PLOS Genetics - Číslo 2/2012

Perspective

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Upsetting the Dogma: Germline Selection in Human Males
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Diced Triplets Expose Neurons to RISC
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The Williams-Beuren Syndrome—A Window into Genetic Variants Leading to the Development of Cardiovascular Disease

Research Article

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A Strong Deletion Bias in Nonallelic Gene Conversion
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The Dynamics and Prognostic Potential of DNA Methylation Changes at Stem Cell Gene Loci in Women's Cancer
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A Regulatory Network for Coordinated Flower Maturation
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Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes
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The Empirical Power of Rare Variant Association Methods: Results from Sanger Sequencing in 1,998 Individuals
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Systematic Detection of Epistatic Interactions Based on Allele Pair Frequencies
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Familial Identification: Population Structure and Relationship Distinguishability
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Raf1 Is a DCAF for the Rik1 DDB1-Like Protein and Has Separable Roles in siRNA Generation and Chromatin Modification
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Loss of Function of the Cik1/Kar3 Motor Complex Results in Chromosomes with Syntelic Attachment That Are Sensed by the Tension Checkpoint
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Computational Prediction and Molecular Characterization of an Oomycete Effector and the Cognate Resistance Gene
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GTPase Activity and Neuronal Toxicity of Parkinson's Disease–Associated LRRK2 Is Regulated by ArfGAP1
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The Role of Glypicans in Wnt Inhibitory Factor-1 Activity and the Structural Basis of Wif1's Effects on Wnt and Hedgehog Signaling
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Evaluation of the Role of Functional Constraints on the Integrity of an Ultraconserved Region in the Genus
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Neurophysiological Defects and Neuronal Gene Deregulation in Mutants
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Genetic and Functional Analyses of Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders
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Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated Mutagenesis
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Rewiring of PDZ Domain-Ligand Interaction Network Contributed to Eukaryotic Evolution
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The Eph Receptor Activates NCK and N-WASP, and Inhibits Ena/VASP to Regulate Growth Cone Dynamics during Axon Guidance
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Repression of a Potassium Channel by Nuclear Hormone Receptor and TGF-β Signaling Modulates Insulin Signaling in
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The Retrohoming of Linear Group II Intron RNAs in Occurs by Both DNA Ligase 4–Dependent and –Independent Mechanisms
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Cell Lineage Analysis of the Mammalian Female Germline
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Nondisjunction of a Single Chromosome Leads to Breakage and Activation of DNA Damage Checkpoint in G2
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Discovery of a Modified Tetrapolar Sexual Cycle in and the Evolution of in the Species Complex
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Positive Selection for New Disease Mutations in the Human Germline: Evidence from the Heritable Cancer Syndrome Multiple Endocrine Neoplasia Type 2B
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The Origin and Nature of Tightly Clustered Deletions in Precursor B-Cell Acute Lymphoblastic Leukemia Support a Model of Multiclonal Evolution
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Genome-Wide Association Study in East Asians Identifies Novel Susceptibility Loci for Breast Cancer
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Mixed Effects Modeling of Proliferation Rates in Cell-Based Models: Consequence for Pharmacogenomics and Cancer
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Reduction of NADPH-Oxidase Activity Ameliorates the Cardiovascular Phenotype in a Mouse Model of Williams-Beuren Syndrome
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Genome-Wide Association Study Identifies Chromosome 10q24.32 Variants Associated with Arsenic Metabolism and Toxicity Phenotypes in Bangladesh
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Structural Basis of Transcriptional Gene Silencing Mediated by MOM1
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Genomic Restructuring in the Tasmanian Devil Facial Tumour: Chromosome Painting and Gene Mapping Provide Clues to Evolution of a Transmissible Tumour
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Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations
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Contrasting Properties of Gene-Specific Regulatory, Coding, and Copy Number Mutations in : Frequency, Effects, and Dominance
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Ultrafast Evolution and Loss of CRISPRs Following a Host Shift in a Novel Wildlife Pathogen,
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Sequestration of Highly Expressed mRNAs in Cytoplasmic Granules, P-Bodies, and Stress Granules Enhances Cell Viability
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Phosphorylation of Chromosome Core Components May Serve as Axis Marks for the Status of Chromosomal Events during Mammalian Meiosis
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Psoriasis Patients Are Enriched for Genetic Variants That Protect against HIV-1 Disease
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A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity
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The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity
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Homeobox Genes Critically Regulate Embryo Implantation by Controlling Paracrine Signaling between Uterine Stroma and Epithelium
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Developmental Transcriptional Networks Are Required to Maintain Neuronal Subtype Identity in the Mature Nervous System
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Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan
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Gene Expression and Stress Response Mediated by the Epigenetic Regulation of a Transposable Element Small RNA
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Loss of Tgif Function Causes Holoprosencephaly by Disrupting the Shh Signaling Pathway
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Association of a Functional Variant in the Wnt Co-Receptor with Early Onset Ileal Crohn's Disease

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