Clinical Features and Therapeutic Alternatives in Eyes with Secondary Vasoproliferative Tumors: A Single-Center Turkish Perspective
Clinical Features and Therapeutic Alternatives in Eyes with Secondary Vasoproliferative Tumors: A Single-Center Turkish Perspective
Aims: To evaluate retrospectively the clinical characteristics and therapeutic outcomes in eyes with secondary vasoproliferative retinal tumors (VPRT) at a tertiary center in Turkey.
Material and Methods: Patients diagnosed with secondary VPRT between 2005 and 2025 with a follow-up of 6 months or more were included. 24 eyes of 21 patients were evaluated. Their charts and multimodal imaging features were analyzed, and treatments noted.
Results: Mean age was 26.1 years (6–57). Mean follow-up was 61.1 months (6–151). Baseline BCVA was 0.77 LogMAR (0.00–2.30). VPRT was linked to non-infectious uveitis in 12 patients, retinitis pigmentosa in 5 patients, X-linked Juvenile Retinoschisis, Coats’ disease, retinal dystrophy and retinopathy of prematurity in 1 patient each. The inferotemporal quadrant was the most common site (66.7%). Treatments included dexamethasone implant, transscleral cryotherapy, systemic immunosuppressive therapy, laser photocoagulation, CyberKnife, intravitreal anti-VEGF, vitreoretinal surgery, photodynamic therapy, intravitreal triamcinolone acetonide and enucleation. At baseline, 15 eyes had macular intraretinal fluid. At the final visit, dry macula was achieved in 9 of 15 eyes. Mean final BCVA was 1.01 LogMAR (0.00–3.00). Two eyes deteriorated to no light perception. One was enucleated.
Conclusion: This largest cohort of patients from Turkey with secondary VPRT reflects the diverse underlying etiologic associations and heterogeneous clinical manifestations at a tertiary center. Various therapeutic techniques were required to cope with this difficult-to-treat, challenging disease entity.
Keywords:
Retina – Vitrectomy – intravitreal injection – cyberknife – Dexamethasone implant – cryotherapy – laser photocoagulation – vasoproliferative retinal tumor
Autoři:
Gorkem Polat 1; Omer Kart 1; Ziya Ayhan 1; Murat Tunc 2; Remzi Avc 3; Ali Osman Saatci 1
Působiště autorů:
Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey
1; Tunc Eye Clinic, Ankara, Turkey
2; Bursa Retina Eye Hospital, Bursa, Turkey
3
Vyšlo v časopise:
Čes. a slov. Oftal., 82, 2026, No. Ahead of Print, p. 1-12
Kategorie:
Původní práce
doi:
https://doi.org/10.31348/2026/18
Souhrn
Aims: To evaluate retrospectively the clinical characteristics and therapeutic outcomes in eyes with secondary vasoproliferative retinal tumors (VPRT) at a tertiary center in Turkey.
Material and Methods: Patients diagnosed with secondary VPRT between 2005 and 2025 with a follow-up of 6 months or more were included. 24 eyes of 21 patients were evaluated. Their charts and multimodal imaging features were analyzed, and treatments noted.
Results: Mean age was 26.1 years (6–57). Mean follow-up was 61.1 months (6–151). Baseline BCVA was 0.77 LogMAR (0.00–2.30). VPRT was linked to non-infectious uveitis in 12 patients, retinitis pigmentosa in 5 patients, X-linked Juvenile Retinoschisis, Coats’ disease, retinal dystrophy and retinopathy of prematurity in 1 patient each. The inferotemporal quadrant was the most common site (66.7%). Treatments included dexamethasone implant, transscleral cryotherapy, systemic immunosuppressive therapy, laser photocoagulation, CyberKnife, intravitreal anti-VEGF, vitreoretinal surgery, photodynamic therapy, intravitreal triamcinolone acetonide and enucleation. At baseline, 15 eyes had macular intraretinal fluid. At the final visit, dry macula was achieved in 9 of 15 eyes. Mean final BCVA was 1.01 LogMAR (0.00–3.00). Two eyes deteriorated to no light perception. One was enucleated.
Conclusion: This largest cohort of patients from Turkey with secondary VPRT reflects the diverse underlying etiologic associations and heterogeneous clinical manifestations at a tertiary center. Various therapeutic techniques were required to cope with this difficult-to-treat, challenging disease entity.
Štítky
OftalmologieČlánek vyšel v časopise
Česká a slovenská oftalmologie
2026 Číslo Ahead of Print
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