PLOS Pathogens - Číslo 5/2014


Surveillance for Emerging Biodiversity Diseases of Wildlife
Are We There Yet? The Smallpox Research Agenda Using Variola Virus
Cellular Superspreaders: An Epidemiological Perspective on HIV Infection inside the Body


The Emerging Role of Urease as a General Microbial Virulence Factor
PARV4: An Emerging Tetraparvovirus
HIV-1 Envelope gp41 Broadly Neutralizing Antibodies: Hurdles for Vaccine Development

Research Article

Epigenetic Changes Modulate Schistosome Egg Formation and Are a Novel Target for Reducing Transmission of Schistosomiasis
The Human Adenovirus E4-ORF1 Protein Subverts Discs Large 1 to Mediate Membrane Recruitment and Dysregulation of Phosphatidylinositol 3-Kinase
A Multifactorial Role for Malaria in Endemic Burkitt's Lymphoma Pathogenesis
Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating Activity of SARS-CoV Papain-Like Protease
Cathepsin-L Can Resist Lysis by Human Serum in
Epstein-Barr Virus Down-Regulates Tumor Suppressor Expression
BCA2/Rabring7 Targets HIV-1 Gag for Lysosomal Degradation in a Tetherin-Independent Manner
The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification
Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection
T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence
Dynamics of HIV Latency and Reactivation in a Primary CD4+ T Cell Model
HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon
Virus and Autoantigen-Specific CD4+ T Cells Are Key Effectors in a SCID Mouse Model of EBV-Associated Post-Transplant Lymphoproliferative Disorders
Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis
Squalene Synthase As a Target for Chagas Disease Therapeutics
The Contribution of Viral Genotype to Plasma Viral Set-Point in HIV Infection
Combined Systems Approaches Reveal Highly Plastic Responses to Antimicrobial Peptide Challenge in
Anthrax Lethal Factor as an Immune Target in Humans and Transgenic Mice and the Impact of HLA Polymorphism on CD4 T Cell Immunity
Ly49C-Dependent Control of MCMV Infection by NK Cells Is -Regulated by MHC Class I Molecules
Two Novel Human Cytomegalovirus NK Cell Evasion Functions Target MICA for Lysosomal Degradation
A Large Family of Antivirulence Regulators Modulates the Effects of Transcriptional Activators in Gram-negative Pathogenic Bacteria
Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response
Malaria Parasite Infection Compromises Control of Concurrent Systemic Non-typhoidal Infection via IL-10-Mediated Alteration of Myeloid Cell Function
A Role for in Higher Order Structure and Complement Binding of the Capsule
Hip1 Modulates Macrophage Responses through Proteolysis of GroEL2
CD8 T Cells from a Novel T Cell Receptor Transgenic Mouse Induce Liver-Stage Immunity That Can Be Boosted by Blood-Stage Infection in Rodent Malaria
Phosphorylation of KasB Regulates Virulence and Acid-Fastness in
HIV-Infected Individuals with Low CD4/CD8 Ratio despite Effective Antiretroviral Therapy Exhibit Altered T Cell Subsets, Heightened CD8+ T Cell Activation, and Increased Risk of Non-AIDS Morbidity and Mortality
A Novel Mechanism Inducing Genome Instability in Kaposi's Sarcoma-Associated Herpesvirus Infected Cells
Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin
Hepatitis C Virus Cell-Cell Transmission and Resistance to Direct-Acting Antiviral Agents
Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G
TNFα and IFNγ but Not Perforin Are Critical for CD8 T Cell-Mediated Protection against Pulmonary Infection
Large Scale RNAi Reveals the Requirement of Nuclear Envelope Breakdown for Nuclear Import of Human Papillomaviruses
The Cytoplasmic Domain of Varicella-Zoster Virus Glycoprotein H Regulates Syncytia Formation and Skin Pathogenesis
A New Class of Multimerization Selective Inhibitors of HIV-1 Integrase
High-Efficiency Targeted Editing of Large Viral Genomes by RNA-Guided Nucleases
Dynamic Functional Modulation of CD4 T Cell Recall Responses Is Dependent on the Inflammatory Environment of the Secondary Stimulus
Bacterial Superantigens Promote Acute Nasopharyngeal Infection by in a Human MHC Class II-Dependent Manner
Follicular Helper T Cells Promote Liver Pathology in Mice during Infection
A Nasal Epithelial Receptor for WTA Governs Adhesion to Epithelial Cells and Modulates Nasal Colonization
Unexpected Role for IL-17 in Protective Immunity against Hypervirulent HN878 Infection
Human Cytomegalovirus Fcγ Binding Proteins gp34 and gp68 Antagonize Fcγ Receptors I, II and III
Expansion of Murine Gammaherpesvirus Latently Infected B Cells Requires T Follicular Help
Venus Kinase Receptors Control Reproduction in the Platyhelminth Parasite
Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Antibodies against Influenza A Viruses
The Downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 Axis and by Human Cytomegalovirus (HCMV) Associated Factors Allows the Activation of the HCMV Major IE Promoter and the Transition to Productive Infection
Inactivation of Fructose-1,6-Bisphosphate Aldolase Prevents Optimal Co-catabolism of Glycolytic and Gluconeogenic Carbon Substrates in
New Insights into Rotavirus Entry Machinery: Stabilization of Rotavirus Spike Conformation Is Independent of Trypsin Cleavage
Prophenoloxidase Activation Is Required for Survival to Microbial Infections in
SslE Elicits Functional Antibodies That Impair Mucinase Activity and Colonization by Both Intestinal and Extraintestinal Strains
Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza
The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in
The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis
Papillomavirus Genomes Associate with BRD4 to Replicate at Fragile Sites in the Host Genome
Integrative Functional Genomics of Hepatitis C Virus Infection Identifies Host Dependencies in Complete Viral Replication Cycle
Co-assembly of Viral Envelope Glycoproteins Regulates Their Polarized Sorting in Neurons
Targeting Membrane-Bound Viral RNA Synthesis Reveals Potent Inhibition of Diverse Coronaviruses Including the Middle East Respiratory Syndrome Virus
Dual-Site Phosphorylation of the Control of Virulence Regulator Impacts Group A Streptococcal Global Gene Expression and Pathogenesis

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