The Value of 18- Fdg PET/ CT Imaging in a Patient with Atypical Metastatic Colorectal Cancer –  Case Report: 18- FDG  PET/CT in Colorectal Cancer


Hodnota zobrazenia 18- FDG PET/ CT u pacientov s atypickým metastatickým karcinómom –  kazuistika: 18- FDG  PET/CT pri kolorektálnych karcinómoch

Východiská:
Metastázovanie do kostrových svalov je veľmi vzácne. Najčastejšie referovanými primárnymi nádormi bývajú pľúcny karcinóm, nádor obličky a malígny melanóm. Je viac ako problematické stanoviť diagnózu svalovej metastázy z iného primárneho nádoru. Prípad: V našej kazuistike popisujeme prípad 44- ročného muža s metastatickým kolorektálnym karcinómom, ktorý podstúpil ľavostrannú hemikolektómiu pre nádor lienálnej flexúry s následnou metastazektómiou pečeňových ložísk a kryodeštrukciou neresekovateľnej metastázy v VII. segmente. V ďalšom období bol pacient liečený dvoma líniami chemoterapie. Krátko po zahájení druhej línie chemoterapie však začal trpieť neznesiteľnou bolesťou v lumbosakrálnej oblasti. Ani MR vyšetrenie, ani abdominálne CT vyšetrenie ako aj scintigrafia skeletu neobjasnili pôvod bolestí. Až zrealizované PET/ CT vyšetrenie preukázalo masívne hypermetabolické metastatické ložiská vo svaloch, čo potvrdili aj pitevné nálezy. Záver: Prípad dokumentuje, že spomedzi rôznych zobrazovacích techník FDG PET/ CT ponúka zachytenie vysoko metabolicky aktívnych nádorových lézií, ktoré sa konvenčnými vyšetreniami detekovať nedali.

Kľúčové slová:
kolorektálny karcinóm –  metastázovanie do svalu –  18-FDG  PET/ CT vyšetrenie


Authors: Z. Hlavatá 1;  N. Pazderová 1;  P. Povinec 2;  P. Paulíny 2;  A. Majidi 3;  P. Fiala 3;  P. Martanovič 3;  T. Šálek 1
Authors place of work: National Cancer Institute, Bratislava, Slovak Republic 1;  PET Center BIONT, Bratislava, Slovak Republic 2;  Pathology Department of the Slovak Health Care Surveillance Authority, Bratislava, Slovak Republic 3
Published in the journal: Klin Onkol 2009; 22(6): 284-287
Category: Kazuistiky

Summary

Backgrounds:
Cancer metastasis to skeletal muscle is very rare. Lung cancer, renal cell carcinoma and malignant melanoma have been reported as the most frequent primary tumours. Diagnosis of muscle metastasis from other primary cancer sites is more than problematic.Case:In this paper we report a case of metastasis of colorectal cancer in a 44‑year‑ old man who underwent left‑ sided hemicolectomy due to the tumour mass in his left colic flexure followed by liver metastasectomy and cryocautery of the non‑resectable metastasis in the VII segment. Subsequently, the patient was treated with two lines of chemotherapy. However, shortly after initiation of the second chemotherapy line he started to suffer from unbearable pain in the lumbosacral region. Neither a whole spinal cord MRI nor abdominal CT scan and scintigraphy explained the origin of the pain. Finally, PET/ CT examination clarified the origin of the pain and showed massive hypermetabolic metastatic lesions in the muscles, further confirmed by autopsy.Conclusion:Thus, among the different imaging techniques, FDG PET/ CT enables the detection of metabolically highly active tumour cells, undetectable by other conventional imaging means.

Key words:
colorectal cancer –  muscle metastasis –  FDG‑ PET/ CT examination

Backgrounds

Cancer metastasis to the skeletal muscle is very rare. While only 8 cases were reported till 2000, now, due to rapid improvements in the field of modern imaging techniques the clinicians are confronted with increasing amount of atypical metastatic sites in cancer patients in general. The most frequent primary tumours reported are lung cancer, renal cell carcinoma and malignant melanoma [1]. Usually, metastases of adenocarcinoma to the skeletal muscle form painfull mass of different sizes predominantly localised in lower extremity [2–3]. Diagnosis of muscle disturbance from other primary cancer sites is more problematic. Several imaging techniques like CT alone, MRI and PET/CT can be employed to detect recurrence of cancer disease. Rappeport and colleagues compared specificity and sensitivity of each paricular technique in liver metastases and extrahepatic colorectal cancer. The most important conclusion from this study was, that PET/CT can detect more patients with extrahepatic tumour than CT alone [4].

Case

A 44 year old man suffered from change of constipation and diarrhoea was examined by colonoscopy. He also noticed blood in his stool. The colonoscopy proved the finding of the tumour mass in left colic flexure. CT scan showed synchronously metastatic disease in his liver, specifically of the VI and VII segments. In July 2005 hemicolectomy on the left side followed by liver metastasectomy of segments VI, II, III and cryocautery of the metastases in VII segment was perfomed.

