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Predicting longevity responses to dietary restriction: A stepping stone toward precision geroscience


Autoři: Maria C. Perez-Matos aff001;  William B. Mair aff001
Působiště autorů: Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, United States of America aff001
Vyšlo v časopise: Predicting longevity responses to dietary restriction: A stepping stone toward precision geroscience. PLoS Genet 16(7): e32767. doi:10.1371/journal.pgen.1008833
Kategorie: Perspective
doi: https://doi.org/10.1371/journal.pgen.1008833


Zdroje

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4. Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, et al. Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell. 2013;12(6):1050–61. doi: 10.1111/acel.12130 23837470

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6. Zhu C-T, Ingelmo P, Rand DM. G×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity. PLoS Genet. 2014 May 15;10(5):e1004354. doi: 10.1371/journal.pgen.1004354 24832080

7. Gao AW, Sterken MG, Uit de Bos J, van Creij J, Kamble R, Snoek BL, et al. Natural genetic variation in C. elegans identified genomic loci controlling metabolite levels. Genome Res. 2018 Sep;28(9):1296–308. doi: 10.1101/gr.232322.117 30108180

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9. Tyshkovskiy A, Bozaykut P, Borodinova AA, Gerashchenko MV, Ables GP, Garratt M, et al. Identification and Application of Gene Expression Signatures Associated with Lifespan Extension. Cell Metab. 2019 Sep 3;30(3):573–93.e8. doi: 10.1016/j.cmet.2019.06.018 31353263

10. Nelson CS, Beck JN, Wilson KA, Pilcher ER, Kapahi P, Brem RB. Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila. BMC Genomics. 2016 Nov 4;17(1):867. doi: 10.1186/s12864-016-3137-9 27809764

11. Jin K, Wilson KA, Beck JN, Nelson CS, Brownridge GW III, Harrison B, et al. Genetic and metabolomic architecture of variation in diet restriction-mediated lifespan extension in Drosophila. PLoS Genet. 2020 Jul;16(7):e1008835

12. Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014 Jun 19;510(7505):397–401 doi: 10.1038/nature13264 24828042


Článek vyšel v časopise

PLOS Genetics


2020 Číslo 7
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