Current treatment options in Maturity-Onset Diabetes of the Young

Authors: Ludmila Brunerová 1;  Jana Urbanová 1;  Jan Brož 2
Authors place of work: Diabetologické centrum II. interní kliniky 3. LF UK a FN Královské Vinohrady, Praha 1;  Interní klinika 2. LF UK a FN Motol, Praha 2
Published in the journal: Vnitř Lék 2018; 64(4): 375-379
Category: Přehledné referáty


The discovery of MODY (Maturity-Onset Diabetes of the Young) and the elucidation of its heritability enabled more precise clinical characteristics of different MODY subtypes and led to understanding that glucokinase MODY (GCK-MODY) is not associated with vascular complications in long term follow-up, whereas MODY of transcription factors (e.g. HNF1A-MODY) is in case of bad metabolic control connected with the acceleration of particularly microvascular complications. There is a strong evidence of the needlessness of any specific antidiabetic treatment in prognosticaly favourable GCK-MODY (except for the pregnancy). On the contrary, in MODY of transcription factors, including the most common one – HNF1A-MODY, the treatment, traditionally based on sulphonylurea derivatives (and after their failure on insulin) is required. Due to wider spectrum of available antidiabetic agents offering individualization of the treatment, the question of efficacy of other antidiabetic agents in MODY patients arises. This review article summarizes current knowledge of therapeutic options in patients with MODY.

Key words:
insulin – MODY – oral hypoglycemic drugs – treatment


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