Morphometric Parameters of Nucleiof EBV-Positive and EBV-Negative Hodgkin’sLymphoma Cells

Authors: J. Mačák;  P. Řiháková
Authors‘ workplace: Ústav patologie LF UP, Olomouc Laboratoř molekulární patologie. Centrum molekulární biologie a medicíny LF UP, Olomouc
Published in: Čes.-slov. Patol., , 2001, No. 2, p. 57-60


Five morphometric parameters of nuclei of EBV-positive and EBV-negative Hodgkin’s lymphomacells were assessed for length, width, area, circumference, and circularity. For the measurementof the nuclei of the tumor cells (Hodgkin, Reed-Sternberg cells) the system of image analysis„Lucie“ was used. In comparison with EBV-positive Reed-Sternberg cells, the nuclei of the EBV -negative Reed-Sternberg cells had significantly larger circumference, area and width. The nucleiof the Hodgkin cells in EBV-negative Hodgkin’s lymphomas had significantly larger width andcircularity. The authors assume that the altered morphometric parameters are related to a latentEBV infection.

Key words:
Hodgkin’s lymphoma - EBV-positivity - morphometry of nuclei

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