1. VidalJE, HernandezAV, de OliveiraAC, DauarRF, BarbosaSPJr, et al. (2005) Cerebral toxoplasmosis in HIV-positive patients in Brazil: clinical features and predictors of treatment response in the HAART era. AIDS Patient Care STDS 19: 626–634.
2. LyonsRE, McLeodR, RobertsCW (2002) Toxoplasma gondii tachyzoite-bradyzoite interconversion. Trends Parasitol 18: 198–201.
3. BhadraR, GigleyJP, KhanIA (2011) The CD8 T-cell road to immunotherapy of toxoplasmosis. Immunotherapy 3: 789–801.
4. CraverMP, RooneyPJ, KnollLJ (2010) Isolation of Toxoplasma gondii development mutants identifies a potential proteophosphogylcan that enhances cyst wall formation. Mol Biochem Parasitol 169: 120–123.
5. PorterSB, SandeMA (1992) Toxoplasmosis of the central nervous system in the acquired immunodeficiency syndrome. N Engl J Med 327: 1643–1648.
6. AhmedR, AkondyRS (2011) Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines. Immunol Cell Biol 89: 340–345.
7. BhadraR, GigleyJP, WeissLM, KhanIA (2011) Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade. Proc Natl Acad Sci U S A 108: 9196–9201.
8. YiJS, DuM, ZajacAJ (2009) A vital role for interleukin-21 in the control of a chronic viral infection. Science 324: 1572–1576.
9. BettsMR, NasonMC, WestSM, De RosaSC, MiguelesSA, et al. (2006) HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107: 4781–4789.
10. BhadraR, GigleyJP, KhanIA (2011) Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cells. J Immunol 187: 4421–4425.
11. IntlekoferAM, TakemotoN, WherryEJ, LongworthSA, NorthrupJT, et al. (2005) Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol 6: 1236–1244.
12. BhadraR, GigleyJP, KhanIA (2012) PD-1 mediated attrition of polyfunctional memory CD8+ T cells in chronic Toxoplasma infection. J Infect Dis 206: 125–34.
13. ChangJT, PalanivelVR, KinjyoI, SchambachF, IntlekoferAM, et al. (2007) Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science 315: 1687–1691.
14. NolzJC, HartyJT (2011) Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection. Immunity 34: 781–793.
15. ZammitDJ, CauleyLS, PhamQM, LefrancoisL (2005) Dendritic cells maximize the memory CD8 T cell response to infection. Immunity 22: 561–570.
16. HikonoH, KohlmeierJE, TakamuraS, WittmerST, RobertsAD, et al. (2007) Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells. J Exp Med 204: 1625–1636.
17. GraysonJM, ZajacAJ, AltmanJD, AhmedR (2000) Cutting edge: increased expression of Bcl-2 in antigen-specific memory CD8+ T cells. J Immunol 164: 3950–3954.
18. BhadraR, GuanH, KhanIA (2010) Absence of both IL-7 and IL-15 severely impairs the development of CD8 T cell response against Toxoplasma gondii. PLoS One 5: e10842 doi:10.1371/journal.pone.0010842.
19. BlackburnSD, ShinH, HainingWN, ZouT, WorkmanCJ, et al. (2009) Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat Immunol 10: 29–37.