Vaginálny myofibroblastóm so žliazkami exprimujúcimi mamárne a prostatické antigeny

English version

Autoři: M. Zámečník ¹; T. Sedláček ¹; I. Wallenfels ²; A. Chlumská ^3,4
Působiště autorů: Medicyt s. r. o., Laboratory Trenčín, Slovak Republic ¹; Department of Gynecology and Obstetrics, Faculty Hospital, Trenčín, Slovak Republic ²; Šikl`s Department of Pathology, Faculty Hospital, Charles University, Pilsen, Czech Republic ³; Laboratory of Surgical Pathology, Pilsen, Czech Republic ⁴
Vyšlo v časopise: Čes.-slov. Patol., 48, 2012, No. 1, p. 40-43
Kategorie: Původní práce

Souhrn

Popísaný je prípad vaginálneho myofibroblastómu, ktorý obsahoval žliazky pozitívne imunohistochemicky na mamárne a prostatické markery. Jednalo sa o tumor zistený u70-ročnej pacientky v proximálnej tretine vagíny. Morfológia a imunofenotyp lézie boli typické pre cervikovaginálny myofibroblastóm. Periférna subepitelová zóna tumoru obsahovala niekoľko skupín žliazok, u ktorých bola predpokladaná pri prvom vyšetrení diagnóza vaginálnej adenózy alebo prostatických žliazok. Imunohistochémia ukázala prekvapujúcu pozitivitu týchto žliazok na prostatické i mamárne markery súčasne (prostatický špecifický antigén, prostatická kyslá fosfatáza, mamaglobín, GCDFP-15). Myoepitel žliazok exprimoval hladkosvalový aktín, p63 a CD10. Nález ukazuje, že pri vyšetrení glandulárnych lézií dolného genitálneho traktu ženy môže simultánne vyšetrenie na prostatické a mamárne antigény byť prínosom pre diagnózu i pre ďalšie poznanie mamárnej a prostatickej diferenciácie v tejto lokalizácii.

Kľúčové slová:
myofibroblastóm –⁠ vagína –⁠ mamárna žľaza –⁠ prostata –⁠ imunohistochémia

Zdroje

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