Sarcomatoid Carcinoma of the Lung –  a Case Report


Sarkomatoidní karcinom plic –  kazuistika

Východiska:
Sarkomatoidní karcinom (sarcomatoid carcinoma – SARC) plic patří mezi velmi vzácné a agresívní typy nemalobuněčného karcinomu plic. Jedná se o skupinu nízce diferencovaných karcinomů s částečnou sarkomatoidní diferenciací nebo přímo s komponentou sarkomu. Charakteristickým nálezem bývá objemný nádor se sklonem k invazi, brzká rekurence a systémové metastazování.

Případ:
Autoři prezentují případ SARC u 77leté pa­cientky. Před­operační staging prokázal sarkomatoidní karcinom dolního laloku levé plíce bez generalizace na PET CT, ale s infiltrací více než 2/ 3 bránice. Byla provedena resekce –  dolní lobektomie s resekcí bránice a náhradou svalovým lalokem z  m. latissimus dorsi na cévní stopce. Histologický nález potvrdil dia­gnózu sarkomatoidního (pleomorfního) karcinomu pT3N0M0. Pa­cientka prodělala adjuvantní chemoterapii, za 20 měsíců došlo k relapsu a systémové diseminaci nádoru, pa­cientka zemřela 21 měsíců od operace.

Klíčová slova:
karcinom plic – nádorová invaze – svalový lalok – bránice – sarkomatoidní karcinom

Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.

Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do biomedicínských časopisů.

Obdrženo:
15. 10. 2014

Přijato:
2. 12. 2014


Authors: M. Szkorupa;  T. Bohanes;  C. Neoral;  K. Vomackova;  J. Chudacek
Authors place of work: Department of Surgery I, Faculty of Medicine and Dentistry of Palacky University Olomouc and University Hospital Olomouc
Published in the journal: Klin Onkol 2015; 28(1): 57-60
Category: Kazuistika
doi: 10.14735/amko201557

Summary

Background:
Sarcomatoid carcinoma (SARC) of the lung is a very rare and aggressive type of non‑small cell lung cancer. It belongs to a group of poorly differentiated carcinomas with partial sarcomatoid differentiation or with a direct sarcoma component. Characteristic findings include a large tumor with an invasive tendency, early recurrence and systemic metastases.

Case:
The authors present a case of SARC in the 77‑year‑ old patient. Preoperative staging confirmed sarcomatoid carcinoma of the lower lobe of the left lung without generalization on PET/ CT. However, an infiltration of more than 2/ 3 of the diaphragm was ascertained. A resection was performed –  a left lower lobectomy with resection of the diaphragm and its replacement by a muscle flap made from the latissimus dorsi muscle with vascular pedicle. Histological findings confirmed the dia­gnosis of sarcomatoid (pleomorphic) carcinoma pT3N0M0. The patient underwent adjuvant chemotherapy; recurrence and systemic dissemination of the disease occurred after 20 months; the patient died 21 months after the surgery.

Key words:
lung cancer – neoplasm invasion – surgical flaps – diaphragm – sarcomatoid carcinoma

Introduction

The dia­gnosis of sarcomatoid carcinoma (SARC) of the lung includes a group of poorly differentiated non‑small cell lung tumors, which include a component with sarcomatoid differentiation (spindle‑ cell and/ or giant cell population) or a sarcoma component. The incidence is only 0.1– 1.3% of all malignant lung tumors [1]. They affect more frequently males than females (2– 10 : 1), primarily smokers; the average age at dia­gnosis is 60 years [2]. SARC is characterized by rapid growth, invasion, disease recur­rence and metastases.

