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ReklamaPLOS Genetics - Číslo 4/2021
Research Article
1008973Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studiesHelian Feng, Nicholas Mancuso, Alexander Gusev, Arunabha Majumdar, Megan Major, Bogdan Pasaniuc, Peter Kraft
1009112Functional assessment of the “two-hit” model for neurodevelopmental defects in Drosophila and X. laevisLucilla Pizzo, Micaela Lasser, Tanzeen Yusuff, Matthew Jensen, Phoebe Ingraham, Emily Huber, Mayanglambam Dhruba Singh, Connor Monahan, Janani Iyer, Inshya Desai, Siddharth Karthikeyan, Dagny J. Gould, Sneha Yennawar, Alexis T. Weiner, Vijay Kumar Pounraja, Arjun Krishnan, Melissa M. Rolls, Laura Anne Lowery, Santhosh Girirajan
1009238ARID1A regulates R-loop associated DNA replication stressShuhe Tsai, Louis-Alexandre Fournier, Emily Yun-chia Chang, James P. Wells, Sean W. Minaker, Yi Dan Zhu, Alan Ying-Hsu Wang, Yemin Wang, David G. Huntsman, Peter C. Stirling
1009240Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behaviorColleen M. Palmateer, Shawn C. Moseley, Surjyendu Ray, Savannah G. Brovero, Michelle N. Arbeitman
1009275Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasisDavid Mellis, Katherine A. Staines, Silvia Peluso, Ioanna Ch. Georgiou, Natalie Dora, Malgorzata Kubiak, Rob van’t Hof, Michela Grillo, Colin Farquharson, Elaine Kinsella, Anna Thornburn, Stuart H. Ralston, Donald M. Salter, Natalia A. Riobo-Del Galdo, Robert E. Hill, Mark Ditzel
1009324Virus-derived variation in diverse human genomesShohei Kojima, Anselmo Jiro Kamada, Nicholas F. Parrish
1009327Aurora kinase A is essential for meiosis in mouse oocytesCecilia S. Blengini, Patricia Ibrahimian, Michaela Vaskovicova, David Drutovic, Petr Solc, Karen Schindler
1009329Pathways and signatures of mutagenesis at targeted DNA nicksYinbo Zhang, Luther Davis, Nancy Maizels
1009336LuxT controls specific quorum-sensing-regulated behaviors in Vibrionaceae spp. via repression of qrr1, encoding a small regulatory RNAMichaela J. Eickhoff, Chenyi Fei, Xiuliang Huang, Bonnie L. Bassler
1009364A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spotsBraedan M. McCluskey, Susumu Uji, Joseph L. Mancusi, John H. Postlethwait, David M. Parichy
1009366Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexesYing Li, Han Gong, Rui Zhan, Shushan Ouyang, Kyung-Tae Park, Joe Lutkenhaus, Shishen Du
1009406PLD3 is a neuronal lysosomal phospholipase D associated with β-amyloid plaques and cognitive function in Alzheimer’s diseaseAlex G. Nackenoff, Timothy J. Hohman, Sarah M. Neuner, Carolyn S. Akers, Nicole C. Weitzel, Alena Shostak, Shawn M. Ferguson, Bret Mobley, David A. Bennett, Julie A. Schneider, Angela L. Jefferson, Catherine C. Kaczorowski, Matthew S. Schrag
1009418Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowersFindley R. Finseth, Thomas C. Nelson, Lila Fishman
1009428Sex-stratified genome-wide association study of multisite chronic pain in UK BiobankKeira J. A. Johnston, Joey Ward, Pradipta R. Ray, Mark J. Adams, Andrew M. McIntosh, Blair H. Smith, Rona J. Strawbridge, Theodore J. Price, Daniel J. Smith, Barbara I. Nicholl, Mark E. S. Bailey
1009438Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosomeAlison H. Nguyen, Doris Bachtrog
1009455MRLocus: Identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneityAnqi Zhu, Nana Matoba, Emma P. Wilson, Amanda L. Tapia, Yun Li, Joseph G. Ibrahim, Jason L. Stein, Michael I. Love
1009457Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosisHirohisa Chiyoda, Masahiko Kume, Carla Cadena del Castillo, Kenji Kontani, Anne Spang, Toshiaki Katada, Masamitsu Fukuyama
1009464Tissue specificity-aware TWAS (TSA-TWAS) framework identifies novel associations with metabolic, immunologic, and virologic traits in HIV-positive adultsBinglan Li, Yogasudha Veturi, Anurag Verma, Yuki Bradford, Eric S. Daar, Roy M. Gulick, Sharon A. Riddler, Gregory K. Robbins, Jeffrey L. Lennox, David W. Haas, Marylyn D. Ritchie
