Mukoadhezivní filmy jako perspektivní lékové formy pro orální podání


Autoři: Hana Landová ;  Zdeněk Daněk ;  Jan Gajdziok ;  David Vetchý ;  Jan Štembírek
Vyšlo v časopise: Čes. slov. Farm., 2013; 62, 4-11
Kategorie: Přehledy a odborná sdělení

Souhrn

Mukoadheze představuje specifický proces vytváření vazeb během těsného kontaktu mezi biologickými povrchy pokrytými slizovou vrstvou a mukoadhezivním materiálem. V posledních letech vstupují do popředí zájmu farmaceutického průmyslu moderní lékové formy založené na tomto procesu. Filmy složené z mukoadhezivních polymerů (deriváty celulosy, polyakryláty, polyoxyethylen atd.) připravené některou ze zavedených metod (odpařování rozpouštědla, extruze taveniny atd.) mohou být perspektivními kandidáty pro orální aplikaci mnoha léků, především pro jejich flexibilitu a pohodlné použití. K dalším výhodám této lékové formy patří zlepšení relativně krátké doby setrvání konvenčních orálních lékových forem na sliznici a dodání přesné dávky léčiva na místo aplikace. Kromě toho mohou také překrytím chránit povrch slizniční léze, což napomáhá ke snížení bolestivosti a zlepšení účinnosti léčby. Cílem tohoto článku je poskytnout přehled o principech vzniku mukoadhezivních vazeb a o inovativní lékové formě – mukoadhezivních filmech z hlediska jejich složení, přípravy a praktického využití.

Klíčová slova:
sliznice dutiny ústní • principy mukoadheze • mukoadhezivní lékové formy • filmy • disky


Zdroje

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Farmacie Farmakologie

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Česká a slovenská farmacie

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2013 Číslo 1

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