Progresivní multifokální leukoencefalopatie – epidemiologie, imunitní odpověď, klinické rozdíly, léčba


Autoři: S. Snopková 1;  P. Štourač 2;  L. Fašaneková 1;  M. Mihalčin 1;  K. Havlíčková 1;  R. Svačinka 1;  P. Volfová 3;  P. Snopek 4;  P. Husa 1
Působiště autorů: Klinika infekčních chorob FN Brno a LF MU, Brno 1;  Neurologická klinika FN Brno a LF MU, Brno 2;  Interní hematoonkologická klinika FN Brno a LF MU, Brno 3;  Fakulta humanitních studií UTB, Zlín 4
Vyšlo v časopise: Epidemiol. Mikrobiol. Imunol. 68, 2019, č. 1, s. 24-31
Kategorie: Souhrnné sdělení

Souhrn

Progresivní multifokální leukoencefalopatie (PML) je závažné onemocnění centrální nervové soustavy s velmi vysokou mortalitou. Příčinou onemocnění je JC virus s vysokou séroprevalencí dosahující až 80 %. PML je typické oportunní onemocnění vyskytující se zejména u syndromu získané imunodeficience u pacientů s hlubokým imunodeficitem. Počet případů PML se však v posledních letech zvyšuje také u všeobecné populace jako důsledek vysoce účinných imunosupresivních a imunomodulačních léčebných postupů. V tomto článku autoři uvádějí virologické a epidemiologické souvislosti a charakteristické projevy PML. Jsou diskutovány možné vztahy humorální a buněčné imunity a jsou zmíněny omezené možnosti léčby včetně profylaxe.

Klíčová slova:

buněčná imunita – poměr CD4/CD8 – HIV – sclerosis multiplex – progresivní multifokální leukoencefalopatie


Zdroje

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Štítky
Hygiena a epidemiologie Infekční lékařství Mikrobiologie

Článek vyšel v časopise

Epidemiologie, mikrobiologie, imunologie

Číslo 1

2019 Číslo 1

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