Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans
Autoři:
Pratima Pandey aff001; Anuradha Singh aff001; Harjot Kaur aff002; Anindya Ghosh-Roy aff002; Kavita Babu aff001
Působiště autorů:
Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Mohali, India
aff001; National Brain Research Centre, Gurgaon, India
aff002; Centre for Neuroscience, Indian Institute of Science (IISc), Bangalore, India
aff003
Vyšlo v časopise:
Increased dopaminergic neurotransmission results in ethanol dependent sedative behaviors in Caenorhabditis elegans. PLoS Genet 17(2): e1009346. doi:10.1371/journal.pgen.1009346
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pgen.1009346
Souhrn
Ethanol is a widely used drug, excessive consumption of which could lead to medical conditions with diverse symptoms. Ethanol abuse causes dysfunction of memory, attention, speech and locomotion across species. Dopamine signaling plays an essential role in ethanol dependent behaviors in animals ranging from C. elegans to humans. We devised an ethanol dependent assay in which mutants in the dopamine autoreceptor, dop-2, displayed a unique sedative locomotory behavior causing the animals to move in circles while dragging the posterior half of their body. Here, we identify the posterior dopaminergic sensory neuron as being essential to modulate this behavior. We further demonstrate that in dop-2 mutants, ethanol exposure increases dopamine secretion and functions in a DVA interneuron dependent manner. DVA releases the neuropeptide NLP-12 that is known to function through cholinergic motor neurons and affect movement. Thus, DOP-2 modulates dopamine levels at the synapse and regulates alcohol induced movement through NLP-12.
Klíčová slova:
Animal behavior – Behavior – Biological locomotion – Caenorhabditis elegans – Dopamine – Graphs – Motor neurons – Neurons
Zdroje
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