PLOS Genetics - Číslo 8/2012

Review

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Advances in Quantitative Trait Analysis in Yeast

Perspective

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Chromosome Territories Meet a Condensin
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It's All in the Timing: Too Much E2F Is a Bad Thing
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CDK9 and H2B Monoubiquitination: A Well-Choreographed Dance

Research Article

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Mutational Signatures of De-Differentiation in Functional Non-Coding Regions of Melanoma Genomes
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Identification of Human Proteins That Modify Misfolding and Proteotoxicity of Pathogenic Ataxin-1
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A Luminal Glycoprotein Drives Dose-Dependent Diameter Expansion of the Hindgut Tube
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Human Developmental Enhancers Conserved between Deuterostomes and Protostomes
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NOL11, Implicated in the Pathogenesis of North American Indian Childhood Cirrhosis, Is Required for Pre-rRNA Transcription and Processing
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Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of
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Rare Copy Number Variations in Adults with Tetralogy of Fallot Implicate Novel Risk Gene Pathways
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and Link Transcription of Phospholipid Biosynthetic Genes to ER Stress and the UPR
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Dissecting the Gene Network of Dietary Restriction to Identify Evolutionarily Conserved Pathways and New Functional Genes
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Dynamic Distribution of Linker Histone H1.5 in Cellular Differentiation
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Reduced Prostasin (CAP1/PRSS8) Activity Eliminates HAI-1 and HAI-2 Deficiency–Associated Developmental Defects by Preventing Matriptase Activation
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Phylogenetic and Transcriptomic Analysis of Chemosensory Receptors in a Pair of Divergent Ant Species Reveals Sex-Specific Signatures of Odor Coding
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SLX-1 Is Required for Maintaining Genomic Integrity and Promoting Meiotic Noncrossovers in the Germline
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HAL-2 Promotes Homologous Pairing during Meiosis by Antagonizing Inhibitory Effects of Synaptonemal Complex Precursors
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Genetic Modulation of Lipid Profiles following Lifestyle Modification or Metformin Treatment: The Diabetes Prevention Program
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Role of Mex67-Mtr2 in the Nuclear Export of 40S Pre-Ribosomes
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Melanophore Migration and Survival during Zebrafish Adult Pigment Stripe Development Require the Immunoglobulin Superfamily Adhesion Molecule Igsf11
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Combining Comparative Proteomics and Molecular Genetics Uncovers Regulators of Synaptic and Axonal Stability and Degeneration
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The Mi-2 Chromatin-Remodeling Factor Regulates Higher-Order Chromatin Structure and Cohesin Dynamics
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Modulating the Strength and Threshold of NOTCH Oncogenic Signals by
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Rapid-Throughput Skeletal Phenotyping of 100 Knockout Mice Identifies 9 New Genes That Determine Bone Strength
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The MicroRNA Inhibits Calcium Signaling by Targeting the TIR-1/Sarm1 Adaptor Protein to Control Stochastic L/R Neuronal Asymmetry in
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Cohesin Rings Devoid of Scc3 and Pds5 Maintain Their Stable Association with the DNA
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ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice
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Acetyl-CoA-Carboxylase Sustains a Fatty Acid–Dependent Remote Signal to Waterproof the Respiratory System
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Loss of Axonal Mitochondria Promotes Tau-Mediated Neurodegeneration and Alzheimer's Disease–Related Tau Phosphorylation Via PAR-1
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Epigenetic Remodeling of Meiotic Crossover Frequency in DNA Methyltransferase Mutants
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Chemical Genetics Reveals a Specific Requirement for Cdk2 Activity in the DNA Damage Response and Identifies Nbs1 as a Cdk2 Substrate in Human Cells
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UNC-40/DCC, SAX-3/Robo, and VAB-1/Eph Polarize F-Actin during Embryonic Morphogenesis by Regulating the WAVE/SCAR Actin Nucleation Complex
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Multiple Roles and Interactions of and in Development of the Respiratory System
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A General G1/S-Phase Cell-Cycle Control Module in the Flowering Plant
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Mutations in a P-Type ATPase Gene Cause Axonal Degeneration
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Rates of Gyrase Supercoiling and Transcription Elongation Control Supercoil Density in a Bacterial Chromosome
