1. HathcockKS, HodesRJ (1996) Role of the CD28-B7 costimulatory pathways in T cell-dependent B cell responses. Adv Immunol 62: 131–166.
2. NoelPJ, BoiseLH, GreenJM, ThompsonCB (1996) CD28 costimulation prevents cell death during primary T cell activation. J Immunol 157: 636–642.
3. SalomonB, BluestoneJA (2001) Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol 19: 225–252.
4. BluestoneJA (1995) New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2: 555–559.
5. SharpeAH (1995) Analysis of lymphocyte costimulation in vivo using transgenic and ‘knockout’ mice. Curr Opin Immunol 7: 389–395.
6. KingCL, XianliJ, JuneCH, AbeR, LeeKP (1996) CD28-deficient mice generate an impaired Th2 response to Schistosoma mansoni infection. Eur J Immunol 26: 2448–2455.
7. CorryDB, ReinerSL, LinsleyPS, LocksleyRM (1994) Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis. J Immunol 153: 4142–4148.
8. HarrisNL, PeachRJ, RoncheseF (1999) CTLA4-Ig inhibits optimal T helper 2 cell development but not protective immunity or memory response to Nippostrongylus brasiliensis. Eur J Immunol 29: 311–316.
9. LiuZ, LiuQ, PesceJ, WhitmireJ, EkkensMJ, et al. (2002) Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo. J Immunol 169: 6959–6968.
10. GauseWC, ChenSJ, GreenwaldRJ, HalvorsonMJ, LuP, et al. (1997) CD28 dependence of T cell differentiation to IL-4 production varies with the particular type 2 immune response. J Immunol 158: 4082–4087.
11. LaneP, BurdetC, HubeleS, ScheideggerD, MullerU, et al. (1994) B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells. J Exp Med 179: 819–830.
12. FergusonSE, HanS, KelsoeG, ThompsonCB (1996) CD28 is required for germinal center formation. J Immunol 156: 4576–4581.
13. LenschowDJ, WalunasTL, BluestoneJA (1996) CD28/B7 system of T cell costimulation. Annu Rev Immunol 14: 233–258.
14. WalkerLS, Gulbranson-JudgeA, FlynnS, BrockerT, RaykundaliaC, et al. (1999) Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J Exp Med 190: 1115–1122.
15. KingC, TangyeSG, MackayCR (2008) T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol 26: 741–766.
16. CampbellDJ, KimCH, ButcherEC (2001) Separable effector T cell populations specialized for B cell help or tissue inflammation. Nat Immunol 2: 876–881.
17. SchaerliP, WillimannK, LangAB, LippM, LoetscherP, et al. (2000) CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 192: 1553–1562.
18. EkkensMJ, LiuZ, LiuQ, FosterA, WhitmireJ, et al. (2002) Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite. J Immunol 168: 6344–6351.
19. WuthrichM, WarnerT, KleinBS (2005) CD28 is required for optimal induction, but not maintenance, of vaccine-induced immunity to Blastomyces dermatitidis. Infect Immun 73: 7436–7441.
20. BertramEM, DawickiW, SedgmenB, BramsonJL, LynchDH, et al. (2004) A switch in costimulation from CD28 to 4-1BB during primary versus secondary CD8 T cell response to influenza in vivo. J Immunol 172: 981–988.
21. BertramEM, DawickiW, WattsTH (2004) Role of T cell costimulation in anti-viral immunity. Semin Immunol 16: 185–196.
22. DawickiW, BertramEM, SharpeAH, WattsTH (2004) 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. J Immunol 173: 5944–5951.
23. VillegasEN, EllosoMM, ReichmannG, PeachR, HunterCA (1999) Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii. J Immunol 163: 3344–3353.
24. FuseS, ZhangW, UsherwoodEJ (2008) Control of memory CD8+ T cell differentiation by CD80/CD86-CD28 costimulation and restoration by IL-2 during the recall response. J Immunol 180: 1148–1157.
