PLOS Genetics - Číslo 2/2014

Perspective

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Fifteen Years Later: Hard and Soft Selection Sweeps Confirm a Large Population Number for HIV In Vivo
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The Same but Different: Worms Reveal the Pervasiveness of Developmental System Drift

Research Article

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Serine Carboxypeptidase SCPEP1 and Cathepsin A Play Complementary Roles in Regulation of Vasoconstriction via Inactivation of Endothelin-1
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Chk2 and P53 Regulate the Transmission of Healed Chromosomes in the Male Germline
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DNA Sequence Explains Seemingly Disordered Methylation Levels in Partially Methylated Domains of Mammalian Genomes
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Insights into the Genomic Landscape: Comparative Genomics Reveals Variations in Ploidy and Nutrient Utilisation Potential amongst Wine Isolates
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Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses
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The Centriolar Satellite Protein AZI1 Interacts with BBS4 and Regulates Ciliary Trafficking of the BBSome
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Fine-Mapping the Region Detects Common Variants Tagging a Rare Coding Allele: Evidence for Synthetic Association in Prostate Cancer
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Transmission Distortion Affecting Human Noncrossover but Not Crossover Recombination: A Hidden Source of Meiotic Drive
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A Variant in the Neuropeptide Receptor is a Major Determinant of Growth and Physiology
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Mutation of SLC35D3 Causes Metabolic Syndrome by Impairing Dopamine Signaling in Striatal D1 Neurons
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NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly
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MicroRNA-133 Inhibits Behavioral Aggregation by Controlling Dopamine Synthesis in Locusts
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Convergence of Light and ABA Signaling on the Promoter
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Arf4 Is Required for Mammalian Development but Dispensable for Ciliary Assembly
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Distinct Requirements for Cranial Ectoderm and Mesenchyme-Derived Wnts in Specification and Differentiation of Osteoblast and Dermal Progenitors
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Ddc2 Mediates Mec1 Activation through a Ddc1- or Dpb11-Independent Mechanism
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Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation
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Mapping the Fitness Landscape of Gene Expression Uncovers the Cause of Antagonism and Sign Epistasis between Adaptive Mutations
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Euchromatic Transposon Insertions Trigger Production of Novel Pi- and Endo-siRNAs at the Target Sites in the Germline
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miR-100 Induces Epithelial-Mesenchymal Transition but Suppresses Tumorigenesis, Migration and Invasion
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Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding
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Within-Host Spatiotemporal Dynamics of Plant Virus Infection at the Cellular Level
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Analysis of Meiosis in SUN1 Deficient Mice Reveals a Distinct Role of SUN2 in Mammalian Meiotic LINC Complex Formation and Function
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Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links
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Mechanistically Distinct Mouse Models for -Associated Retinopathy
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DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in
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Chromosome I Controls Chromosome II Replication in
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Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma
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The Iodotyrosine Deiodinase Ortholog SUP-18 Functions through a Conserved Channel SC-Box to Regulate the Muscle Two-Pore Domain Potassium Channel SUP-9
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The Genome of Highlights a Fish Pathogen Adapted to Fluctuating Environments
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Distinct DNA Binding Sites Contribute to the TCF Transcriptional Switch in and
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Negative Feedback and Transcriptional Overshooting in a Regulatory Network for Horizontal Gene Transfer
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Sex-Specific Embryonic Gene Expression in Species with Newly Evolved Sex Chromosomes
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Coherent Functional Modules Improve Transcription Factor Target Identification, Cooperativity Prediction, and Disease Association
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Uncoupling of Molecular Maturation from Peripheral Target Innervation in Nociceptors Expressing a Chimeric TrkA/TrkC Receptor
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A Long-Chain Flavodoxin Protects from Oxidative Stress and Host Bacterial Clearance
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Mammalian E-type Cyclins Control Chromosome Pairing, Telomere Stability and CDK2 Localization in Male Meiosis
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Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective
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Transcriptome-Wide Analyses of 5′-Ends in RNase J Mutants of a Gram-Positive Pathogen Reveal a Role in RNA Maturation, Regulation and Degradation
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Selective Disruption of Aurora C Kinase Reveals Distinct Functions from Aurora B Kinase during Meiosis in Mouse Oocytes
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X Chromosome Control of Meiotic Chromosome Synapsis in Mouse Inter-Subspecific Hybrids
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A Cohesin-Independent Role for NIPBL at Promoters Provides Insights in CdLS
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Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa
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Classic Selective Sweeps Revealed by Massive Sequencing in Cattle
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Genomic Networks of Hybrid Sterility
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Natural Polymorphisms in Influence Negative Selection and CD4∶CD8 Lineage Commitment in the Rat
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Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations
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Molecular Identification of Collagen 17a1 as a Major Genetic Modifier of Laminin Gamma 2 Mutation-Induced Junctional Epidermolysis Bullosa in Mice
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MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis
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Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning
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Loss of Trabid, a New Negative Regulator of the Immune-Deficiency Pathway at the Level of TAK1, Reduces Life Span
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Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response
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Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease
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CEP-1, the p53 Homolog, Mediates Opposing Longevity Outcomes in Mitochondrial Electron Transport Chain Mutants
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Transcriptomics and Functional Genomics of ROS-Induced Cell Death Regulation by
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Quantitative Genome-Wide Genetic Interaction Screens Reveal Global Epistatic Relationships of Protein Complexes in
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Cascades of Genetic Instability Resulting from Compromised Break-Induced Replication
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Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging
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Zfp322a Regulates Mouse ES Cell Pluripotency and Enhances Reprogramming Efficiency
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Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a -Dependent Bottleneck in Lymphomagenesis
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DAAM Is Required for Thin Filament Formation and Sarcomerogenesis during Muscle Development in Drosophila
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Plasma Cholesterol–Induced Lesion Networks Activated before Regression of Early, Mature, and Advanced Atherosclerosis
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High-Resolution Profiling of Stationary-Phase Survival Reveals Yeast Longevity Factors and Their Genetic Interactions
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Comparative RNAi Screens in and Reveal the Impact of Developmental System Drift on Gene Function
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The Streamlined Genome of spp. Relative to Human Pathogenic Kinetoplastids Reveals a Parasite Tailored for Plants

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