Oral mucositis in patients after allogeneic stem cells transplantation with fludarabine and melphalan containing FLU/MEL conditioning regimen

Česká verze

Authors: S. Vokurka; J. Škardová; K. Kabátová-Maxová; K. Steinerová; M. Karas
Authors place of work: Hematologicko-onkologické odd., Fakultní nemocnice v Plzni
Published in the journal: Transfuze Hematol. dnes,15, 2009, No. 1, p. 13-16.
Category: Souhrnné práce, původní práce, kazuistiky

Summary

Allogeneic stem cells transplantation after reduced intensity conditioning regimen is, due to its lower toxicity, a suitable choice for older and pretreated patients. Characteristics of oral mucositis (OM) were observed in 71 patients after FLU/MEL conditioning regimen with fludarabine total dose 120 mg/m² and melphalan 140 mg/m². The OM occurred in 78% of patients with median duration of 12 (1–34) days. OM was significantly more often in women and in patients with melphalan dose ≥3.5 mg/kg. In conclusion, in respect of oral mucosa damage the FLU/MEL conditioning regimen cannot be considered low-toxic. Generally recommended prophylactic cryotherapy should be basic approach implemented into this protocol to help reduce OM.

Key words:
mucositis, oral cavity, allogeneic transplantation, melphalan, toxicity

Zdroje

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