PLOS Genetics - Číslo 11/2012

Review

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Lessons from Model Organisms: Phenotypic Robustness and Missing Heritability in Complex Disease

Perspective

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The Covariate's Dilemma
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Plan B for Stimulating Stem Cell Division
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Genome Instability Caused by a Germline Mutation in the Human DNA Repair Gene

Research Article

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Inference of Population Splits and Mixtures from Genome-Wide Allele Frequency Data
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Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration
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Mitosis in Neurons: Roughex and APC/C Maintain Cell Cycle Exit to Prevent Cytokinetic and Axonal Defects in Photoreceptor Neurons
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CELF4 Regulates Translation and Local Abundance of a Vast Set of mRNAs, Including Genes Associated with Regulation of Synaptic Function
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Mechanisms Employed by to Prevent Ribonucleotide Incorporation into Genomic DNA by Pol V
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The Genomes of the Fungal Plant Pathogens and Reveal Adaptation to Different Hosts and Lifestyles But Also Signatures of Common Ancestry
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A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease
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Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites
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Tissue-Specific Regulation of Chromatin Insulator Function
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Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome
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Genome, Functional Gene Annotation, and Nuclear Transformation of the Heterokont Oleaginous Alga CCMP1779
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Antagonistic Gene Activities Determine the Formation of Pattern Elements along the Mediolateral Axis of the Fruit
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Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma
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Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel Syndrome
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Cooperativity of , , and in Malignant Breast Cancer Evolution
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Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations
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A Combination of H2A.Z and H4 Acetylation Recruits Brd2 to Chromatin during Transcriptional Activation
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MicroRNA–Mediated Repression of the Seed Maturation Program during Vegetative Development in
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Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme
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The Tumor Suppressor Gene Retinoblastoma-1 Is Required for Retinotectal Development and Visual Function in Zebrafish
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Regions of Homozygosity in the Porcine Genome: Consequence of Demography and the Recombination Landscape
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Histone Methyltransferases MES-4 and MET-1 Promote Meiotic Checkpoint Activation in
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Polyadenylation-Dependent Control of Long Noncoding RNA Expression by the Poly(A)-Binding Protein Nuclear 1
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A Unified Method for Detecting Secondary Trait Associations with Rare Variants: Application to Sequence Data
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Genetic and Biochemical Dissection of a HisKA Domain Identifies Residues Required Exclusively for Kinase and Phosphatase Activities
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Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
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Biochemical Diversification through Foreign Gene Expression in Bdelloid Rotifers
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Genomic Variation and Its Impact on Gene Expression in
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Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a HSP Model
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Lamin B1 Polymorphism Influences Morphology of the Nuclear Envelope, Cell Cycle Progression, and Risk of Neural Tube Defects in Mice
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A Targeted Glycan-Related Gene Screen Reveals Heparan Sulfate Proteoglycan Sulfation Regulates WNT and BMP Trans-Synaptic Signaling
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Network Analysis of a -Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier
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Notch-Mediated Suppression of TSC2 Expression Regulates Cell Differentiation in the Intestinal Stem Cell Lineage
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Plant Vascular Cell Division Is Maintained by an Interaction between PXY and Ethylene Signalling
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Interallelic and Intergenic Incompatibilities of the () Gene in Mouse Hybrid Sterility
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Discovering Thiamine Transporters as Targets of Chloroquine Using a Novel Functional Genomics Strategy
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Is a Modifier of Mutations in Retinitis Pigmentosa with Incomplete Penetrance
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Evolutionarily Ancient Association of the FoxJ1 Transcription Factor with the Motile Ciliogenic Program
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Transcription Factor Oct1 Is a Somatic and Cancer Stem Cell Determinant
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Controls of Nucleosome Positioning in the Human Genome
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Disruption of Causes Defective Meiotic Recombination in Male Mice
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A Novel Human-Infection-Derived Bacterium Provides Insights into the Evolutionary Origins of Mutualistic Insect–Bacterial Symbioses
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Trps1 and Its Target Gene Regulate Epithelial Proliferation in the Developing Hair Follicle and Are Associated with Hypertrichosis
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Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival
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Population-Based Resequencing of in 10,330 Individuals: Spectrum of Genetic Variation, Phenotype, and Comparison with Extreme Phenotype Approach
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HP1a Recruitment to Promoters Is Independent of H3K9 Methylation in
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Transcription Elongation and Tissue-Specific Somatic CAG Instability
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A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation
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Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations
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CtIP Is Required to Initiate Replication-Dependent Interstrand Crosslink Repair
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Mutations in the Transcription Elongation Factor SPT5 Disrupt a Reporter for Dosage Compensation in Drosophila
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Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors
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Blockade of Pachytene piRNA Biogenesis Reveals a Novel Requirement for Maintaining Post-Meiotic Germline Genome Integrity
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RHOA Is a Modulator of the Cholesterol-Lowering Effects of Statin
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MIG-10 Functions with ABI-1 to Mediate the UNC-6 and SLT-1 Axon Guidance Signaling Pathways
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Loss of the DNA Methyltransferase MET1 Induces H3K9 Hypermethylation at PcG Target Genes and Redistribution of H3K27 Trimethylation to Transposons in
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Genome-Wide Association Studies Reveal a Simple Genetic Basis of Resistance to Naturally Coevolving Viruses in
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The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the Class I Antigen Recognition Groove
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Molecular, Physiological, and Motor Performance Defects in DMSXL Mice Carrying >1,000 CTG Repeats from the Human DM1 Locus
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Genomic Study of RNA Polymerase II and III SNAP-Bound Promoters Reveals a Gene Transcribed by Both Enzymes and a Broad Use of Common Activators
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Long Telomeres Produced by Telomerase-Resistant Recombination Are Established from a Single Source and Are Subject to Extreme Sequence Scrambling
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The Yeast SR-Like Protein Npl3 Links Chromatin Modification to mRNA Processing
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Deubiquitylation Machinery Is Required for Embryonic Polarity in
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dJun and Vri/dNFIL3 Are Major Regulators of Cardiac Aging in Drosophila
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Dopaminergic D2-Like Receptors Delimit Recurrent Cholinergic-Mediated Motor Programs during a Goal-Oriented Behavior

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