Association between metabolic surgery and cardiovascular outcome in patients with hypertension: A nationwide matched cohort study

English version

Autoři: Erik Stenberg ^aff001; Yang Cao ^aff002; Richard Marsk ^aff003; Magnus Sundbom ^aff004; Tomas Jernberg ^aff005; Erik Näslund ^aff003
Působiště autorů: Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden ^aff001; Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden ^aff002; Division of Surgery, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden ^aff003; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden ^aff004; Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden ^aff005
Vyšlo v časopise: Association between metabolic surgery and cardiovascular outcome in patients with hypertension: A nationwide matched cohort study. PLoS Med 17(9): e32767. doi:10.1371/journal.pmed.1003307
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pmed.1003307

Souhrn

Background

Hypertension, together with obesity, is a leading cause of mortality and disability. Whilst metabolic surgery offers remission of several metabolic comorbidities, the effect for patients with hypertension remains controversial. The objective of the present study was to evaluate the effect of metabolic surgery on cardiovascular events and mortality on patients with morbid obesity (body mass index [BMI] ≥ 35 kg/m²) and hypertension.

Methods and findings

We conducted a matched cohort study of 11,863 patients with morbid obesity and pharmacologically treated hypertension operated on with metabolic surgery and a matched non-operated–on control group of 26,199 subjects with hypertension (matched by age, sex, and area of residence) of varied matching ratios from 1 : 1 to 1 : 9, using data from the Scandinavian Obesity Surgery Register (SOReg), the Swedish National Patient Registers (NPR) for in-hospital and outpatient care, the Swedish Prescribed Drug Register, and Statistics Sweden. The main outcome was major adverse cardiovascular event (MACE), defined as first occurrence of acute coronary syndrome (ACS) event, cerebrovascular event, fatal cardiovascular event, or unattended sudden cardiac death. The mean age in the study group was 52.1 ± 7.46 years, with 65.8% being women (n = 7,810), and mean BMI was 41.9 ± 5.43 kg/m². MACEs occurred in 379 operated-on patients (3.2%) and 1,125 subjects in the control group (4.5%). After adjustment for duration of hypertension, comorbidities, and education, a reduction in risk was seen in the metabolic surgery group (adjusted hazard ratio [HR] 0.73, 95% confidence intervals [CIs] 0.64–0.84, P < 0.001). The surgery group had lower risk for ACS events (adjusted HR 0.52, 95% CI 0.41–0.66, P < 0.001) and a tendency towards lower risk for cerebrovascular events (adjusted HR 0.81, 95% CI 0.63–1.01, P = 0.060) compared with controls. The main limitations with the study were the lack of information on BMI and history of smoking in the control group and the nonrandomised study design.

Conclusion

Metabolic surgery on patients with morbid obesity and pharmacologically treated hypertension was associated with lower risk for MACEs and all-cause mortality compared with age -⁠ and sex-matched controls with hypertension from the general population.

Klíčová slova:

Cardiovascular disease risk – Digestive system procedures – Epidemiology – Hypertension – Morbid obesity – Surgical and invasive medical procedures – Type 2 diabetes – Type 2 diabetes risk

Zdroje

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