1009465Two transcriptionally distinct pathways drive female development in a reptile with both genetic and temperature dependent sex determinationSarah L. Whiteley, Clare E. Holleley, Susan Wagner, James Blackburn, Ira W. Deveson, Jennifer A. Marshall Graves, Arthur Georges
1009469Extracellular spreading of Wingless is required for Drosophila oogenesisXiaoxi Wang, Kimberly S. LaFever, Indrayani Waghmare, Andrea Page-McCaw
1009471Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtiiAmy E. Ikui, Noriko Ueki, Kresti Pecani, Frederick R. Cross
1009476Quantifying evolutionary importance of protein sites: A Tale of two measuresAvital Sharir-Ivry, Yu Xia
1009479Optogenetic delivery of trophic signals in a genetic model of Parkinson’s diseaseAlvaro Ingles-Prieto, Nikolas Furthmann, Samuel H. Crossman, Alexandra-Madelaine Tichy, Nina Hoyer, Meike Petersen, Vanessa Zheden, Julia Biebl, Eva Reichhart, Attila Gyoergy, Daria E. Siekhaus, Peter Soba, Konstanze F. Winklhofer, Harald Janovjak
1009482Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer’s dementiaShizhen Tang, Aron S. Buchman, Philip L. De Jager, David A. Bennett, Michael P. Epstein, Jingjing Yang
1009484A mouse model of Bardet-Biedl Syndrome has impaired fear memory, which is rescued by lithium treatmentThomas K. Pak, Calvin S. Carter, Qihong Zhang, Sunny C. Huang, Charles Searby, Ying Hsu, Rebecca J. Taugher, Tim Vogel, Christopher C. Cychosz, Rachel Genova, Nina N. Moreira, Hanna Stevens, John A. Wemmie, Andrew A. Pieper, Kai Wang, Val C. Sheffield
1009485Sperm acrosome overgrowth and infertility in mice lacking chromosome 18 pachytene piRNAHeejin Choi, Zhengpin Wang, Jurrien Dean
1009491Widespread imprinting of transposable elements and variable genes in the maize endospermSarah N. Anderson, Peng Zhou, Kaitlin Higgins, Yaniv Brandvain, Nathan M. Springer
1009492A structural signature motif enlightens the origin and diversification of nuclear receptorsBrice Beinsteiner, Gabriel V. Markov, Stéphane Erb, Yassmine Chebaro, Alastair G. McEwen, Sarah Cianférani, Vincent Laudet, Dino Moras, Isabelle M. L. Billas
1009498DNA methylation patterns expose variations in enhancer-chromatin modifications during embryonic stem cell differentiationAdi Alajem, Hava Roth, Sofia Ratgauzer, Danny Bavli, Alex Motzik, Shlomtzion Lahav, Itay Peled, Oren Ram
1009499Ionotropic Receptor-dependent cool cells control the transition of temperature preference in Drosophila larvaeJordan J. Tyrrell, Jackson T. Wilbourne, Alisa A. Omelchenko, Jin Yoon, Lina Ni
1009500Opposing roles for Egalitarian and Staufen in transport, anchoring and localization of oskar mRNA in the Drosophila oocyteSabine Mohr, Andrew Kenny, Simon T. Y. Lam, Miles B. Morgan, Craig A. Smibert, Howard D. Lipshitz, Paul M. Macdonald
1009501ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary diseasePyry Helkkula, Tuomo Kiiskinen, Aki S. Havulinna, Juha Karjalainen, Seppo Koskinen, Veikko Salomaa, Mark J. Daly, Aarno Palotie, Ida Surakka, Samuli Ripatti,
10095021009505The canonical α-SNAP is essential for gametophytic development in ArabidopsisFei Liu, Ji-Peng Li, Lu-Shen Li, Qi Liu, Shan-Wei Li, Ming-Lei Song, Sha Li, Yan Zhang
1009512The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosisVirginia L. King, Nathan K. Leclair, Alyssa M. Coulter, Kenneth G. Campellone
1009514Subunit P60 of phosphatidylinositol 3-kinase promotes cell proliferation or apoptosis depending on its phosphorylation statusYu-Qin Di, Yu-Meng Zhao, Ke-Yan Jin, Xiao-Fan Zhao
1009521Dynamic post-transcriptional regulation by Mrn1 links cell wall homeostasis to mitochondrial structure and functionKendra Reynaud, Molly Brothers, Michael Ly, Nicholas T. Ingolia
1009523Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regionsKiwon Park, Jeongmin Ryoo, Heena Jeong, Minsu Kim, Sungwon Lee, Sung-Yeon Hwang, Jiyoung Ahn, Doyeon Kim, Hyungseok C. Moon, Daehyun Baek, Kwangsoo Kim, Hye Yoon Park, Kwangseog Ahn
