PLOS Pathogens - Číslo 5/2014

Opinion

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Surveillance for Emerging Biodiversity Diseases of Wildlife
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Are We There Yet? The Smallpox Research Agenda Using Variola Virus
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Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body

Pearls

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The Emerging Role of Urease as a General Microbial Virulence Factor
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PARV4: An Emerging Tetraparvovirus
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HIV-1 Envelope gp41 Broadly Neutralizing Antibodies: Hurdles for Vaccine Development

Research Article

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Epigenetic Changes Modulate Schistosome Egg Formation and Are a Novel Target for Reducing Transmission of Schistosomiasis
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Venus Kinase Receptors Control Reproduction in the Platyhelminth Parasite
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TNFα and IFNγ but Not Perforin Are Critical for CD8 T Cell-Mediated Protection against Pulmonary Infection
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Large Scale RNAi Reveals the Requirement of Nuclear Envelope Breakdown for Nuclear Import of Human Papillomaviruses
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The Cytoplasmic Domain of Varicella-Zoster Virus Glycoprotein H Regulates Syncytia Formation and Skin Pathogenesis
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A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase
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High-Efficiency Targeted Editing of Large Viral Genomes by RNA-Guided Nucleases
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Dynamic Functional Modulation of CD4 T Cell Recall Responses Is Dependent on the Inflammatory Environment of the Secondary Stimulus
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Bacterial Superantigens Promote Acute Nasopharyngeal Infection by in a Human MHC Class II-Dependent Manner
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Follicular Helper T Cells Promote Liver Pathology in Mice during Infection
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A Nasal Epithelial Receptor for WTA Governs Adhesion to Epithelial Cells and Modulates Nasal Colonization
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Unexpected Role for IL-17 in Protective Immunity against Hypervirulent HN878 Infection
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Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III
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Expansion of Murine Gammaherpesvirus Latently Infected B Cells Requires T Follicular Help
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Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses
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Hepatitis C Virus Cell-Cell Transmission and Resistance to Direct-Acting Antiviral Agents
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The Downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 Axis and by Human Cytomegalovirus (HCMV) Associated Factors Allows the Activation of the HCMV Major IE Promoter and the Transition to Productive Infection
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Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in
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New Insights into Rotavirus Entry Machinery: Stabilization of Rotavirus Spike Conformation Is Independent of Trypsin Cleavage
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Prophenoloxidase Activation Is Required for Survival to Microbial Infections in
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SslE Elicits Functional Antibodies That Impair Mucinase Activity and Colonization by Both Intestinal and Extraintestinal Strains
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Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza
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The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in
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The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis
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Papillomavirus Genomes Associate with BRD4 to Replicate at Fragile Sites in the Host Genome
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Integrative Functional Genomics of Hepatitis C Virus Infection Identifies Host Dependencies in Complete Viral Replication Cycle
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Co-assembly of Viral Envelope Glycoproteins Regulates Their Polarized Sorting in Neurons
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Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus
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Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G
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Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin
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The Human Adenovirus E4-ORF1 Protein Subverts Discs Large 1 to Mediate Membrane Recruitment and Dysregulation of Phosphatidylinositol 3-Kinase
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Squalene Synthase As a Target for Chagas Disease Therapeutics
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A Multifactorial Role for Malaria in Endemic Burkitt's Lymphoma Pathogenesis
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Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease
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Cathepsin-L Can Resist Lysis by Human Serum in
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Epstein-Barr Virus Down-Regulates Tumor Suppressor Expression
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BCA2/Rabring7 Targets HIV-1 Gag for Lysosomal Degradation in a Tetherin-Independent Manner
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The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification
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Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection
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T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence
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Dynamics of HIV Latency and Reactivation in a Primary CD4+ T Cell Model
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HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon
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Virus and Autoantigen-Specific CD4+ T Cells Are Key Effectors in a SCID Mouse Model of EBV-Associated Post-Transplant Lymphoproliferative Disorders
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Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis
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The Contribution of Viral Genotype to Plasma Viral Set-Point in HIV Infection
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A Novel Mechanism Inducing Genome Instability in Kaposi's Sarcoma-Associated Herpesvirus Infected Cells
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Combined Systems Approaches Reveal Highly Plastic Responses to Antimicrobial Peptide Challenge in
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Anthrax Lethal Factor as an Immune Target in Humans and Transgenic Mice and the Impact of HLA Polymorphism on CD4 T Cell Immunity
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Ly49C-Dependent Control of MCMV Infection by NK Cells Is -Regulated by MHC Class I Molecules
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Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation
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A Large Family of Antivirulence Regulators Modulates the Effects of Transcriptional Activators in Gram-negative Pathogenic Bacteria
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Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response
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Malaria Parasite Infection Compromises Control of Concurrent Systemic Non-typhoidal Infection via IL-10-Mediated Alteration of Myeloid Cell Function
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A Role for in Higher Order Structure and Complement Binding of the Capsule
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Hip1 Modulates Macrophage Responses through Proteolysis of GroEL2
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CD8 T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria
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Phosphorylation of KasB Regulates Virulence and Acid-Fastness in
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HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality
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Dual-Site Phosphorylation of the Control of Virulence Regulator Impacts Group A Streptococcal Global Gene Expression and Pathogenesis

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