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Undifferentiated Carcinoma of the Pancreas – a Case Report


Authors: B. Kašperová 1;  S. Jurišová 1;  J. Macúch 2;  M. Bumberová 3;  P. Janega 4,5;  J. Dolinský 1;  M. Mego 1
Authors place of work: II. onkologická klinika LF UK a Národný onkologický ústav, Bratislava 1;  Oddelenie patologickej anatómie, Národný onkologický ústav, Bratislava 2;  Oddelenie radiodiagnostiky, Národný onkologický ústav, Bratislava 3;  Ústav patologickej anatómie LF UK a UN Bratislava 4;  Ústav normálnej a patologickej fyziológie, Slovenská akadémia vied, Bratislava 5
Published in the journal: Klin Onkol 2018; 31(6): 453-456
Category: Kazuistika
doi: https://doi.org/10.14735/amko2018453

Summary

Background:

Undifferentiated carcinoma of pancreas (pancreatic cancer – PC) is a rare subtype of malignant PC. It was thought to be a sarcoma of the pancreas due to its typical morphological pattern. There are three histomorphological variants: anaplastic, sarcomatoid, and carcinosarcoma. There is also a separate category: undifferentiated pancreatic carcinoma with osteoclast-like giant cells. In contrast to ductal adenocarcinoma of the pancreas, undifferentiated carcinoma of pancreas is characterized by more aggressive behavior, other predilection localization of tumor and different predilection for localization of tumor and metastasis, a larger primary tumor, and different symptomatology at the time of diagnosis.

Case:

We present the case of a patient who was diagnosed with undifferentiated PC and was treated at the National Cancer Institute in Bratislava. We provide information about the clinical, radiological, and histomorphological characteristics of the disease, along with the diagnostic and therapeutic approach and a brief review of the literature.

Results:

The patient was diagnosed with inoperable locally advanced disease and was treated with first line chemotherapy comprising gemcitabine and cisplatin, followed by second line treatment with FOLFIRINOX. No response was achieved; on the contrary, we observed progression of the disease and deterioration in the patient’s condition. Overall survival was 4.5 months from the time of diagnosis.

Conclusion:

The only appropriate therapeutic approach to this highly malignant disease is most likely “en-bloc” resection, which is possible only at the early stage of the disease. At present, no curative chemotherapy or radiotherapy regimen exists. The dominant features of undifferentiated PC described in the literature are aggressive behavior, an unfavorable prognosis, and chemo-refractoriness.

Key words:

pancreatic cancer – prognosis – chemotherapy

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE recommendation for biomedical papers.

Submitted: 4. 6. 2018

Accepted: 25. 10. 2018


Zdroje

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5. Lewandrowski KB, Weston L, Dickersin GR et al. Giant cell tumor of the pancreas of mixed osteoclastic and pleomorphic cell type: evidence for a histogenetic relationship and mesenchymal differentiation. Hum Pathol 1990; 21(11): 1184–1187.

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8. Sakhi R, Hamza A, Khurram MS et al. Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells reported in an asymptomatic patient: a rare case and literature review. Autops Case Rep 2017; 7(4): 51. doi: 10.4322/acr.2017.042.

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Štítky
Dětská onkologie Chirurgie všeobecná Onkologie

Článek vyšel v časopise

Klinická onkologie

Číslo 6

2018 Číslo 6
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