OPTIMIZED CONVECTIVE VOLUME IN ONLINE HEMODIAFILTRATION
František Lopot 1,2; Vratislav Fabián 3
Department of Medicine, General University Hospital in Prague, Prague-Strahov, Czech Republic
1; Institute of Biophysics and Medical Informatics, First Faculty of Medicine, Charles University, Prague, Czech Republic
2; Department of Physics, Faculty of Electrical Engineering, Czech Technical University in Prague, Czech Republic
Vyšlo v časopise:
Lékař a technika - Clinician and Technology No. 3, 2020, 50, 77-84
Hemodiafiltration (HDF) adds convective elimination of middle molecules (MM), proportional to filtered volume (Vconv) on the top of diffusion-based elimination of small molecules (SM) by conventional hemodialysis (HD). Studies, both observational and randomized controlled ones, performed so far generally indicated positive impact of higher Vconv on all-cause mortality in HDF patients, although the magnitude of Vconv at which HDF becomes apparently superior to HD differed widely among the studies. Also the issue of a suitable anthropometric parameter by which the Vconv should be normalized has not yet been solved. Data from the ESHOL study seems to indicate that patient´s body surface area (BSA) could well be used for this—mortality was decreasing with increasing Vconv/BSA with a bottom plateau starting at about 15 L/m2. We have therefore devised a formula and a graph for determination of Vconv which fulfils the requirement Vconv/BSA = 15. Assuming maximum feasible and safe filtration fraction QF/QB = 0.3, the Vconv actually defines the necessary blood flow (QB) to reach Vconv/BSA = 15 as QB = 15·BSA/(0.3·t) (t – session time). It is also possible to check what QB is needed in terms of sufficient diffusion-based transport (target Kt/V) and compare both QB values to see if adequate combined elimination of both SM and MM can be achieved at the same time and under what conditions, respectively.
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