A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli


Autoři: Debarghya Dutta Banik aff001;  Eric D. Benfey aff001;  Laura E. Martin aff002;  Kristen E. Kay aff002;  Gregory C. Loney aff002;  Amy R. Nelson aff001;  Zachary C. Ahart aff001;  Barrett T. Kemp aff001;  Bailey R. Kemp aff001;  Ann-Marie Torregrossa aff002;  Kathryn F. Medler aff001
Působiště autorů: Department of Biological Sciences, University at Buffalo, Buffalo, New York, United States of America aff001;  Department of Psychology, University at Buffalo, Buffalo, New York, United States of America aff002;  Center for Ingestive Behavior Research, University at Buffalo, Buffalo, New York, United States of America aff003
Vyšlo v časopise: A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli. PLoS Genet 16(8): e32767. doi:10.1371/journal.pgen.1008925
Kategorie: Research Article
doi: 10.1371/journal.pgen.1008925

Souhrn

Taste receptor cells use multiple signaling pathways to detect chemicals in potential food items. These cells are functionally grouped into different types: Type I cells act as support cells and have glial-like properties; Type II cells detect bitter, sweet, and umami taste stimuli; and Type III cells detect sour and salty stimuli. We have identified a new population of taste cells that are broadly tuned to multiple taste stimuli including bitter, sweet, sour, and umami. The goal of this study was to characterize these broadly responsive (BR) taste cells. We used an IP3R3-KO mouse (does not release calcium (Ca2+) from internal stores in Type II cells when stimulated with bitter, sweet, or umami stimuli) to characterize the BR cells without any potentially confounding input from Type II cells. Using live cell Ca2+ imaging in isolated taste cells from the IP3R3-KO mouse, we found that BR cells are a subset of Type III cells that respond to sour stimuli but also use a PLCβ signaling pathway to respond to bitter, sweet, and umami stimuli. Unlike Type II cells, individual BR cells are broadly tuned and respond to multiple stimuli across different taste modalities. Live cell imaging in a PLCβ3-KO mouse confirmed that BR cells use this signaling pathway to respond to bitter, sweet, and umami stimuli. Short term behavioral assays revealed that BR cells make significant contributions to taste driven behaviors and found that loss of either PLCβ3 in BR cells or IP3R3 in Type II cells caused similar behavioral deficits to bitter, sweet, and umami stimuli. Analysis of c-Fos activity in the nucleus of the solitary tract (NTS) also demonstrated that functional Type II and BR cells are required for normal stimulus induced expression.

Klíčová slova:

Animal behavior – Behavior – Citric acid – Mice – Neurons – Taste – Taste buds – Gustatory system


Zdroje

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