1009524Trehalose and α-glucan mediate distinct abiotic stress responses in Pseudomonas aeruginosaStuart D. Woodcock, Karl Syson, Richard H. Little, Danny Ward, Despoina Sifouna, James K. M. Brown, Stephen Bornemann, Jacob G. Malone
1009525Using genetic variants to evaluate the causal effect of cholesterol lowering on head and neck cancer risk: A Mendelian randomization studyMark Gormley, James Yarmolinsky, Tom Dudding, Kimberley Burrows, Richard M. Martin, Steven Thomas, Jessica Tyrrell, Paul Brennan, Miranda Pring, Stefania Boccia, Andrew F. Olshan, Brenda Diergaarde, Rayjean J. Hung, Geoffrey Liu, Danny Legge, Eloiza H. Tajara, Patricia Severino, Martin Lacko, Andrew R. Ness, George Davey Smith, Emma E. Vincent, Rebecca C. Richmond
1009532Evolutionary dynamics of the human pseudoautosomal regionsBruno Monteiro, Miguel Arenas, Maria Joao Prata, António Amorim
1009535Intercellular viral spread and intracellular transposition of Drosophila gypsyRichard M. Keegan, Lillian R. Talbot, Yung-Heng Chang, Michael J. Metzger, Josh Dubnau
1009536An insulator blocks access to enhancers by an illegitimate promoter, preventing repression by transcriptional interferenceMiki Fujioka, Anastasiya Nezdyur, James B. Jaynes
1009537Coordinating the morphogenesis-differentiation balance by tweaking the cytokinin-gibberellin equilibriumAlon Israeli, Yogev Burko, Sharona Shleizer-Burko, Iris Daphne Zelnik, Noa Sela, Mohammad R. Hajirezaei, Alisdair R. Fernie, Takayuki Tohge, Naomi Ori, Maya Bar
1009538Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiaeKotchaphorn Mangkalaphiban, Feng He, Robin Ganesan, Chan Wu, Richard Baker, Allan Jacobson
1009541Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clusteringLeonor García-Bayona, Michael J. Coyne, Laurie E. Comstock
1009549DNA methylation-mediated modulation of rapid desiccation tolerance acquisition and dehydration stress memory in the resurrection plant Boea hygrometricaRun-Ze Sun, Jie Liu, Yuan-Yuan Wang, Xin Deng
Perspective
1009494Putting the brakes on centromere drive in MimulusChing-Ho Chang, Harmit S. Malik
Viewpoints
1009496Multiplexed assays reveal effects of missense variants in MSH2 and cancer predispositionSofie V. Nielsen, Rasmus Hartmann-Petersen, Amelie Stein, Kresten Lindorff-Larsen
Correction
1009503Correction: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver diseaseConnor A. Emdin, Mary E. Haas, Amit V. Khera, Krishna Aragam, Mark Chaffin, Derek Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, Qiping Feng, Juha Karjalainen, Aki Havulinna, Tuomo Kiiskinen, Alexander Bick, Diego Ardissino, James G. Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J. Bown, Nilesh J. Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Ben Voight, Scott Damrauer, Julie Lynch, David Kaplan, Marina Serper, Philip Tsao, Million Veteran Program, Josep Mercader, Craig Hanis, Mark Daly, Joshua Denny, Stacey Gabriel, Sekar Kathiresan
1009504Correction: Inference of past demography, dormancy and self-fertilization rates from whole genome sequence dataThibaut Paul Patrick Sellinger, Diala Abu Awad, Markus Moest, Aurélien Tellier
1009509Correction: Genome-Wide Reprogramming of Transcript Architecture by Temperature Specifies the Developmental States of the Human Pathogen HistoplasmaSarah A. Gilmore, Mark Voorhies, Dana Gebhart, Anita Sil
PLOS Genetics
2021 Číslo 4
Nejčtenější v tomto čísle- Aicardi-Goutières syndrome-associated gene SAMHD1 preserves genome integrity by preventing R-loop formation at transcription–replication conflict regions
- Functional assessment of the “two-hit” model for neurodevelopmental defects in Drosophila and X. laevis
- Aurora kinase A is essential for meiosis in mouse oocytes
- Pathways and signatures of mutagenesis at targeted DNA nicks
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