Case presentation

The 77‑year‑ old patient was examined due to shortness of breath, chest pain on the left side of the chest and dry cough. X‑ray and CT findings showed a left‑ sided pleural effusion and a large heterogeneous tumor measur­ing 110 × 95 × 95 mm. Endobronchial findings were with no direct signs of the tumor; cytology findings from brush bio­psy were suspected to be malignant. A transparietal bio­psy under CT was performed and dia­gnosed sarcomatoid granuloma. PET CT confirmed an extensive tumor arising from the lower lobe of the left lung with infiltration of approximately 2/ 3 of the diaphragm, with no signs of invasion into the abdominal cavity or pericardium and with no signs of dis­semination of the disease (Fig. 1). Laboratory findings showed only slight elevation of CA125, while other markers were with no pathological values. Primary staging was concluded to be cT3N0M0. The patient was indicated for surgical resection, which, due to the extent of the tumor, was performed through a double thoracotomy in the 5th and 8th intercostal space. The resection included a left‑ sided lower lobectomy and resection of 3/4 of the surface of the diaphragm. The extensive defect resulting from the diaphragm resection was reconstructed using a muscle flap made from the latissimus dorsi muscle with vascular pedicle (Fig. 2). No serious complications were observed in the postoperative course (Fig. 3). The patient was discharged on the 14th postoperative day.

Fig. 1. CT images of the tumor before the surgery. The tumor arises from the lower left lung lobe and invades the diaphragm.
Fig. 1. CT images of the tumor before the surgery. The tumor arises from the lower left lung lobe and invades the diaphragm.

Fig. 2. Intraoperative pictures. A. preparation of the muscular fl ap; B, C. resection of the tumor with the diaphragm; D. the resected tumor; E, F. the diaphragm repair with the muscular fl ap.
Fig. 2. Intraoperative pictures. A. preparation of the muscular fl ap; B, C. resection of the tumor with the diaphragm; D. the resected tumor; E, F. the diaphragm repair with the muscular fl ap.

Fig. 3. Postoperative X-ray three months after the surgery.
Fig. 3. Postoperative X-ray three months after the surgery.

Histological findings confirmed sarcomatoid cancer –  pleomorphic subtype pT3N0MX, imunohistochemically positive vimentin 100%, TTF1 5– 20%, AE1AE3 80%, only sporadic positivity of CK7. The patient subsequently underwent adjuvant chemotherapy with carboplatin and gemcitabine. PET CT performed 11 months after the resection showed the disease recurrence. Nine months later the patient complained of back pain, weight loss and weakness. Fol­low‑up PET CT revealed disease recur­rence with generalization. The patient died 21 months after the operation.

Discussion

The histogenesis of SARC remained unclear for a long time due to its histological heterogeneity. Years ago led this to the proposal of numerous theories. Only with the help of modern molecular methods could be the origin of sarcomatoid differentiation partially re­vealed. Currently, support for the so‑ called totipotent hypothesis prevails, which assumes the origin of the tumor cell to be from stem cells, which can differentiate into an individual epithelial or mesenchymal component [3]. This theory was also supported by the convincing determination of monoclonality and clonal identity of cell lines of carcinoma and sarcoma [4].

In an earlier WHO classification, individual types of SARC were included among conventional non‑small cell cancers. Since 2004, the WHO classification has remained stable and the SARC group contains five subgroups –  pleomorfic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma and pulmonary blastoma [5].

Histopathological dia­gnosis of SARC and its subtypes may cause certain prob­lems. Due to difficulties with captur­ing all the possible components, which may be within a tumor represented only in a minority, the tumor should be processed for histological analysis extensively. Certain subtypes may be identified by means of basic staining with hematoxylin‑eosine; however, usually other methods must be used for specification. Immunohistochemical analysis must show cytokeratin positivity (most often AE1AE3, CAM5.2, CK18, CK7). Vimentin, CEA and smooth‑ muscle markers are also positive. Positivity of epithelial markers is not essential if components of conventional cancer are morphologi­cal­ly present [5].

