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Vplyv spôsobu pôrodu na epigenetické zmeny u novorodencov a ich zdravotné následky


Autoři: Zuzana Turcsányiová ;  Petra Gašparová ;  Zuzana Ballová ;  Erik Dosedla
Působiště autorů: Department of Gynaecology and Obstetrics, Faculty of Medicine, Pavol Jozef Safarik University in Košice, Hospital AGEL Košice-Šaca Inc., Slovak Republic
Vyšlo v časopise: Ceska Gynekol 2024; 89(4): 329-334
Kategorie: Přehledová práce
doi: https://doi.org/10.48095/cccg2024329

Souhrn

V posledných desaťročiach sme zaznamenali výrazný nárast počtu cisárskych rezov. Hoci je pôrod cisárskym rezom život zachraňujúci, je spojený so zvýšeným rizikom nepriaznivých zdravotných následkov u novorodencov, vrátane respiračných a atopických ochorení, obezity, cukrovky a závažných autoimunitných ochorení. Presné mechanizmy, ktoré sú základom týchto spojitostí zostávajú nepochopené; epigenetické modifikácie sa však ukázali ako pravdepodobný molekulárny základ spájajúci perinatálne faktory s budúcou náchylnosťou na ochorenie. Tento prehľad spája súčasnú literatúru a odhaľuje, že spôsob pôrodu môže ovplyvniť epigenetické markery u novorodencov, predovšetkým prostredníctvom zmien globálnej metylácie DNA a génovo špecifických metylačných vzorcov.

Klíčová slova:

cisársky rez – metylácia DNA – epigenetika


Zdroje

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ORCID authors
Z. Turcsányiová 0000-0002-6376-0790
P. Gašparová 0000-0002-6354-6911
Z. Ballová 0000-0002-0605-948X
E. Dosedla 0000-0001-8319-9008
Submitted/Doručené: 18. 10. 2023
Accepted/Prijaté: 20. 10. 2023
Assoc. Prof. Erik Dosedla, MD, PhD, MBA
Department of Gynaecology and Obstetrics
Faculty of Medicine
Pavol Jozef Safarik University
Hospital AGEL Košice-Šaca Inc.
Lúčna 57
040 15 Košice-Šaca
Slovak Republic
erik.dosedla@nke.agel.sk
Štítky
Dětská gynekologie Gynekologie a porodnictví Reprodukční medicína

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