PLOS Genetics - Číslo 5/2014


More of a Good Thing or Less of a Bad Thing: Gene Copy Number Variation in Polyploid Cells of the Placenta
More of a Good Thing or Less of a Bad Thing: Gene Copy Number Variation in Polyploid Cells of the Placenta


The Case for Junk DNA

Research Article

Genetic Interactions Involving Five or More Genes Contribute to a Complex Trait in Yeast
A Mutation in the Gene in Dogs with Hereditary Footpad Hyperkeratosis (HFH)
Loss of Function Mutation in the Palmitoyl-Transferase HHAT Leads to Syndromic 46,XY Disorder of Sex Development by Impeding Hedgehog Protein Palmitoylation and Signaling
Heterogeneity in the Frequency and Characteristics of Homologous Recombination in Pneumococcal Evolution
Genome-Wide Nucleosome Positioning Is Orchestrated by Genomic Regions Associated with DNase I Hypersensitivity in Rice
Null Mutation in PGAP1 Impairing Gpi-Anchor Maturation in Patients with Intellectual Disability and Encephalopathy
Single Nucleotide Variants in Transcription Factors Associate More Tightly with Phenotype than with Gene Expression
Ribosomal Protein Mutations Induce Autophagy through S6 Kinase Inhibition of the Insulin Pathway
Recent Mitochondrial DNA Mutations Increase the Risk of Developing Common Late-Onset Human Diseases
Epistatically Interacting Substitutions Are Enriched during Adaptive Protein Evolution
Meiotic Drive Impacts Expression and Evolution of X-Linked Genes in Stalk-Eyed Flies
G×G×E for Lifespan in : Mitochondrial, Nuclear, and Dietary Interactions that Modify Longevity
Population Genomic Analysis of Ancient and Modern Genomes Yields New Insights into the Genetic Ancestry of the Tyrolean Iceman and the Genetic Structure of Europe
p53 Requires the Stress Sensor USF1 to Direct Appropriate Cell Fate Decision
Whole Exome Re-Sequencing Implicates and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction
Allelic Expression of Deleterious Protein-Coding Variants across Human Tissues
R-loops Associated with Triplet Repeat Expansions Promote Gene Silencing in Friedreich Ataxia and Fragile X Syndrome
PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix
The Impairment of MAGMAS Function in Human Is Responsible for a Severe Skeletal Dysplasia
Octopamine Neuromodulation Regulates Gr32a-Linked Aggression and Courtship Pathways in Males
Mlh2 Is an Accessory Factor for DNA Mismatch Repair in
Activating Transcription Factor 6 Is Necessary and Sufficient for Alcoholic Fatty Liver Disease in Zebrafish
The Spatiotemporal Program of DNA Replication Is Associated with Specific Combinations of Chromatin Marks in Human Cells
Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus Conflicts
Genome-Wide Inference of Ancestral Recombination Graphs
Mutations in Four Glycosyl Hydrolases Reveal a Highly Coordinated Pathway for Rhodopsin Biosynthesis and N-Glycan Trimming in
SHP2 Regulates Chondrocyte Terminal Differentiation, Growth Plate Architecture and Skeletal Cell Fates
The Impact of Population Demography and Selection on the Genetic Architecture of Complex Traits
Retinoid-X-Receptors (α/β) in Melanocytes Modulate Innate Immune Responses and Differentially Regulate Cell Survival following UV Irradiation
Genetic Dissection of the Female Head Transcriptome Reveals Widespread Allelic Heterogeneity
Genome Sequencing and Comparative Genomics of the Broad Host-Range Pathogen AG8
Copy Number Variation Is a Fundamental Aspect of the Placental Genome
GOLPH3 Is Essential for Contractile Ring Formation and Rab11 Localization to the Cleavage Site during Cytokinesis in
Hox Transcription Factors Access the RNA Polymerase II Machinery through Direct Homeodomain Binding to a Conserved Motif of Mediator Subunit Med19
Drosha Promotes Splicing of a Pre-microRNA-like Alternative Exon
Predicting the Minimal Translation Apparatus: Lessons from the Reductive Evolution of
PAX6 Regulates Melanogenesis in the Retinal Pigmented Epithelium through Feed-Forward Regulatory Interactions with MITF
Enhanced Interaction between Pseudokinase and Kinase Domains in Gcn2 stimulates eIF2α Phosphorylation in Starved Cells
A HECT Ubiquitin-Protein Ligase as a Novel Candidate Gene for Altered Quinine and Quinidine Responses in
dGTP Starvation in Provides New Insights into the Thymineless-Death Phenomenon
Phosphorylation Modulates Clearance of Alpha-Synuclein Inclusions in a Yeast Model of Parkinson's Disease
RPM-1 Uses Both Ubiquitin Ligase and Phosphatase-Based Mechanisms to Regulate DLK-1 during Neuronal Development
Heritable Transmission of Stress Resistance by High Dietary Glucose in
Revertant Mutation Releases Confined Lethal Mutation, Opening Pandora's Box: A Novel Genetic Pathogenesis
Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification
A Genome-Wide Assessment of the Role of Untagged Copy Number Variants in Type 1 Diabetes
Selectivity in Genetic Association with Sub-classified Migraine in Women
A Lack of Parasitic Reduction in the Obligate Parasitic Green Alga
The Proper Splicing of RNAi Factors Is Critical for Pericentric Heterochromatin Assembly in Fission Yeast
Discovery and Functional Annotation of SIX6 Variants in Primary Open-Angle Glaucoma
Six Homeoproteins and a linc-RNA at the Fast MYH Locus Lock Fast Myofiber Terminal Phenotype
EDR1 Physically Interacts with MKK4/MKK5 and Negatively Regulates a MAP Kinase Cascade to Modulate Plant Innate Immunity
Genes That Bias Mendelian Segregation
An In Vivo EGF Receptor Localization Screen in Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of Signaling
Mosaic Epigenetic Dysregulation of Ectodermal Cells in Autism Spectrum Disorder
Hyperactivated Wnt Signaling Induces Synthetic Lethal Interaction with Rb Inactivation by Elevating TORC1 Activities
Mutations in the Cholesterol Transporter Gene Are Associated with Excessive Hair Overgrowth
Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland
A Novel CH Transcription Factor that Regulates Expression Interdependently with GliZ in
Phosphorylation of a WRKY Transcription Factor by MAPKs Is Required for Pollen Development and Function in
Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics
Spermatid Cyst Polarization in Depends upon and the CPEB Family Translational Regulator
Insights into the Genetic Structure and Diversity of 38 South Asian Indians from Deep Whole-Genome Sequencing
Intron Retention in the 5′UTR of the Novel ZIF2 Transporter Enhances Translation to Promote Zinc Tolerance in
A Dominant-Negative Mutation of Mouse Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation
Biased, Non-equivalent Gene-Proximal and -Distal Binding Motifs of Orphan Nuclear Receptor TR4 in Primary Human Erythroid Cells
Ras-Mediated Deregulation of the Circadian Clock in Cancer
Retinoic Acid-Related Orphan Receptor γ (RORγ): A Novel Participant in the Diurnal Regulation of Hepatic Gluconeogenesis and Insulin Sensitivity
Extensive Diversity of Prion Strains Is Defined by Differential Chaperone Interactions and Distinct Amyloidogenic Regions
Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2
Paternal Poly (ADP-ribose) Metabolism Modulates Retention of Inheritable Sperm Histones and Early Embryonic Gene Expression
Allele-Specific Genome-wide Profiling in Human Primary Erythroblasts Reveal Replication Program Organization

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