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PLOS Genetics - Číslo 11/2012

Research Article

32767

Inference of Population Splits and Mixtures from Genome-Wide Allele Frequency Data

Plant Vascular Cell Division Is Maintained by an Interaction between PXY and Ethylene Signalling

Discovering Thiamine Transporters as Targets of Chloroquine Using a Novel Functional Genomics Strategy

Is a Modifier of Mutations in Retinitis Pigmentosa with Incomplete Penetrance

Evolutionarily Ancient Association of the FoxJ1 Transcription Factor with the Motile Ciliogenic Program

Transcription Factor Oct1 Is a Somatic and Cancer Stem Cell Determinant

Controls of Nucleosome Positioning in the Human Genome

Disruption of Causes Defective Meiotic Recombination in Male Mice

A Novel Human-Infection-Derived Bacterium Provides Insights into the Evolutionary Origins of Mutualistic Insect–Bacterial Symbioses

Trps1 and Its Target Gene Regulate Epithelial Proliferation in the Developing Hair Follicle and Are Associated with Hypertrichosis

Zcchc11 Uridylates Mature miRNAs to Enhance Neonatal IGF-1 Expression, Growth, and Survival

Population-Based Resequencing of in 10,330 Individuals: Spectrum of Genetic Variation, Phenotype, and Comparison with Extreme Phenotype Approach

HP1a Recruitment to Promoters Is Independent of H3K9 Methylation in

Transcription Elongation and Tissue-Specific Somatic CAG Instability

A Germline Polymorphism of DNA Polymerase Beta Induces Genomic Instability and Cellular Transformation

Interallelic and Intergenic Incompatibilities of the () Gene in Mouse Hybrid Sterility

Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations

Mutations in the Transcription Elongation Factor SPT5 Disrupt a Reporter for Dosage Compensation in Drosophila

Evolution of Minimal Specificity and Promiscuity in Steroid Hormone Receptors

Blockade of Pachytene piRNA Biogenesis Reveals a Novel Requirement for Maintaining Post-Meiotic Germline Genome Integrity

RHOA Is a Modulator of the Cholesterol-Lowering Effects of Statin

MIG-10 Functions with ABI-1 to Mediate the UNC-6 and SLT-1 Axon Guidance Signaling Pathways

Loss of the DNA Methyltransferase MET1 Induces H3K9 Hypermethylation at PcG Target Genes and Redistribution of H3K27 Trimethylation to Transposons in

Genome-Wide Association Studies Reveal a Simple Genetic Basis of Resistance to Naturally Coevolving Viruses in

The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the Class I Antigen Recognition Groove

Molecular, Physiological, and Motor Performance Defects in DMSXL Mice Carrying >1,000 CTG Repeats from the Human DM1 Locus

Genomic Study of RNA Polymerase II and III SNAP-Bound Promoters Reveals a Gene Transcribed by Both Enzymes and a Broad Use of Common Activators

Long Telomeres Produced by Telomerase-Resistant Recombination Are Established from a Single Source and Are Subject to Extreme Sequence Scrambling

The Yeast SR-Like Protein Npl3 Links Chromatin Modification to mRNA Processing

Deubiquitylation Machinery Is Required for Embryonic Polarity in

dJun and Vri/dNFIL3 Are Major Regulators of Cardiac Aging in Drosophila

CtIP Is Required to Initiate Replication-Dependent Interstrand Crosslink Repair

Notch-Mediated Suppression of TSC2 Expression Regulates Cell Differentiation in the Intestinal Stem Cell Lineage

A Combination of H2A.Z and H4 Acetylation Recruits Brd2 to Chromatin during Transcriptional Activation

Network Analysis of a -Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier

Mitosis in Neurons: Roughex and APC/C Maintain Cell Cycle Exit to Prevent Cytokinetic and Axonal Defects in Photoreceptor Neurons

CELF4 Regulates Translation and Local Abundance of a Vast Set of mRNAs, Including Genes Associated with Regulation of Synaptic Function

Mechanisms Employed by to Prevent Ribonucleotide Incorporation into Genomic DNA by Pol V

The Genomes of the Fungal Plant Pathogens and Reveal Adaptation to Different Hosts and Lifestyles But Also Signatures of Common Ancestry

A Genome-Scale RNA–Interference Screen Identifies RRAS Signaling as a Pathologic Feature of Huntington's Disease

Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites

Tissue-Specific Regulation of Chromatin Insulator Function

Disruption of Mouse Cenpj, a Regulator of Centriole Biogenesis, Phenocopies Seckel Syndrome

Genome, Functional Gene Annotation, and Nuclear Transformation of the Heterokont Oleaginous Alga CCMP1779

Antagonistic Gene Activities Determine the Formation of Pattern Elements along the Mediolateral Axis of the Fruit

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma

Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel Syndrome

Cooperativity of , , and in Malignant Breast Cancer Evolution

Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations

MicroRNA–Mediated Repression of the Seed Maturation Program during Vegetative Development in

Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme

The Tumor Suppressor Gene Retinoblastoma-1 Is Required for Retinotectal Development and Visual Function in Zebrafish

Regions of Homozygosity in the Porcine Genome: Consequence of Demography and the Recombination Landscape

Histone Methyltransferases MES-4 and MET-1 Promote Meiotic Checkpoint Activation in

Polyadenylation-Dependent Control of Long Noncoding RNA Expression by the Poly(A)-Binding Protein Nuclear 1

A Unified Method for Detecting Secondary Trait Associations with Rare Variants: Application to Sequence Data

Genetic and Biochemical Dissection of a HisKA Domain Identifies Residues Required Exclusively for Kinase and Phosphatase Activities

Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies

Biochemical Diversification through Foreign Gene Expression in Bdelloid Rotifers

Genomic Variation and Its Impact on Gene Expression in

Spastic Paraplegia Mutation N256S in the Neuronal Microtubule Motor KIF5A Disrupts Axonal Transport in a HSP Model

Lamin B1 Polymorphism Influences Morphology of the Nuclear Envelope, Cell Cycle Progression, and Risk of Neural Tube Defects in Mice

A Targeted Glycan-Related Gene Screen Reveals Heparan Sulfate Proteoglycan Sulfation Regulates WNT and BMP Trans-Synaptic Signaling

Dopaminergic D2-Like Receptors Delimit Recurrent Cholinergic-Mediated Motor Programs during a Goal-Oriented Behavior

Perspective

32767

The Covariate's Dilemma

Plan B for Stimulating Stem Cell Division

Genome Instability Caused by a Germline Mutation in the Human DNA Repair Gene

Review

32767

Lessons from Model Organisms: Phenotypic Robustness and Missing Heritability in Complex Disease

PLOS Genetics

2012 Číslo 11

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