Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study


Autoři: Jee Wook Kim aff001;  Min Soo Byun aff003;  Dahyun Yi aff003;  Jun Ho Lee aff004;  Kang Ko aff005;  So Yeon Jeon aff006;  Bo Kyung Sohn aff007;  Jun-Young Lee aff008;  Yu Kyeong Kim aff010;  Seong A Shin aff010;  Chul-Ho Sohn aff011;  Dong Young Lee aff003
Působiště autorů: Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea aff001;  Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea aff002;  Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea aff003;  Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea aff004;  Department of Geriatric Psychiatry, National Center for Mental Health, Seoul, Republic of Korea aff005;  Department of Psychiatry, Chungnam National University Hospital, Daejeon, Republic of Korea aff006;  Department of Psychiatry, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea aff007;  Department of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea aff008;  Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea aff009;  Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea aff010;  Department of Radiology, Seoul National University College of Medicine, Seoul, Republic of Korea aff011
Vyšlo v časopise: Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study. PLoS Med 17(2): e32767. doi:10.1371/journal.pmed.1003022
Kategorie: Research Article
doi: 10.1371/journal.pmed.1003022

Souhrn

Background

An emerging body of literature has indicated that moderate alcohol intake may be protective against Alzheimer disease (AD) dementia. However, little information is available regarding whether moderate alcohol intake is related to reductions in amyloid-beta (Aβ) deposition, or is protective via amyloid-independent mechanisms in the living human brain. Here we examined the associations of moderate alcohol intake with in vivo AD pathologies, including cerebral Aβ deposition, neurodegeneration of AD-signature regions, and cerebral white matter hyperintensities (WMHs) in the living human brain.

Methods and findings

The present study was part of the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE), an ongoing prospective cohort study that started in 2014. As of November 2016, 414 community-dwelling individuals with neither dementia nor alcohol-related disorders (280 cognitively normal [CN] individuals and 134 individuals with mild cognitive impairment [MCI]) between 56 and 90 years of age (mean age 70.9 years ± standard deviation 7.8; male, n [%] = 180 [43.5]) were recruited from 4 sites (i.e., 2 university hospitals and 2 public centers for dementia prevention and management) around Seoul, South Korea. All the participants underwent comprehensive clinical assessments comprising lifetime and current histories of alcohol intake and multimodal brain imaging, including [11C] Pittsburgh compound B positron emission tomography (PET), [18F] fluorodeoxyglucose (FDG) PET, and magnetic resonance imaging (MRI) scans. Lifetime and current alcohol intake were categorized as follows: no drinking, <1 standard drink (SD)/week, 1–13 SDs/week, and 14+ SDs/week. A moderate lifetime alcohol intake (1–13 SDs/week) was significantly associated with a lower Aβ positivity rate compared to the no drinking group, even after controlling for potential confounders (odds ratio 0.341, 95% confidence interval 0.163–0.714, p = 0.004). In contrast, current alcohol intake was not associated with amyloid deposition. Additionally, alcohol intake was not related to neurodegeneration of AD-signature regions or cerebral WMH volume. The present study had some limitations in that it had a cross-sectional design and depended on retrospective recall for alcohol drinking history.

Conclusions

In this study, we observed in middle- and old-aged individuals with neither dementia nor alcohol-related disorders that moderate lifetime alcohol intake was associated with lower cerebral Aβ deposition compared to a lifetime history of not drinking. Moderate lifetime alcohol intake may have a beneficial influence on AD by reducing pathological amyloid deposition rather than amyloid-independent neurodegeneration or cerebrovascular injury.

Klíčová slova:

Alcohol consumption – Alzheimer's disease – Cognitive impairment – Dementia – Magnetic resonance imaging – Memory recall – Neuroimaging – Positron emission tomography


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