Biologická role mědi jako základního stopového prvku v lidském organismu


Autoři: Miroslava Pavelková Jakub Vysloužil Kateřina Kubová David Vetchý
Vyšlo v časopise: Čes. slov. Farm., 2018; 67, 143-153
Kategorie: Review article

Souhrn

Tento článek popisuje přehledem fyziologických vlastností mědi (Cu) jako základního stopového prvku hrajícího důležitou roli v metabolismu člověka, a to především jako kofaktor mnoha metaloenzymů. Pro správnou funkci lidského těla je zásadní potřeba udržovat homeostázu Cu, protože při jejím narušení dochází k silným patologickým projevům. Příklady těžkých vrozených onemocnění jater, při kterých dochází k výraznému hromadění mědi v játrech, jsou Wilsonova choroba a idiopatická toxikóza. Naopak, vrozené onemocnění Menkesova choroba se projevuje závažným nedostatkem Cu v organismu. Ačkoliv je Cu nezbytná pro mnoho životních procesů, představuje také silnou zbraň používanou od starověku proti mnoha mikroorganismům. Nakonec jsou v příspěvku shrnuty teorie antimikrobiálního a antivirového působení Cu spolu s přehledem současných a možných budoucích využití v medicínských i nemedicínských oblastech lidského života.

Klíčová slova:

měď • metaloenzymy • toxicita mědi • nedostatek mědi • nemoci spojené s mědí • aplikace mědi


Zdroje

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Farmacie Farmakologie

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Česká a slovenská farmacie

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