Functional consequences of mutations in the nucleophosmin gene in acute myeloid leukaemia

Česká verze

Authors: K. Kuželová; B. Brodská; P. Soukup
Authors place of work: Ústav hematologie a krevní transfuze, Praha
Published in the journal: Transfuze Hematol. dnes,23, 2017, No. Supplementum1, p. 26-32.
Category: ZVLÁŠTNÍ VYDÁNÍ SUPLEMENTU K 65. VÝROČÍ ÚHKT

Summary

Characteristic mutations in the gene coding for nucleophosmin are found in a third of patients with acute myeloid leukaemia (AML). Due to these mutations, nucleophosmin is translocated from the cell nucleoli to the cytoplasm and a large number of essential cellular processes are affected. Our results suggest that an immune response against mutated nucleophosmin is induced in patients with a suitable HLA type and this lowers the risk of leukaemia development. However, the effect of the immune system can be impeded by various inhibitory mechanisms, which are currently being intensely explored mainly in solid tumours, but are probably also active in haemato-oncological diseases.

KEY WORDS:
AML –⁠ nucleophosmin –⁠ HLA –⁠ immune response

Zdroje

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