PLOS Genetics - Číslo 5/2012

Perspective

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Slowing Replication in Preparation for Reduction
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Chromosome Pairing: A Hidden Treasure No More

Interview

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Scientist Citizen: An Interview with Bruce Alberts

Research Article

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Loss of Imprinting Differentially Affects REM/NREM Sleep and Cognition in Mice
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Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in and Enrichment for Risk Variants in Lean Compared to Obese Cases
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Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma
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Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone
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Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator
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Repeated, Selection-Driven Genome Reduction of Accessory Genes in Experimental Populations
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Allelic Variation and Differential Expression of the mSIN3A Histone Deacetylase Complex Gene Promote Mammary Tumor Growth and Metastasis
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DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse
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Knowledge-Driven Analysis Identifies a Gene–Gene Interaction Affecting High-Density Lipoprotein Cholesterol Levels in Multi-Ethnic Populations
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A Duplication CNV That Conveys Traits Reciprocal to Metabolic Syndrome and Protects against Diet-Induced Obesity in Mice and Men
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EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice
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Inactivation of a Novel FGF23 Regulator, FAM20C, Leads to Hypophosphatemic Rickets in Mice
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Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women
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New Insight into the History of Domesticated Apple: Secondary Contribution of the European Wild Apple to the Genome of Cultivated Varieties
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TBC-8, a Putative RAB-2 GAP, Regulates Dense Core Vesicle Maturation in
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Activated Cdc42 Kinase Has an Anti-Apoptotic Function
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The Region Is Critical for Birth Defects and Electrocardiographic Dysfunctions Observed in a Down Syndrome Mouse Model
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COP9 Signalosome Integrity Plays Major Roles for Hyphal Growth, Conidial Development, and Circadian Function
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Bmps and Id2a Act Upstream of Twist1 To Restrict Ectomesenchyme Potential of the Cranial Neural Crest
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Psip1/Ledgf p52 Binds Methylated Histone H3K36 and Splicing Factors and Contributes to the Regulation of Alternative Splicing
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The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice
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Target Gene Analysis by Microarrays and Chromatin Immunoprecipitation Identifies HEY Proteins as Highly Redundant bHLH Repressors
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Acquisition Order of Ras and p53 Gene Alterations Defines Distinct Adrenocortical Tumor Phenotypes
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ELK1 Uses Different DNA Binding Modes to Regulate Functionally Distinct Classes of Target Genes
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Histone H1 Depletion Impairs Embryonic Stem Cell Differentiation
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IDN2 and Its Paralogs Form a Complex Required for RNA–Directed DNA Methylation
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Separation of DNA Replication from the Assembly of Break-Competent Meiotic Chromosomes
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Regulating Repression: Roles for the Sir4 N-Terminus in Linker DNA Protection and Stabilization of Epigenetic States
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Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue
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Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases
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Re-Patterning Sleep Architecture in through Gustatory Perception and Nutritional Quality
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Regulation by the Noncoding RNA
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UDP-Galactose 4′-Epimerase Activities toward UDP-Gal and UDP-GalNAc Play Different Roles in the Development of
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Deletion of PTH Rescues Skeletal Abnormalities and High Osteopontin Levels in Mice
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Karyotypic Determinants of Chromosome Instability in Aneuploid Budding Yeast
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Genome-Wide Copy Number Analysis Uncovers a New HSCR Gene:
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MicroRNA-277 Modulates the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats
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Functional Centromeres Determine the Activation Time of Pericentric Origins of DNA Replication in
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Dynamic Deposition of Histone Variant H3.3 Accompanies Developmental Remodeling of the Transcriptome
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YY1 Regulates Melanocyte Development and Function by Cooperating with MITF
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Congenital Heart Disease–Causing Gata4 Mutation Displays Functional Deficits
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Recombination Drives Vertebrate Genome Contraction
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KATNAL1 Regulation of Sertoli Cell Microtubule Dynamics Is Essential for Spermiogenesis and Male Fertility
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Using Whole-Genome Sequence Data to Predict Quantitative Trait Phenotypes in
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Hypersensitive to Red and Blue 1 and Its Modification by Protein Phosphatase 7 Are Implicated in the Control of Arabidopsis Stomatal Aperture
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Genome-Wide Analysis of GLD-1–Mediated mRNA Regulation Suggests a Role in mRNA Storage
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Meiotic Chromosome Pairing Is Promoted by Telomere-Led Chromosome Movements Independent of Bouquet Formation
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LINT, a Novel dL(3)mbt-Containing Complex, Represses Malignant Brain Tumour Signature Genes
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The H3K27 Demethylase UTX-1 Is Essential for Normal Development, Independent of Its Enzymatic Activity
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Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant -Induced Lung Tumorigenesis
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Genome-Wide Association of Pericardial Fat Identifies a Unique Locus for Ectopic Fat
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An Essential Role for Katanin p80 and Microtubule Severing in Male Gamete Production
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Identification of Genes That Promote or Antagonize Somatic Homolog Pairing Using a High-Throughput FISH–Based Screen
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Principles of Carbon Catabolite Repression in the Rice Blast Fungus: Tps1, Nmr1-3, and a MATE–Family Pump Regulate Glucose Metabolism during Infection
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Integrin α PAT-2/CDC-42 Signaling Is Required for Muscle-Mediated Clearance of Apoptotic Cells in
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Histone H3 Localizes to the Centromeric DNA in Budding Yeast
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Collapse of Telomere Homeostasis in Hematopoietic Cells Caused by Heterozygous Mutations in Telomerase Genes
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Genomic Hypomethylation in the Human Germline Associates with Selective Structural Mutability in the Human Genome

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