Aquaporiny a regulace cirkulace plodové vody

Aquaporins and the regulation of amniotic fluid circulation

The purpose of this study was to focuse on aquaporins and their role in the regulation of amniotic fluid circulation.


Department of Obstetrics and Gynecology Medical Faculty Charles University Hradec Kralove.

The summary about aquaporins which were first described as channels increased permeability of lipid membranes to water in response to osmotic and/or hydrostatic gradients.

The present review summarizes the results of clinical and experimental research on aquaporins and the regulation of amniotic fluid circulation.

Key words:
aquaporin, amniotic fluid, fetal membrane.

Autoři: P. Škapinec ;  M. Kacerovský
Působiště autorů: Lékařská fakulta Hradec Králové, Univerzita Karlova, Praha, Porodnická a gynekologická klinika FN, Hradec Králové, přednosta doc. MUDr. J. Tošner, CSc.
Vyšlo v časopise: Čes. Gynek.2010, 75, č. 2 s. 84-87


Cíl studie:
Shrnutí současných poznatků o aquaporinech a jejich významu v regulaci plodové vody.

Typ studie:

Název a sídlo pracoviště:
Lékařská fakulta Hradec Králové, Univerzita Karlova, Praha. Porodnická a gynekologická klinika FN Hradec Králové.

Shrnutí literárních údajů o aquaporinech a jejich vztahu k plodové vodě, plodovým obalům a placentě.

Práce sumarizuje výsledky klinických a vědeckých prací zaměřených na vztah aquaporinů k cirkulaci plodové vody.

Klíčová slova:
aquaporin, plodová voda, plodové obaly.

MUDr. Marian Kacerovský

Porodnická a gynekologická klinika

FN a LF Hradec Králové

Sokolská 581

500 05 Hradec Králové


1. Agre, P. Nobel Lecture. Aquaporin water channels. Biosci Rep 2004, 24, p.127-163.

2. Beall, MH., Chaudhri, N., Amidi, F., et al. Increased expression of aquaporins in placenta of the late gestation mouse fetus. J Soc Gynecol Invest 2005, 12, p. 780-785.

3. Beall, MH., van den Wijngaard, JP.,van Gemert, MJ., Ross, MG. Amniotic fluid water dynamics. Placenta 2007, 28, p. 816-823.

4. Beall, MH., Wang, S., Yang, B., et al. Placental and membrane aquaporin water channels: Correlation with amniotic fluid volume and composition. placenta 2007, 28, p. 421-428.

5. Beall, MH., Wijngaard, JHM., van Gemert, MJC., Ross, MG. Regulation of amniotic fluid volume. Placenta 2006, 28, p. 824-832.

6. Belge, H., Devuyst, O. Aquaporin-1-a water channel on the move. Nephrol Dial Transplant 2006, 21, p. 69-71.

7. Bos, HB., Nygard, KL., Gratton, RJ., Richardson, BS. Expression of aquaporin 1 (AQP1) in chorioallantoic membranes of near term ovine foetuses with induced hypoxia. J Soc Gynecol Invest 2005, 12, p. 333-338.

8. Camerino, GM., Nicchia, GP., Dinardo, MM., et al. In vivo silencing of aquaporin-1 by RNA interference inhibits angiogenesis in the chicken embryo chorioallantoic membrane assai. Cell Mol Biol 2006, 56, p. 51-56.

9. Cartlidge, P. The epidermal barrier. Semin Neonatol 2000, 5, p. 273-280.

10. Coleman, RA., Wu, DC., Liu, J., Wade, JB. Expression of aquaporins in the renal connecting tubule. Am J Physiol Renal Physiol 2000, 279, p. 874-883.

11. Damiano, A., Zotta, E., Goldstein, J., et al. Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta. Placenta 2001, 22, p. 776-781.

12. Damiano, A., Zotta, E., Ibarra, C. Functional and molecular expression of AQP 9 channel and UT-A transporter in normal and preeclamptic human placentas. Placenta 2006, 27, p. 1073-1081.

13. Denker, BM., Smith, BL., Kuhajda, FP., Agre, P. Identification, purification and partial characterization of a novel mRNA 28,000 integral membrane protein from erythrocytes and renal tubules. J Biol Chem 1988, 263, p. 634‑642.

14. Echeverria, M., Windhager, EE., Tate, SS., Frindt, G. Cloning and expression of AQP 3, a water channel from the medullary collecting duct of rat kidney. Proc Natl Acad Sci USA 1994, 91, p. 997-1001.