25. NdejembiMP, TeijaroJR, PatkeDS, BingamanAW, ChandokMR, et al. (2006) Control of memory CD4 T cell recall by the CD28/B7 costimulatory pathway. J Immunol 177: 7698–7706.
26. BorowskiAB, BoesteanuAC, MuellerYM, CarafidesC, TophamDJ, et al. (2007) Memory CD8+ T cells require CD28 costimulation. J Immunol 179: 6494–6503.
27. BarnerM, MohrsM, BrombacherF, KopfM (1998) Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses. Curr Biol 8: 669–672.
28. UrbanJFJr, Noben-TrauthN, DonaldsonDD, MaddenKB, MorrisSC, et al. (1998) IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis. Immunity 8: 255–264.
29. FowellDJ, MagramJ, TurckCW, KilleenN, LocksleyRM (1997) Impaired Th2 subset development in the absence of CD4. Immunity 6: 559–569.
30. KhanWI, CollinsSM (2004) Immune-mediated alteration in gut physiology and its role in host defence in nematode infection. Parasite Immunol 26: 319–326.
31. KopfM, Le GrosG, BachmannM, LamersMC, BluethmannH, et al. (1993) Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362: 245–248.
32. FinkelmanFD, Shea-DonohueT, GoldhillJ, SullivanCA, MorrisSC, et al. (1997) Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. Annu Rev Immunol 15: 505–533.
33. UrbanJFJr, MaddenKB, SveticA, CheeverA, TrottaPP, et al. (1992) The importance of Th2 cytokines in protective immunity to nematodes. Immunol Rev 127: 205–220.
34. KatonaIM, UrbanJ, FinkelmanFD (1988) The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis. J Immunol 140: 3206–3211.
35. KnottML, MatthaeiKI, GiacominPR, WangH, FosterPS, et al. (2007) Impaired resistance in early secondary Nippostrongylus brasiliensis infections in mice with defective eosinophilopoeisis. Int J Parasitol 37: 1367–1378.
36. VoehringerD, ReeseTA, HuangX, ShinkaiK, LocksleyRM (2006) Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med 203: 1435–1446.
37. GiacominPR, GordonDL, BottoM, DahaMR, SandersonSD, et al. (2008) The role of complement in innate, adaptive and eosinophil-dependent immunity to the nematode Nippostrongylus brasiliensis. Mol Immunol 45: 446–455.
38. HarvieM, CamberisM, TangSC, DelahuntB, PaulW, et al. (2010) The lung is an important site for priming CD4 T-cell-mediated protective immunity against gastrointestinal helminth parasites. Infect Immun 78: 3753–3762.
39. ThawerSG, HorsnellWG, DarbyM, HovingJC, DewalsB, et al. (2013) Lung-resident CD4 T cells are sufficient for IL-4Ralpha-dependent recall immunity to Nippostrongylus brasiliensis infection. Mucosal Immunol doi:10.1038/mi.2013.40
40. LiuQ, KreiderT, BowdridgeS, LiuZ, SongY, et al. (2010) B cells have distinct roles in host protection against different nematode parasites. J Immunol 184: 5213–5223.
41. HorsnellWGC, DarbyM, HovingJC, NieuwenhuizenN, BobatS, et al. (2013) IL-4Rα associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection. PLoS Pathog 9 DOI:10.1371/journal.ppat.1003662
42. HorsnellWG, CutlerAJ, HovingJC, MearnsH, MyburghE, et al. (2007) Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice. PLoS Pathog 3: e1.
43. KhanWI, AbeT, IshikawaN, NawaY, YoshimuraK (1995) Reduced amount of intestinal mucus by treatment with anti-CD4 antibody interferes with the spontaneous cure of Nippostrongylus brasiliensis-infection in mice. Parasite Immunol 17: 485–491.
44. McKenzieGJ, BancroftA, GrencisRK, McKenzieAN (1998) A distinct role for interleukin-13 in Th2-cell-mediated immune responses. Curr Biol 8: 339–342.