Histopathologically, the resected colorectal carcinoma confirmed the ulcerative, moderately to poorly differentiated adenocarcinoma of the large bowel (G 2–3). The tumour had an invasive growth pattern, invading intramurally all the layers of the large bowel, focally with incipient signs of invading the pericolic fat tissue. In some parts were caught foci of extracellular mucus as well as signs of intracellular mucus production with the formation of sigiloid elements and foci of endolymphatic embolisation too. Foci of perineural spreading of the tumour masses were seen. Fifteen lymph nodes were examined; 13 out of them were positive for metastases of the adenocarcinoma, in one case a perinodal spreading was presented as well; pT3N3M1.

Between 10/2005 and 7/2006 the patient received „mIFL“ as first line chemotherapy with Bevacizumab regimen (Irinotecan 100mg/m2, 5FU 450mg/m2 and CaLV weekly on D1,8,15,22, one week pause, Bevacizumab 5mg/kg on D1,15). Because of the disease progression, again only in the liver, the patient underwent second cryocautery of three metastases in segments V, VII and VIII. From 10/2006 Irinotecan with Cetuximab as a second line of chemotherapy was administered (Irinotecan 100mg/m2 on D1,8,15,22, one week pause, Cetuximab 400mg/m2 initially, 250mg/m2 in subsequent weeks). In the following months the patient was suffering from severe pain in the lumbosacral region with irradiation along the spinal cord into the gluteal muscles bilaterally. Neither a whole spinal cord MRI nor abdominal CT scan (both recommended by the neurologist) explained the origin of the pain. How­ever, disease progression in the liver was proved. Scintigraphy of the skeleton was negative. An increasing tendency for unbearable pain resulted in continual high dose opiate derivates application. Disease progression was supposed in lumbosacral region, however crucial origin of the pain was still unclear. The lumbar puncture was not performed due to severe pain. The paraneoplastic myo­pathy was also considered in differential diagnosis.

Finally, PET/CT examination showed massive hypermetabolic metastatic lesions in the muscles; the largest lesion was in the deconfigurated left psoas major muscle (Fig. 1A, thick arrow) with many smaller lesions in the other psoas and iliopsoas muscles, and a smaller metastatic lesion on the jejunum wall (Fig. 1A, thin arrow), in the muscles of the pelvis, in the gluteal muscles, and in the adductor magnum (Fig. 1B, thin arrows), in the muscles of the thorax and abdominal wall, in the muscles of the upper and lower extremities, which elucidated the cause of pain. In addition, hypermetabolic metastatic lymphadenopathy in different regions, multiple metastatic lesions in the liver, other multiple intraabdominal lesions and two intrapulmonary metastases as well as two metastatic lesions in the brain – in the left hemisphere of the cerebellum and in the area of the right meatus acusticus internus were detected (Fig. 2). Palliative external beam radiotherapy on the cranium was applied. In March 2007 the patient died of disease progression. The autopsy confirmed the presence of metastases in all localities, as shown previously on PET/CT.

Fig. 1. Axial fused 18-FDG PET / CT image. A – Hypermetabolic metastatic lesion in the psoas major muscle (thick arrow) and a smaller metastatic lesion on the jejunum wall (thin arrow). B – Two hypermetabolic metastatic lesions in the gluteus maximus muscle and in the adductor magnus muscle (thin arrows).
Fig. 1. Axial fused 18-FDG PET / CT image. A – Hypermetabolic metastatic lesion in the psoas major muscle (thick arrow) and a smaller metastatic lesion on the jejunum wall (thin arrow). B – Two hypermetabolic metastatic lesions in the gluteus maximus muscle and in the adductor magnus muscle (thin arrows).

Fig. 2. Maximum intensity projection (MiP) image of the 18‑Fdg Pet study.
Fig. 2. Maximum intensity projection (MiP) image of the 18‑Fdg Pet study.

Histopathological analysis showed metastasis of adenocarcinoma to the psoas major muscle with adenostructures (black thick arrow) infiltrating the muscle fibers (white arrows) and endolymphatic spreading of the tumour cells (black thin arrow) (Fig. 3A) and infiltration of the adenostructures (black thick arrow) into the muscle (white arrow) and perineural spreading (black thin arrow) (Fig. 3B).

Fig. 3. Metastasis of adenocarcinoma to the psoas major muscle (he). A – adenostructures (black thick arrow) infiltrating the muscle fibers (white arrows) and endolymphatic spreading of the tumor cells (black thin arrow). B – infiltration of the adenostructures (black thick arrow) into the muscle (white arrow) and perineural spreading (black thin arrow).
Fig. 3. Metastasis of adenocarcinoma to the psoas major muscle (he). A – adenostructures (black thick arrow) infiltrating the muscle fibers (white arrows) and endolymphatic spreading of the tumor cells (black thin arrow). B – infiltration of the adenostructures (black thick arrow) into the muscle (white arrow) and perineural spreading (black thin arrow).

