Published in the journal: Vnitř Lék 2017; 63(1): 49
Definite familial hypercholesterolemia (FH) is defined as follows:
a) cholesterol levels > 6.7 in children under 16 years of age and > 7.5 in adults; or LDL-C levels > 4.9 in adults
and
b) tendinous xanthomas in a patient or a first-/second-degree relative.
Possible familial hypercholesterolemia is defined as follows:
and one of the following criteria:
b) family history of myocardial infarction prior to 50 years of age in second-degree relatives, or prior to 60 years in first-degree relatives
c) family history of elevated cholesterol > 7.5 in first-/second-degree relatives.
Tab. 1. Total cholesterol cutpoints (in mmol/l) used in FH diagnosis in MedPed Diagnosis: FH is diagnosed if total cholesterol levels exceed the Cut Point
Tab. 2. Dutch criteria points CAD – coronary artery disease M – male F – female LDL-C – low density cholesterol
The Dutch criteria are then interpreted as follows: For a definite diagnosis of FH, the subject must have more than 8 points; a probable diagnosis of FH requires 6–8 points; and a possible diagnosis of FH is indicated by 3–5 points. Patients who score 0–2 points most likely do not have FH.
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