PLOS Genetics - Číslo 2/2014


Fifteen Years Later: Hard and Soft Selection Sweeps Confirm a Large Population Number for HIV In Vivo
The Same but Different: Worms Reveal the Pervasiveness of Developmental System Drift

Research Article

Serine Carboxypeptidase SCPEP1 and Cathepsin A Play Complementary Roles in Regulation of Vasoconstriction via Inactivation of Endothelin-1
Coherent Functional Modules Improve Transcription Factor Target Identification, Cooperativity Prediction, and Disease Association
A Long-Chain Flavodoxin Protects from Oxidative Stress and Host Bacterial Clearance
Mammalian E-type Cyclins Control Chromosome Pairing, Telomere Stability and CDK2 Localization in Male Meiosis
Influenza Virus Drug Resistance: A Time-Sampled Population Genetics Perspective
Transcriptome-Wide Analyses of 5′-Ends in RNase J Mutants of a Gram-Positive Pathogen Reveal a Role in RNA Maturation, Regulation and Degradation
Selective Disruption of Aurora C Kinase Reveals Distinct Functions from Aurora B Kinase during Meiosis in Mouse Oocytes
X Chromosome Control of Meiotic Chromosome Synapsis in Mouse Inter-Subspecific Hybrids
A Cohesin-Independent Role for NIPBL at Promoters Provides Insights in CdLS
Extreme Population Differences in the Human Zinc Transporter ZIP4 (SLC39A4) Are Explained by Positive Selection in Sub-Saharan Africa
Classic Selective Sweeps Revealed by Massive Sequencing in Cattle
Genomic Networks of Hybrid Sterility
Natural Polymorphisms in Influence Negative Selection and CD4∶CD8 Lineage Commitment in the Rat
Oxidative Stress Is Not a Major Contributor to Somatic Mitochondrial DNA Mutations
Molecular Identification of Collagen 17a1 as a Major Genetic Modifier of Laminin Gamma 2 Mutation-Induced Junctional Epidermolysis Bullosa in Mice
Uncoupling of Molecular Maturation from Peripheral Target Innervation in Nociceptors Expressing a Chimeric TrkA/TrkC Receptor
MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis
Loss of Trabid, a New Negative Regulator of the Immune-Deficiency Pathway at the Level of TAK1, Reduces Life Span
Targeted Ablation of Nesprin 1 and Nesprin 2 from Murine Myocardium Results in Cardiomyopathy, Altered Nuclear Morphology and Inhibition of the Biomechanical Gene Response
Identification of Novel Genetic Loci Associated with Thyroid Peroxidase Antibodies and Clinical Thyroid Disease
CEP-1, the p53 Homolog, Mediates Opposing Longevity Outcomes in Mitochondrial Electron Transport Chain Mutants
Transcriptomics and Functional Genomics of ROS-Induced Cell Death Regulation by
Quantitative Genome-Wide Genetic Interaction Screens Reveal Global Epistatic Relationships of Protein Complexes in
Cascades of Genetic Instability Resulting from Compromised Break-Induced Replication
Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging
Zfp322a Regulates Mouse ES Cell Pluripotency and Enhances Reprogramming Efficiency
Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a -Dependent Bottleneck in Lymphomagenesis
DAAM Is Required for Thin Filament Formation and Sarcomerogenesis during Muscle Development in Drosophila
Plasma Cholesterol–Induced Lesion Networks Activated before Regression of Early, Mature, and Advanced Atherosclerosis
High-Resolution Profiling of Stationary-Phase Survival Reveals Yeast Longevity Factors and Their Genetic Interactions
Comparative RNAi Screens in and Reveal the Impact of Developmental System Drift on Gene Function
Accurate and Robust Genomic Prediction of Celiac Disease Using Statistical Learning
Sex-Specific Embryonic Gene Expression in Species with Newly Evolved Sex Chromosomes
Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation
Negative Feedback and Transcriptional Overshooting in a Regulatory Network for Horizontal Gene Transfer
DNA Sequence Explains Seemingly Disordered Methylation Levels in Partially Methylated Domains of Mammalian Genomes
Insights into the Genomic Landscape: Comparative Genomics Reveals Variations in Ploidy and Nutrient Utilisation Potential amongst Wine Isolates
Molecular Evidence for the Inverse Comorbidity between Central Nervous System Disorders and Cancers Detected by Transcriptomic Meta-analyses
The Centriolar Satellite Protein AZI1 Interacts with BBS4 and Regulates Ciliary Trafficking of the BBSome
Fine-Mapping the Region Detects Common Variants Tagging a Rare Coding Allele: Evidence for Synthetic Association in Prostate Cancer
Transmission Distortion Affecting Human Noncrossover but Not Crossover Recombination: A Hidden Source of Meiotic Drive
A Variant in the Neuropeptide Receptor is a Major Determinant of Growth and Physiology
Mutation of SLC35D3 Causes Metabolic Syndrome by Impairing Dopamine Signaling in Striatal D1 Neurons
NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly
MicroRNA-133 Inhibits Behavioral Aggregation by Controlling Dopamine Synthesis in Locusts
Convergence of Light and ABA Signaling on the Promoter
Arf4 Is Required for Mammalian Development but Dispensable for Ciliary Assembly
Distinct Requirements for Cranial Ectoderm and Mesenchyme-Derived Wnts in Specification and Differentiation of Osteoblast and Dermal Progenitors
Chk2 and P53 Regulate the Transmission of Healed Chromosomes in the Male Germline
Ddc2 Mediates Mec1 Activation through a Ddc1- or Dpb11-Independent Mechanism
Mapping the Fitness Landscape of Gene Expression Uncovers the Cause of Antagonism and Sign Epistasis between Adaptive Mutations
Euchromatic Transposon Insertions Trigger Production of Novel Pi- and Endo-siRNAs at the Target Sites in the Germline
miR-100 Induces Epithelial-Mesenchymal Transition but Suppresses Tumorigenesis, Migration and Invasion
Canine Hereditary Ataxia in Old English Sheepdogs and Gordon Setters Is Associated with a Defect in the Autophagy Gene Encoding
Within-Host Spatiotemporal Dynamics of Plant Virus Infection at the Cellular Level
Analysis of Meiosis in SUN1 Deficient Mice Reveals a Distinct Role of SUN2 in Mammalian Meiotic LINC Complex Formation and Function
Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links
Mechanistically Distinct Mouse Models for -Associated Retinopathy
DAF-16/FoxO Directly Regulates an Atypical AMP-Activated Protein Kinase Gamma Isoform to Mediate the Effects of Insulin/IGF-1 Signaling on Aging in
Chromosome I Controls Chromosome II Replication in
Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma
The Iodotyrosine Deiodinase Ortholog SUP-18 Functions through a Conserved Channel SC-Box to Regulate the Muscle Two-Pore Domain Potassium Channel SUP-9
The Genome of Highlights a Fish Pathogen Adapted to Fluctuating Environments
Distinct DNA Binding Sites Contribute to the TCF Transcriptional Switch in and
The Streamlined Genome of spp. Relative to Human Pathogenic Kinetoplastids Reveals a Parasite Tailored for Plants

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