PLOS Genetics - Číslo 3/2020


The emerging role of transcriptional regulation in the oocyte-to-zygote transition

Paulo Navarro-Costa, Rui Gonçalo Martinho

ESCRTing proteasomes to the lysosome

Nava Segev


Correction: Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes

Fergal M. Waldron, Graham N. Stone, Darren J. Obbard

Correction: Mck1 kinase is a new player in the DNA damage checkpoint pathway
Correction: Co-Evolution of Mitochondrial tRNA Import and Codon Usage Determines Translational Efficiency in the Green Alga Chlamydomonas

Thalia Salinas, Francéline Duby, Véronique Larosa, Nadine Coosemans, Nathalie Bonnefoy, Patrick Motte, Laurence Maréchal-Drouard, Claire Remacle

Opinion Piece

What is ancestry?

Iain Mathieson, Aylwyn Scally

Research Article

Bayesian network analysis incorporating genetic anchors complements conventional Mendelian randomization approaches for exploratory analysis of causal relationships in complex data

Richard Howey, So-Youn Shin, Caroline Relton, George Davey Smith, Heather J. Cordell

Disentangling group specific QTL allele effects from genetic background epistasis using admixed individuals in GWAS: An application to maize flowering

Simon Rio, Tristan Mary-Huard, Laurence Moreau, Cyril Bauland, Carine Palaffre, Delphine Madur, Valérie Combes, Alain Charcosset

Drosophila insulin-like peptide 2 mediates dietary regulation of sleep intensity

Elizabeth B. Brown, Kreesha D. Shah, Richard Faville, Benjamin Kottler, Alex C. Keene

The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis

Heinrich Schäfer, Bertrand Beckert, Christian K. Frese, Wieland Steinchen, Aaron M. Nuss, Michael Beckstette, Ingo Hantke, Kristina Driller, Petra Sudzinová, Libor Krásný, Volkhard Kaever, Petra Dersch, Gert Bange, Daniel N. Wilson, Kürşad Turgay

RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination

Jose F. Victorino, Melanie J. Fox, Whitney R. Smith-Kinnaman, Sarah A. Peck Justice, Katlyn H. Burriss, Asha K. Boyd, Megan A. Zimmerly, Rachel R. Chan, Gerald O. Hunter, Yunlong Liu, Amber L. Mosley

Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis

Marcel Hohl, Aditya Mojumdar, Sarem Hailemariam, Vitaly Kuryavyi, Fiorella Ghisays, Kyle Sorenson, Matthew Chang, Barry S. Taylor, Dinshaw J. Patel, Peter M. Burgers, Jennifer A. Cobb, John H. J. Petrini

The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion

Ting Deng, Przemyslaw Stempor, Alex Appert, Michael Daube, Julie Ahringer, Alex Hajnal, Evelyn Lattmann

Transcription-replication conflicts as a source of common fragile site instability caused by BMI1-RNF2 deficiency

Anthony Sanchez, Angelo de Vivo, Peter Tonzi, Jeonghyeon Kim, Tony T. Huang, Younghoon Kee

The Lid/KDM5 histone demethylase complex activates a critical effector of the oocyte-to-zygote transition

Daniela Torres-Campana, Shuhei Kimura, Guillermo A. Orsi, Béatrice Horard, Gérard Benoit, Benjamin Loppin

Tracking human population structure through time from whole genome sequences

Ke Wang, Iain Mathieson, Jared O’Connell, Stephan Schiffels

FLS2 is a CDK-like kinase that directly binds IFT70 and is required for proper ciliary disassembly in Chlamydomonas

Qin Zhao, Shufen Li, Shangjin Shao, Zhengmao Wang, Junmin Pan

Cell cycle transcriptomics of Capsaspora provides insights into the evolution of cyclin-CDK machinery

Alberto Pérez-Posada, Omaya Dudin, Eduard Ocaña-Pallarès, Iñaki Ruiz-Trillo, Andrej Ondracka

Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease

Nicola Ferreira, Christopher E. Andoniou, Kara L. Perks, Judith A. Ermer, Danielle L. Rudler, Giulia Rossetti, Ambika Periyakaruppiah, Jamie K. Y. Wong, Oliver Rackham, Peter G. Noakes, Mariapia A. Degli-Esposti, Aleksandra Filipovska

The influence of rare variants in circulating metabolic biomarkers

Fernando Riveros-Mckay, Clare Oliver-Williams, Savita Karthikeyan, Klaudia Walter, Kousik Kundu, Willem H. Ouwehand, David Roberts, Emanuele Di Angelantonio, Nicole Soranzo, John Danesh, Eleanor Wheeler, Eleftheria Zeggini, Adam S. Butterworth, Inês Barroso,

