PLOS Pathogens - Číslo 7/2015

Research Matters

Basic Prion Science “Spreads” Insight
Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses


Mosquitoes Reset Malaria Parasites


Cross Kingdom Activators of Five Classes of Bacterial Effectors
Deploying FLAREs to Visualize Functional Outcomes of Host—Pathogen Encounters
The Lung Microbiome: New Principles for Respiratory Bacteriology in Health and Disease
Extracellular Virions: The Advance Guard of Poxvirus Infections
Risks of Antibiotic Exposures Early in Life on the Developing Microbiome
RNA Virus Reassortment: An Evolutionary Mechanism for Host Jumps and Immune Evasion
Exploiting Fungal Virulence-Regulating Transcription Factors As Novel Antifungal Drug Targets
N-acetylglucosamine Regulates Virulence Properties in Microbial Pathogens
Periodontal Diseases: Bug Induced, Host Promoted
Mechanisms of Host Behavioral Change in Rodent Association
The Emerging Role for RNA Polymerase II in Regulating Virulence Gene Expression in Malaria Parasites
Turning Up the Heat: Inflammasome Activation by Fungal Pathogens
On and Under the Skin: Emerging Basidiomycetous Yeast Infections Caused by Species


The DSF Family of Cell–Cell Signals: An Expanding Class of Bacterial Virulence Regulators

Research Article

Vaccination Drives Changes in Metabolic and Virulence Profiles of
Expression of the Blood-Group-Related Gene Alters Susceptibility to Infection
Transmission Properties of Human PrP 102L Prions Challenge the Relevance of Mouse Models of GSS
Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival
Intraperitoneal Infection of Wild-Type Mice with Synthetically Generated Mammalian Prion
Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4 T Lymphocytes
An In-Depth Comparison of Latency-Reversing Agent Combinations in Various and HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression
α-Macroglobulin Can Crosslink Multiple Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes
Should Symbionts Be Nice or Selfish? Antiviral Effects of Wolbachia Are Costly but Reproductive Parasitism Is Not
A Unique Human Norovirus Lineage with a Distinct HBGA Binding Interface
The Broad Neutralizing Antibody Responses after HIV-1 Superinfection Are Not Dominated by Antibodies Directed to Epitopes Common in Single Infection
Rapidly Evolving Genes Are Key Players in Host Specialization and Virulence of the Fungal Wheat Pathogen ()
MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease
Age-Dependent Cell Trafficking Defects in Draining Lymph Nodes Impair Adaptive Immunity and Control of West Nile Virus Infection
Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria
Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease
Macrophages Subvert Adaptive Immunity to Urinary Tract Infection
Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions
Activation of TLR2 and TLR6 by Dengue NS1 Protein and Its Implications in the Immunopathogenesis of Dengue Virus Infection
K-bZIP Mediated SUMO-2/3 Specific Modification on the KSHV Genome Negatively Regulates Lytic Gene Expression and Viral Reactivation
Phosphoproteomic Analysis of KSHV-Infected Cells Reveals Roles of ORF45-Activated RSK during Lytic Replication
CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway
IFNγ and IL-12 Restrict Th2 Responses during Helminth/ Co-Infection and Promote IFNγ from Th2 Cells
THY-1 Cell Surface Antigen (CD90) Has an Important Role in the Initial Stage of Human Cytomegalovirus Infection
Human Enterovirus Nonstructural Protein 2C Functions as Both an RNA Helicase and ATP-Independent RNA Chaperone
IL-27 Signaling Is Crucial for Survival of Mice Infected with African Trypanosomes via Preventing Lethal Effects of CD4 T Cells and IFN-γ
Synergistic Reactivation of Latent HIV Expression by Ingenol-3-Angelate, PEP005, Targeted NF-kB Signaling in Combination with JQ1 Induced p-TEFb Activation
Vpu Exploits the Cross-Talk between BST2 and the ILT7 Receptor to Suppress Anti-HIV-1 Responses by Plasmacytoid Dendritic Cells
Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses
A Comprehensive Analysis of Replicating Merkel Cell Polyomavirus Genomes Delineates the Viral Transcription Program and Suggests a Role for mcv-miR-M1 in Episomal Persistence
Analysis of the SUMO2 Proteome during HSV-1 Infection
Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent
A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein
The Endosymbiotic Bacterium Selectively Kills Male Hosts by Targeting the Masculinizing Gene
HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV Remission
Ubiquilin 1 Promotes IFN-γ-Induced Xenophagy of
Transfer of Immunity from Mother to Offspring Is Mediated via Egg-Yolk Protein Vitellogenin
Suppression of Long-Lived Humoral Immunity Following Infection
The Role of VP1 Amino Acid Residue 145 of Enterovirus 71 in Viral Fitness and Pathogenesis in a Cynomolgus Monkey Model
Utilizing Chemical Genomics to Identify Cytochrome as a Novel Drug Target for Chagas Disease
EhVps32 Is a Vacuole-Associated Protein Involved in Pinocytosis and Phagocytosis of
Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein
The Serine Protease EspC from Enteropathogenic Regulates Pore Formation and Cytotoxicity Mediated by the Type III Secretion System
Existing Infection Facilitates Establishment and Density of Malaria Parasites in Their Mosquito Vector
Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice
Neuronal Interferon Signaling Is Required for Protection against Herpes Simplex Virus Replication and Pathogenesis
Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57
Colonization of the Mouse Gastrointestinal Tract Is Modulated by Wall Teichoic Acid, Capsule, and Surface Proteins
Virulence of Group A Streptococci Is Enhanced by Human Complement Inhibitors
Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense Responses
Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Infections
Type VI Secretion System Transports Zn to Combat Multiple Stresses and Host Immunity
Lv4 Is a Capsid-Specific Antiviral Activity in Human Blood Cells That Restricts Viruses of the SIV/SIV/HIV-2 Lineage Prior to Integration
Phenylbutyrate Is Bacteriostatic against and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D₃
An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction

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