Průtoková cytometrie u monoklonálních gamapatií


Autoři: L. Kovářová 1,2;  T. Varmužová 1,2;  P. Zarbochová 3;  R. Suská 1;  Muthu Raja K. R. 2,4;  J. Štossová 2;  M. Penka 4;  R. Hájek 1,2,5
Působiště autorů: Laboratory of Experimental Hematology and Cell Immunotherapy, Department of Clinical Hematology, University Hospital Brno, Czech Republic 1;  Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic 2;  Institute of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic 3;  Department of Clinical Hematology, University Hospital Brno, Czech Republic 4;  Department of Internal Medicine – Hematooncology, University Hospital Brno, Czech Republic 5
Vyšlo v časopise: Klin Onkol 2011; 24(Supplementum 1): 24-29

Souhrn

Technologický rozvoj průtokové cytometrie (flow cytometry, FC) spolu s nejnovějšími poznatky z oblasti imunofenotypizace monoklonálních gamapatií (MG) odhalil nezbytnost tohoto vyšetření zejména pro jeho diagnostický, prognostický a prediktivní význam. Cílem Evropské myelomové sítě (European Myeloma Network, EMN) je standardizovat tuto analytickou metodu a zařadit ji mezi rutinní klinická vyšetření. Jelikož celkový význam a možné aplikace FC jsou stále analyzovány, je zřejmé, že standardizace může napomoci zisku relevantních klinických výstupů z oblasti patofyziologie MG.

Klíčová slova:
mnohočetný myelom – monoklonální gamapatie – průtoková cytometrie – plazmatická buňka

Tato práce byla podpořena granty Ministerstva školství, mládeže a tělovýchovy: LC06027, MSM0021622434; výzkumnými projekty IGA Ministerstva zdravotnictví: NT12425, NS10406, NS10408 a granty GAČR GAP304/10/1395, GP301/09/P457.

Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.

Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do bi omedicínských časopisů.


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Štítky
Dětská onkologie Chirurgie všeobecná Onkologie

Článek vyšel v časopise

Klinická onkologie

Číslo Supplementum 1

2011 Číslo Supplementum 1

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