The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

Gerrit Brandis, Diarmaid Hughes

Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against pathogenic bacteria

Dae-Eun Jeong, Yujin Lee, Seokjin Ham, Dongyeop Lee, Sujeong Kwon, Hae-Eun H. Park, Sun-Young Hwang, Joo-Yeon Yoo, Tae-Young Roh, Seung-Jae V. Lee

Histone H4 dosage modulates DNA damage response in the pathogenic yeast Candida glabrata via homologous recombination pathway

Kundan Kumar, Romila Moirangthem, Rupinder Kaur

A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions

Pierre Coste de Bagneaux, Leonie von Elsner, Tatjana Bierhals, Marta Campiglio, Jessika Johannsen, Gerald J. Obermair, Maja Hempel, Bernhard E. Flucher, Kerstin Kutsche

Transcriptional regulation of genes bearing intronic heterochromatin in the rice genome

Nino A. Espinas, Le Ngoc Tu, Leonardo Furci, Yasuka Shimajiri, Yoshiko Harukawa, Saori Miura, Shohei Takuno, Hidetoshi Saze

Autophagy compensates for defects in mitochondrial dynamics

Simon Haeussler, Fabian Köhler, Michael Witting, Madeleine F. Premm, Stéphane G. Rolland, Christian Fischer, Laetitia Chauve, Olivia Casanueva, Barbara Conradt

The conserved regulatory basis of mRNA contributions to the early Drosophila embryo differs between the maternal and zygotic genomes

Charles S. Omura, Susan E. Lott

Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages

Yufeng Fang, Marco A. Coelho, Haidong Shu, Klaas Schotanus, Bhagya C. Thimmappa, Vikas Yadav, Han Chen, Ewa P. Malc, Jeremy Wang, Piotr A. Mieczkowski, Brent Kronmiller, Brett M. Tyler, Kaustuv Sanyal, Suomeng Dong, Minou Nowrousian, Joseph Heitman

A fly model establishes distinct mechanisms for synthetic CRISPR/Cas9 sex distorters

Barbara Fasulo, Angela Meccariello, Maya Morgan, Carl Borufka, Philippos Aris Papathanos, Nikolai Windbichler

A kinesin Klp10A mediates cell cycle-dependent shuttling of Piwi between nucleus and nuage

Zsolt G. Venkei, Charlotte Choi, Suhua Feng, Cuie Chen, Steven E. Jacobsen, John K. Kim, Yukiko M. Yamashita, Charlotte P. Choi

Non-lethal exposure to H2O2 boosts bacterial survival and evolvability against oxidative stress

Alexandro Rodríguez-Rojas, Joshua Jay Kim, Paul Johnston, Olga Makarova, Murat Eravci, Christoph Weise, Regine Hengge, Jens Rolff, Paul R. Johnston

GLP-1 Notch—LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1

Jian Chen, Ariz Mohammad, Nanette Pazdernik, Huiyan Huang, Beth Bowman, Eric Tycksen, Tim Schedl

Recessive missense LAMP3 variant associated with defect in lamellar body biogenesis and fatal neonatal interstitial lung disease in dogs

Kati J. Dillard, Matthias Ochs, Julia E. Niskanen, Meharji Arumilli, Jonas Donner, Kaisa Kyöstilä, Marjo K. Hytönen, Marjukka Anttila, Hannes Lohi

Global mistranslation increases cell survival under stress in Escherichia coli

Laasya Samhita, Parth K. Raval, Deepa Agashe

E2f5 is a versatile transcriptional activator required for spermatogenesis and multiciliated cell differentiation in zebrafish

Haibo Xie, Yunsi Kang, Shuo Wang, Pengfei Zheng, Zhe Chen, Sudipto Roy, Chengtian Zhao

A putative silencer variant in a spontaneous canine model of retinitis pigmentosa

Maria Kaukonen, Ileana B. Quintero, Abdul Kadir Mukarram, Marjo K. Hytönen, Saila Holopainen, Kaisa Wickström, Kaisa Kyöstilä, Meharji Arumilli, Sari Jalomäki, Carsten O. Daub, Juha Kere, Hannes Lohi,

Evidence of defined temporal expression patterns that lead a gram-negative cell out of dormancy

Nandhini Ashok, Carl E. Bauer

Rsph4a is essential for the triplet radial spoke head assembly of the mouse motile cilia

