Morfometrické parametry jadernádorových buněk EBV pozitivních a EBV negativníchHodgkinských lymfomů

Morphometric Parameters of Nucleiof EBV-Positive and EBV-Negative Hodgkin’sLymphoma Cells

Five morphometric parameters of nuclei of EBV-positive and EBV-negative Hodgkin’s lymphomacells were assessed for length, width, area, circumference, and circularity. For the measurementof the nuclei of the tumor cells (Hodgkin, Reed-Sternberg cells) the system of image analysis„Lucie“ was used. In comparison with EBV-positive Reed-Sternberg cells, the nuclei of the EBV -negative Reed-Sternberg cells had significantly larger circumference, area and width. The nucleiof the Hodgkin cells in EBV-negative Hodgkin’s lymphomas had significantly larger width andcircularity. The authors assume that the altered morphometric parameters are related to a latentEBV infection.

Key words:
Hodgkin’s lymphoma -⁠ EBV-positivity -⁠ morphometry of nuclei