Conclusion

Despite the fact, that metastasis of carcinoma to the skeletal muscle is a rare event, it should be taken into consideration by the clinicians especially in the case of unexplainable pain occurence. Based on the literature data, the size of the painful mass ranged from 2 to 12cm [2]. The skeletal muscle metastases occurred either as a solitary mass without any other clinically detectable metastases or as part of disseminated disease similar as in our case. The metastatic lesions can be treated with wide excision or radiotherapy or with combination of both.

Overall, there is not universal and specific imaging technique for skeletal muscle metastasis. However MR imaging with intravenous gadolinium enhancement is useful to evaluate the vascularity of the tumour which is helpful for the planning of further bio­psy [2]. The authors believe that the extensive peritumoral enhancement associated with central necrosis in patients with painful soft tissue mass is one of the characteristic features of the skeletal muscle metastasis.

18-FDG PET is a molecular imaging technique enabling non invasive in vivo visualisation of glucose metabolism. This „functional“ diagnostic modality has proven to be invaluable for the detection, staging and restaging of many malignancies. The increased sensitivity of PET in comparison to with CT or MRI can be attributed to the ability of PET to detect changes in metabolic activity that precede the morphological abnormalities. Fused 18-FDG PET/CT significantly improves the anatomic localisation of abnormal FDG activity, which is paramount for the surgical evaluation [5]. However, sensitivity of FDG PET varies with the size of the lesion and its anatomic location and specificity depends on histology of the primary tumor, where well differentiated tumours may exhibit very low or even absent FDG uptake. On the other hand relatively high FDG activity may be observed at the sites of inflammation or granulation tissue, that can be indistiguishable from malignant disease [6]. The reported sensitivity and specificity of FDG PET for the detec­tion of recurrent disease have been estimated at 97% (95% CI 95–99%) and 76% (95% CI 64–88%) respectively, with a change at clinical management in 29% of patients [7]. The FDG PET scan identifies recurrence in two out of three cases of patients with occult metastatic disease with increased tumour markers (CEA) and negative conventional imaging [8].

This manuscript documents the occurrence of metastasis of the colorectal cancer at atypical muscle location. We can speculate that this atypical bio­logical behaviour could be connected with the application of targeted bio­logical molecules, such as Bevacizumab. Consistent with increasing frequency of administration of targeted therapy we should be prepared to handle various unusual clinical pictures. Among the different imaging techniques, 18-FDG PET/CT allows detection of high metabolic active tumour cells, undetectable by means of other conventional imaging. Consistent with previous literature data 18-FDG PET/CT represents a valuable source of additional information about extrahepatic lesions with an impact on clinical management of the patient. In light of these facts we feel that our case report offers multiple questions and speculations useful for daily practice with cancer patients in the presence and for the future.

The authors declare they have no potential conflicts of interest concerning drugs, pruducts, or services used in the study.
Autoři deklarují, že v souvislosti s předmětem studie nemají žádné komerční zájmy.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Redakční rada potvrzuje, že rukopis práce splnil ICMJE kritéria pro publikace zasílané do biomedicínských časopisů.

MUDr. Zuzana Hlavatá
Department of Internal Medicine
National Cancer Institute
Klenova 1
SK-833 10 Bratislava
Slovak Republic
e-mail: zuzana.hlavata@nou.sk


Zdroje

1. Hasegawa S, Sakurai Y, Imazu H et al. Metastasis to the forearm skeletal muscle from an adenocarcinoma of the colon: Report of a case. Surg Today 2000; 30: 1118– 1123.

2. Tuoheti Y, Okada K, Osanai T et al. Skeletal muscle metastases of carcinoma: a clinicopathological study of 12 cases. Jpn J Clin Oncol 2004; 34: 210– 214.

3. Herring CL Jr, Harrelson JM, Scully SP. Metastatic carcinoma to skeletal muscle. A report of 15 patients. Clin Orthop 1998; 355: 272– 281.

4. Rappeport ED, Loft A, Berthelsen AK et al. Contrast‑ enhanced FDG‑ PET/ CT vs SPIO‑ enhanced MRI vs. FDG‑ PET vs. CT in patients with liver metastases from colorectal cancer: a prospective study with intraoperative confirmation. Acta Radiol 2007; 48: 369– 378.

5. Cohade C, Osman M, Leal J et al. Direct comparison of (18)F‑ FDG PET and PET/ CT in patients with colorectal carcinoma. J Nucl Med 2003; 44: 1797– 1803.

6. Herbertson RA, Lee ST, Tebbutt N et al. The expanding role of PET technology in the management of patients with colorectal cancer. Ann Oncol 2007; 18: 1774– 1781.

7. Huebner RH, Park KC, Shepherd JE et al. A meta‑analysis of the literature for whole‑ body FDG PET detection of recurrent colorectal cancer. J Nucl Med 2000; 41: 1177– 1189.

8. Flanagan FL, Dehdashti F, Ogunbiyi OA et al. Utility of FDG‑ PET for investigating unexplained plasma CEA elevation in patients with colorectal cancer. Ann Surg 1998; 227: 319– 323.

Štítky
Dětská onkologie Chirurgie všeobecná Onkologie

Článek vyšel v časopise

Klinická onkologie

Číslo 6

2009 Číslo 6

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