45. HorsnellWG, ViraA, KirsteinF, MearnsH, HovingJC, et al. (2011) IL-4Ralpha-responsive smooth muscle cells contribute to initiation of TH2 immunity and pulmonary pathology in Nippostrongylus brasiliensis infections. Mucosal Immunol 4: 83–92.
46. HunigT, LuhderF, ElfleinK, GogishviliT, FrohlichM, et al. (2010) CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation. Med Microbiol Immunol 199: 239–246.
47. GogishviliT, LuhderF, KirsteinF, NieuwenhuizenNE, GoebbelsS, et al. (2012) Interruption of CD28-mediated costimulation during allergen challenge protects mice from allergic airway disease. J Allergy Clin Immunol 130: 1394–403.e4.
48. SeiblerJ, ZevnikB, Kuter-LuksB, AndreasS, KernH, et al. (2003) Rapid generation of inducible mouse mutants. Nucleic Acids Res 31: e12.
49. WoerlyG, LacyP, YounesAB, RogerN, LoiseauS, et al. (2002) Human eosinophils express and release IL-13 following CD28-dependent activation. J Leukoc Biol 72: 769–779.
50. HuH, HustonG, DusoD, LepakN, RomanE, et al. (2001) CD4(+) T cell effectors can become memory cells with high efficiency and without further division. Nat Immunol 2: 705–710.
51. SallustoF, LangenkampA, GeginatJ, LanzavecchiaA (2000) Functional subsets of memory T cells identified by CCR7 expression. Curr Top Microbiol Immunol 251: 167–171.
52. SallustoF, LenigD, ForsterR, LippM, LanzavecchiaA (1999) Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401: 708–712.
53. BingamanAW, PatkeDS, ManeVR, AhmadzadehM, NdejembiM, et al. (2005) Novel phenotypes and migratory properties distinguish memory CD4 T cell subsets in lymphoid and lung tissue. Eur J Immunol 35: 3173–3186.
54. FinkelmanFD, HolmesJ, KatonaIM, UrbanJFJr, BeckmannMP, et al. (1990) Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 8: 303–333.
55. KuboM, YamashitaM, AbeR, TadaT, OkumuraK, et al. (1999) CD28 costimulation accelerates IL-4 receptor sensitivity and IL-4-mediated Th2 differentiation. J Immunol 163: 2432–2442.
56. TaoX, ConstantS, JorritsmaP, BottomlyK (1997) Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation. J Immunol 159: 5956–5963.
57. SallustoF, LanzavecchiaA (2001) Exploring pathways for memory T cell generation. J Clin Invest 108: 805–806.
58. ZaretskyAG, TaylorJJ, KingIL, MarshallFA, MohrsM, et al. (2009) T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med 206: 991–999.
59. KingIL, MohrsM (2009) IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med 206: 1001–1007.
60. AkibaH, TakedaK, KojimaY, UsuiY, HaradaN, et al. (2005) The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J Immunol 175: 2340–2348.
61. HerbertDR, HolscherC, MohrsM, ArendseB, SchwegmannA, et al. (2004) Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 20: 623–635.
62. Bonne-AnneeS, KerepesiLA, HessJA, O'ConnellAE, LokJB, et al. (2013) Human and mouse macrophages collaborate with neutrophils to kill larval Strongyloides stercoralis. Infect Immun 81: 3346–3355.
63. NeillDR, WongSH, BellosiA, FlynnRJ, DalyM, et al. (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464: 1367–1370.
64. BreitfeldD, OhlL, KremmerE, EllwartJ, SallustoF, et al. (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192: 1545–1552.
65. KimCH, RottLS, Clark-LewisI, CampbellDJ, WuL, et al. (2001) Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J Exp Med 193: 1373–1381.
66. MohrsM, LedermannB, KohlerG, DorfmullerA, GessnerA, et al. (1999) Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling. J Immunol 162: 7302–7308.