Vyhodnocení výživových zvyklostí ve studii karcinomu pankreatu

English version

Autoři: K. Azeem ¹; D. Horáková ¹; H. Tomaskova ²; V. Procházka ³ ; O. Shonová ⁴; A. Martínek ⁵; Z. Kyselý ¹; V. Janout ¹; H. Kollárová ¹
Působiště autorů: Department of Preventive Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic ¹; Department of Epidemiology and Public Health, Faculty of Medicine, University of Ostrava, Czech Republic ²; Department of Internal Medicine II – Gastroenterology and Hepatology, University Hospital Olomouc, Czech Republic ³; Department of Gastroenterology, Ceske Budejovice Hospital, Czech Republic ⁴; Department of Internal Medicine, University Hospital Ostrava, Czech Republic ⁵
Vyšlo v časopise: Klin Onkol 2016; 29(3): 196-203
Kategorie: Původní práce
doi: https://doi.org/10.14735/amko2016196

Souhrn

Východiska:
Karcinom pankreatu je závažnou a rychle progredující diagnózou. Méně je známo o úloze výživy v etiologii karcinomu pankreatu. Studie se zaměřila na roli vybraných výživových zvyklostí u karcinomu pankreatu.

Materiál a metody:
Studie případů a kontrol probíhala v České republice ve třech centrech (Olomouc, Ostrava, České Budějovice) v letech 2006– 2009. Soubor tvořilo celkem 530 osob (310 případů karcinomu pankreatu a 220 kontrolních osob). Údaje byly získávány od subjektů přímo formou rozhovoru se školeným tazatelem a zaznamenány do standardizovaného dotazníku. Data byla vyhodnocena pomocí hrubého odds ratio (OR) a multivariabilní logistické regrese na 95% CI. Statistická analýza byla provedena za použití softwaru STATA v. 10.

Výsledky:
Velmi silný protektivní efekt byl nalezen u nakládaného zelí (OR 0,32; 95% CI 0,19– 0,55), brokolice (OR 0,37; 95% CI 0,25– 0,53), vařené cibule (OR 0,14; 95% CI 0,08– 0,27), rajčat (OR 0,28; 95% CI 0,13– 0,60), syrové mrkve (OR 0,33; 95% CI 0,20– 0,56), vařené mrkve (OR 0,35; 95% CI 0,19– 0,62). V modelu logistické regrese byl nalezen statisticky významný protektivní vliv u konzumace tří a více porcí vařené zeleniny týdně (OR 0,16; 95% CI 0,05– 0,55) a vysoké konzumace citrusového ovoce (OR 0,46; 95% CI 0,23– 0,90).

Závěr:
Studie nalezla signifikantní protektivní vliv konzumace tří a více porcí vařené zeleniny týdně a vysoké konzumace citrusového ovoce u karcinomu pankreatu.

Klíčová slova:
karcinom pankreatu – výživa – riziko – studie případů a kontrol

Práce byla podpořena grantem „Effectivity of secondary prevention for cancer in a general practitioner’s office” from Research Support Foundation, Vaduz a grantem IGA_LF_UPOL_2016_003.

Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.

Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do biomedicínských časopisů.

Obdrženo:
5. 11. 2015

Přijato:
9. 1. 2016

Zdroje

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