morphogenesis, Induces Tumorigenesis, and Associates with the Activated b-Raf-ERK1/2-mTOR Pathway in Breast Cancer Patients
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Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria
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Phosphorylation of the RNA–Binding Protein HOW by MAPK/ERK Enhances Its Dimerization and Activity
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Heritability and Genetic Correlations Explained by Common SNPs for Metabolic Syndrome Traits
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The Ciliogenic Transcription Factor RFX3 Regulates Early Midline Distribution of Guidepost Neurons Required for Corpus Callosum Development
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The Nucleoside Diphosphate Kinase Gene Acts as Quantitative Trait Locus Promoting Non-Mendelian Inheritance
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Promoter Nucleosome Organization Shapes the Evolution of Gene Expression
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A Splice Site Variant in the Bovine Gene Compromises Growth and Regulation of the Inflammatory Response
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Genetic Analysis of Floral Symmetry in Van Gogh's Sunflowers Reveals Independent Recruitment of Genes in the Asteraceae
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DNA Resection at Chromosome Breaks Promotes Genome Stability by Constraining Non-Allelic Homologous Recombination
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DNA Damage in Nijmegen Breakage Syndrome Cells Leads to PARP Hyperactivation and Increased Oxidative Stress
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A Genome-Wide Association Study of Nephrolithiasis in the Japanese Population Identifies Novel Susceptible Loci at 5q35.3, 7p14.3, and 13q14.1
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The Atypical Calpains: Evolutionary Analyses and Roles in Cellular Degeneration
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Rapid Analysis of Genome Rearrangements by Multiplex Ligation–Dependent Probe Amplification
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Genomic Analysis of the Hydrocarbon-Producing, Cellulolytic, Endophytic Fungus
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PIF4–Mediated Activation of Expression Integrates Temperature into the Auxin Pathway in Regulating Hypocotyl Growth
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Interpreting Meta-Analyses of Genome-Wide Association Studies
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APOBEC3G-Induced Hypermutation of Human Immunodeficiency Virus Type-1 Is Typically a Discrete “All or Nothing” Phenomenon
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Synthetic Lethality of Cohesins with PARPs and Replication Fork Mediators
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Transcriptional Control in Cardiac Progenitors: Tbx1 Interacts with the BAF Chromatin Remodeling Complex and Regulates
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Mouse Genetics Suggests Cell-Context Dependency for Myc-Regulated Metabolic Enzymes during Tumorigenesis
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A Meta-Analysis and Genome-Wide Association Study of Platelet Count and Mean Platelet Volume in African Americans
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Critical Evaluation of Imprinted Gene Expression by RNA–Seq: A New Perspective
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Variation in Modifies Risk of Neonatal Intestinal Obstruction in Cystic Fibrosis
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-Dependent Chemosensory Functions Contribute to Courtship Behavior in
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Evidence for Positive Selection on a Number of MicroRNA Regulatory Interactions during Recent Human Evolution
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A Fundamental Regulatory Mechanism Operating through OmpR and DNA Topology Controls Expression of Pathogenicity Islands SPI-1 and SPI-2
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MNS1 Is Essential for Spermiogenesis and Motile Ciliary Functions in Mice
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Exploring the Complexity of the HIV-1 Fitness Landscape
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Genetic Architecture of Highly Complex Chemical Resistance Traits across Four Yeast Strains
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Akirin Links Twist-Regulated Transcription with the Brahma Chromatin Remodeling Complex during Embryogenesis
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Networks of Neuronal Genes Affected by Common and Rare Variants in Autism Spectrum Disorders
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Error-Prone ZW Pairing and No Evidence for Meiotic Sex Chromosome Inactivation in the Chicken Germ Line
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Diverse Forms of Splicing Are Part of an Evolving Autoregulatory Circuit
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Temporal Transcriptional Profiling of Somatic and Germ Cells Reveals Biased Lineage Priming of Sexual Fate in the Fetal Mouse Gonad
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Age-Dependent Brain Gene Expression and Copy Number Anomalies in Autism Suggest Distinct Pathological Processes at Young Versus Mature Ages
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Repression of Germline RNAi Pathways in Somatic Cells by Retinoblastoma Pathway Chromatin Complexes
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Probing the Informational and Regulatory Plasticity of a Transcription Factor DNA–Binding Domain
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Cell Size and the Initiation of DNA Replication in Bacteria
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A Natural System of Chromosome Transfer in
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Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
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-by- Regulatory Divergence Causes the Asymmetric Lethal Effects of an Ancestral Hybrid Incompatibility Gene
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A Genome-Wide Association Study Identifies Variants Underlying the Shade Avoidance Response
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Intronic -Regulatory Modules Mediate Tissue-Specific and Microbial Control of / Transcription
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Phenotypic Plasticity of the Drosophila Transcriptome
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REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells
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Tcf7 Is an Important Regulator of the Switch of Self-Renewal and Differentiation in a Multipotential Hematopoietic Cell Line
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Mammalian Neurogenesis Requires Treacle-Plk1 for Precise Control of Spindle Orientation, Mitotic Progression, and Maintenance of Neural Progenitor Cells
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Mitochondrial Oxidative Stress Alters a Pathway in Strongly Resembling That of Bile Acid Biosynthesis and Secretion in Vertebrates
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Accurate Prediction of Inducible Transcription Factor Binding Intensities In Vivo
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Igf1r Signaling Is Indispensable for Preimplantation Development and Is Activated via a Novel Function of E-cadherin
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Precocious Metamorphosis in the Juvenile Hormone–Deficient Mutant of the Silkworm,
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Physiological Notch Signaling Maintains Bone Homeostasis via RBPjk and Hey Upstream of NFATc1
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A Downstream CpG Island Controls Transcript Initiation and Elongation and the Methylation State of the Imprinted Macro ncRNA Promoter

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