Genetic analysis of the modern Australian labradoodle dog breed reveals an excess of the poodle genome


Autoři: Muhammad Basil Ali aff001;  Jacquelyn M. Evans aff001;  Heidi G. Parker aff001;  Jaemin Kim aff001;  Susan Pearce-Kelling aff004;  D. Thad Whitaker aff001;  Jocelyn Plassais aff001;  Qaiser M. Khan aff002;  Elaine A. Ostrander aff001
Působiště autorů: Cancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda MD, United States of America aff001;  National Institute for Biotechnology and Genetic Engineering (NIBGE), Jhang Road Faisalabad, Punjab, Pakistan aff002;  Pakistan Institute of Engineering and Applied Sciences (PIEAS), Islamabad, Punjab, Pakistan aff003;  OptiGen, LLC Cornell Business and Technology Park, Ithaca, NY, United States of America aff004
Vyšlo v časopise: Genetic analysis of the modern Australian labradoodle dog breed reveals an excess of the poodle genome. PLoS Genet 16(9): e32767. doi:10.1371/journal.pgen.1008956
Kategorie: Research Article
doi: 10.1371/journal.pgen.1008956

Souhrn

The genomic diversity of the domestic dog is an invaluable resource for advancing understanding of mammalian biology, evolutionary biology, morphologic variation, and behavior. There are approximately 350 recognized breeds in the world today, many established through hybridization and selection followed by intense breeding programs aimed at retaining or enhancing specific traits. As a result, many breeds suffer from an excess of particular diseases, one of many factors leading to the recent trend of “designer breed” development, i.e. crossing purebred dogs from existing breeds in the hope that offspring will be enriched for desired traits and characteristics of the parental breeds. We used a dense panel of 150,106 SNPs to analyze the population structure of the Australian labradoodle (ALBD), to understand how such breeds are developed. Haplotype and admixture analyses show that breeds other than the poodle (POOD) and Labrador retriever (LAB) contributed to ALBD formation, but that the breed is, at the genetic level, predominantly POOD, with all small and large varieties contributing to its construction. Allele frequency analysis reveals that the breed is enhanced for variants associated with a poodle-like coat, which is perceived by breeders to have an association with hypoallergenicity. We observed little enhancement for LAB-specific alleles. This study provides a blueprint for understanding how dog breeds are formed, highlighting the limited scope of desired traits in defining new breeds.

Klíčová slova:

Alleles – Dogs – Haplotypes – Homozygosity – Mammalian genomics – Pets and companion animals – Phylogenetic analysis – Single nucleotide polymorphisms


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PLOS Genetics


2020 Číslo 9

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