Biological sex impacts COVID-19 outcomes


Autoři: Sabra L. Klein aff001;  Santosh Dhakal aff001;  Rebecca L. Ursin aff002;  Sharvari Deshpande aff001;  Kathryn Sandberg aff003;  Franck Mauvais-Jarvis aff004
Působiště autorů: W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America aff001;  Department of Biochemistry and Molecular Biology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America aff002;  Departments of Medicine and Nephrology & Hypertension, Georgetown University, Washington, DC, United States of America aff003;  Diabetes Discovery & Sex-Based Medicine Laboratory, Section of Endocrinology, John W. Deming Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America aff004;  Southeast Louisiana Veterans Health Care System Medical Center, New Orleans, Louisiana, United States of America aff005
Vyšlo v časopise: Biological sex impacts COVID-19 outcomes. PLoS Pathog 16(6): e32767. doi:10.1371/journal.ppat.1008570
Kategorie: Opinion
doi: 10.1371/journal.ppat.1008570

Souhrn

The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male–female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.

Klíčová slova:

Diabetes mellitus – Health care facilities – Immune response – Kidneys – Mouse models – New York – SARS – SARS coronavirus


Zdroje

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Článek vyšel v časopise

PLOS Pathogens


2020 Číslo 6

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