Avidita antifosfolipidových protilátek – naše současné znalosti

English version

Autoři: L. Fialová
Působiště autorů: Ústav lékařské biochemie a laboratorní diagnostiky, 1. lékařská fakulta, Univerzita Karlova v Praze a Všeobecná fakultní nemocnice v Praze
Vyšlo v časopise: Epidemiol. Mikrobiol. Imunol. 63, 2014, č. 3, s. 220-224
Kategorie: Souhrnná sdělení, původní práce, kazuistiky

Souhrn

Antifosfolipidové protilátky (APL), které představují sérový marker antifosfolipidového syndromu, zahrnují mimořádně heterogenní skupinu protilátek namířených proti různým fosfolipidům a proteinovým kofaktorům. Heterogenita APL se týká nejen specifity vazebných míst, ale také jejich avidity. Cílem studie bylo shrnout dosavadní znalosti o běžně užívaných postupech pro stanovení avidity se speciálním zaměřením na APL a zhodnocení jejího klinického významu. Často užívanou technikou pro stanovení avidity protilátek jsou ELISA metody v přítomnosti různých chaotropních látek. Nálezy klinických studií ukazují, že APL o vysoké aviditě se vyskytují u pacientů s trombózou a antifosfolipidovým syndromem (APS). Vyšetření avidity APL by mohlo být doplňujícím laboratorním ukazatelem, který by přinesl informaci využitelnou pro klasifikaci APS.

Klíčová slova:
protilátky proti ß2-glykoproteinu I –⁠ antikardiolipinové protilátky –⁠ antifosfolipidové protilátky –⁠ avidita –⁠ chaotropní látky –⁠ ELISA

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