Hiroshi Yoke, Hironori Ueno, Akihiro Narita, Takafumi Sakai, Kahoru Horiuchi, Chikako Shingyoji, Hiroshi Hamada, Kyosuke Shinohara

DNA methylation and cis-regulation of gene expression by prostate cancer risk SNPs

James Y. Dai, Xiaoyu Wang, Bo Wang, Wei Sun, Kristina M. Jordahl, Suzanne Kolb, Yaw A. Nyame, Jonathan L. Wright, Elaine A. Ostrander, Ziding Feng, Janet L. Stanford

Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin

Yuh Chwen G. Lee, Yuki Ogiyama, Nuno M. C. Martins, Brian J. Beliveau, David Acevedo, C.-ting Wu, Giacomo Cavalli, Gary H. Karpen

Girdin is a component of the lateral polarity protein network restricting cell dissemination

Cornélia Biehler, Li-Ting Wang, Myriam Sévigny, Alexandra Jetté, Clémence L. Gamblin, Rachel Catterall, Elise Houssin, Luke McCaffrey, Patrick Laprise

Germ cell-intrinsic effects of sex chromosomes on early oocyte differentiation in mice

Norio Hamada, Nobuhiko Hamazaki, So Shimamoto, Orie Hikabe, Go Nagamatsu, Yuki Takada, Kiyoko Kato, Katsuhiko Hayashi

A Snf1-related nutrient-responsive kinase antagonizes endocytosis in yeast

Jessica M. Tumolo, Nathaniel L. Hepowit, Samika S. Joshi, Jason A. MacGurn

Light affects tissue patterning of the hypocotyl in the shade-avoidance response

Esther Botterweg-Paredes, Anko Blaakmeer, Shin-Young Hong, Bin Sun, Lorenzo Mineri, Valdeko Kruusvee, Yakun Xie, Daniel Straub, Delphine Ménard, Edouard Pesquet, Stephan Wenkel

Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study

Yao Hu, Mariaelisa Graff, Jeffrey Haessler, Steven Buyske, Stephanie A. Bien, Ran Tao, Heather M. Highland, Katherine K. Nishimura, Niha Zubair, Yingchang Lu, Marie Verbanck, Austin T. Hilliard, Derek Klarin, Scott M. Damrauer, Yuk-Lam Ho, , Peter W. F. Wilson, Kyong-Mi Chang, Philip S. Tsao, Kelly Cho, Christopher J. O’Donnell, Themistocles L. Assimes, Lauren E. Petty, Jennifer E. Below, Ozan Dikilitas, Daniel J. Schaid, Matthew L. Kosel, Iftikhar J. Kullo, Laura J. Rasmussen-Torvik, Gail P. Jarvik, Qiping Feng, Wei-Qi Wei, Eric B. Larson, Frank D. Mentch, Berta Almoguera, Patrick M. Sleiman, Laura M. Raffield, Adolfo Correa, Lisa W. Martin, Martha Daviglus, Tara C. Matise, Jose Luis Ambite, Christopher S. Carlson, Ron Do, Ruth J. F. Loos, Lynne R. Wilkens, Loic Le Marchand, Chris Haiman, Daniel O. Stram, Lucia A. Hindorff, Kari E. North, Charles Kooperberg, Iona Cheng, Ulrike Peters

pH-dependent activation of cytokinesis modulates Escherichia coli cell size

Elizabeth A. Mueller, Corey S. Westfall, Petra Anne Levin

Quantitative genetic analysis deciphers the impact of cis and trans regulation on cell-to-cell variability in protein expression levels

Michael D. Morgan, Etienne Patin, Bernd Jagla, Milena Hasan, Lluís Quintana-Murci, John C. Marioni

WHIMP links the actin nucleation machinery to Src-family kinase signaling during protrusion and motility

Shail Kabrawala, Margaret D. Zimmer, Kenneth G. Campellone

Reciprocal c-di-GMP signaling: Incomplete flagellum biogenesis triggers c-di-GMP signaling pathways that promote biofilm formation

Daniel C. Wu, David Zamorano-Sánchez, Fernando A. Pagliai, Jin Hwan Park, Kyle A. Floyd, Calvin K. Lee, Giordan Kitts, Christopher B. Rose, Eric M. Bilotta, Gerard C. L. Wong, Fitnat H. Yildiz

Pleiotropy facilitates local adaptation to distant optima in common ragweed (Ambrosia artemisiifolia)

Tuomas Hämälä, Amanda J. Gorton, David A. Moeller, Peter Tiffin

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