15. Fisher, H., Stenling, R., Rubio, C., Lindblom, A. Differential expression of aquaporin 8 in human colon epithelial cells and colorectal tumors. BMC Physiol 2001, 1, p. 1-10.

16. Gilbert, WM., Brace, RA. The missing link in amniotic fluid volume regulation: intramembranous absorption. Obstet Gynecol 1989, 74, p.748-754.

17. Gilbert, WM., Eby-Wilknes, E., Tarantal, AF. The missing link in rhesus monkey amniotic fluid volume regulation: intramembranous absorption. Obstet Gynecol 1997, 89, p. 462-465.

18. Gradilone, SA., Garcia, F., Huebert, RC., et al. Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes. Hepatology 2003, 37, p. 1435-1441.

19. Hara, M., Verkman, AS. Glycerol replacement corrects defective skin hydratation, elasticity, and barrier function in aquaporin-3-deficient mice. Proc Natl Acad Sci USA 2003, 100, p. 7360-7365.

20. Hasegawa, H., Lian, SC., Finkbeiner, WE., Verkman, AS. Extrarenal tissue distribution of CHIP28 water channels by in situ hybridization and antibody staining. Am J Physiol 1994, 266, p. 893-903.

21. Huang, HF., He, RH., Sun, CC., et al. Function of aquaporins in female and male reproductive systems. Human Reprod 2006, p.1-11

22. Ishibashi, K., Sasaki, S., Fushimi, K., et al. Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells. Proc Natl Acad Sci USA 1994, 91, p. 6269-6273.

23. Ishibasi, K., Sasaki, S., Saito, F., et al. Structure and chromosomal localization of a human water channel aquaporin-3. Genomics 1995, 27, p. 352-354.

24. Jansson, T., Powell, TL., Illsley, NP. Gestational development of water and non-electrolyte permeability of human syncytiotrophoblast plasma membranes. Placenta 1999, 20, p. 155-160.

25. Jeyasselan, K., Sepramaniam, S., Armugam, A.,Wintour, EM. Aquaporins: a promising target for drug development. Expert Opin Ther Targets 2006, 10, p. 889-909.

26. Johnston, H., Koukoulas, I., Jeyaseelan, K., et al. Ontogeny of aquaporins 1 and 3 in ovine placenta and fetal membranes. Placenta 2000, 21, p. 88-99.

27. Knepper, MA., Nielsen, S., Agre, P. 2003 Nobel Prize Winter in chemistry. J Am Soc Nephrol 2004, 15, p. 1039-1045.

28. Knepper, MA., Wade, JB., Terris, J., ET AL. Renal aquaporins. Kidney Int 1996, 49, p. 1712-1727.

29. Koyama, Y., Ishibashi, K., Kuwahara, M., et al. Cloning and functional expression of human aquaporin8 c DNA and analysis of its gene. Genomics 1998, 54, p. 169-172.

30. Liu, H., Koukoulas, I., Ross, MC., ET AL. Quantitative comparison of placental expression of free aquaporin genes. Placenta 2004, 25, p. 475-478.

31. Liu, H., Wintour, EM. Aquaporins in development-a review. Reprod Biol Endocrinol 2005, 3, p. 18-21

32. Liu, H., Zheng, Z., Wintour, EM. Aquaporins and Fetal Fluid Balance. Placenta 2008, 29, p. 840-847

33. Magann, EF., Chauhan, SP., Doherty, DA., et al. A review of idiopathic hydramnios and pregnancy outcomes. Obstet Gynecol Surv 2007, 62, p. 795-802.

34. Magann, EF., Chauhan, SP., Doherty, DA., et al. The evidence for abandoning the amniotic fluid index in favor of the single deepest pocket. Am J Perinatol 2007, 24, p. 549-555.

35. Mann, SE., Dvorak, N., Gilbert, H., Taylor, RN. Steady-state levels of aquaporin 1 mRNA expression are increased in idiopathic polyhydramnios. Am J Obstet Gynecol 2006, 194, p. 884-887.

36. Mann, SE., Nijland, MJ., Ross, MG. Mathematic modelling of human amniotic fluid dynamics. Am J Obstet Gynecol 1996, 175, p. 937-944.

37. Mann, SE., Ricke, EA., Torres, EA., Taylor, RN. A novel model of polyhydramnios: amniotic fluid volume is increased in aquaporin 1 knockout mice. Am J Obstet Gynecol 2005, 192, p. 2041-2044.

38. Mann, SE., Ricke, EA., Yang, BA., et al. Expression and localization of aquaporins 1 and 3 in human fetal membranes. Am J Obstet Gynecol 2002, 187, p. 902-907.