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Experimental Relocation of the Mitochondrial Gene to the Nucleus Reveals Forces Underlying Mitochondrial Genome Evolution
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Comparative Analysis of the Genomes of Two Field Isolates of the Rice Blast Fungus
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Cell-Nonautonomous Signaling of FOXO/DAF-16 to the Stem Cells of
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Rescuing Alu: Recovery of Inserts Shows LINE-1 Preserves Alu Activity through A-Tail Expansion
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A Single Origin for Nymphalid Butterfly Eyespots Followed by Widespread Loss of Associated Gene Expression
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Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis
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Use of Allele-Specific FAIRE to Determine Functional Regulatory Polymorphism Using Large-Scale Genotyping Arrays
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A Sexual Ornament in Chickens Is Affected by Pleiotropic Alleles at and , Selected during Domestication
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The PARN Deadenylase Targets a Discrete Set of mRNAs for Decay and Regulates Cell Motility in Mouse Myoblasts
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Retrovolution: HIV–Driven Evolution of Cellular Genes and Improvement of Anticancer Drug Activation
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Cryptocephal, the ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2
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, a Gene Involved in Axonal Pathfinding, Is Mutated in Patients with Kallmann Syndrome
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Uncovering the Genome-Wide Transcriptional Responses of the Filamentous Fungus to Lignocellulose Using RNA Sequencing
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Variation of Contributes to Dog Breed Skull Diversity
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Experimental Evolution of a Novel Sexually Antagonistic Allele
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A Combinatorial Amino Acid Code for RNA Recognition by Pentatricopeptide Repeat Proteins
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Genome Patterns of Selection and Introgression of Haplotypes in Natural Populations of the House Mouse ()
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Fine-Mapping and Initial Characterization of QT Interval Loci in African Americans
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Genetics and Regulatory Impact of Alternative Polyadenylation in Human B-Lymphoblastoid Cells
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The Genetic Basis of Pollinator Adaptation in a Sexually Deceptive Orchid
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Inheritance Beyond Plain Heritability: Variance-Controlling Genes in
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S Phase–Coupled E2f1 Destruction Ensures Homeostasis in Proliferating Tissues
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Reprogramming of H3K27me3 Is Critical for Acquisition of Pluripotency from Cultured Tissues
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Simple Methods for Generating and Detecting Locus-Specific Mutations Induced with TALENs in the Zebrafish Genome
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Comparative Analysis of Regulatory Elements between and by Genome-Wide Transcription Start Site Profiling
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Minibrain/Dyrk1a Regulates Food Intake through the Sir2-FOXO-sNPF/NPY Pathway in and Mammals
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A Quantitative Comparison of the Similarity between Genes and Geography in Worldwide Human Populations
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Hox and Sex-Determination Genes Control Segment Elimination through EGFR and Activity
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Transgene Induced Co-Suppression during Vegetative Growth in
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Stromal Liver Kinase B1 [STK11] Signaling Loss Induces Oviductal Adenomas and Endometrial Cancer by Activating Mammalian Target of Rapamycin Complex 1
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The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits
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Polysome Profiling in Liver Identifies Dynamic Regulation of Endoplasmic Reticulum Translatome by Obesity and Fasting
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Components of a Fanconi-Like Pathway Control Pso2-Independent DNA Interstrand Crosslink Repair in Yeast
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Population Genomics of the Facultatively Mutualistic Bacteria and
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A Dynamic Response Regulator Protein Modulates G-Protein–Dependent Polarity in the Bacterium
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PTEN Negatively Regulates MAPK Signaling during Vulval Development
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Condensin II Promotes the Formation of Chromosome Territories by Inducing Axial Compaction of Polyploid Interphase Chromosomes
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Reprogramming to Pluripotency Can Conceal Somatic Cell Chromosomal Instability
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The Genes Define Unique Classes of Two-Partner Secretion and Contact Dependent Growth Inhibition Systems

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