Long noncoding RNA functionality in imprinted domain regulation

Autoři: William A. MacDonald aff001;  Mellissa R. W. Mann aff003
Působiště autorů: Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America aff001;  Rangos Research Center, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America aff002;  Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America aff003;  Magee-Womens Research Institute, Pittsburgh, Pennsylvania, United States of America aff004
Vyšlo v časopise: Long noncoding RNA functionality in imprinted domain regulation. PLoS Genet 16(8): e32767. doi:10.1371/journal.pgen.1008930
Kategorie: Review
doi: 10.1371/journal.pgen.1008930


Genomic imprinting is a parent-of-origin dependent phenomenon that restricts transcription to predominantly one parental allele. Since the discovery of the first long noncoding RNA (lncRNA), which notably was an imprinted lncRNA, a body of knowledge has demonstrated pivotal roles for imprinted lncRNAs in regulating parental-specific expression of neighboring imprinted genes. In this Review, we will discuss the multiple functionalities attributed to lncRNAs and how they regulate imprinted gene expression. We also raise unresolved questions about imprinted lncRNA function, which may lead to new avenues of investigation. This Review is dedicated to the memory of Denise Barlow, a giant in the field of genomic imprinting and functional lncRNAs. With her passion for understanding the inner workings of science, her indominable spirit and her consummate curiosity, Denise blazed a path of scientific investigation that made many seminal contributions to genomic imprinting and the wider field of epigenetic regulation, in addition to inspiring future generations of scientists.

Klíčová slova:

DNA transcription – Gene expression – Gene regulation – Genetic interference – Genomic imprinting – Chromatin – Long non-coding RNA – RNA structure


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