39. Manzanares, S., Carrillo, MP., Gonzalez-Peran, E., et al. Isolated oligohydramnios in term pregnancy as an indication for induction of labor. J Matern Fetal Neonatal Med 2007, 20, p. 221-2218.

40. Maunsbach, AB., Marples, D., Chin, E., et al. Aquaporin-1 water channel expression in human kidney. J Am Soc Nephrol 1997, 8, p. 1-14.

41. Nicchia, GP., Nico, B., Camassa, LM., et al. The role of aquaporin-4 in the blood –brain barrier development and integrity: studies in animal and cell culture models. Neuroscience 2004, 129, p. 935-945.

42. Nielsen, S., Frokiaer, J., Marples, D., et al. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 2002, 82, p. 235-244.

43. Nielsen, S., King, LS., Christensen, BM., Agre, P. Aquaporins in complex tissues. Subcellular distribution in respiratory and glandular tissues of rat. Am J Physiol 1997, 273, p. 1549-1561.

44. Papadopoulos, MC., Saadoun, S., Verkman, AS. Aquaporins and cell migration. Pflugers Arch Eur J Physiol 2007, 456, p. 647-649.

45. Pritchard, JA. Fetal swallowing and amniotic fluid volume. Obstet Gynecol 1996, 28, p. 606-610.

46. Ross, MG., Ervin, MG., Rappaport, VJ., et al. Ovine fetal urine contribution to amniotic and allantoic compartments. Biol Neonate 1988, 53, p. 98-104.

47. Saparov, SM., Liu, K., Agre, P., Pohl, P. Fast and selective ammonia transport by aquaporin-8. J Biol Chem 2007, 282, p. 5296-5301.

48. Seeds, AE. Current concepts of amniotic fluid dynamics. Am J Obstet Gynecol 1980, 138, p. 575-586.

49. Shioji, M., Fukuda, H., Kanzaki, T., et al. Reduction of aquaporin-8 on fetal membranes under oligohydramnios in mice lacking prostaglandin F2 alpha receptor. Am J Obstet Gynaecol Res 2006, 32, p. 373-378.

50. Sugiyama, Y., Ota, Y., Hara, M., Inoue, S. Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytes. Biochem Biophys Acta 2001, 1522, p. 82-88.

51. Takata, K., Tajika, Y., Matsuzaki, T., et al. Molecular mechanisms and drug development in aquaporin water channel diseases: water channel aquaporin-2 of kidney collecting duct cells. J Pharmacol Sci 2004, 96 p. 255-259.

52. Umenishi, F., Verkman, AS., Gropper, MA. Quantitative analysis of aquaporin mRNA expression in rat tissues by mRNA protection assai. DNA Cell Biol 1996, 15, p. 475-480.

53. Verkman, AS., Shi, LB., Frigeri, A., et al. Structure and function of kidney water channels. Kidney Int 1995, 48, p. 1069-1081.

54. Wang, S., Kallichanda, N., Song, W., et al. Expression of aquaporin-8 in human placenta and chorioamniotic membranes: Evidence of molecular mechanism for intramembranous amniotic fluid resorption. Am J Obstet Gynecol 2001, 185, p. 1226-1231.

55. Zhu, XQ., Jiang, SS., Zhu, XJ., et al. Expression of Aquaporin 1 and Aquaporin 3 in Fetal Membranes and Placenta in Human Term Pregnancies with Oligohydramnions. Placenta 2009, 630, p. 670-676.

Dětská gynekologie Gynekologie a porodnictví Reprodukční medicína

Článek vyšel v časopise

Česká gynekologie

Číslo 2

2010 Číslo 2

Nejčtenější v tomto čísle

Tomuto tématu se dále věnují…


Zvyšte si kvalifikaci online z pohodlí domova

Cesta pacienta s CHOPN
nový kurz
Autoři: doc. MUDr. Vladimír Koblížek, Ph.D.

Arteriální hypertenze ve světle nových evropských guidelines
Autoři: MUDr. Libor Jelínek

Precizní medicína v onkologii

Kožní toxicita cílené terapie inhibitory EGFR a VEGF
Autoři: MUDr. Karolína Svobodová

Jak na psoriázu v každodenní ambulantní praxi?
Autoři: MUDr. Jan Šternberský, Ph. D.

Všechny kurzy
Kurzy Doporučená témata Časopisy
Zapomenuté heslo

Nemáte účet?  Registrujte se

Zapomenuté heslo

Zadejte e-mailovou adresu se kterou jste vytvářel(a) účet, budou Vám na ni zaslány informace k nastavení nového hesla.


Nemáte účet?  Registrujte se