Authors: Klára Balcárová 1 ; Petra Bretová 1 ; Munachiso Iheme Ndukwe 1,2 ; Daniel Leško 1; Martin Štěpán 1 ; Jiří Špaček 1 Authors place of work: Porodnická a gynekologická klinika LF UK a FN Hradec Králové 1; Klinika onkologie a radioterapie LF UK a FN Hradec Králové 2 Published in the journal: Ceska Gynekol 2025; 90(6): 495-502 Category: Přehledová práce doi: https://doi.org/10.48095/cccg2025495
Negative pressure wound therapy is a modern and effective method for the prevention and treatment of postoperative wound healing complications, with growing applications in gynecology, especially in gynecologic oncology. Its mechanism of action includes enhanced drainage, reduction of edema, promotion of angiogenesis, and stimulation of granulation tissue formation, ultimately contributing to faster healing and a lower risk of infection, seroma, and wound dehiscence. Negative pressure wound therapy has been shown to be effective in the therapeutic management of complex, infected, or dehiscent wounds following gynecologic-oncologic surgery. Recent studies also suggest that its prophylactic application to primarily closed incisions after laparotomy or vulvectomy may significantly reduce surgical complications, shorten hospitalization, and accelerate recovery, which is particularly important in patients scheduled for adjuvant therapy. However, because most available evidence is based on retrospective studies, further prospective randomized trials are needed to confirm the role of this method in both therapeutic and prophylactic use and to guide its integration into standard perioperative care in gynecologic oncology.
Wound healing – negative pressure wound therapy – Gynecologic surgery – surgical wound dehiscence – gynecologic malignancies
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ORCID autorů
K. Balcarová 0009-0007-9197-2073
P. Bretová 0000-0003-1082-433X
M. I. Ndukwe 0000-0001-8900-8057
M. Štěpán 0000-0002-5976-2291
Doručeno/ Submitted: 4. 8. 2025
Přijato/ Accepted: 5. 8. 2025
MU Dr. Petra Bretová, Ph.D.
Porodnická a gynekologická klinika
LF UK a FN Hradec Králové
Sokolská 581
500 05 Hradec Králové
petra.bretova1@fnhk.cz
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