Pseudotumors of the central nervous system

Česká verze

Authors: J. Zámečník ¹; L. Mrázková ²
Authors place of work: Ústav patologie a molekulární medicíny, 2. LF UK a FN Motol, Praha ¹; Klinika zobrazovacích metod, 2. LF UK a FN Motol, Praha ²
Published in the journal: Čes.-slov. Patol., 48, 2012, No. 4, p. 184-189
Category: Přehledový článek

Summary

The histopathological differentiation of the pseudoneoplastic lesions from the tumors of the central nervous system (CNS) is not easy in a proportion of cases and the risk of diagnostic misinterpretation in biopsies of the CNS remains relatively high. Here we discuss selected CNS lesions, which can be easily mistaken for a tumor, particularly in the absence of relevant clinical and neuroradiological data -⁠ gliosis, tumefactive demyelination, radionecrosis and focal cortical dysplasia. With the exception of the recently available IDH1 immunohistochemistry, there is a lack of simple and reliable histochemical or molecular markers which could facilitate this differential diagnosis. To avoid a diagnostic error, pathologists have to rely on careful microscopic analysis along with its correlation with clinical data and neuroradiological findings.

Keywords:
pseudotumor –⁠ brain biopsy –⁠ glioma –⁠ gliosis –⁠ demyelination –⁠ radionecrosis

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