To date, no prospective studies regarding SARC are available. This is primarily due to the low incidence of this type of carcinoma, and also due to more complicated dia­gnostics, when in a high number of cases it is recognized as late as according to the postoperative histological findings. Furthermore, due to tumor aggressiveness, majority of patients are SARC dia­gnosed in advanced stages or even upon autop­­sy. To date, only retrospective studies with mainly small numbers of patients with SARC have been documented, and these patients are usually compared to the groups of patients with conventional non‑small cell cancer. These studies differ somewhat in their results. In most of these studies, patients with SARC had significantly worse results in terms of median of survival, disease progression as well as overall survival [6,7]. On the other hand, some studies did not find any difference in survival between the two aforementioned groups of patients [8,9].

Nonetheless, SARC dia­gnosis is gen­erally considered to be a disease with a significantly poorer prognosis in terms of survival and early disease relapse. A complete resection in the early stages of disease brings the best results; how­ever, five‑year survival in stage I is achieved by only 37% of patients [10].

SARC has a low sensitivity to radiochemotherapy and improved responses to this modality have not been recorded, none­theless it is recommended especial­­ly for bulky disease tumors, tumors in­vad-ing the thoracic wall or in cases of metastatic lymph node involvement. This is due to the higher incidence of locoregional and distant disease recurrence. In advanced stages, where surgical treatment is not indicated, palliative oncological therapy is recommended [7].

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

MUDr. Marek Szkorupa, Ph.D.
Department of Surgery IFaculty of Medicine and Dentistry of Palacky University Olomouc and University Hospital Olomouc
I. P. Pavlova 6
Olomouc
Czech Republic
e-mail: Marek.Szkorupa@fnol.cz

Submitted: 15. 10. 2014

Accepted: 2. 12. 2014


Zdroje

1. Travis WD (ed.). Pathology and genetics of tumours of the lung, pleura, thymus and heart. Oxford: Oxford University Press 2004.

2. Kikuchi R, Isowa N, Tokuyasu H et al. Three cases of resected pleomorphic carcinoma. Ann Thorac Cardiovasc Surg 2010; 16(4): 264– 269.

3. Wick MR, Swanson PE. Carcinosarcomas: current perspectives and an historical review of nosological concepts. Semin Dia­gn Pathol 1993; 10(2): 118– 127.

4. Thompson L, Chang B, Barsky SH. Monoclonal origins of malignant mixed tumors (carcinosarcomas). Evidence for a divergent histogenesis. Am J Surg Pathol 1996; 20(3): 277– 285.

5. Franks TJ, Galvin JR. Sarcomatoid carcinoma of the lung: histologic criteria and common lesions in the differential dia­gnosis. Arch Pathol Lab Med 2010; 134(1): 49– 54.

6. Fishback NF, Travis WD, Moran CA et al. Pleomorphic (spindle/ giant cell) carcinoma of the lung. A clinicopathologic correlation of 78 cases. Cancer 1994; 73(12): 2936– 2945.

7. Martin LW, Correa AM, Ordonez MG et al. Sarcomatoid carcinoma of the lung: a predictor of poor prognosis. Ann Thorac Surg 2007; 84(3): 973– 980.

8. Nakajima M, Kasai T, Hashimoto H et al. Sarcomatoid carcinoma of the lung: a clinicopathologic study of 37 cases. Cancer 1999; 86(4): 608– 616.

9. Pelosi G, Fraggetta F, Nappi O et al. Pleomorphic carcinomas of the lung show a selective distribution of gene products involved in cell differentiation, cell cycle control, tumor growth, and tumor cell motility: a clinicopathologic and immunohistochemical study of 31 cases. Am J Surg Pathol 2003; 27(9): 1203– 1215.

10. Fujioka S, Nakamura H, Adachi Y et al. Pleomorphic carcinoma of the lung in which the sarcomatous element grew rapidly: a case report. Ann Thorac Cardiovasc Surg 2009; 15(2): 111– 114.

Štítky
Dětská onkologie Chirurgie všeobecná Onkologie

Článek vyšel v časopise

Klinická onkologie

Číslo 1

2015 Číslo 1

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