Factors influencing the presence of Klebsiella pneumoniae and Klebsiella oxytoca species complexes in the developing gut microbiota

Česká verze

Authors: K. Horváthová ¹; N. Modráčková ¹ ; J. Vinkler ¹; I. Šplíchal ² ; A. Šplíchalová ² ; E. Vlková ¹ ; V. Neužil Bunešová ¹
Authors place of work: Katedra mikrobiologie, výživy a dietetiky, Fakulta agrobiologie, potravinových a přírodních zdrojů, Česká zemědělská univerzita v Praze ¹; Laboratoř gnotobiologie, Mikrobiologický ústav AV ČR, v. v. i., Nový Hrádek ²
Published in the journal: Epidemiol. Mikrobiol. Imunol. 75, 2026, č. 2, s. 79-88
Category: Souhrnná sdělení
doi: https://doi.org/10.61568/emi/11-6717/20260323/143211

Summary

Bacteria of the genus Klebsiella, particularly members of the Klebsiella pneumoniae and Klebsiella oxytoca species complexes, are common commensals of the intestinal microbiota in neonates and infants. Under certain conditions, they may exhibit pathogenic behaviour and cause severe nosocomial infections, especially in preterm and immunocompromised children. Colonization by Klebsiella spp. is influenced by a range of perinatal and postnatal factors. The clinical significance of these opportunistically pathogenic strains is further amplified by their ability to acquire multidrug resistance, which complicates the treatment of infections and increases the risk of adverse clinical outcomes. This review focuses on the analysis of conditions and factors involved in the occurrence of Klebsiella species in the developing neonatal and infant gut microbiota and their role in nosocomial infections. Particular attention is given to species within the K. pneumoniae and K. oxytoca complexes, which include the most clinically relevant opportunistically pathogenic strains of this genus in this age group. In addition, this review discusses the potential of experimental animal models in studying the pathogenesis of these infections.

Keywords:

gut microbiota – Animal models – Neonates – Antibiotic resistance – Nosocomial infections – Klebsiella spp.

Zdroje

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