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Atypický fibroxantóm, zriedkavý a často nerozpoznaný kožný mäkko-tkanivový nádor – kazuistika a prehľad literatúry


Autoři: Zuzana Čierna 1;  Rastislav Trška 2
Vyšlo v časopise: Čes.-slov. Patol., 55, 2019, No. 3, p. 182-186
Kategorie: Původní práce

Souhrn

Atypický fibroxantóm (AFX) je zriedkavý kožný mäkko-tkanivový nádor typicky sa vyskytujúci u starších ľudí na koži vystavenej slnečnému žiareniu. Histologicky je tvorený pleomorfnými atypickými bunkami s početnými mitózami vrátane atypických mitóz, čím pripomína nediferencovaný malígny nádor. AFX je považovaný za benígny nádor s takmer výlučne excelentnou prognózou po konzervatívnej liečbe, ak sú použité prísne diagnostické kritériá. Prezentujeme prípad 68-ročného muža s nádorom kože v temporo-parietálnej oblasti. Histomorfologické a imunohistochemické nálezy zodpovedali diagnóze atypického fibroxantómu. Ponúkame prehľad terminológie a kategorizácie tohto nádoru a spektrum imunohistochemických markerov nápomocných v diferenciálne-diagnostickom procese na vylúčenie iných malígnych nádorov, pretože AFX je diagnóza per exclusionem. Správnou diagnózou sa vyhneme nepotrebnej liečbe pacienta.

Klíčová slova:

Atypický fibroxantóm – nediferencovaný pleomorfný sarkóm – imunohistochémia.


Zdroje

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Štítky
Patologie Soudní lékařství Toxikologie

Článek vyšel v časopise

Česko-slovenská patologie

Číslo 3

2019 Číslo 3

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